Yuji Matsuzawa

Summary

Affiliation: Sumitomo Hospital
Country: Japan

Publications

  1. ncbi request reprint Adipocytokines: emerging therapeutic targets
    Yuji Matsuzawa
    Sumitomo Hospital, Kita ku, Osaka 530 0005, Japan
    Curr Atheroscler Rep 7:58-62. 2005
  2. ncbi request reprint The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka, Japan
    J Atheroscler Thromb 18:629-39. 2011
  3. ncbi request reprint Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease
    Yuji Matsuzawa
    Sumitomo Hospital, 5 3 20, Nakanoshima Kita ku, Osaka 530 0005, Japan
    Atheroscler Suppl 6:7-14. 2005
  4. ncbi request reprint White adipose tissue and cardiovascular disease
    Yuji Matsuzawa
    Sumitomo Hospital and Osaka University, 5 3 20 Nakanoshima, Osaka, Japan
    Best Pract Res Clin Endocrinol Metab 19:637-47. 2005
  5. ncbi request reprint Importance of adipocytokines in obesity-related diseases
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Horm Res 60:56-9. 2003
  6. ncbi request reprint Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka, Japan
    Nat Clin Pract Cardiovasc Med 3:35-42. 2006
  7. ncbi request reprint Adiponectin and metabolic syndrome
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School, Sumitomo Hospital, Osaka, Japan
    Arterioscler Thromb Vasc Biol 24:29-33. 2004
  8. ncbi request reprint The metabolic syndrome and adipocytokines
    Yuji Matsuzawa
    Sumitomo Hospital, Professor Emeritus Osaka University, 5 3 20 Nakanoshima, Kita ku, Osaka 530 0005, Japan
    FEBS Lett 580:2917-21. 2006
  9. doi request reprint The role of fat topology in the risk of disease
    Y Matsuzawa
    Sumitomo Hospital, Professor Emeritus Osaka University, Kita ku, Osaka, Japan
    Int J Obes (Lond) 32:S83-92. 2008
  10. ncbi request reprint Adiponectin: a key player in obesity related disorders
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka, Japan
    Curr Pharm Des 16:1896-901. 2010

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Adipocytokines: emerging therapeutic targets
    Yuji Matsuzawa
    Sumitomo Hospital, Kita ku, Osaka 530 0005, Japan
    Curr Atheroscler Rep 7:58-62. 2005
    ..In this review, the importance of adipocytokines, including adiponectin, is discussed with respect to atherosclerosis...
  2. ncbi request reprint The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka, Japan
    J Atheroscler Thromb 18:629-39. 2011
    ....
  3. ncbi request reprint Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease
    Yuji Matsuzawa
    Sumitomo Hospital, 5 3 20, Nakanoshima Kita ku, Osaka 530 0005, Japan
    Atheroscler Suppl 6:7-14. 2005
    ..Current management strategies that may increase endogenous adiponectin production in humans include weight loss, soy protein and therapy with peroxisome proliferator-activating receptor gamma (PPARgamma) agonists...
  4. ncbi request reprint White adipose tissue and cardiovascular disease
    Yuji Matsuzawa
    Sumitomo Hospital and Osaka University, 5 3 20 Nakanoshima, Osaka, Japan
    Best Pract Res Clin Endocrinol Metab 19:637-47. 2005
    ..In this review, the importance of adipocytokines, including adiponectin, is discussed with respect to cardiovascular disease...
  5. ncbi request reprint Importance of adipocytokines in obesity-related diseases
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Horm Res 60:56-9. 2003
    ..Adiponectin knockout mice showed severe insulin resistance and impaired glucose metabolism when fed a high-fat, high-sucrose diet. Knockout mice also developed intimal thickening in response to endothelial injury...
  6. ncbi request reprint Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka, Japan
    Nat Clin Pract Cardiovasc Med 3:35-42. 2006
    ..In this review, the importance of adipocytokines, particularly adiponectin, is discussed with respect to cardiovascular diseases...
  7. ncbi request reprint Adiponectin and metabolic syndrome
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School, Sumitomo Hospital, Osaka, Japan
    Arterioscler Thromb Vasc Biol 24:29-33. 2004
    ..Adiponectin plasma levels decrease with the accumulation of visceral adipose tissue. In this review, we discuss the link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases...
  8. ncbi request reprint The metabolic syndrome and adipocytokines
    Yuji Matsuzawa
    Sumitomo Hospital, Professor Emeritus Osaka University, 5 3 20 Nakanoshima, Kita ku, Osaka 530 0005, Japan
    FEBS Lett 580:2917-21. 2006
    ..In this review, the importance of adipocytokines, especially focusing on adiponectin is discussed with respect to cardiovascular diseases...
  9. doi request reprint The role of fat topology in the risk of disease
    Y Matsuzawa
    Sumitomo Hospital, Professor Emeritus Osaka University, Kita ku, Osaka, Japan
    Int J Obes (Lond) 32:S83-92. 2008
    ..Plasma levels of adiponectin decreased in individuals with visceral fat accumulation, and hypoadiponectinemia caused by visceral fat accumulation might be one of the major causes of metabolic syndrome...
  10. ncbi request reprint Adiponectin: a key player in obesity related disorders
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka, Japan
    Curr Pharm Des 16:1896-901. 2010
    ..In this review, the mechanisms of obesity-related diseases including nonalcoholic fatty liver disease will be discussed from the aspect of important roles of adipocytokines, especially adiponectin...
  11. ncbi request reprint The metabolic syndrome and adipocytokines
    Yuji Matsuzawa
    Sumitomo Hospital, 5 3 20 Nakanoshima, Kita ku, Osaka 5300005 Japan
    Expert Rev Clin Immunol 3:39-46. 2007
    ..In this article, the importance of adipocytokines, focusing particularly on adiponectin, is discussed with respect to lifestyle-related diseases, such as diabetes mellitus and cardiovascular disease...
  12. ncbi request reprint Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    Koji Ohashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    J Am Coll Cardiol 43:1195-200. 2004
    ..This study examined the association of mutations in adiponectin gene with the prevalence of coronary artery disease (CAD)...
  13. ncbi request reprint The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation
    Kenji Fukui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita Osaka 565 0871, Japan
    Cell Metab 2:373-84. 2005
    ..Therefore, collectrin is a regulator of SNARE complex function, which thereby controls insulin exocytosis...
  14. ncbi request reprint Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 109:2046-9. 2004
    ..The present study was designed to elucidate the effects of adiponectin on matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in human monocyte-derived macrophages...
  15. pmc Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:17801-6. 2004
    ..Our findings indicate that the lack of effective glycerol transport from adipocytes by glycerol gateway molecule causes defective adaptation to prolonged fasting...
  16. ncbi request reprint Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9
    Hiroshi Kuriyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Diabetes 51:2915-21. 2002
    ..Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance...
  17. ncbi request reprint Association of hypoadiponectinemia with impaired vasoreactivity
    Noriyuki Ouchi
    Department of Internal Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, 565 0671 Osaka, Japan
    Hypertension 42:231-4. 2003
    ..Our observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction...
  18. ncbi request reprint Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis
    Morihiro Matsuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:37487-91. 2002
    ..The current study suggests an adipo-vascular axis, a direct link between fat and artery. A therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty...
  19. ncbi request reprint Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
    Yoshihiro Kamada
    Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2 2, K1, Yamada oka, Suita, Osaka 565 0871, Japan
    J Hepatol 47:556-64. 2007
    ..The aim of this study was to examine the effects of adiponectin on the progression of NASH to cirrhosis and tumor formation using adiponectin-knockout (KO) mice...
  20. ncbi request reprint Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 107:671-4. 2003
    ..The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue...
  21. ncbi request reprint Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin
    Hideki Kobayashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circ Res 94:e27-31. 2004
    ..These data suggest that HMW adiponectin specifically confers the vascular-protective activities of this adipocytokine. The full text of this article is available online at http://circres.ahajournals.org...
  22. ncbi request reprint Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
    Yoshihiro Kamada
    Department of Internal Medicine and Molecular Science, Osaka University, Graduate School of Medicine, Suita, Japan
    Gastroenterology 125:1796-807. 2003
    ..Adiponectin suppresses the proliferation and migration of vascular smooth muscle cells, whose characteristics are similar to those of hepatic stellate cells. Adiponectin could have biological significances in liver fibrosis...
  23. ncbi request reprint Analysis of expression profiles of islet-associated transcription and growth factors during beta-cell neogenesis from duct cells in partially duct-ligated mice
    Ming Li
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Pancreas 27:345-55. 2003
    ..Beta-cell neogenesis from pancreatic duct cells has been reported to occur in duct-ligated rat. Nevertheless, detailed process of this phenomenon has not been clarified...
  24. doi request reprint Gene expression levels of S100 protein family in blood cells are associated with insulin resistance and inflammation (Peripheral blood S100 mRNAs and metabolic syndrome)
    Masaya Yamaoka
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 433:450-5. 2013
    ..In a series of studies, we herein investigated the association of visceral fat adiposity and mRNA levels relating to inflammatory genes in peripheral blood cells...
  25. doi request reprint Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus
    Susumu Kashine
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Metabolism 59:690-6. 2010
    ..The present results of prevalence of SDB may be relevant to the higher incidence of cardiovascular disease in diabetic patients, which need to be clarified in future studies...
  26. doi request reprint Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis
    Shunsuke Yamamoto
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, and Sumitomo Hospital, Osaka, Japan
    Dig Dis Sci 56:2354-60. 2011
    ..Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear...
  27. ncbi request reprint Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice
    Hitoshi Matsumoto
    Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Suita, Japan
    World J Gastroenterol 12:3352-8. 2006
    ..To examine the effects of adiponectin on the functions of Kupffer cells, key modulators of lipopolysaccharide (LPS) -induced liver injury...
  28. ncbi request reprint Basic fibroblast growth factor promotes the trans-differentiation of mouse bone marrow cells into hepatic lineage cells via multiple liver-enriched transcription factors
    Yukiko Saji
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Hepatol 41:545-50. 2004
    ..However, the molecular mechanism underlying this phenomenon is unclear. To address this issue, we investigated the parameters involved in the trans-differentiation of bone marrow cells into a hepatic lineage...
  29. ncbi request reprint CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells
    Yoko Murayama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5, Yamadaoka, Suita 565 0871, Japan
    J Cell Sci 117:3379-88. 2004
    ..These results suggest that CD9 might regulate apoptosis through the specialized signals in human cancer cell lines...
  30. ncbi request reprint Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    Atsunori Fukuhara
    Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Science 307:426-30. 2005
    ..Surprisingly, visfatin binds to and activates the insulin receptor. Further study of visfatin's physiological role may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes...
  31. ncbi request reprint Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    Masanori Iwaki
    Department of Medicine and Pathophysiology, Graduate School of Frontier Biosciences, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 52:1655-63. 2003
    ..Our results indicate that PPAR-gamma and LRH-1 play significant roles in the transcriptional activation of adiponectin gene via the PPRE and the LRH-RE in its promoter...
  32. ncbi request reprint Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
    Yoshihisa Okamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 106:2767-70. 2002
    ..The current study investigated whether the increased plasma adiponectin could actually reduce atherosclerosis in vivo...
  33. ncbi request reprint Expression of ephrin-B1 in hepatocellular carcinoma: possible involvement in neovascularization
    Yoshiyuki Sawai
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Hepatol 39:991-6. 2003
    ..Hepatocellular carcinoma (HCC) is, in general, a hypervascular tumor. Ephrin/Eph molecules have recently been reported as possible regulators of angiogenesis. We aimed to clarify the role of ephrin-Bs (B1-B3) in the progression of HCC...
  34. ncbi request reprint Life style and cardiovascular risk factors in the Japanese population--from an epidemiological survey on serum lipid levels in Japan 1990 part 2: association of lipid parameters with hypertension
    Akira Yamamoto
    National Cardiovascular Center Research Institute, Osaka, Japan
    J Atheroscler Thromb 10:176-85. 2003
    ..Considering that hypertension is a common and the greatest risk factor in the Japanese population, TG and non-HDL-C appear to be more important than LDL-C as major lipid parameters related to atherogenesis...
  35. ncbi request reprint Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients
    Kazuo Kinoshita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    J Pathol 202:80-5. 2004
    ..These results suggest that the pathogenesis of GISTs in NF1 patients is different from that in non-NF1 patients...
  36. ncbi request reprint Adiponectin as a biomarker of the metabolic syndrome
    Miwa Ryo
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circ J 68:975-81. 2004
    ..Adiponectin is an adipose-derived plasma protein with anti-atherogenic and insulin-sensitizing activities...
  37. ncbi request reprint Association of hypoadiponectinemia with coronary artery disease in men
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 23:85-9. 2003
    ..This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD)...
  38. ncbi request reprint Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 8:731-7. 2002
    ..Our results indicate that adiponectin/ACRP30 deficiency and high TNF-alpha levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance...
  39. ncbi request reprint Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men
    Sachiko Tamba
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Intern Med 47:1175-80. 2008
    ..Hypoadiponectinemia is one of the key molecules of the MetS. In the present study, we investigated the relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men...
  40. ncbi request reprint Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers
    Yukiyoshi Okauchi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Atheroscler Thromb 17:1237-45. 2010
    ....
  41. ncbi request reprint Disturbed secretion of mutant adiponectin associated with the metabolic syndrome
    Ken Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2, Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 306:286-92. 2003
    ..Our results suggest that I164T mutation is associated with hypoadiponectinemia through disturbed secretion into plasma, which may contribute to the development of the metabolic syndrome...
  42. ncbi request reprint Beta cell neogenesis from ducts and phenotypic conversion of residual islet cells in the adult pancreas of glucose intolerant mice induced by selective alloxan perfusion
    Ming Li
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    Endocr J 49:561-72. 2002
    ..In addition, transcription factors that appear in the processes of endocrine cell development may also play essential roles during beta cell neogenesis from duct cells...
  43. ncbi request reprint Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors
    Hui Chen
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 105:130-5. 2003
    ....
  44. ncbi request reprint Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy
    Shinichi Kiso
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Gastroenterology 124:701-7. 2003
    ..This study describes the effects of HB-EGF on liver regeneration after 70% partial hepatectomy in proHB-EGF transgenic mice with liver-specific expression. Methods &..
  45. ncbi request reprint RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation
    Hanjun Zhao
    Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Circ J 70:615-24. 2006
    ..The present study was designed to assess whether RECS1 KO mice have altered gelatinase (matrix metalloproteinase (MMP)-2 and MMP-9) levels and whether they are prone to aortic dilation...
  46. doi request reprint Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes
    Yoshinari Obata
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
    Clin Endocrinol (Oxf) 79:204-10. 2013
    ..This study aimed to investigate the relationship between serum adiponectin levels and age in several physiological states...
  47. ncbi request reprint Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men
    Yukiyoshi Okauchi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes Care 30:2392-4. 2007
  48. ncbi request reprint Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    Hitoshi Nishizawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2734-41. 2002
    ..Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men...
  49. ncbi request reprint Reduction of visceral fat correlates with the decrease in the number of obesity-related cardiovascular risk factors in Japanese with Abdominal Obesity (VACATION-J Study)
    Aki Hiuge-Shimizu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Atheroscler Thromb 19:1006-18. 2012
    ..The present study investigated whether one-year reduction of the visceral fat area (VFA) correlates with a decrease in the number of such factors in Japanese with or without visceral fat accumulation...
  50. ncbi request reprint Effects of growth factors on the growth and differentiation of mouse fetal liver epithelial cells in primary cultures
    Takako Kawasaki
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gastroenterol Hepatol 20:857-64. 2005
    ..Growth factors (GF) are thought to affect the growth and differentiation of hepatocytes during liver development. However, in the midfetal liver, little is known concerning the role of GF...
  51. ncbi request reprint Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells
    Arisa Ihara
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Biochem Biophys Res Commun 329:984-90. 2005
    ..The information presented here would be helpful for the better understanding of MODY1/HNF4alpha diabetes...
  52. ncbi request reprint Obesity, adiponectin and vascular inflammatory disease
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Curr Opin Lipidol 14:561-6. 2003
    ..Chronic inflammatory processes contribute to the development of atherosclerosis. In this review, the authors focus on the relationship between adiponectin, a recently discovered anti-atherogenic adipocytokine, and vascular inflammation...
  53. pmc Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1
    Shin ichiro Kawamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Virol 77:9622-31. 2003
    ..The unique signals and the fewer properties of myelosuppression suggest that a human homolog of limitin may be used as a new antiviral drug...
  54. ncbi request reprint Relationships between circulating adiponectin levels and fat distribution in obese subjects
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
    J Atheroscler Thromb 18:592-5. 2011
    ..The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects...
  55. ncbi request reprint Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells
    Masahide Yamada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Eur J Immunol 34:221-30. 2004
    ..Taken together, C1q may regulate innate and adaptive immune systems via modification of signals mediated by interactions between invading pathogens and TLR...
  56. doi request reprint Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men
    Sachiko Tamba
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 211:601-5. 2010
    ..The present study investigated the relationship between visceral fat accumulation and urinary albumin-creatinine ratio (UACR) in Japanese men...
  57. ncbi request reprint c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors
    Kazuo Kinoshita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, Suita, Japan
    J Gastroenterol Hepatol 18:147-51. 2003
    ..In the present study, we examined the mutations at exon 17 and exon 13 by using direct sequencing...
  58. ncbi request reprint A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance
    Miwa Ryo
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Care 28:451-3. 2005
  59. ncbi request reprint Divergent effects of soy protein diet on the expression of adipocytokines
    Azumi Nagasawa
    Department of Molecular Science and Internal Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 311:909-14. 2003
    ..Our data suggest that dietary SPI alters the gene expressions in adipose tissue and has beneficial effects on the expression of adipocytokines...
  60. ncbi request reprint Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome
    Hidehiko Kondo
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, B5 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 51:2325-8. 2002
    ..Our findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes...
  61. ncbi request reprint Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumours
    Kazuo Kinoshita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, Japan
    Eur J Gastroenterol Hepatol 15:1189-93. 2003
    ..The relationship between tumour growth and c-kit mutation was also examined...
  62. doi request reprint Association of adiponectin with blood pressure in healthy people
    Megu Y Baden
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
    Clin Endocrinol (Oxf) 78:226-31. 2013
    ..As there is limited information regarding serum adiponectin levels in normotensive people, we undertook the large-scale study to determine the association of adiponectin with blood pressure (BP) in mainly normotensive people...
  63. doi request reprint Relationship between serum cystatin C and serum adiponectin level in type 2 diabetic patients
    Yoshiya Hosokawa
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
    Clin Exp Nephrol 16:399-405. 2012
    ..To investigate the relationship between serum levels of cystatin C and adiponectin in patients with type 2 diabetes...
  64. doi request reprint Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups
    Motohiko Kato
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gastroenterol 46:1361-7. 2011
    ..Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between adiponectin and erosive esophagitis...
  65. ncbi request reprint Association of serum adiponectin levels with breast cancer risk
    Yasuo Miyoshi
    Department of Surgical Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 9:5699-704. 2003
    ..Thus, in the present study, the association of the serum adiponectin levels with breast cancer risk was investigated...
  66. ncbi request reprint [High sensitivity C-reactive protein analysis in th diagnosis of arteriosclerosis]
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
    Nihon Rinsho 62:292-5. 2004
  67. ncbi request reprint Matrix metalloproteinases as novel disease markers in Takayasu arteritis
    Akifumi Matsuyama
    Department of Internal Medicine and Molecular Science, B5, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 108:1469-73. 2003
    ..Given the histological findings characterized by destruction of elastic fibers, we hypothesized that matrix metalloproteinases (MMPs) could be useful as markers of disease activity in TA...
  68. ncbi request reprint Life style and cardiovascular risk factors in the Japanese population--from an epidemiological survey on serum lipid levels in Japan 1990 part 1: influence of life style and excess body weight on HDL-cholesterol and other lipid parameters in men
    Akira Yamamoto
    National Cardiovascular Center Research Institute, Osaka, Japan
    J Atheroscler Thromb 10:165-75. 2003
    ..The influence of life style on serum lipid parameters appeared to be mostly expressed as a function of BMI in younger men, while it appeared to be independent of BMI in older men...
  69. ncbi request reprint Adipocytokines and metabolic syndrome
    Yuji Matsuzawa
    Sumitomo Hospital, Osaka University, Osaka, Japan
    Semin Vasc Med 5:34-9. 2005
    ..In this review, the importance of adipocytokines, including adiponectin, is discussed with respect to atherosclerosis...
  70. ncbi request reprint [Glucose intolerance in visceral fat syndrome]
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School
    Nihon Rinsho 60:746-51. 2002
  71. ncbi request reprint 4. Life-style related disease and adipocytes
    Tadashi Nakamura
    The Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita
    Intern Med 41:68-70. 2002
  72. ncbi request reprint Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level
    Yoshiya Hosokawa
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka
    Intern Med 48:1957-61. 2009
    ..This is a rare case of thyroid follicular adenoma producing PTHrP in a patient with a normal serum calcium level despite elevation of plasma PTHrP...
  73. ncbi request reprint Increased plasma HB-EGF associated with obesity and coronary artery disease
    Satoru Matsumoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 292:781-6. 2002
    ..These results suggest that increased plasma HB-EGF derived from the accumulated fat contributes to the higher incidence of vascular disease in obesity, proposing HB-EGF as an adipocytokine directly linking adipovascular axis...
  74. ncbi request reprint A Japanese family of typical Loeys-Dietz syndrome with a TGFBR2 mutation
    Yosuke Togashi
    Department of Internal Medicine, Sumitomo Hospital, Osaka
    Intern Med 46:1995-2000. 2007
    ..This is the first Japanese family case report of typical Loeys-Dietz syndrome...
  75. ncbi request reprint [Visceral fat]
    Tadashi Nakamura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
    Nihon Rinsho 60:699-705. 2002
  76. ncbi request reprint Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    Yukio Arita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka and First Institute of New Drug Research, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan
    Circulation 105:2893-8. 2002
    ..Adiponectin also reduced PDGF-AA-stimulated or HB-EGF-stimulated ERK phosphorylation in a dose-dependent manner without affecting autophosphorylation of PDGF alpha-receptor or EGF receptor...
  77. ncbi request reprint Hypoadiponectinemia: a common basis for diseases associated with overnutrition
    Tohru Funahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Curr Atheroscler Rep 8:433-8. 2006
    ..Hypoadiponectinemia might be at least in part the molecular basis of various diseases associated with overnutrition...
  78. ncbi request reprint Molecular mechanism of vascular disease in metabolic syndrome X
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Diabetes Complications 16:17-8. 2002
  79. ncbi request reprint Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer
    Yoko Murayama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Osaka, Japan
    Int J Cancer 98:505-13. 2002
    ..These results indicate that the coexpression of proHB-EGF and CD9 may be involved in the tumorigenesis and/or proliferation of gastric cancers in a juxtacrine manner...
  80. ncbi request reprint Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease
    Noriyuki Komura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Circ J 72:23-8. 2008
    ..Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated..
  81. ncbi request reprint T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein
    Kenji Oritani
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Blood 101:178-85. 2003
    ..Although the longer limitin protein is structurally and characteristically related to type I interferons, its production is uniquely regulated by translation as well as transcription...
  82. ncbi request reprint Adiponectin: a key adipocytokine in metabolic syndrome
    Yoshihisa Okamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Clin Sci (Lond) 110:267-78. 2006
    ..Although evaluation of adiponectin as a novel therapy will ultimately require clinical intervention studies, this mediator may represent a novel target for the prevention and treatment of visceral obesity metabolic syndrome...
  83. ncbi request reprint Metabolic syndrome: clinical concept and molecular basis
    Tohru Funahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Ann Med 39:482-94. 2007
    ..Such 'Adipo-Do-It' movement is an incentive to encourage physical exercise to reduce visceral fat and is a big challenge to prevent life-style-related diseases and CVD...
  84. ncbi request reprint Metabolic syndrome--definition and diagnostic criteria in Japan
    Yuji Matsuzawa
    Sumitomo Hospital, Japan
    J Atheroscler Thromb 12:301. 2005
  85. ncbi request reprint Metabolic consequence of long-term exposure of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity
    Katsumi Iizuka
    Department of Internal Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Biochim Biophys Acta 1586:23-31. 2002
    ..In conclusion, long-term exposure of FFA to beta cells inhibits glucose-stimulated insulin secretion via the decreased NADPH contents due to the inhibition of pyruvate carboxylase and malate pyruvate shuttle flux...
  86. ncbi request reprint Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 15:292-303. 2008
    ..a potent anti-oxidant and cholesteryl ester transfer protein (CETP) activator is associated with a lowered risk of cardiovascular events in a very high-risk population: familial hypercholesterolemia (FH)...
  87. ncbi request reprint Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats
    Shigeru Sakuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    J Hepatol 36:378-84. 2002
    ..The aims of this study were to identify STAT3-activated cells and to clarify the expression of suppressor of cytokine signal (SOCS), a negative feedback molecule of STAT3, after PH...
  88. pmc Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins
    Takafumi Yokota
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    J Clin Invest 109:1303-10. 2002
    ..They also link adiponectin to the COX-2-dependent PGs that are critical in this process...
  89. ncbi request reprint Hypoadiponectinemia is an independent risk factor for hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 43:1318-23. 2004
    ..01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men...
  90. ncbi request reprint Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina
    Hidetomo Maruyoshi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556 Japan
    Thromb Haemost 91:1026-30. 2004
    ..DM, BMI,TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels...
  91. ncbi request reprint Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy
    Corinne Vigouroux
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    AIDS 17:1503-11. 2003
    ....
  92. ncbi request reprint Adiponectin in essential hypertension
    Francesca Mallamaci
    CNR, Center of Clinical Physiology, Reggio Calabria, Italy
    J Nephrol 15:507-11. 2002
    ..High levels in essential hypertensives may be the expression of a counter-regulatory response aimed at mitigating endothelial damage and cardiovascular risk associated with high arterial pressure...
  93. ncbi request reprint Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003
    ..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
  94. pmc Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
    Ebba Brakenhielm
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:2476-81. 2004
    ..Adiponectin, as a direct endogenous angiogenesis inhibitor, may have therapeutic implications in the treatment of angiogenesis-dependent diseases...
  95. ncbi request reprint [Adiponectin as a key molecule of the metabolic syndrome]
    Tohru Funahashi
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine
    Nihon Rinsho 60:583-92. 2002
  96. ncbi request reprint [Significance of adipocytokine, fat-derived hormones, in metabolic syndrome]
    Iichiro Shimomura
    Tanpakushitsu Kakusan Koso 47:1896-903. 2002
  97. ncbi request reprint Plasma adiponectin concentrations in children: relationships with obesity and insulinemia
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 87:4652-6. 2002
    ....
  98. ncbi request reprint Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells
    Takafumi Yokota
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 171:5091-9. 2003
    ..These results suggest that adiponectin can negatively and selectively influence lymphopoiesis through induction of PG synthesis. They also indicate ways that adipocytes in bone marrow can contribute to regulation of blood cell formation...
  99. ncbi request reprint Decreased plasma adiponectin concentration in patients with essential hypertension
    Marcin Adamczak
    Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian University School of Medicine, Katowice, Poland
    Am J Hypertens 16:72-5. 2003
    ..In all subjects a significant negative correlation was found between plasma adiponectin concentration and mean, systolic, and diastolic BP, suggesting that adiponectin contributes to the clinical course of essential hypertension...
  100. ncbi request reprint Adipocytokines, body composition, and fitness in children
    Dan Nemet
    Department of Pediatrics, Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, California 92868, U S A
    Pediatr Res 53:148-52. 2003
    ..The novel data on adiponectin suggest that deleterious dysregulation of adipocytokines associated with obesity may occur relatively early in life...
  101. ncbi request reprint [Involvement of adiponectin in the pathogenesis of hypertension and hypertensive target-organ damage]
    Yukio Arita
    Department of Cardiology, Sumitomo Hospital
    Nihon Rinsho 62:222-7. 2004