Tamostu Sugai

Summary

Country: Japan

Publications

  1. ncbi request reprint Analysis of Ki-ras gene mutations associated with DNA diploid, aneuploid, and multiploid colorectal carcinomas using a crypt isolation technique
    T Sugai
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    Cytometry 46:345-50. 2001
  2. ncbi request reprint Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer
    Wataru Habano
    Division of DNA Laboratory, School of Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Oncol Rep 10:1375-80. 2003
  3. ncbi request reprint Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Japan
    Hum Pathol 35:587-93. 2004
  4. ncbi request reprint Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    Int J Cancer 114:337-45. 2005
  5. ncbi request reprint Association between tumor necrosis factor-alpha and Fc-gamma receptor polymorphisms with infliximab in Crohn's disease
    Kazumitsu Tomita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate 020 8505, Japan
    Hepatogastroenterology 57:535-9. 2010
  6. pmc The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells
    Seiya Yokoyama
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    BMC Cancer 12:67. 2012
  7. pmc Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype
    Tamotsu Sugai
    Division of Diagnostic Molecular Pathology, Department of Pathology, School of Medicine, Iwate Medical University, 19 1 Morioka City 020 8505, Japan
    BMC Gastroenterol 10:55. 2010
  8. ncbi request reprint Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa
    Tamotsu Sugai
    Department of Pathology, Division of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Iwate, Japan
    Oncol Rep 23:25-33. 2010
  9. ncbi request reprint Analysis of mucin, p53 protein and Ki-67 expressions in gastric differentiated-type intramucosal neoplastic lesions obtained from endoscopic mucosal resection samples: a proposal for a new classification of intramucosal neoplastic lesions based on nuclear
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Pathol Int 54:425-35. 2004
  10. ncbi request reprint Esophageal squamous cell carcinoma characterized by extensive chondroid differentiation
    T Sugai
    Division of Pathology, Central Clinical Laboratory, Department of Clinical Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
    Pathol Int 50:514-9. 2000

Collaborators

  • Wataru Habano
  • S Nakamura
  • Minoru Toyota
  • Tomio Arai
  • Ryoko Sasaki
  • M Terashima
  • Hiroshi Takahashi
  • H Sato
  • Hiromu Suzuki
  • Shiro Noguchi
  • Yoshihiro Shioi
  • Ryo Takagi
  • M Sawabe
  • S Ozawa
  • Tomoyuki Masuda
  • Junko Aida
  • Gen Tamura
  • Tadashi Hasegawa
  • W Kimura
  • N Honma
  • Kohzoh Imai
  • Yu Fei Jiao
  • Noriyuki Uesugi
  • Takayuki Suto
  • Go Wakabayashi
  • Seiya Yokoyama
  • Akinori Takagane
  • Kiminori Kanno
  • Toru Yoshida
  • Chihaya Maesawa
  • Masamichi Suzuki
  • Shoji Kanno
  • Kazumitsu Tomita
  • Masaki Yamashita
  • Kuniyuki Kato
  • Suguru Yonezawa
  • Michiyo Higashi
  • Daiya Ishigaki
  • Toshimi Chiba
  • Tomofumi Hamada
  • Tatsuya Ando
  • Kazuyuki Suzuki
  • Motohiro Ishii
  • Norihiko Kudara
  • Tomohiro Tozawa
  • Akihiro Noro
  • Inako Kikuchi
  • Sho Kitamoto
  • Izumi Houjou
  • Kyoichi Takaori
  • Norishige Yamada
  • Hiroyuki Nitta
  • Yoshifumi Arisaka
  • Masahiro Kai
  • Yasuhisa Shinomura
  • Yasushi Sasaki
  • Masanori Nojima
  • Hirofumi Akashi
  • Yoshiyuki Watanabe
  • Takashi Tokino
  • Fumio Itoh
  • Seiko Kamimae
  • Reo Maruyama
  • Hiroo Yamano
  • Eiichiro Yamamoto
  • Tetsuya Itabashi
  • Hiroshi Tada
  • Koji Kotani
  • Koki Otsuka
  • Kentaro Fujisawa
  • Hiroki Oikawa
  • Yoshinori Tatemichi
  • Toru Obuchi
  • Naoko Ito
  • Noriyuki Yamada
  • Hiroshi Arai
  • Akira Ogawa
  • Kuniaki Ogasawara
  • Masayuki Sasoh
  • Osamu Shimooki
  • Yuko Baba
  • Mitsuharu Nomoto
  • Masamichi Goto
  • Tadashi Abe
  • Hideaki Tsutsumida
  • Masaaki Inomata
  • Toshimi Yoshida
  • Masaki Endoh
  • Seishi Orii
  • Tatsuya Andoh

Detail Information

Publications48

  1. ncbi request reprint Analysis of Ki-ras gene mutations associated with DNA diploid, aneuploid, and multiploid colorectal carcinomas using a crypt isolation technique
    T Sugai
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    Cytometry 46:345-50. 2001
    ..The present study attempts to clarify whether Ki-ras gene mutations are associated with DNA ploidy status in sporadic colorectal carcinomas using a crypt isolation technique coupled with DNA cytometric sorting...
  2. ncbi request reprint Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer
    Wataru Habano
    Division of DNA Laboratory, School of Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Oncol Rep 10:1375-80. 2003
    ..We suggest that SDHD alterations can affect mitochondrial respiratory chain functions and play a role in colorectal and gastric cancers as a distinct type of tumor suppressor...
  3. ncbi request reprint Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Japan
    Hum Pathol 35:587-93. 2004
    ..To our knowledge, the present study is the first to report flow cytometric DNA content in a large number of gastric cancer samples obtained using the crypt isolation technique...
  4. ncbi request reprint Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    Int J Cancer 114:337-45. 2005
    ..This suggests that knowledge of the different genotypes of multiple single tumor glands may help clarify the process of tumor progression...
  5. ncbi request reprint Association between tumor necrosis factor-alpha and Fc-gamma receptor polymorphisms with infliximab in Crohn's disease
    Kazumitsu Tomita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate 020 8505, Japan
    Hepatogastroenterology 57:535-9. 2010
    ..The aim of this study was to evaluate the association between these polymorphisms and IFX treatment of CD...
  6. pmc The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells
    Seiya Yokoyama
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    BMC Cancer 12:67. 2012
    ..However, conventional analytical methods for DNA methylation require a large amount of DNA and have low sensitivity...
  7. pmc Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype
    Tamotsu Sugai
    Division of Diagnostic Molecular Pathology, Department of Pathology, School of Medicine, Iwate Medical University, 19 1 Morioka City 020 8505, Japan
    BMC Gastroenterol 10:55. 2010
    ..Thus, expression patterns of cell cycle-related proteins were investigated in the early phase of differentiated-type gastric cancers to ascertain any mechanistic relationships with mucin phenotypes...
  8. ncbi request reprint Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa
    Tamotsu Sugai
    Department of Pathology, Division of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Iwate, Japan
    Oncol Rep 23:25-33. 2010
    ..In conclusion, the present data on tumor and corresponding intestinal metaplastic and nonmetaplastic glands suggest that genetic alterations already occur within the surrounding of the noncancerous mucosa...
  9. ncbi request reprint Analysis of mucin, p53 protein and Ki-67 expressions in gastric differentiated-type intramucosal neoplastic lesions obtained from endoscopic mucosal resection samples: a proposal for a new classification of intramucosal neoplastic lesions based on nuclear
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Pathol Int 54:425-35. 2004
    ....
  10. ncbi request reprint Esophageal squamous cell carcinoma characterized by extensive chondroid differentiation
    T Sugai
    Division of Pathology, Central Clinical Laboratory, Department of Clinical Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
    Pathol Int 50:514-9. 2000
    ..In addition, our findings suggest that BMP produced by carcinomatous cells lead to chondroid differentiation of the carcinoma cells...
  11. ncbi request reprint Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers--a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Mod Pathol 17:1223-34. 2004
    ..We suggest that the cellular mucin phenotypes of the differentiated-type adenocarcinomas result from distinct genetic alterations...
  12. ncbi request reprint Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Oncology 68:548-57. 2005
    ..In the present study, we established an association between DNA ploidy status and genetic alterations in gastric cancer...
  13. doi request reprint Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers
    Tamotsu Sugai
    Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
    Int J Cancer 127:2500-9. 2010
    ..Importantly, the results also show that gastric submucosal progression is characterized by the accumulation of specific genetic alterations. In addition, changes of cell cycle-related proteins are associated with cancer progression...
  14. pmc Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, 19 1 Morioka, 020 8505, Japan
    J Mol Diagn 8:193-201. 2006
    ..Our data confirm that distinct molecular pathways to colorectal cancer dominate in the left and right sides of the bowel...
  15. ncbi request reprint Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of colorectal adenomas and early colorectal carcinomas
    Tamostu Sugai
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    J Pathol 200:168-76. 2003
    ..On the other hand, MSI may be associated with the development of some diploid tumours. In addition, the incidence of genetic alterations in the colorectal adenomas that we examined appears to be independent of the tumour's DNA index...
  16. ncbi request reprint DNA mapping of gastric cancers using flow cytometric analysis
    T Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Cytometry 42:270-6. 2000
    ....
  17. ncbi request reprint Genetic alterations in DNA diploid, aneuploid and multiploid colorectal carcinomas identified by the crypt isolation technique
    T Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Int J Cancer 88:614-9. 2000
    ..Furthermore, all diploid, aneuploid and both the diploid and aneuploid fractions of the multiploid tumors that were non-MSI exhibited a high rate of LOH, suggesting that LOH is independent of the tumor's ploidy status...
  18. ncbi request reprint Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas
    T Sugai
    Division of Pathology, Central Clinical Laboratory School of Medicine, Iwate Medical University, 19 1, Morioka, 020 8505, Japan
    Oncogene 20:6095-101. 2001
    ..Our results suggest that ATM allelic imbalance and p53 gene mutations occur during the progression from diploid to aneuploid cell populations in multiploid colorectal carcinomas...
  19. pmc Molecular validation of the modified Vienna classification of colorectal tumors
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory and the First Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    J Mol Diagn 4:191-200. 2002
    ..In addition, MSI-positive tumors may represent a specific subtype of colorectal adenomas...
  20. ncbi request reprint Analysis of microsatellite alterations in gastric carcinoma using the crypt isolation technique
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    J Pathol 204:200-7. 2004
    ..The results suggest that the crypt isolation technique is useful for accurate allelic loss analysis in gastric carcinoma and that LOH and MSI are more common in intestinal- and solid-type tumours than in diffuse-type tumors...
  21. ncbi request reprint Application of the crypt isolation technique to the assessment of genetic alterations of colorectal carcinomas
    Hiroshi Takahashi
    Division of Pathology, Iwate Medical University, Japan
    Pathol Int 52:628-35. 2002
    ..In addition, it may also be of benefit in clarifying the genetic profile of multiploid tumor cell populations...
  22. ncbi request reprint Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:597-603. 2006
    ..These results indicate that an age-related increase of medullary-type tumors in poorly differentiated adenocarcinoma may play an important role in the increase of absent hMLH1 expression and MSI in colorectal carcinoma...
  23. ncbi request reprint Evolution of DNA ploidy state and DNA index in colorectal adenomas and carcinomas using the crypt isolation technique: new hypothesis in colorectal tumorigenesis
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, First Department of Internal Medicine and First Department of Surgery, School of Medicine, Iwate Medical University, Morioka, Japan
    Pathol Int 53:154-62. 2003
    ..Therefore, the evolution of the DNA index might play an important role in the development of colorectal tumors...
  24. ncbi request reprint Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
    Wataru Habano
    Division of DNA Laboratory, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Int J Cancer 121:1487-93. 2007
    ..SALL4 may be one of important key players that act as "caretakers" for chromosomal stability. Our new approach is a powerful tool for the global identification of such key players...
  25. ncbi request reprint Clinicopathological significance of loss of heterozygosity in intestinal- and solid-type gastric carcinomas: a comprehensive study using the crypt isolation technique
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Japan
    Mod Pathol 19:548-55. 2006
    ..1 and 22q13.31 is associated with tumor progression...
  26. ncbi request reprint Analysis of Ki-ras and p53 gene mutations in laterally spreading tumors of the colorectum
    Akihiro Noro
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, Morioka, Japan
    Pathol Int 53:828-36. 2003
    ..We suggest that the LST exhibited a characteristic pattern in terms of the Ki-ras as well as the p53 gene mutation pattern, thereby supporting the hypothesis that LST is a specific subtype of colorectal tumors...
  27. ncbi request reprint Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas
    Tatsuya Ando
    First Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    J Gastroenterol 40:708-15. 2005
    ..Therefore, we attempted to clarify the role of the SMAD4/DPC4 gene during tumor progression of colorectal carcinoma...
  28. ncbi request reprint Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients
    Tomohiro Tozawa
    Department of Pathology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Cancer Sci 95:736-40. 2004
    ..Hypermethylation of DAP-kinase appears to be a significant prognostic factor in primary biliary tract carcinomas...
  29. ncbi request reprint DNA hypomethylation at the CpG island is involved in aberrant expression of the L1 cell adhesion molecule gene in colorectal cancer
    Kuniyuki Kato
    Department of Pathology, Iwate Medical University School of Medicine, 18 1 Uchimaru, Morioka, Japan
    Int J Oncol 35:467-76. 2009
    ..These results suggest that DNA hypomethylation at the L1CAM CpG islands might induce L1CAM aberrant expression and contribute to the acquisition of aggressive tumor behavior in CRC...
  30. ncbi request reprint Analysis of Ki-ras gene mutations within the same tumor using a single tumor crypt in colorectal carcinomas
    Motohiro Ishii
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, 19 1, 020 8505, Morioka, Japan
    J Gastroenterol 39:544-9. 2004
    ..Ki- ras gene mutations have been examined using the crypt isolation method to determine whether multiclonarity is present within the same tumor...
  31. ncbi request reprint CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers
    Wataru Habano
    Department of Pharmacodynamics and Molecular Genetics, School of Pharmaceutical Sciences, Iwate Medical University, Yahaba Cho, Shiwa Gun, Iwate 028 3694, Japan
    Int J Oncol 34:1085-91. 2009
    ..Moreover, cancers with aberrant CYP1B1 expression might show altered response to procarcinogen metabolism and chemotherapy...
  32. doi request reprint DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae
    Masaki Yamashita
    Department of Gastroenterology and Hepatology, St Marianna Medical University, School of Medicine, Kawasaki, Japan
    Cancer Sci 101:1708-16. 2010
    ..Our findings indicate that epigenetic IRF inactivation plays a key role in tumorigenesis of gastric cancer, and that inhibition of DNA methylation may restore the antitumor activity of interferons through up-regulation of IRFs...
  33. doi request reprint Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of morphogenesis
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    Oncology 74:127-34. 2008
    ..The aim of this study was to clarify the relationship between the serrated architecture and proliferation/differentiation process in SAs...
  34. ncbi request reprint Allelotype analysis of the PTEN, Smad4 and DCC genes in biliary tract cancer
    Takayuki Suto
    Department of Surgery I, School of Medicine, Iwate Medical University, Morioka, Japan
    Anticancer Res 22:1529-36. 2002
    ..3%, respectively, of ampullary cancer cases. Our results suggest that (a) alteration of the Smad4 gene is a major factor in the development of ampullary cancer and (b) PTEN, Smad4 and DCC genes are altered infrequently in EHBD cancers...
  35. ncbi request reprint Adenoma, adenocarcinoma and mixed carcinoid-adenocarcinoma arising in a small lesion of the colon
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Japan
    Pathol Int 53:457-62. 2003
    ..The morphological appearances of the present case strongly suggests the histogenesis of this tumor in an adenoma-adenocarcinoma-carcinoid tumor sequence...
  36. doi request reprint Overexpression of histone deacetylase 6 contributes to accelerated migration and invasion activity of hepatocellular carcinoma cells
    Kiminori Kanno
    Department of Tumor Biology, Institute of Biomedical Science, School of Medicine, Iwate Medical University, Morioka, Japan
    Oncol Rep 28:867-73. 2012
    ..These results suggest that overexpression of the HDAC6 protein is involved in the migration and invasion activities of HCC cells, and may be a good biomarker for prediction of intrahepatic metastasis...
  37. ncbi request reprint Clinicopathological study of depth of subserosal invasion in patients with pT2 gallbladder carcinoma
    Ryoko Sasaki
    Department of Surgery I, and Division of Pathology, Department of Central Clinical Laboratory, Iwate Medical University School of Medicine, Morioka, Japan
    J Surg Oncol 92:83-8. 2005
    ....
  38. ncbi request reprint Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: genetic, immunohistochemical and ultrastructural study of a case
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Morioka, Japan
    Pathol Int 52:135-40. 2002
    ..To our knowledge, the present study is the first molecular genetic study of this rare lesion. Further studies will be necessary to clarify the molecular basis of tumorigenesis of this rare lesion...
  39. doi request reprint Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings
    Yoshihiro Shioi
    Division of Molecular Diagnostic Pathology, Department of Pathology, Iwate Medical University School of Medicine, Uchimaru, Morioka, Japan
    Pathol Int 60:472-6. 2010
    ..Accumulation of cases of SCLS is necessary to facilitate a more accurate evaluation of the pathology and clinical behavior of this tumor...
  40. ncbi request reprint Meningioma in the posterior fossa without dural attachment
    Daiya Ishigaki
    Department of Neurosurgery, Iwate Medical University, Morioka, Iwate, Japan
    Neurol Med Chir (Tokyo) 47:364-6. 2007
    ..Histological and immunohistochemical studies established the diagnosis of meningothelial meningioma (World Health Organization grade I)...
  41. ncbi request reprint Synovial sarcoma of the thyroid. Report of a case with aspiration cytology findings and gene analysis
    Inako Kikuchi
    Division of Pathology, Central Clinical Laboratory, Morioka, Japan
    Acta Cytol 47:495-500. 2003
    ..Cytologic findings are important to differentiate the tumor from other types of neoplasms arising in the thyroid gland...
  42. ncbi request reprint Resection of liver metastasis from extrahepatic bile duct carcinoma previously treated by pancreatoduodenectomy
    Ryoko Sasaki
    Department of Surgery I, Iwate Medical University School of Medicine, Morioka, Japan
    Hepatogastroenterology 51:245-6. 2004
    ..When a patient has a solitary metastasis of the liver with no other evidence of recurrence, surgical resection of the liver metastasis should be considered a valid option...
  43. ncbi request reprint p53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Japan
    APMIS 110:165-71. 2002
    ..Our results suggest that p53 gene mutations and MDM2 overexpression may play an important role in the tumorigenesis. To our knowledge, the present report is the first genetic study of this rare lesion...
  44. ncbi request reprint Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing
    Tomofumi Hamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Cancer Lett 227:175-84. 2005
    ..Our mapping data provide an essential basis for further studies of methylation-regulated MUC2 inactivation...
  45. ncbi request reprint [A case of hepatic hemangioma with pedunculated extrahepatic growth simulating submucosal tumor of the stomach]
    Norihiko Kudara
    First Department of Internal Medicine, Iwate Medical University
    Nihon Shokakibyo Gakkai Zasshi 101:293-9. 2004
  46. ncbi request reprint [Assessment of dihydropyrimidine dehydrogenase and thymidylate synthase expression in gastric carcinoma and colonic carcinoma]
    Toru Yoshida
    Division of Surgery, Iwate Prefectural Shiwa Hospital
    Gan To Kagaku Ryoho 32:183-7. 2005
    ..DPD and TS protein were partially overexpressed in some cases. Heterogeneity of the tumor is thought to be one of the reasons for the discrepancy between quantitative measurement and immunohistochemical overexpression...
  47. ncbi request reprint [A case of complete response in supraclavicular lymph node involvement from cancer of the sigmoid colon to FOLFOX4 therapy after laparoscopy-assisted colectomy]
    Takayuki Suto
    Department of Surgery, Morioka Municipal Hospital
    Gan To Kagaku Ryoho 35:669-72. 2008
    ..CR has been maintained at present. She has been treated with FOLFOX4 therapy without oxaliplatin to prevent neuropathy. Establishment of maintenance therapy following CR to FOLFOX4 is awaited...
  48. ncbi request reprint Significance of ductal margin status in patients undergoing surgical resection for extrahepatic cholangiocarcinoma
    Ryoko Sasaki
    Department of Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    World J Surg 31:1788-96. 2007
    ....