Research Topics
| N SugayaSummaryCountry: Japan Publications
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Publications
Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7Norio Sugaya
Department of Pediatrics, Nippon Kokan Hospital, Kawasaki, Kanagawa 210 0852, Japan
Clin Infect Dis 34:461-6. 2002..Another possibility is that latent HHV-6 or HHV-7 in the brain is reactivated by influenza, causing encephalopathy or febrile convulsions...
Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infectionNorio Sugaya
Department of Pediatrics, Keiyu Hospital, Yokohama, Japan
Antimicrob Agents Chemother 56:369-77. 2012....- Influenza-associated encephalopathy in JapanNorio Sugaya
Department of Pediatrics, Nippon Kokan Hospital, 1 2 1 Kokandori, Kawasaki ku, Kawasaki, Kanagawa 210 0852, Japan
Semin Pediatr Infect Dis 13:79-84. 2002..Similar encephalopathic symptoms probably occur in North America and European countries... - Mass vaccination of schoolchildren against influenza and its impact on the influenza-associated mortality rate among children in JapanNorio Sugaya
Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, Japan
Clin Infect Dis 41:939-47. 2005..The purpose of this study was to investigate changes in influenza-related mortality among young children before and after discontinuation of mass vaccination of schoolchildren... - Influenza vaccine, anti-influenza drugs, and rapid diagnosis in JapanN Sugaya
Department of Pediatrics, Nippon Kokan Hospital, 1 2 1 Kokandori, Kawasaki ku, Kawasaki, Kanagawa 210 0852, Japan
J Infect Chemother 6:77-80. 2000.... - Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in childrenNorio Sugaya
Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, 220 0012, Japan
Clin Infect Dis 44:197-202. 2007..This study assesses the effectiveness of oseltamivir against influenza A (H3N2) and influenza B in children on the basis of the duration of febrile illness... - Influenza-associated encephalopathy in Japan: pathogenesis and treatmentN Sugaya
Department of Pediatrics, Nippon Kokan Hospital, Kanagawa, Japan
Pediatr Int 42:215-8. 2000.... 
Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in childrenNorio Sugaya
Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, Japan
Clin Infect Dis 47:339-45. 2008..We compared the clinical effectiveness of oseltamivir and zanamivir in children with influenza A (H1N1) virus, influenza A (H3N2) virus, and influenza B virus infections...- The impact of winter epidemics of influenza and respiratory syncytial virus on paediatric admissions to an urban general hospitalN Sugaya
Department of Paediatrics, Nippon Kokan Hospital, Kawasaki, Japan
J Med Virol 60:102-6. 2000..Influenza and RSV infection are leading causes of pediatric hospital admissions during the winter. Effective methods of prophylaxis are needed not only for high-risk patients, but for healthy young children... - Long-acting neuraminidase inhibitor laninamivir octanoate (CS-8958) versus oseltamivir as treatment for children with influenza virus infectionNorio Sugaya
Keiyu Hospital, Department of Pediatrics, Nishi ku, Yokohama, Kanagawa, Japan
Antimicrob Agents Chemother 54:2575-82. 2010..Further study will be needed to confirm clinical efficacy against influenza A (H3N2) or B virus infection. Its ease of administration is noteworthy, because a single inhalation is required during the course of illness... - Very low pandemic influenza A (H1N1) 2009 mortality associated with early neuraminidase inhibitor treatment in Japan: analysis of 1000 hospitalized childrenNorio Sugaya
Department of Paediatrics, Keiyu Hospital, 3 7 3 Minatomirai, Nishi ku, Yokohama, 220 0012 Kanagawa, Japan
J Infect 63:288-94. 2011..We analyzed the clinical manifestations and treatment of children hospitalized because of H1N1/09 infection in order to clarify the association between treatment with neuraminidase inhibitors and the low mortality rate... - [Impact of influenza A virus infection as a cause of pediatric hospitalization and use of rapid antigen test of influenza A virus]K Mitamura
Department of Pediatrics, Nippon Kokan Hospital
Kansenshogaku Zasshi 72:883-9. 1998..The rapid test showed about 90% sensitivity and specificity, as compared with isolation and serum hemagglutination inhibition test. Directigen Flu A proved to be a reliable, rapid screen for influenza A from symptomatic patients... - [Evaluation of the rapid detection test for influenza A and B viruses using neuraminidase activity]K Mitamura
Department of Pediatrics, Nippon Kokan Hospital
Kansenshogaku Zasshi 74:12-6. 2000..Therefore, this test demonstrated high specificity and positive predictive value. In conclusion, the ZstatFlu test is useful for the rapid detection of influenza A and B viruses to identify patients who need antiviral treatment... - Influenza A-associated encephalopathy with bilateral thalamic necrosis in JapanM Shinjoh
Department of Pediatrics, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
Clin Infect Dis 31:611-3. 2000..Other factors in addition to influenza virus infection may have contributed to the etiology of encephalopathy in our case patients... - [Optical immunoassay test for rapid detection of influenza A and B viruses: an evaluation]K Mitamura
Department of Pediatrics, Nippon Kokan Hospital
Kansenshogaku Zasshi 73:1069-73. 1999..Nasopharyngeal aspirates showed higher sensitivity than throat swabs for detection of influenza virus by FLU OIA. We believe this rapid test kit is useful for the detection of influenza A and B viruses... - [A revolutionary change in the diagnosis and treatment of influenza]Norio Sugaya
Department of Pediatrics, Keiyu Hospital, 3-7-3 Minatomirai, Nishi-ku, Yokohama, Kanagawa
Uirusu 52:47-53. 2002 - [A case of influenza A virus associated encephalopathy with bilateral thalamic hemorrhage]M Shinjoh
Department of Pediatrics, Nippon Kokan Hospital
Kansenshogaku Zasshi 73:778-82. 1999..Although it is clear that influenza A virus triggered this case, we cannot confirm that it was a pathogen. Also, it might be advisable to consider other possible contributing factors such as drugs administered before hospitalization... - [Anti-virals for influenza virus infection]Norio Sugaya
Department of Pediatrics, Keiyu Hospital, Kanagawa, Japan
Uirusu 55:111-4. 2005..Therefore, we should carefully observe the appearance of resistance strains and side effects to neuraminidase inhibitors... - [Diagnosis and Treatment of influenza--clinical investigation on viral shedding in children with influenza]Keiko Mitamura
Department of Pediatrics, Eiju General Hospital, Japan
Uirusu 56:109-16. 2006..It is very important for influenza control to investigate on viral shedding and resistant viruses... - [Influenza virus infection in children]Norio Sugaya
Department of Pediatrics, Keiyu Hospital
Nippon Rinsho 61:1931-5. 2003..Vaccinating schoolchildren against influenza reduces mortality from influenza among the elderly. Moreover, the programs probably protected young children from developing severe complications of influenza... - [Influenza vaccine: past, present and future]Norio Sugaya
Department of Pediatrics, Nippon Kokan Hospital
Kansenshogaku Zasshi 76:9-17. 2002..Although vaccination rate of Japan is the lowest in developed countries at present, the supply of influenza vaccine increases double every year... - [Treatment of influenza virus infection with anti-virals]Norio Sugaya
Department of Pediatrics, Keiyu Hospital
Nippon Rinsho 64:1840-4. 2006..Zanamivir will be used widely in Japan, because it is characterized of lower rate of resistance. Stockpiling of those antivirals is essential for pandemic preparedness plan... - Prospective surveillance for atypical pathogens in children with community-acquired pneumonia in JapanMasahiro Bamba
Department of Pediatrics, Yokosuka Kyosai Hospital, 1 16 Yonegahamadori, Yokosuka shi, Kanagawa 238 8558, Japan
J Infect Chemother 12:36-41. 2006..In patients suspected of having atypical pneumonia, macrolides are recommended... - [Effectiveness of oseltamivir treatment against influenza type A and type B infection in children]Keiko Mitamura
Department of Pediatrics, Nippon Kokan Hospital
Kansenshogaku Zasshi 76:946-52. 2002..No differences in the effectiveness of oseltamivir treatment were observed between young children (< 4 years of age) and school-aged children (> 6 years of age). No obvious side effects were observed... - [Influenza]Norio Sugaya
Department of Pediatrics, Keiyu General Hospital
Nippon Rinsho 61:135-40. 2003 - Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitorsShuji Hatakeyama
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
JAMA 297:1435-42. 2007..Furthermore, transmission of resistant virus, whether influenza A or B, has not been recognized to date... - [Dosage of inactivated influenza vaccine for infants]Daisuke Tamura
Department of Pediatrics, Jichi Medical School
Kansenshogaku Zasshi 79:427-32. 2005..To obtain protective levels of antibodies by influenza vaccines in infants, they must be inoculated with enough dosage... - [Patient assessment for zanamivir therapy (second report) -- a survey of patients with influenza who were prescribed zanamivir during the 2001/2002 season in Japan]Keizo Matsumoto
Nagasaki University and Aino Memorial Hospital
Kansenshogaku Zasshi 76:1016-24. 2002..3% found the device easy or very easy to use. These results showed that the effect of zanamivir started very fast and the diskhaer was well accepted. This was the same as the previous results... - High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenzaKyoko Shiraishi
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
J Infect Dis 188:57-61. 2003..These results suggest that resistant viruses emerge in a much higher proportion of amantadine-treated patients than has been suggested by previous studies... - [Countermeasures for newly-emerging influenza]Norio Sugaya
Nippon Naika Gakkai Zasshi 96:2393-9. 2007 - WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virusHolger J Schunemann
Italian National Cancer Institute Regina Elena, INFORMA Unit, Department of Epidemiology, Istituto Regina Elena, Rome, Italy
Lancet Infect Dis 7:21-31. 2007..Emergence of other novel influenza A viral subtypes with pandemic potential, or changes in the pathogenicity of H5N1 virus strains, will require an update of these guidelines and WHO will be monitoring this closely... - [Effect of post-exposure prophylaxis with oseltamivir for those in contacts with influenza patients in pediatric wards]Masayoshi Shinjoh
Department of Pediatrics, School of Medicine, Keio University
Kansenshogaku Zasshi 78:262-9. 2004..No significant adverse effects due to oseltamivir were observed among those who were enrolled in this study... - Resistant influenza A viruses in children treated with oseltamivir: descriptive studyMaki Kiso
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Lancet 364:759-65. 2004..Furthermore, children can be a source of viral transmission, even after 5 days of treatment with oseltamivir... - Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virusDarwyn Kobasa
Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Nature 431:703-7. 2004.... - [The issue in Japanese pandemic preparedness plan stockpiling of oseltamivir to treat 25% of Japanese population]Norio Sugaya
Keiyu Hospital
Kansenshogaku Zasshi 80:8-12. 2006 - [Evaluation of immunochromatography test for rapid detection of influenza A and B viruses]Masahiko Yamazaki
Zama Children's Clinic
Kansenshogaku Zasshi 79:29-30. 2005 - Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitorShuji Hatakeyama
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
J Clin Microbiol 43:4139-46. 2005..We conclude that the human ST6Gal I-expressing MDCK cell line is useful not only for evaluating their sensitivity to NA inhibitors, but also for isolation of influenza viruses from clinical samples... - [Evaluation of an immunochromatography test using enzyme immunoassay for rapid detection of influenza A and B viruses]Keiko Mitamura
Department of Pediatrics, Kawasaki Municipal Hospital
Kansenshogaku Zasshi 78:597-603. 2004..6% (81/83) for nasal swabs, and 100% (52/52) for throat swabs. We conclude that the new Espline Influenza A&B-N rapid diagnostic test is easy to use and has a high sensitivity and specificity, especially for influenza A...