N Ariyoshi

Summary

Affiliation: St. Marianna University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats
    Toshio Kumai
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki 2168511, Japan
    Life Sci 81:1193-8. 2007
  2. ncbi request reprint Nipradilol induces vasodilation of canine isolated posterior ciliary artery via stimulation of the guanylyl cyclase-cGMP pathway
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University of School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki shi, Kanagawa, 216 8511, Japan
    Life Sci 71:1115-24. 2002
  3. ncbi request reprint Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, 216 8511 Japan
    Life Sci 67:663-9. 2000
  4. ncbi request reprint Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension
    H Shimizu
    Department of Pharmacology, St Marianna University School of Medicine, Kanagawa, Japan
    Jpn J Pharmacol 85:306-12. 2001
  5. ncbi request reprint Biochemical and morphological characterization of spontaneously hypertensive hyperlipidaemic rats
    Toshio Kumai
    Departments of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    Clin Exp Pharmacol Physiol 30:537-44. 2003
  6. ncbi request reprint Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4
    Ryoko Taniguchi
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    J Pharmacol Sci 97:83-90. 2005
  7. ncbi request reprint Pleiotropic effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: candidate mechanisms for anti-lipid deposition in blood vessels
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Miyamae ku, Kawasaki shi, Kanagawa, Japan
    Curr Med Chem Cardiovasc Hematol Agents 3:195-201. 2005
  8. ncbi request reprint Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis
    Yuko Takeba
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1, Sugao, Miyamae ku, Kawasaski, Kanagawa 216 8511, Japan
    J Pharmacol Sci 104:232-42. 2007
  9. ncbi request reprint Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats
    T Kumai
    Dept of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    Life Sci 67:1993-9. 2000
  10. ncbi request reprint Effects of nitric oxide synthase inhibitor on tyrosine hydroxylase mRNA in the adrenal medulla of spontaneously hypertensive and Wistar Kyoto rats
    T Kumai
    Department of Pharmacology, Department of Pediatrics, St Marianna University School of Medicine, 2 16 1 Sugao, Kanagawa, Miyamae ku, 216 8511, Japan
    Nitric Oxide 3:321-6. 1999

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats
    Toshio Kumai
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki 2168511, Japan
    Life Sci 81:1193-8. 2007
    ..These results suggest that the depressor effects of fasudil on hypertension in spontaneously hypertensive rats may be related to inhibition of the catecholamine synthetic pathway...
  2. ncbi request reprint Nipradilol induces vasodilation of canine isolated posterior ciliary artery via stimulation of the guanylyl cyclase-cGMP pathway
    Yasushi Kitaoka
    Department of Ophthalmology, St Marianna University of School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki shi, Kanagawa, 216 8511, Japan
    Life Sci 71:1115-24. 2002
    ..These findings indicate that nipradilol-induced vasorelaxation in the canine posterior ciliary artery occurs via stimulation of the guanylyl cyclase-cGMP pathway...
  3. ncbi request reprint Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, 216 8511 Japan
    Life Sci 67:663-9. 2000
    ..These results suggest that interferon-alpha-induced depression may be related to change in the catecholamine synthetic pathway in the central nervous system...
  4. ncbi request reprint Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension
    H Shimizu
    Department of Pharmacology, St Marianna University School of Medicine, Kanagawa, Japan
    Jpn J Pharmacol 85:306-12. 2001
    ..These results suggest that cyclosporine increased blood pressure via activation of the catecholamine synthetic pathway due to the activation of transcription factor CREB...
  5. ncbi request reprint Biochemical and morphological characterization of spontaneously hypertensive hyperlipidaemic rats
    Toshio Kumai
    Departments of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    Clin Exp Pharmacol Physiol 30:537-44. 2003
    ..The SHHR may be valuable in the study of mechanisms of atherosclerosis and the evaluation of anti-atherosclerosis drugs as a new strain of cardiovascular disease...
  6. ncbi request reprint Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4
    Ryoko Taniguchi
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    J Pharmacol Sci 97:83-90. 2005
    ..CYP2C8 is the primary metabolic pathway of paclitaxel, but there is a "shifting phenomenon" in the metabolic pathway of paclitaxel in the liver of some human subjects...
  7. ncbi request reprint Pleiotropic effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: candidate mechanisms for anti-lipid deposition in blood vessels
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Miyamae ku, Kawasaki shi, Kanagawa, Japan
    Curr Med Chem Cardiovasc Hematol Agents 3:195-201. 2005
    ..However, the pleiotropic effects occur regardless of statin hydrophilicity and lipophilicity. This review summarizes the pleiotropic effects of statins on lipid deposition in blood vessels...
  8. ncbi request reprint Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis
    Yuko Takeba
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1, Sugao, Miyamae ku, Kawasaski, Kanagawa 216 8511, Japan
    J Pharmacol Sci 104:232-42. 2007
    ..These results suggest that the p53-mediated apoptosis pathway is important in the anticancer effects of irinotecan in hepatocellular carcinoma...
  9. ncbi request reprint Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats
    T Kumai
    Dept of Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan
    Life Sci 67:1993-9. 2000
    ..alpha-Methyl-p-tyrosine prevented the DEX-induced blood pressure increase. These results suggest that the catecholamine synthetic pathway may be involved in DEX-induced hypertension...
  10. ncbi request reprint Effects of nitric oxide synthase inhibitor on tyrosine hydroxylase mRNA in the adrenal medulla of spontaneously hypertensive and Wistar Kyoto rats
    T Kumai
    Department of Pharmacology, Department of Pediatrics, St Marianna University School of Medicine, 2 16 1 Sugao, Kanagawa, Miyamae ku, 216 8511, Japan
    Nitric Oxide 3:321-6. 1999
    ..Our results also suggest that this effect is suppressed in SHR due to decreased NOS activity in the adrenal medulla...
  11. ncbi request reprint Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population
    T Tateishi
    Department of Pharmacology, St Marianna University School of Medicine, Kanagawa, Kawasaki, Japan
    Clin Pharmacol Ther 65:570-5. 1999
    ..To analyze the CYP2D6 allele frequencies in a Japanese population and to evaluate the effects of CYP2D6 variants on in vivo CYP2D6 activity as measured by the dextromethorphan metabolic ratio (MR)...
  12. ncbi request reprint Irinotecan-induced apoptosis is inhibited by increased P-glycoprotein expression and decreased p53 in human hepatocellular carcinoma cells
    Yuko Takeba
    Department of Pharmacology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Biol Pharm Bull 30:1400-6. 2007
    ..These results suggest that the accumulation of irinotecan in HCC leads to the development of drug resistance...
  13. ncbi request reprint Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki shi, Japan
    J Hypertens 19:1769-73. 2001
    ..These findings suggest that peripheral systemic injection of TH AS ODN may be effective as hypotensive therapy in SHR...
  14. ncbi request reprint A novel single nucleotide polymorphism altering stability and activity of CYP2a6
    N Ariyoshi
    Laboratory of Drug Metabolism, Hokkaido University, Sapporo, 060 0812, Japan
    Biochem Biophys Res Commun 281:810-4. 2001
    ..These data suggest that individuals homozygous for the T1412C variant allele or heterozygous for this and a defect allele such as the CYP2A6*4 may be poor metabolizer of nicotine, but not coumarin...
  15. ncbi request reprint Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples
    J R Baker
    National Research Centre for Environmental Toxicology, Brisbane, Australia
    Biochem Pharmacol 62:713-21. 2001
    ....
  16. ncbi request reprint Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
    M A Loriot
    INSERM U490, Molecular Toxicology, University of Rene Descartes, Paris, France
    Pharmacogenetics 11:39-44. 2001
    ..1, 95% confidence interval = 0.7-1.9)...
  17. ncbi request reprint Characterization of the rat Star gene that encodes the predominant 3.5-kilobase pair mRNA. ACTH stimulation of adrenal steroids in vivo precedes elevation of Star mRNA and protein
    N Ariyoshi
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 273:7610-9. 1998
    ..Although elevation of STAR protein by ACTH does not cause the acute increase in adrenal cholesterol metabolism, changes in the turnover or distribution of an active STAR subfraction cannot be excluded...
  18. ncbi request reprint CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes
    H Nakamura
    Division of Pharmacy, University Hospital, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Curr Drug Metab 6:469-80. 2005
    ..This is the first report demonstrating the substantial contribution of CYP1A1 to the metabolism of a drug, although its role in the metabolism of environmental compounds is well established...
  19. ncbi request reprint Comparison of the levels of enzymes involved in drug metabolism between transgenic or gene-knockout and the parental mice
    N Ariyoshi
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Toxicol Pathol 29:161-72. 2001
    ..The content or activities of almost all other enzymes examined in the present study do not appear to be affected by the gene manipulation...
  20. ncbi request reprint A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation
    N Ariyoshi
    Laboratory of Drug Metabolism, Hokkaido University, Sapporo, 060 0812, Japan
    Biochem Biophys Res Commun 281:1256-60. 2001
    ..This is the first evidence demonstrating that only one amino acid substitution, Gln172His, caused by natural SNP enhances the catalytic activity of CYP by obtaining the character of homotropic cooperativity...
  21. ncbi request reprint Accumulation of the 1-methyl-4-phenylpyridinium ion in suncus (Suncus murinus) brain: implication for flavin-containing monooxygenase activity in brain microvessels
    T Mushiroda
    Laboratory of Drug Metabolism, Division of Pharmacobio-dynamics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan
    Chem Res Toxicol 14:228-32. 2001
    ..These results suggest that FMO(s) plays a significant role in the detoxification of MPTP in cerebral endothelial cells...
  22. ncbi request reprint Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism: reduced triose phosphate content in rat liver cytosol
    Y Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan
    Fukuoka Igaku Zasshi 92:190-200. 2001
    ..The suppression of triose phosphate metabolism could be a cause of the wasting syndrome provoked by highly toxic coplanar PCB...
  23. ncbi request reprint Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl
    Y Ishii
    Faculty of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Toxicology 116:193-9. 1997
    ..The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB...