Hiroyoshi Takeuchi

Summary

Country: Japan

Publications

  1. ncbi request reprint Lack of effect of risperidone or olanzapine dose reduction on subjective experiences in stable patients with schizophrenia
    Hiroyoshi Takeuchi
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Schizophrenia Division, Complex Mental Illness Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8 Electronic address
    Psychiatry Res 218:244-6. 2014
  2. ncbi request reprint Impact of once- versus twice-daily perphenazine dosing on clinical outcomes: an analysis of the CATIE data
    Hiroyoshi Takeuchi
    Schizophrenia Division, Complex Mental Illness Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, M5T 1R8, Canada
    J Clin Psychiatry 75:506-11. 2014
  3. ncbi request reprint Estimated dopamine D2 receptor occupancy from plasma concentrations of atypical antipsychotics and subjective experience/drug attitude in schizophrenia: an analysis of the CATIE data
    Hiroyoshi Takeuchi
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Schizophrenia Division, Complex Mental Illness Program, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Psychiatry, University of Toronto, ON, Canada Electronic address
    Schizophr Res 150:373-9. 2013
  4. doi request reprint Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithms
    Hiroyoshi Takeuchi
    Keio University, School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    Schizophr Res 134:219-25. 2012
  5. doi request reprint How long to wait before reducing antipsychotic dosage in stabilized patients with schizophrenia? A retrospective chart review
    Hiroyoshi Takeuchi
    Keio University, School of Medicine, Department of Neuropsychiatry, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Psychiatr Res 45:1083-8. 2011
  6. doi request reprint A systematic review of reported cases involving psychotic symptoms worsened by aripiprazole in schizophrenia or schizoaffective disorder
    Hiroyoshi Takeuchi
    Schizophrenia Division Complex Mental Illness Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 228:175-85. 2013
  7. pmc Effects of risperidone and olanzapine dose reduction on cognitive function in stable patients with schizophrenia: an open-label, randomized, controlled, pilot study
    Hiroyoshi Takeuchi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Bull 39:993-8. 2013
  8. doi request reprint A randomized, open-label comparison of 2 switching strategies to aripiprazole treatment in patients with schizophrenia: add-on, wait, and tapering of previous antipsychotics versus add-on and simultaneous tapering
    Hiroyoshi Takeuchi
    Oizumi Hospital, 6 9 1 Oizumigakuen cho, Nerima ku, Tokyo 178 0061, Japan
    J Clin Psychopharmacol 28:540-3. 2008
  9. doi request reprint Augmentation of atypical antipsychotics with valproic acid. An open-label study for most difficult patients with schizophrenia
    Takefumi Suzuki
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Hum Psychopharmacol 24:628-38. 2009
  10. doi request reprint Effectiveness of antipsychotic polypharmacy for patients with treatment refractory schizophrenia: an open-label trial of olanzapine plus risperidone for those who failed to respond to a sequential treatment with olanzapine, quetiapine and risperidone
    Takefumi Suzuki
    Department of Neuro Psychiatry, School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Hum Psychopharmacol 23:455-63. 2008

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Lack of effect of risperidone or olanzapine dose reduction on subjective experiences in stable patients with schizophrenia
    Hiroyoshi Takeuchi
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Schizophrenia Division, Complex Mental Illness Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8 Electronic address
    Psychiatry Res 218:244-6. 2014
    ..Subjective experiences were assessed at baseline and 28 weeks using three different self-rating scales. No significant differences in changes of subjective experiences were observed between the two groups. ..
  2. ncbi request reprint Impact of once- versus twice-daily perphenazine dosing on clinical outcomes: an analysis of the CATIE data
    Hiroyoshi Takeuchi
    Schizophrenia Division, Complex Mental Illness Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, M5T 1R8, Canada
    J Clin Psychiatry 75:506-11. 2014
    ..The objective of this study was to evaluate the impact of once- versus twice-daily dosing of perphenazine, which has a plasma half-life of 8-12 hours, on clinical outcomes in patients with schizophrenia...
  3. ncbi request reprint Estimated dopamine D2 receptor occupancy from plasma concentrations of atypical antipsychotics and subjective experience/drug attitude in schizophrenia: an analysis of the CATIE data
    Hiroyoshi Takeuchi
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Schizophrenia Division, Complex Mental Illness Program, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Psychiatry, University of Toronto, ON, Canada Electronic address
    Schizophr Res 150:373-9. 2013
    ....
  4. doi request reprint Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithms
    Hiroyoshi Takeuchi
    Keio University, School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    Schizophr Res 134:219-25. 2012
    ..Antipsychotic treatment strategy for the maintenance phase of schizophrenia has been inconsistent in the literature. The purpose of this systematic review is to overview recommendations in various guidelines and algorithms...
  5. doi request reprint How long to wait before reducing antipsychotic dosage in stabilized patients with schizophrenia? A retrospective chart review
    Hiroyoshi Takeuchi
    Keio University, School of Medicine, Department of Neuropsychiatry, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Psychiatr Res 45:1083-8. 2011
    ..Antipsychotic dose reduction is generally recommended to occur after six months of clinical stabilization despite inadequate evidence. This timing issue was addressed in this study...
  6. doi request reprint A systematic review of reported cases involving psychotic symptoms worsened by aripiprazole in schizophrenia or schizoaffective disorder
    Hiroyoshi Takeuchi
    Schizophrenia Division Complex Mental Illness Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 228:175-85. 2013
    ..Numerous case reports have suggested that aripiprazole can worsen psychotic symptoms in schizophrenia...
  7. pmc Effects of risperidone and olanzapine dose reduction on cognitive function in stable patients with schizophrenia: an open-label, randomized, controlled, pilot study
    Hiroyoshi Takeuchi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Bull 39:993-8. 2013
    ..Moreover, potential risks of relapse following antipsychotic dose reduction should be thoroughly investigated in longer term studies. ..
  8. doi request reprint A randomized, open-label comparison of 2 switching strategies to aripiprazole treatment in patients with schizophrenia: add-on, wait, and tapering of previous antipsychotics versus add-on and simultaneous tapering
    Hiroyoshi Takeuchi
    Oizumi Hospital, 6 9 1 Oizumigakuen cho, Nerima ku, Tokyo 178 0061, Japan
    J Clin Psychopharmacol 28:540-3. 2008
    ..Taken together with similar results from subjective assessments, it would be reasonable to choose either of these 2 strategies in clinical practice based on a patients' preference...
  9. doi request reprint Augmentation of atypical antipsychotics with valproic acid. An open-label study for most difficult patients with schizophrenia
    Takefumi Suzuki
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Hum Psychopharmacol 24:628-38. 2009
    ..Most difficult inpatients with schizophrenia are in serious needs but obviously underrepresented in clinical trials...
  10. doi request reprint Effectiveness of antipsychotic polypharmacy for patients with treatment refractory schizophrenia: an open-label trial of olanzapine plus risperidone for those who failed to respond to a sequential treatment with olanzapine, quetiapine and risperidone
    Takefumi Suzuki
    Department of Neuro Psychiatry, School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Hum Psychopharmacol 23:455-63. 2008
    ..To evaluate the effectiveness of antipsychotic polypharmacy in a methodologically sound manner...
  11. ncbi request reprint How effective is it to sequentially switch among Olanzapine, Quetiapine and Risperidone?--A randomized, open-label study of algorithm-based antipsychotic treatment to patients with symptomatic schizophrenia in the real-world clinical setting
    Takefumi Suzuki
    Department of Neuro Psychiatry, School of Medicine, Keio University, 35, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Psychopharmacology (Berl) 195:285-95. 2007
    ..Evidence on sequential trial with atypical antipsychotics has been scarce...
  12. pmc Dental conditions in inpatients with schizophrenia: a large-scale multi-site survey
    Hideaki Tani
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Oral Health 12:32. 2012
    ..The objective of this study was to examine dental caries and to identify clinical and demographic variables associated with poor dental condition in patients with schizophrenia...
  13. doi request reprint Survey of benzodiazepine and antidepressant use in outpatients with mood disorders in Japan
    Hiroyuki Uchida
    Keio University, School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 63:244-6. 2009
    ..The frequent use of benzodiazepines is a cause for concern because they are not preferred treatment, given their well-known adverse effects especially in the elderly...
  14. doi request reprint Novel rating scales for schizophrenia - Targeted Inventory on Problems in Schizophrenia (TIP-Sz) and Functional Assessment for Comprehensive Treatment of Schizophrenia (FACT-Sz)
    Takefumi Suzuki
    Keio University, School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    Schizophr Res 106:328-36. 2008
    ..Relevant, quick, and user-friendly assessment scales are needed to facilitate measurement-based treatment of schizophrenia...
  15. doi request reprint A cross-sectional study of plasma risperidone levels with risperidone long-acting injectable: implications for dopamine D2 receptor occupancy during maintenance treatment in schizophrenia
    Saeko Ikai
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    J Clin Psychiatry 73:1147-52. 2012
    ..The data are especially scarce for long-acting antipsychotic formulations...
  16. doi request reprint Benzodiazepine and antidepressant use in elderly patients with anxiety disorders: a survey of 796 outpatients in Japan
    Hiroyuki Uchida
    Keio University, School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
    J Anxiety Disord 23:477-81. 2009
    ..The very high use of anxiolytics in the elderly, especially in the absence of concomitant antidepressant use, is a cause for concern since they are not a preferred long-term treatment strategy given their adverse effects in the elderly...
  17. doi request reprint The evolution of antipsychotic switch and polypharmacy in natural practice--a longitudinal perspective
    Chisa Tsutsumi
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Schizophr Res 130:40-6. 2011
    ..The objective of this study was to examine the evolution of antipsychotic switch and polypharmacy in the real-world from a longitudinal perspective...
  18. ncbi request reprint Is switching antidepressants following early nonresponse more beneficial in acute-phase treatment of depression?: a randomized open-label trial
    Shinichiro Nakajima
    Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1983-9. 2011
    ....
  19. doi request reprint Magnitude of rater differences in assessment scales for schizophrenia
    Takefumi Suzuki
    Department of Neuropsychiatry, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Clin Psychopharmacol 30:607-11. 2010
    ..The magnitude of differences described herein seems to be an underestimation, and the baseline scores by the independent new raters might need to be corrected for those by the PICs...
  20. ncbi request reprint Simplifying psychotropic medication regimen into a single night dosage and reducing the dose for patients with chronic schizophrenia
    Takefumi Suzuki
    Department of Neuropsychiatry, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    Psychopharmacology (Berl) 181:566-75. 2005
    ..Taking psychotropic medications is frequently problematic from both consumers' and caregivers' perspective. Occasionally missed doses may lead to pervasive non-adherence with relapse a likely outcome...
  21. doi request reprint Changes in metabolic parameters following a switch to aripiprazole in Japanese patients with schizophrenia: One-year follow-up study
    Hiroyoshi Takeuchi
    Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 64:104-6. 2010
    ..Given known detrimental metabolic and hormonal effects of some atypical antipsychotics, a switch to aripiprazole may warrant serious consideration also in Asian patients who suffer those side-effects...
  22. pmc Low dose vs standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysis
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Schizophr Bull 37:788-99. 2011
    ....
  23. doi request reprint Dopamine D2 receptor occupancy and clinical effects: a systematic review and pooled analysis
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    J Clin Psychopharmacol 31:497-502. 2011
    ....
  24. pmc Factor structure of the targeted inventory on problems in schizophrenia
    Shoji Tanaka
    Department of Information and Communication Sciences, Sophia University, Tokyo, Japan
    Clin Psychopharmacol Neurosci 11:18-23. 2013
    ..Determining the factor structure will be useful in the brief evaluation of medication and non-medication treatment of the disease...
  25. doi request reprint Patient's trust in their psychiatrist: a cross-sectional survey
    Atsumi Minamisawa
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Eur Arch Psychiatry Clin Neurosci 261:603-8. 2011
    ..Furthermore, this likely holds more true for patients with neurotic disorders...
  26. doi request reprint Predicting dopamine D₂ receptor occupancy from plasma levels of antipsychotic drugs: a systematic review and pooled analysis
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    J Clin Psychopharmacol 31:318-25. 2011
    ..1 (-3.3 to 3.1) and 12.3 (8.8-15.7) for ziprasidone (n = 31), respectively. These findings suggest that D₂ occupancy of antipsychotics could be estimated with a high degree of accuracy using widely available plasma levels...
  27. ncbi request reprint Combined treatment with sulpiride and paroxetine for accelerated response in patients with major depressive disorder
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan
    J Clin Psychopharmacol 25:545-51. 2005
    ..The combination treatment may be a safe and effective strategy for accelerating antidepressant response...
  28. doi request reprint Impacts of switching antidepressants after successful electroconvulsive therapy on the maintenance of clinical remission in patients with treatment-resistant depression: a chart review
    Shinichiro Nakajima
    Oizumi Hospital and daggerDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan
    J ECT 25:178-81. 2009
    ..In this study, we conducted a chart review to examine impacts of the antidepressant switch after the successful ECT on 1-year outcome in patients with TRD...
  29. ncbi request reprint Effect of antipsychotic medication on overall life satisfaction among individuals with chronic schizophrenia: Findings from the NIMH CATIE study
    Gagan Fervaha
    Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8 Institute of Medical Science, University of Toronto, Toronto, Canada Electronic address
    Eur Neuropsychopharmacol 24:1078-85. 2014
    ..Clinicians should be aware that these two domains are not inextricably linked. ..
  30. pmc The potential role of dopamine D₃ receptor neurotransmission in cognition
    Shinichiro Nakajima
    Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Canada M5T 1R8
    Eur Neuropsychopharmacol 23:799-813. 2013
    ..Clinical trials are needed to confirm these effects...
  31. doi request reprint The neurobiology of relapse in schizophrenia
    Gary Remington
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada Electronic address
    Schizophr Res 152:381-90. 2014
    ..We propose that it is shaped by the form of illness and in place from the outset, modified by constitutional factors like resilience, as well as treatment, and confounded by secondary forms of relapse. ..
  32. ncbi request reprint Incidence of deep vein thrombosis in restrained psychiatric patients
    Takuto Ishida
    Department of Psychiatry, Sakuragaoka Memorial Hospital, Tokyo, Japan Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Electronic address
    Psychosomatics 55:69-75. 2014
    ..Although physical restraint is still used in psychiatric inpatient settings, it sometimes causes serious side effects, including deep vein thrombosis (DVT) and resulting pulmonary embolism...
  33. doi request reprint Clinical determinants of life satisfaction in chronic schizophrenia: data from the CATIE study
    Gagan Fervaha
    Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Canada Institute of Medical Science, University of Toronto, Toronto, Canada Electronic address
    Schizophr Res 151:203-8. 2013
    ..The present study sought to focus on global life satisfaction as a key subjective domain and determine its relationship with clinical variables...
  34. pmc Melancholic and reactive depression: a reappraisal of old categories
    Jin Mizushima
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Psychiatry 13:311. 2013
    ..We therefore conducted a survey to examine how psychiatrists in Japan differentiate patients with major depressive disorder who present mainly with melancholic features and those with reactive features...