N Sugaya

Summary

Country: Japan

Publications

  1. ncbi request reprint Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7
    Norio Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, Kawasaki, Kanagawa 210 0852, Japan
    Clin Infect Dis 34:461-6. 2002
  2. pmc Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Japan
    Antimicrob Agents Chemother 56:369-77. 2012
  3. ncbi request reprint Influenza-associated encephalopathy in Japan
    Norio Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, 1 2 1 Kokandori, Kawasaki ku, Kawasaki, Kanagawa 210 0852, Japan
    Semin Pediatr Infect Dis 13:79-84. 2002
  4. ncbi request reprint Mass vaccination of schoolchildren against influenza and its impact on the influenza-associated mortality rate among children in Japan
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, Japan
    Clin Infect Dis 41:939-47. 2005
  5. ncbi request reprint Influenza vaccine, anti-influenza drugs, and rapid diagnosis in Japan
    N Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, 1 2 1 Kokandori, Kawasaki ku, Kawasaki, Kanagawa 210 0852, Japan
    J Infect Chemother 6:77-80. 2000
  6. ncbi request reprint Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, 220 0012, Japan
    Clin Infect Dis 44:197-202. 2007
  7. ncbi request reprint Influenza-associated encephalopathy in Japan: pathogenesis and treatment
    N Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, Kanagawa, Japan
    Pediatr Int 42:215-8. 2000
  8. doi request reprint Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, Japan
    Clin Infect Dis 47:339-45. 2008
  9. ncbi request reprint The impact of winter epidemics of influenza and respiratory syncytial virus on paediatric admissions to an urban general hospital
    N Sugaya
    Department of Paediatrics, Nippon Kokan Hospital, Kawasaki, Japan
    J Med Virol 60:102-6. 2000
  10. pmc Long-acting neuraminidase inhibitor laninamivir octanoate (CS-8958) versus oseltamivir as treatment for children with influenza virus infection
    Norio Sugaya
    Keiyu Hospital, Department of Pediatrics, Nishi ku, Yokohama, Kanagawa, Japan
    Antimicrob Agents Chemother 54:2575-82. 2010

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7
    Norio Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, Kawasaki, Kanagawa 210 0852, Japan
    Clin Infect Dis 34:461-6. 2002
    ..Another possibility is that latent HHV-6 or HHV-7 in the brain is reactivated by influenza, causing encephalopathy or febrile convulsions...
  2. pmc Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Japan
    Antimicrob Agents Chemother 56:369-77. 2012
    ....
  3. ncbi request reprint Influenza-associated encephalopathy in Japan
    Norio Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, 1 2 1 Kokandori, Kawasaki ku, Kawasaki, Kanagawa 210 0852, Japan
    Semin Pediatr Infect Dis 13:79-84. 2002
    ..Similar encephalopathic symptoms probably occur in North America and European countries...
  4. ncbi request reprint Mass vaccination of schoolchildren against influenza and its impact on the influenza-associated mortality rate among children in Japan
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, Japan
    Clin Infect Dis 41:939-47. 2005
    ..The purpose of this study was to investigate changes in influenza-related mortality among young children before and after discontinuation of mass vaccination of schoolchildren...
  5. ncbi request reprint Influenza vaccine, anti-influenza drugs, and rapid diagnosis in Japan
    N Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, 1 2 1 Kokandori, Kawasaki ku, Kawasaki, Kanagawa 210 0852, Japan
    J Infect Chemother 6:77-80. 2000
    ....
  6. ncbi request reprint Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, 220 0012, Japan
    Clin Infect Dis 44:197-202. 2007
    ..This study assesses the effectiveness of oseltamivir against influenza A (H3N2) and influenza B in children on the basis of the duration of febrile illness...
  7. ncbi request reprint Influenza-associated encephalopathy in Japan: pathogenesis and treatment
    N Sugaya
    Department of Pediatrics, Nippon Kokan Hospital, Kanagawa, Japan
    Pediatr Int 42:215-8. 2000
    ....
  8. doi request reprint Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, Japan
    Clin Infect Dis 47:339-45. 2008
    ..We compared the clinical effectiveness of oseltamivir and zanamivir in children with influenza A (H1N1) virus, influenza A (H3N2) virus, and influenza B virus infections...
  9. ncbi request reprint The impact of winter epidemics of influenza and respiratory syncytial virus on paediatric admissions to an urban general hospital
    N Sugaya
    Department of Paediatrics, Nippon Kokan Hospital, Kawasaki, Japan
    J Med Virol 60:102-6. 2000
    ..Influenza and RSV infection are leading causes of pediatric hospital admissions during the winter. Effective methods of prophylaxis are needed not only for high-risk patients, but for healthy young children...
  10. pmc Long-acting neuraminidase inhibitor laninamivir octanoate (CS-8958) versus oseltamivir as treatment for children with influenza virus infection
    Norio Sugaya
    Keiyu Hospital, Department of Pediatrics, Nishi ku, Yokohama, Kanagawa, Japan
    Antimicrob Agents Chemother 54:2575-82. 2010
    ..Further study will be needed to confirm clinical efficacy against influenza A (H3N2) or B virus infection. Its ease of administration is noteworthy, because a single inhalation is required during the course of illness...
  11. doi request reprint Very low pandemic influenza A (H1N1) 2009 mortality associated with early neuraminidase inhibitor treatment in Japan: analysis of 1000 hospitalized children
    Norio Sugaya
    Department of Paediatrics, Keiyu Hospital, 3 7 3 Minatomirai, Nishi ku, Yokohama, 220 0012 Kanagawa, Japan
    J Infect 63:288-94. 2011
    ..We analyzed the clinical manifestations and treatment of children hospitalized because of H1N1/09 infection in order to clarify the association between treatment with neuraminidase inhibitors and the low mortality rate...
  12. ncbi request reprint [Impact of influenza A virus infection as a cause of pediatric hospitalization and use of rapid antigen test of influenza A virus]
    K Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 72:883-9. 1998
    ..The rapid test showed about 90% sensitivity and specificity, as compared with isolation and serum hemagglutination inhibition test. Directigen Flu A proved to be a reliable, rapid screen for influenza A from symptomatic patients...
  13. ncbi request reprint [Evaluation of the rapid detection test for influenza A and B viruses using neuraminidase activity]
    K Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 74:12-6. 2000
    ..Therefore, this test demonstrated high specificity and positive predictive value. In conclusion, the ZstatFlu test is useful for the rapid detection of influenza A and B viruses to identify patients who need antiviral treatment...
  14. ncbi request reprint Influenza A-associated encephalopathy with bilateral thalamic necrosis in Japan
    M Shinjoh
    Department of Pediatrics, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
    Clin Infect Dis 31:611-3. 2000
    ..Other factors in addition to influenza virus infection may have contributed to the etiology of encephalopathy in our case patients...
  15. ncbi request reprint [Optical immunoassay test for rapid detection of influenza A and B viruses: an evaluation]
    K Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 73:1069-73. 1999
    ..Nasopharyngeal aspirates showed higher sensitivity than throat swabs for detection of influenza virus by FLU OIA. We believe this rapid test kit is useful for the detection of influenza A and B viruses...
  16. ncbi request reprint [A revolutionary change in the diagnosis and treatment of influenza]
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, 3 7 3 Minatomirai, Nishi ku, Yokohama, Kanagawa
    Uirusu 52:47-53. 2002
  17. ncbi request reprint [A case of influenza A virus associated encephalopathy with bilateral thalamic hemorrhage]
    M Shinjoh
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 73:778-82. 1999
    ..Although it is clear that influenza A virus triggered this case, we cannot confirm that it was a pathogen. Also, it might be advisable to consider other possible contributing factors such as drugs administered before hospitalization...
  18. ncbi request reprint [Anti-virals for influenza virus infection]
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital, Kanagawa, Japan
    Uirusu 55:111-4. 2005
    ..Therefore, we should carefully observe the appearance of resistance strains and side effects to neuraminidase inhibitors...
  19. ncbi request reprint [Diagnosis and Treatment of influenza--clinical investigation on viral shedding in children with influenza]
    Keiko Mitamura
    Department of Pediatrics, Eiju General Hospital, Japan
    Uirusu 56:109-16. 2006
    ..It is very important for influenza control to investigate on viral shedding and resistant viruses...
  20. ncbi request reprint [Influenza virus infection in children]
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital
    Nihon Rinsho 61:1931-5. 2003
    ..Vaccinating schoolchildren against influenza reduces mortality from influenza among the elderly. Moreover, the programs probably protected young children from developing severe complications of influenza...
  21. ncbi request reprint [Influenza vaccine: past, present and future]
    Norio Sugaya
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 76:9-17. 2002
    ..Although vaccination rate of Japan is the lowest in developed countries at present, the supply of influenza vaccine increases double every year...
  22. ncbi request reprint [Treatment of influenza virus infection with anti-virals]
    Norio Sugaya
    Department of Pediatrics, Keiyu Hospital
    Nihon Rinsho 64:1840-4. 2006
    ..Zanamivir will be used widely in Japan, because it is characterized of lower rate of resistance. Stockpiling of those antivirals is essential for pandemic preparedness plan...
  23. ncbi request reprint Prospective surveillance for atypical pathogens in children with community-acquired pneumonia in Japan
    Masahiro Bamba
    Department of Pediatrics, Yokosuka Kyosai Hospital, 1 16 Yonegahamadori, Yokosuka shi, Kanagawa 238 8558, Japan
    J Infect Chemother 12:36-41. 2006
    ..In patients suspected of having atypical pneumonia, macrolides are recommended...
  24. ncbi request reprint [Effectiveness of oseltamivir treatment against influenza type A and type B infection in children]
    Keiko Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 76:946-52. 2002
    ..No differences in the effectiveness of oseltamivir treatment were observed between young children (< 4 years of age) and school-aged children (> 6 years of age). No obvious side effects were observed...
  25. ncbi request reprint [Influenza]
    Norio Sugaya
    Department of Pediatrics, Keiyu General Hospital
    Nihon Rinsho 61:135-40. 2003
  26. ncbi request reprint Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors
    Shuji Hatakeyama
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    JAMA 297:1435-42. 2007
    ..Furthermore, transmission of resistant virus, whether influenza A or B, has not been recognized to date...
  27. ncbi request reprint [Dosage of inactivated influenza vaccine for infants]
    Daisuke Tamura
    Department of Pediatrics, Jichi Medical School
    Kansenshogaku Zasshi 79:427-32. 2005
    ..The dosage is not half as much as that in Europe and the U.S.A. We considered that low efficacy fate of influenza vaccine in children under 1 year old results from its less dosage. So we designed this study to verify this hypothesis...
  28. ncbi request reprint [Patient assessment for zanamivir therapy (second report) -- a survey of patients with influenza who were prescribed zanamivir during the 2001/2002 season in Japan]
    Keizo Matsumoto
    Nagasaki University and Aino Memorial Hospital
    Kansenshogaku Zasshi 76:1016-24. 2002
    ..3% found the device easy or very easy to use. These results showed that the effect of zanamivir started very fast and the diskhaer was well accepted. This was the same as the previous results...
  29. ncbi request reprint High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza
    Kyoko Shiraishi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Infect Dis 188:57-61. 2003
    ..These results suggest that resistant viruses emerge in a much higher proportion of amantadine-treated patients than has been suggested by previous studies...
  30. ncbi request reprint [Countermeasures for newly-emerging influenza]
    Norio Sugaya
    Nihon Naika Gakkai Zasshi 96:2393-9. 2007
  31. ncbi request reprint WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus
    Holger J Schunemann
    Italian National Cancer Institute Regina Elena, INFORMA Unit, Department of Epidemiology, Istituto Regina Elena, Rome, Italy
    Lancet Infect Dis 7:21-31. 2007
    ..Emergence of other novel influenza A viral subtypes with pandemic potential, or changes in the pathogenicity of H5N1 virus strains, will require an update of these guidelines and WHO will be monitoring this closely...
  32. ncbi request reprint [Effect of post-exposure prophylaxis with oseltamivir for those in contacts with influenza patients in pediatric wards]
    Masayoshi Shinjoh
    Department of Pediatrics, School of Medicine, Keio University
    Kansenshogaku Zasshi 78:262-9. 2004
    ..No significant adverse effects due to oseltamivir were observed among those who were enrolled in this study...
  33. ncbi request reprint Resistant influenza A viruses in children treated with oseltamivir: descriptive study
    Maki Kiso
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Lancet 364:759-65. 2004
    ..Our aim was to investigate oseltamivir resistance in a group of children treated for influenza...
  34. ncbi request reprint Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus
    Darwyn Kobasa
    Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Nature 431:703-7. 2004
    ....
  35. ncbi request reprint [The issue in Japanese pandemic preparedness plan stockpiling of oseltamivir to treat 25% of Japanese population]
    Norio Sugaya
    Keiyu Hospital
    Kansenshogaku Zasshi 80:8-12. 2006
  36. ncbi request reprint [Evaluation of immunochromatography test for rapid detection of influenza A and B viruses]
    Masahiko Yamazaki
    Zama Children s Clinic
    Kansenshogaku Zasshi 79:29-30. 2005
  37. pmc Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor
    Shuji Hatakeyama
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Clin Microbiol 43:4139-46. 2005
    ..We conclude that the human ST6Gal I-expressing MDCK cell line is useful not only for evaluating their sensitivity to NA inhibitors, but also for isolation of influenza viruses from clinical samples...
  38. ncbi request reprint [Evaluation of an immunochromatography test using enzyme immunoassay for rapid detection of influenza A and B viruses]
    Keiko Mitamura
    Department of Pediatrics, Kawasaki Municipal Hospital
    Kansenshogaku Zasshi 78:597-603. 2004
    ..6% (81/83) for nasal swabs, and 100% (52/52) for throat swabs. We conclude that the new Espline Influenza A&B-N rapid diagnostic test is easy to use and has a high sensitivity and specificity, especially for influenza A...