Research Topics
Genomes and Genes | Toshi KomurasakiSummaryAffiliation: Taisho Pharmaceutical Co Country: Japan Publications
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Publications
Mechanism of growth promoting activity of epiregulin in primary cultures of rat hepatocytesToshi Komurasaki
Department of Molecular and Cellular Biology, Molecular Biology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
Growth Factors 20:61-9. 2002..Our findings suggest that epiregulin may play significant roles in liver regeneration following partial hepatectomy in cooperation with other growth factors...- Early induction of osteoactivin expression in rat renal tubular epithelial cells after unilateral ureteral obstructionAtsushi Nakamura
Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama shi, Saitama, Japan
Exp Toxicol Pathol 59:53-9. 2007.... - A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cellsShinichi Nishimoto
Department of Molecular and Cellular Biology, Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Yoshino cho, Saitama shi, Japan
Eur J Biochem 270:2521-31. 2003..Our results imply that smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury... - Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compoundsTakako Sudo
Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
Exp Anim 54:385-94. 2005..The DCXR Tg mice and the Tg x KK-A(y) hybrid mice, therefore, serve as specific models for carbonyl metabolism in the kidney with diabetic background... - Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstructionAtsushi Nakamura
Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama Shi 331 9530, Saitama, Japan
Exp Toxicol Pathol 59:1-7. 2007.... - Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin geneCharlotta Lindvall
Department of Molecular Medicine, Karolinska Hospital and Institutet, SE 171 76 Stockholm, Sweden
Cancer Res 63:1743-7. 2003.... - Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activationBradley K Draper
Department of Medicine Dermatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Cell Biochem 89:1126-37. 2003..5-fold increase in p-ERK1/2. When compared with EGF or TGFalpha, EPR is a more potent and more effective inducer of in vitro wound closure due to its ability to promote significantly greater ERK/MAPK activation... - Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cellsMasanori Takahashi
Department of Neuroscience, Osaka University Graduate School of Medicine D13, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Circulation 108:2524-9. 2003..In this study, we sought to identify the dedifferentiation factor(s) derived from vascular SMCs (VSMCs)... 
Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomasShaowei Li
Department of Dermatology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4712, USA
Proc Natl Acad Sci U S A 105:3539-44. 2008..These results suggest that hamartomatous TSC skin tumors are induced by paracrine factors released by two-hit cells in the dermis and that proliferation with mTOR activation of the overlying epidermis is an effect of epiregulin...- Effect of epiregulin on pancreatic beta cell growth and insulin secretionEmmanuelle Kuntz
European Centre for the Study of Diabetes, Faculty of Medicine, Strasbourg, France
Growth Factors 23:285-93. 2005..Finally, in the two cell lines expressing ErbB receptors, we demonstrated that only EGFR/ErbB1 was activated by epiregulin. Thus, epiregulin appears as a new growth and insulinotropic factor in pancreatic beta cell lines... - Psychophysiological stress-regulated gene expression in miceShigenori Murata
DNA Chip Research Inc, 1 1 43 Suehiro, Tsurumi, Yokohama 230 0045, Japan
FEBS Lett 579:2137-42. 2005..These results suggest that some stress-response mechanisms, including transcriptional and post-transcriptional events, are coordinated in the whole body in mice under psychophysiological stress... - Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cellsTatsuro Miyahara
Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, 930 0194, Japan
Toxicology 200:159-67. 2004..From these results, it was suggested that activation of each of the ERK1/2, p38, and JNK MAPK cascades in addition to that of PKC and cPLA2 played an important role in the Cd-stimulated biosynthesis of PGE2 in mouse osteoblastic cells... - Topical epiregulin enhances repair of murine excisional woundsBradley K Draper
Department of Medicine Dermatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Wound Repair Regen 11:188-97. 2003..Furthermore, epiregulin is more potent and more effective than epidermal growth factor in promoting proliferation and maturation of the epidermis as well as enhancement of the neodermis... 
Common behavioral influences of the ErbB1 ligands transforming growth factor alpha and epiregulin administered to mouse neonatesNoriko Tsuda
Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
Brain Dev 30:533-43. 2008..Abnormal ErbB1 ligand production at neonatal and potentially prenatal stages might therefore associate with neurodevelopmental disorders such as schizophrenia...