Toshi Komurasaki

Summary

Affiliation: Taisho Pharmaceutical Co
Country: Japan

Publications

  1. ncbi request reprint Mechanism of growth promoting activity of epiregulin in primary cultures of rat hepatocytes
    Toshi Komurasaki
    Department of Molecular and Cellular Biology, Molecular Biology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Growth Factors 20:61-9. 2002
  2. ncbi request reprint Early induction of osteoactivin expression in rat renal tubular epithelial cells after unilateral ureteral obstruction
    Atsushi Nakamura
    Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama shi, Saitama, Japan
    Exp Toxicol Pathol 59:53-9. 2007
  3. ncbi request reprint A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells
    Shinichi Nishimoto
    Department of Molecular and Cellular Biology, Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Yoshino cho, Saitama shi, Japan
    Eur J Biochem 270:2521-31. 2003
  4. ncbi request reprint Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compounds
    Takako Sudo
    Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Exp Anim 54:385-94. 2005
  5. ncbi request reprint Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction
    Atsushi Nakamura
    Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama Shi 331 9530, Saitama, Japan
    Exp Toxicol Pathol 59:1-7. 2007
  6. ncbi request reprint Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene
    Charlotta Lindvall
    Department of Molecular Medicine, Karolinska Hospital and Institutet, SE 171 76 Stockholm, Sweden
    Cancer Res 63:1743-7. 2003
  7. ncbi request reprint Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation
    Bradley K Draper
    Department of Medicine Dermatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 89:1126-37. 2003
  8. ncbi request reprint Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells
    Masanori Takahashi
    Department of Neuroscience, Osaka University Graduate School of Medicine D13, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 108:2524-9. 2003
  9. pmc Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas
    Shaowei Li
    Department of Dermatology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4712, USA
    Proc Natl Acad Sci U S A 105:3539-44. 2008
  10. ncbi request reprint Effect of epiregulin on pancreatic beta cell growth and insulin secretion
    Emmanuelle Kuntz
    European Centre for the Study of Diabetes, Faculty of Medicine, Strasbourg, France
    Growth Factors 23:285-93. 2005

Collaborators

  • Daisuke Uchida
  • Tatsuya Ohnuki
  • Tatsuro Miyahara
  • Bradley K Draper
  • Marie Henriksson
  • Atsushi Nakamura
  • Shaowei Li
  • Noriko Tsuda
  • Chieri Ohata
  • Aiko Ishii
  • Takako Sudo
  • Shigenori Murata
  • Emmanuelle Kuntz
  • Shinichi Nishimoto
  • Masanori Takahashi
  • Charlotta Lindvall
  • Hiroyuki Nawa
  • Thomas N Darling
  • Ji An Wang
  • Eric M Billings
  • Makoto Mizuno
  • Gustavo Pacheco-Rodriguez
  • Fumiko Takeuchi
  • Takayuki Yamanaka
  • Qingyuan Fan
  • Joel Moss
  • Makoto Yoshimoto
  • Yukiko Sakai
  • Michel Pinget
  • Christiane Damg√©
  • Rene Gross
  • Mitori Kogure
  • Junichi Nakagawa
  • Chun Ren Lim
  • Kenichi Matsubara
  • Yoshikatsu Uematsu
  • Taeko Yoshiara
  • Christophe Broca
  • Norihiro Tada
  • Marie Christine Kaltenbacher
  • Masako Saitoh
  • Maiko Sugino
  • Jun Asami
  • Kenji Yoshida
  • Akira Kitabatake
  • Kenji Sobue
  • Morito Monden
  • John M Sedivy
  • Akira Ogawa
  • Yasuyuki Ohkawa
  • Ken ichiro Hayashi
  • Masahiko Yano
  • Wataru Nishida
  • Mi Hou
  • Junko Tawara
  • Dawei Xu
  • Magnus Nordenskjold
  • Bin Tean Teh
  • Hitoshi Toyoda
  • Kunihiro Kitamura
  • Magnus Bjorkholm
  • Chengyun Zheng

Detail Information

Publications14

  1. ncbi request reprint Mechanism of growth promoting activity of epiregulin in primary cultures of rat hepatocytes
    Toshi Komurasaki
    Department of Molecular and Cellular Biology, Molecular Biology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Growth Factors 20:61-9. 2002
    ..Our findings suggest that epiregulin may play significant roles in liver regeneration following partial hepatectomy in cooperation with other growth factors...
  2. ncbi request reprint Early induction of osteoactivin expression in rat renal tubular epithelial cells after unilateral ureteral obstruction
    Atsushi Nakamura
    Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama shi, Saitama, Japan
    Exp Toxicol Pathol 59:53-9. 2007
    ....
  3. ncbi request reprint A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells
    Shinichi Nishimoto
    Department of Molecular and Cellular Biology, Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Yoshino cho, Saitama shi, Japan
    Eur J Biochem 270:2521-31. 2003
    ..Our results imply that smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury...
  4. ncbi request reprint Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compounds
    Takako Sudo
    Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Exp Anim 54:385-94. 2005
    ..The DCXR Tg mice and the Tg x KK-A(y) hybrid mice, therefore, serve as specific models for carbonyl metabolism in the kidney with diabetic background...
  5. ncbi request reprint Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction
    Atsushi Nakamura
    Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama Shi 331 9530, Saitama, Japan
    Exp Toxicol Pathol 59:1-7. 2007
    ....
  6. ncbi request reprint Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene
    Charlotta Lindvall
    Department of Molecular Medicine, Karolinska Hospital and Institutet, SE 171 76 Stockholm, Sweden
    Cancer Res 63:1743-7. 2003
    ....
  7. ncbi request reprint Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation
    Bradley K Draper
    Department of Medicine Dermatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Biochem 89:1126-37. 2003
    ..5-fold increase in p-ERK1/2. When compared with EGF or TGFalpha, EPR is a more potent and more effective inducer of in vitro wound closure due to its ability to promote significantly greater ERK/MAPK activation...
  8. ncbi request reprint Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells
    Masanori Takahashi
    Department of Neuroscience, Osaka University Graduate School of Medicine D13, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 108:2524-9. 2003
    ..In this study, we sought to identify the dedifferentiation factor(s) derived from vascular SMCs (VSMCs)...
  9. pmc Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas
    Shaowei Li
    Department of Dermatology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4712, USA
    Proc Natl Acad Sci U S A 105:3539-44. 2008
    ..These results suggest that hamartomatous TSC skin tumors are induced by paracrine factors released by two-hit cells in the dermis and that proliferation with mTOR activation of the overlying epidermis is an effect of epiregulin...
  10. ncbi request reprint Effect of epiregulin on pancreatic beta cell growth and insulin secretion
    Emmanuelle Kuntz
    European Centre for the Study of Diabetes, Faculty of Medicine, Strasbourg, France
    Growth Factors 23:285-93. 2005
    ..Finally, in the two cell lines expressing ErbB receptors, we demonstrated that only EGFR/ErbB1 was activated by epiregulin. Thus, epiregulin appears as a new growth and insulinotropic factor in pancreatic beta cell lines...
  11. ncbi request reprint Psychophysiological stress-regulated gene expression in mice
    Shigenori Murata
    DNA Chip Research Inc, 1 1 43 Suehiro, Tsurumi, Yokohama 230 0045, Japan
    FEBS Lett 579:2137-42. 2005
    ..These results suggest that some stress-response mechanisms, including transcriptional and post-transcriptional events, are coordinated in the whole body in mice under psychophysiological stress...
  12. ncbi request reprint Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells
    Tatsuro Miyahara
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, 930 0194, Japan
    Toxicology 200:159-67. 2004
    ..From these results, it was suggested that activation of each of the ERK1/2, p38, and JNK MAPK cascades in addition to that of PKC and cPLA2 played an important role in the Cd-stimulated biosynthesis of PGE2 in mouse osteoblastic cells...
  13. ncbi request reprint Topical epiregulin enhances repair of murine excisional wounds
    Bradley K Draper
    Department of Medicine Dermatology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Wound Repair Regen 11:188-97. 2003
    ..Furthermore, epiregulin is more potent and more effective than epidermal growth factor in promoting proliferation and maturation of the epidermis as well as enhancement of the neodermis...
  14. doi request reprint Common behavioral influences of the ErbB1 ligands transforming growth factor alpha and epiregulin administered to mouse neonates
    Noriko Tsuda
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Brain Dev 30:533-43. 2008
    ..Abnormal ErbB1 ligand production at neonatal and potentially prenatal stages might therefore associate with neurodevelopmental disorders such as schizophrenia...