Yasunari Munemasa

Summary

Affiliation: St. Marianna University School of Medicine
Country: Japan

Publications

  1. doi request reprint Modulation of mitochondria in the axon and soma of retinal ganglion cells in a rat glaucoma model
    Yasunari Munemasa
    Department Ophthalmology, St Marianna University School of Medicine, Kawasaki, Japan
    J Neurochem 115:1508-19. 2010
  2. ncbi request reprint Pro-apoptotic role of c-Jun in NMDA-induced neurotoxicity in the rat retina
    Yasunari Munemasa
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    J Neurosci Res 83:907-18. 2006
  3. ncbi request reprint Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
    Hiroyuki Takeda
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    Brain Res 1184:306-15. 2007
  4. ncbi request reprint Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina
    Yasunari Munemasa
    Department of Ophthalmology, Saint Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1044:227-40. 2005
  5. ncbi request reprint Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina
    Kohei Kuribayashi
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1071:34-41. 2006
  6. doi request reprint Axonal protection by brain-derived neurotrophic factor associated with CREB phosphorylation in tumor necrosis factor-alpha-induced optic nerve degeneration
    Hiromi Fujino
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa, 216 8511, Japan
    Acta Neuropathol 117:75-84. 2009
  7. ncbi request reprint Nuclear factor-kappa B p65 in NMDA-induced retinal neurotoxicity
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    Brain Res Mol Brain Res 131:8-16. 2004
  8. doi request reprint Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage
    Yasunari Munemasa
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Vis Neurosci 25:197-208. 2008
  9. doi request reprint Axonal and cell body protection by nicotinamide adenine dinucleotide in tumor necrosis factor-induced optic neuropathy
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    J Neuropathol Exp Neurol 68:915-27. 2009
  10. doi request reprint Axonal protection by 17β-estradiol through thioredoxin-1 in tumor necrosis factor-induced optic neuropathy
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Endocrinology 152:2775-85. 2011

Collaborators

Detail Information

Publications20

  1. doi request reprint Modulation of mitochondria in the axon and soma of retinal ganglion cells in a rat glaucoma model
    Yasunari Munemasa
    Department Ophthalmology, St Marianna University School of Medicine, Kawasaki, Japan
    J Neurochem 115:1508-19. 2010
    ..Furthermore, modulation of mitochondria through the inhibition of AIF translocation may become a new treatment strategy for neurodegenerative disease, such as glaucoma...
  2. ncbi request reprint Pro-apoptotic role of c-Jun in NMDA-induced neurotoxicity in the rat retina
    Yasunari Munemasa
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    J Neurosci Res 83:907-18. 2006
    ..These results suggest that c-Jun synthesis and phosphorylation participate in NMDA-induced neuronal cell death...
  3. ncbi request reprint Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
    Hiroyuki Takeda
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    Brain Res 1184:306-15. 2007
    ..These results suggest that the activation of CaMKII may regulate CREB phosphorylation and that the transient phosphorylation of CaMKII and CREB may be a neuroprotective response against NMDA-induced neurotoxicity...
  4. ncbi request reprint Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina
    Yasunari Munemasa
    Department of Ophthalmology, Saint Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1044:227-40. 2005
    ..0 nmol U0126) did not suppress NMDA-induced cell death in the RGCL nor thinning of the IPL. These findings suggest that JNK and p38 are proapoptotic in NMDA-induced cell death in the RGCL, but not ERK...
  5. ncbi request reprint Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina
    Kohei Kuribayashi
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1071:34-41. 2006
    ..The ameliorative effect of ANP was inhibited by a dopamine D(1) receptor antagonist. These results suggest that ANP may have a neuroprotective effect through possible involvement of dopamine induction...
  6. doi request reprint Axonal protection by brain-derived neurotrophic factor associated with CREB phosphorylation in tumor necrosis factor-alpha-induced optic nerve degeneration
    Hiromi Fujino
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa, 216 8511, Japan
    Acta Neuropathol 117:75-84. 2009
    ..These results suggest that the protective effect of exogenous BDNF may be associated with increases in CREB phosphorylation and endogenous BDNF in the optic nerve...
  7. ncbi request reprint Nuclear factor-kappa B p65 in NMDA-induced retinal neurotoxicity
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    Brain Res Mol Brain Res 131:8-16. 2004
    ....
  8. doi request reprint Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage
    Yasunari Munemasa
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Vis Neurosci 25:197-208. 2008
    ..The protective effects of M1 were significantly inhibited by U0126, an ERK inhibitor. These results suggest that unoprostone has neuroprotective effects against ET-1-induced neuronal injury through ERK phosphorylation...
  9. doi request reprint Axonal and cell body protection by nicotinamide adenine dinucleotide in tumor necrosis factor-induced optic neuropathy
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    J Neuropathol Exp Neurol 68:915-27. 2009
    ....
  10. doi request reprint Axonal protection by 17β-estradiol through thioredoxin-1 in tumor necrosis factor-induced optic neuropathy
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Endocrinology 152:2775-85. 2011
    ..These results suggest that a Trx1 decrease in RGC bodies and their axons may be associated with TNF-induced optic nerve axonal degeneration. Axonal protection by 17β-E2 may be related to its regulatory effect on Trx1 induction...
  11. ncbi request reprint Neuroprotective effect of 17beta-estradiol against N-methyl-D-aspartate-induced retinal neurotoxicity via p-ERK induction
    Yasuhiro Hayashi
    Department of Ophthalmology, St Marianna University School of Medicine, Miyamae ku, Kawasaki shi, Kanagawa, Japan
    J Neurosci Res 85:386-94. 2007
    ..These results suggest that E2 has an ER-mediated neuroprotective effect against NMDA-induced retinal neurotoxicity and that this effect may be associated with induction of p-ERK in the retina...
  12. ncbi request reprint Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina
    Yuka Kitaoka
    Department of Opthalmology, St Marianna University School of Medicine, Kawasaki shi, Kanagawa, Japan
    Brain Res 1018:111-8. 2004
    ..These results suggest that RhoA and ROCKII are upregulated and may be involved in NMDA-induced retinal neurotoxicity, and that fasudil is neuroprotective against glutamate-related excitotoxicity...
  13. ncbi request reprint NMDA-induced interleukin-1beta expression is mediated by nuclear factor-kappa B p65 in the retina
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki shi, Kanagawa, 216 8511 Japan
    Brain Res 1142:247-55. 2007
    ....
  14. doi request reprint Protective effect of thalidomide against N-methyl-D-aspartate-induced retinal neurotoxicity
    Kazuhide Takada
    5th Year, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    J Neurosci Res 89:1596-604. 2011
    ..These results suggest new indications for thalidomide against neurodegenerative diseases...
  15. doi request reprint Kinesin-1 and degenerative changes in optic nerve axons in NMDA-induced neurotoxicity
    Junko Kuribayashi
    Department of Ophthalmology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1362:133-40. 2010
    ..The depletion of kinesin-1 precedes axonal degeneration of the optic nerve in NMDA-induced neurotoxicity...
  16. doi request reprint Axonal protection via modulation of the amyloidogenic pathway in tumor necrosis factor-induced optic neuropathy
    Kaori Kojima
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 53:7675-83. 2012
    ....
  17. ncbi request reprint N-methyl-D-aspartate induces phosphorylation of cAMP response element (CRE)-binding protein and increases DNA-binding activity of CRE in rat retina
    Kazuyuki Isenoumi
    Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    J Pharmacol Sci 95:108-14. 2004
    ..Our results suggest that phosphorylation of CREB may involved in NMDA-induced excitotoxicity in rat retina. Phosphorylated CREB seems to be the active form and the one that is transcribed...
  18. pmc Molecular mechanisms of retinal ganglion cell degeneration in glaucoma and future prospects for cell body and axonal protection
    Yasunari Munemasa
    Department of Ophthalmology, St Marianna University School of Medicine Kawasaki, Kanagawa, Japan
    Front Cell Neurosci 6:60. 2012
    ..Further study will be needed to clarify whether the combination therapy of axonal protection and cell body protection will have greater protective effects in early or progressive glaucomatous optic neuropathy (GON)...
  19. doi request reprint Expression of heat shock transcription factors and heat shock protein 72 in rat retina after intravitreal injection of low dose N-methyl-D-aspartate
    Jaehong Ahn
    Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA 90075 7000, USA
    Neurosci Lett 433:11-6. 2008
    ..Our findings suggest that the expression of HSF1 and HSF2 is associated with the Hsp72-related stress response...
  20. doi request reprint Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress
    Yasunari Munemasa
    Jules Stein Eye Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    Invest Ophthalmol Vis Sci 49:3535-43. 2008
    ..The authors investigated the expression and cell-protective roles of thioredoxins (cytosolic Trx1 and mitochondrial Trx2), important regulators of the cellular redox state, on RGCs after ONT and pharmacologic oxidative stress induction...