M Ito

Summary

Affiliation: St. Marianna University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint T cells and mast cells as a major source of interleukin-13 in atopic dermatitis
    Wataru Obara
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Dermatology 205:11-7. 2002
  2. ncbi request reprint Establishment and characterization of a mouse neural crest derived cell line (NCCmelan5)
    S Ooka
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Pigment Cell Res 14:268-74. 2001
  3. ncbi request reprint Expression of cutaneous fatty acid-binding protein and its mRNA in rat skin
    R Watanabe
    Department of Dermatology, Niigata University School of Medicine, Japan
    Arch Dermatol Res 288:481-3. 1996
  4. ncbi request reprint High transepidermal water loss induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin
    H Yamaguchi
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Dermatol Sci 17:205-13. 1998
  5. ncbi request reprint mu-Crystallin, thyroid hormone-binding protein, is expressed abundantly in the murine inner root sheath cells
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Invest Dermatol 115:402-5. 2000
  6. ncbi request reprint Stem cell factor and/or endothelin-3 dependent immortal melanoblast and melanocyte populations derived from mouse neural crest cells
    Y Kawa
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Pigment Cell Res 13:73-80. 2000
  7. ncbi request reprint Hair follicle has a novel anagen-specific protein, mKAP13
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Invest Dermatol 111:804-9. 1998
  8. ncbi request reprint A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Invest Dermatol 114:1050-6. 2000
  9. ncbi request reprint Application of confocal laser scanning microscopy to differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita
    T Kazama
    Department of Dermatology, Niigata University School of Medicine, Japan
    Br J Dermatol 138:593-601. 1998
  10. ncbi request reprint A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Niigata, Japan
    J Invest Dermatol 116:359-65. 2001

Collaborators

Detail Information

Publications63

  1. ncbi request reprint T cells and mast cells as a major source of interleukin-13 in atopic dermatitis
    Wataru Obara
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Dermatology 205:11-7. 2002
    ..Recent studies suggest that cytokines expressed locally in the skin play several critical roles in atopic dermatitis (AD), however, little is known about the role of IL-13 in AD lesions...
  2. ncbi request reprint Establishment and characterization of a mouse neural crest derived cell line (NCCmelan5)
    S Ooka
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Pigment Cell Res 14:268-74. 2001
    ..It is clear that our attempt to establish immortal cell lines from murine neural crest cells would have never been successful without the addition of SCF and EDN3, since C57NCC SE and NCCmelan5 cells require those factors to proliferate...
  3. ncbi request reprint Expression of cutaneous fatty acid-binding protein and its mRNA in rat skin
    R Watanabe
    Department of Dermatology, Niigata University School of Medicine, Japan
    Arch Dermatol Res 288:481-3. 1996
    ..Since epidermis and sebaceous glands are active sites of fatty acid synthesis, these results suggest that C-FABP may have important roles in the transport and synthesis of fatty acids...
  4. ncbi request reprint High transepidermal water loss induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin
    H Yamaguchi
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Dermatol Sci 17:205-13. 1998
    ..These results suggest that increase of TEWL itself stimulates C-FABP expression, leading to activation of fatty acid metabolism...
  5. ncbi request reprint mu-Crystallin, thyroid hormone-binding protein, is expressed abundantly in the murine inner root sheath cells
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Invest Dermatol 115:402-5. 2000
    ..These results suggest the possible involvement of mu-crystallin in the development of mouse hair follicles during the anagen phase...
  6. ncbi request reprint Stem cell factor and/or endothelin-3 dependent immortal melanoblast and melanocyte populations derived from mouse neural crest cells
    Y Kawa
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Pigment Cell Res 13:73-80. 2000
    ..This suggests that NCC-S4.1 cells are melanoblasts that have the potential to differentiate into melanocytes. These cell populations will be extremely useful to study factors that affect melanocyte development and melanogenesis...
  7. ncbi request reprint Hair follicle has a novel anagen-specific protein, mKAP13
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Invest Dermatol 111:804-9. 1998
    ..Therefore, we have termed this novel protein mKAP13 according to the unified nomenclature...
  8. ncbi request reprint A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Invest Dermatol 114:1050-6. 2000
    ..Thus, these data suggest the possible involvement of Sh3yl1 in the development of hair follicles during the anagen phase...
  9. ncbi request reprint Application of confocal laser scanning microscopy to differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita
    T Kazama
    Department of Dermatology, Niigata University School of Medicine, Japan
    Br J Dermatol 138:593-601. 1998
    ..These spatial relationships are compatible with their previously described ultrastructural locations. Thus, this method appears to be useful in the differential diagnosis of BP and EBA...
  10. ncbi request reprint A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Niigata, Japan
    J Invest Dermatol 116:359-65. 2001
    ....
  11. ncbi request reprint Atrichia with papular lesions: electron microscopic observations of cystic lesions
    K Nomura
    Department of Dermatology, Aomori Prefectural Central Hospital, Higashi Tsukurimichi 2 1 1, Aomori 030 0913, Japan
    Am J Dermatopathol 23:227-31. 2001
    ..In particular, the structure of the cyst wall corresponded well to infundibular and/or isthmal portions of the outer root sheath of the hair follicle...
  12. ncbi request reprint Cell kinetic study of human and mouse hair tissues using anti-bromodeoxyuridine monoclonal antibody
    M Tezuka
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Dermatol Sci 1:335-46. 1990
    ..The sequential cessation of mitotic activity of these cells is associated with the morphological changes from anagen through catagen to telogen. These findings were common to both human and mouse hair tissues...
  13. ncbi request reprint Netherton syndrome in two Japanese siblings with a novel mutation in the SPINK5 gene: immunohistochemical studies of LEKTI and other epidermal molecules
    Y Shimomura
    Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Niigata 951 8510, Japan
    Br J Dermatol 153:1026-30. 2005
    ..Previous studies have clearly shown a crucial role for LEKTI in skin barrier formation...
  14. ncbi request reprint Fatty acid composition of sebum wax esters and urinary androgen level in normal human individuals
    A Yamamoto
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Dermatol Sci 1:269-76. 1990
    ..This result suggests that the synthesis of iso or anteiso fatty acids may be controlled by complex factors and that there may be a unique source of anteiso fatty acids in human sebaceous glands...
  15. pmc Prophylactic effect of FK463, a novel antifungal lipopeptide, against Pneumocystis carinii infection in mice
    M Ito
    Central Institute for Experimental Animals, Kawasaki, Japan
    Antimicrob Agents Chemother 44:2259-62. 2000
    ..carinii-associated pneumonia. These results suggest that FK463 is potentially useful as a prophylactic agent against P. carinii infection...
  16. ncbi request reprint Histologic study of the regeneration process of human hair follicles grafted onto SCID mice after bulb amputation
    T Hashimoto
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Investig Dermatol Symp Proc 6:38-42. 2001
    ....
  17. ncbi request reprint Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin
    R Watanabe
    Department of Dermatology, Niigata University School of Medicine, Japan
    J Dermatol Sci 16:17-22. 1997
    ..Moreover, it is suggested that C-FABP has important roles in the transport and metabolism of fatty acids in epidermis and that altered lipid metabolism may affect the proliferation and/or differentiation of keratinocyte...
  18. ncbi request reprint Male New Zealand Black/KN mice: a novel model for autoimmune-induced permanent alopecia?
    A Hiroi
    Department of Dermatology, Wakayama Medical University, Kimiidera 811 1, Wakayama, Japan
    Br J Dermatol 155:437-45. 2006
    ..During the course of our studies in a well-established mouse model for chronic rheumatoid arthritis, the New Zealand Black/KN (NZB/KN) mouse, we noticed that ageing male NZB/KN mice developed spontaneous APA...
  19. ncbi request reprint A case of recessive dystrophic epidermolysis bullosa caused by compound heterozygous mutations in the COL7A1 gene
    S Suzuki
    Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Niigata 951 8510, Japan
    Br J Dermatol 155:838-40. 2006
  20. ncbi request reprint A successfully treated case of mycetoma due to Nocardia veterana
    M Kashima
    Department of Dermatology, St Marianna University, Kawasaki, Kanagawa 216 8511, Japan
    Br J Dermatol 152:1349-52. 2005
    ..This is the first case report of mycetoma due to N. veterana in a clinical setting...
  21. doi request reprint Primary cutaneous CD30+ anaplastic large-cell lymphoma with generalized skin involvement and involvement of one peripheral lymph node, successfully treated with low-dose oral etoposide
    N Yamane
    Department of Dermatology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
    Clin Exp Dermatol 34:e56-9. 2009
    ..We reviewed the previously reported cases of PCALCL treated with low-dose etoposide. We suggest that oral etoposide might be a useful effective treatment for treatment of relapsed multifocal PCALCL...
  22. ncbi request reprint Immunoblotting detection of gamma-catenin (plakoglobin) antibody in the serum of a patient with paraneoplastic pemphigus
    M Ishii
    Department of Dermatology, Niigata University School of Medicine, Asahimachi-dori 1, Niigata 951-8510, Japan
    Br J Dermatol 144:377-9. 2001
    ..Immunoblot study using affinity-purified gamma-catenin protein revealed that his serum recognized gamma-catenin (plakoglobin) in epidermal, thymic tumour and mouse bladder extracts...
  23. ncbi request reprint Isolation and characterization of mouse high-glycine/tyrosine proteins
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Biol Chem 272:30512-8. 1997
    ..The novel findings that each gene is activated transcriptionally with a distinct expression pattern spatially and temporally suggest that there is a remarkable difference in the distribution of these proteins in hair...
  24. ncbi request reprint Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients
    M Koyama
    Institute for Digestive Disease, Second Hospital, Nippon Medical School, 1 396, Kosugi cho, Nakahara ku, Kawasaki, Japan
    Mutat Res 406:71-7. 1999
    ..G. Knudson, Hereditary cancer, oncogenes, and anti-oncogenes, Cancer Res. 45 (1985) 1437-1443.]...
  25. ncbi request reprint A case of febrile ulceronecrotic Mucha-Habermann disease requiring debridement of necrotic skin and epidermal autograft
    K Yanaba
    Department of Dermatology, The Jikei University School of Medicine, 25 8 Nishishimbashi 3 chome, Minato ku, Tokyo 105 8461, Japan
    Br J Dermatol 147:1249-53. 2002
    ..Debridement of the necrotic skin and skin grafting using cultured epidermal autografts and meshed allografts of cadaver skin led to prompt reepithelization...
  26. ncbi request reprint Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma
    H Mineta
    Department of Otolaryngology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Hamamatsu, Japan
    Oral Oncol 39:56-63. 2003
    ..FHIT alteration may play an important role in cancer development of HNSCC, however it did not contribute to the prognosis...
  27. ncbi request reprint Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-alpha?
    M Shibasaki
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Diabetologia 45:518-26. 2002
    ..This study addresses this hypothesis and describes a unique method to clarify whether the functional differences between visceral and subcutaneous adipocytes depend on their anatomical location...
  28. ncbi request reprint Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis
    M Ito
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Aliment Pharmacol Ther 16:1449-56. 2002
    ..To investigate the effect of the eradication of Helicobacter pylori on histological gastritis...
  29. ncbi request reprint Helicobacter pylori-associated gastritis is related to babA2 expression without heterogeneity of the 3' region of the cagA genotype in gastric biopsy specimens
    X F Xie
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Pathobiology 74:309-16. 2007
    ..Blood group antigen binding adhesin (BabA) helps the strains adhere to the epithelial cell layer and is the most important adhesin of H. pylori...
  30. ncbi request reprint A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development
    M Nakashima
    Department of Clinical Oral Molecular Biology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Mech Dev 119:21-34. 2002
    ....
  31. pmc UDP-Gal: betaGlcNAc beta1, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumour antigen recognised by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumour
    N Tsuda
    Department of Immunology, Kurume University School of Medicine, 67 Asohi machi, Kurume, Fukuoka 830 0011, Japan
    Br J Cancer 87:1006-12. 2002
    ..These peptides may be useful in the peptide-based specific immunotherapy for patients with malignant brain tumours...
  32. ncbi request reprint Fatal buckwheat dependent exercised-induced anaphylaxis
    T Noma
    Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan
    Asian Pac J Allergy Immunol 19:283-6. 2001
    ..A first case of fatal FEA by buckwheat is reported with reference to specific IgE...
  33. ncbi request reprint The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis
    T Kamada
    Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
    Aliment Pharmacol Ther 18:245-52. 2003
    ..To investigate whether curing Helicobacter pylori infection improves symptoms over the long-term in Japanese patients with nonulcer dyspepsia and fundic atrophic gastritis...
  34. ncbi request reprint Preventive effects of sequential treatment with alendronate and 1 alpha-hydroxyvitamin D3 on bone mass and strength in ovariectomized rats
    M Ito
    Pharmacological Research Department, Teijin Institute for Bio Medical Research, Teijin Ltd, 4 3 2 Asahigaoka, Hino, 191 8512 Tokyo, Japan
    Bone 33:90-9. 2003
    ..Therefore, we propose that 1alpha(OH)D3 may be a good choice to replace alendronate when alendronate treatment cannot be continued for some reason...
  35. ncbi request reprint Disruption of imprinting in cloned mouse fetuses from embryonic stem cells
    H Ogawa
    Department of Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Reproduction 126:549-57. 2003
    ..These results show that inappropriate reprogramming in some imprinted genes affects the development of cloned embryos, and that aberrant P0 Igf2 transcription in particular may cause the overgrowth of cloned fetuses and placentae...
  36. ncbi request reprint Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
    L A O'Reilly
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 11:724-36. 2004
    ..Interestingly, mitogenic stimulation, but not Fas ligation, induced a unique post-translational modification of FADD. These different modifications may determine whether FADD and caspase-8 induce cell death or proliferation...
  37. ncbi request reprint T cell-dependent elimination of dividing Trypanosoma grosi from the bloodstream of Mongolian jirds
    H Sato
    Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Parasitology 128:295-304. 2004
    ..Our findings indicate that T cells play a major role at least in the 'first crisis' during elimination of dividing T. grosi from the bloodstream...
  38. ncbi request reprint Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern
    S Katayama
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Histol Histopathol 20:119-26. 2005
    ....
  39. ncbi request reprint Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines
    J Watanabe
    Department of Urology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Oncogene 25:2500-8. 2006
    ..These results suggested that dicoumarol could enhance cytotoxicity of CDDP in urogenital cancer cells with wild-type p53 through the p53/p21/JNK pathways...
  40. ncbi request reprint Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins
    K Kizawa
    Basic Research Laboratory, Kanebo Cosmetics Inc, Kotobuki cho, Odawara, Japan
    Br J Dermatol 152:314-20. 2005
    ..g. S100A2 in the outer root sheath, S100A3 in the cortex and cuticle, and S100A6 in the inner root sheath), little information is available concerning their distribution in the aberrantly differentiated tissues of pilomatrixoma...
  41. ncbi request reprint Detection of rabies virus RNA isolated from several species of animals in Brazil by RT-PCR
    M Ito
    Department of Preventive Veterinary Medicine and Animal Health, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 63:1309-13. 2001
    ..These results suggest that Brazilian rabies virus isolates could be principally divided into two populations according to genetic difference...
  42. ncbi request reprint [Seizure and developmental prognosis of West syndrome--combination therapy with high-dose vitamin B6, valproate and low-dose ACTH]
    T Miyajima
    Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga
    No To Hattatsu 33:498-504. 2001
    ..In this study, the rate of evolution into intractable epilepsy was low, but long-term mental development was poor. Seizure control by itself seemed to be insufficient to improve long developmental prognosis of West syndrome...
  43. ncbi request reprint Isolation and RNA gel blot analysis of genes that could serve as potential molecular markers for leaf senescence in Arabidopsis thaliana
    S Yoshida
    Department of Biological Sciences, Graduated School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033 Japan
    Plant Cell Physiol 42:170-8. 2001
    ..These expression characteristics of YLS genes will be useful as potential molecular markers, which will enhance our understanding of natural and artificial senescence processes...
  44. ncbi request reprint c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma
    T Hiyama
    First Department of Internal Medicine, Hiroshima University School of Medicine, Minami Ku, Hiroshima 734 8551, Japan
    Oncol Rep 8:289-92. 2001
    ..These data suggest that mutation of the c-myc gene may not be commonly associated with development of gastric MALT lymphoma and DLL, and may not be associated with regression of low-grade MALT lymphoma after H. pylori eradication...
  45. ncbi request reprint Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa
    Y Muramatsu
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Peptides 21:1799-809. 2000
    ..The appearance of urocortin after birth indicates that the exposure to dietary intake and/or luminal bacteria after birth may contribute to the initiation of urocortin expression in human gastrointestinal tract mucosa...
  46. ncbi request reprint T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells
    M Shimoyama
    Department of Medicine, Kobe University School of Medicine, Japan
    Growth Factors 18:63-78. 2000
    ..Among T-cell-derived leukemia cells, the expression level of EphB6 seemed to decrease with maturation of the cells. These results suggest that EphB6 expression is regulated in T-cell development...
  47. ncbi request reprint Human T cell L-plastin bundles actin filaments in a calcium-dependent manner
    Y Namba
    Department of Cell Biology, Kyoto University
    J Biochem 112:503-7. 1992
    ..Under suitable conditions, approximately one molecule of L-plastin bound to 8 molecules of actin monomer in the actin filament...
  48. ncbi request reprint Gene expression during osteoclast-like cell formation induced by antifusion regulatory protein-1/CD98/4F2 monoclonal antibodies (MAbs): c-src is selectively induced by anti-FRP-1 MAb
    Y Higuchi
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture, Japan
    Bone 25:17-24. 1999
    ..On the other hand, no receptor activator of NF-KB ligand (RANKL) mRNA was detectable in any of the samples, suggesting that anti-FRP-1 mAb can induce osteoclast-like cells from blood monocytes without RANKL...
  49. ncbi request reprint AT2 receptor and vascular smooth muscle cell differentiation in vascular development
    H Yamada
    Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 33:1414-9. 1999
    ..Taken together, our results suggest that the AT2 receptor promotes vascular differentiation and contributes to vasculogenesis...
  50. pmc Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II
    M I Oliverio
    Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 95:15496-501. 1998
    ..These studies reaffirm and extend the importance of AT1 receptors to mediate physiological functions of the renin-angiotensin system...
  51. ncbi request reprint Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin
    R Watanabe
    Department of Biochemistry, Niigata University School of Medicine, Japan
    Biochem Biophys Res Commun 200:253-9. 1994
    ..1 kDa and exhibits around 50% identity to myelin P2 protein, adipocyte FABP and heart FABP. Our results propose that C-FABP is a new member of the FABP family...
  52. ncbi request reprint Molecular cloning, functional expression and characterization of d-limonene synthase from Schizonepeta tenuifolia
    T Maruyama
    Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Japan
    Biol Pharm Bull 24:373-7. 2001
    ..Here, we report on the cloning of dLMS, and the putative stereochemical regulation mechanism is discussed based on the comparison of the deduced amino acid sequence of dLMS with those of known l-limonene synthases...
  53. ncbi request reprint Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice
    K Hioki
    Central Institute for Experimental Animals, 1430 Nogawa, Kawasaki 216, Japan
    Exp Anim 50:67-72. 2001
    ..BALB/cA-nu, scid mice may be useful as a recipient in allo- and xeno-transplantation experiments because of the absence of both thymic lymphomas and leakiness, in addition to lack of hair...
  54. ncbi request reprint Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage
    K Hayashi
    Department of Molecular Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Immunol 167:4957-65. 2001
    ..Thus, overexpression of AML1 is able to skew class II-restricted thymocytes into the CD8 SP lineage, but not to drive the maturation of resulting selected CD8 SP cells...
  55. ncbi request reprint Molecular cloning, functional expression and characterization of (E)-beta farnesene synthase from Citrus junos
    T Maruyama
    Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Biol Pharm Bull 24:1171-5. 2001
    ..A possible reaction mechanism for terpene biosynthesis is also discussed on the basis of sequence comparison of CJFS with known sesquiterpene synthase genes...
  56. pmc Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: antibacterial effect of hBD-2 against Helicobacter pylori
    Y Hamanaka
    Department of Molecular Pathology, Nagasaki University School of Medicine, Nagasaki, Japan
    Gut 49:481-7. 2001
    ..CONCLUSIONS: H pylori infection induces hBD-2 expression in the human gastric epithelium. hBD-2 inhibited the growth of H pylori in vitro, suggesting that hBD-2 plays an antibacterial role in H pylori induced gastritis...
  57. pmc Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation
    T Nii
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City 770 8503, Japan
    Biochem J 358:693-704. 2001
    ..These findings indicated that a removal of the block to mRNA elongation stimulates the induction of system-L amino acid transporter gene transcripts (LAT1 and 4F2hc) in activated T-cells...
  58. ncbi request reprint A novel differentiation-inducing therapy for acute promyelocytic leukemia with a combination of arsenic trioxide and GM-CSF
    A Muto
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Leukemia 15:1176-84. 2001
    ..In conclusion, a combination of As2O3 and GM-CSF appears to be a novel differentiation-inducing therapy in patients with APL, including relapsed or RA-resistant cases...
  59. pmc Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID mice
    Y Miura
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
    J Exp Med 193:651-60. 2001
    ..These results suggest that a large number of HIV-1-uninfected CD4+ T cells undergo TRAIL-mediated apoptosis in HIV-infected lymphoid organs...
  60. ncbi request reprint Sertoli cell-specific rescue of fertility, but not testicular pathology, in Dax1 (Ahch)-deficient male mice
    B Jeffs
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Endocrinology 142:2481-8. 2001
    ..However, the failure to completely rescue the testicular pathology of Dax1-deficient mice suggests that Dax1 expression in other somatic cells is essential for normal testicular development...
  61. ncbi request reprint Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability
    T Hiyama
    First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima 734-8551, Japan
    Int J Oncol 18:1207-12. 2001
    ..The treatment may be efficacious as a first-line therapy for patients with high-grade MALT lymphoma. However, our sample size was limited and further studies are needed to clarify the issue...
  62. ncbi request reprint Expansion of cytolytic CD8(+) natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon gamma production
    J Baker
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University Medical Center, Stanford, CA, USA
    Blood 97:2923-31. 2001
    ..These data indicate that CD8(+) NKT cells expanded in this fashion could be useful for preserving graft-versus-leukemia activity without causing GVHD...
  63. ncbi request reprint Interleukin-4 gene expression and IgE responsiveness
    H Okudaira
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    Int Arch Allergy Appl Immunol 94:184-6. 1991
    ..The results obtained in the present study may indicate that high and low IgE responder traits are determined depending on their levels of IL-4 mRNA expression...