Kazuyuki Nakajima

Summary

Affiliation: Soka University
Country: Japan

Publications

  1. request reprint
    Nakajima K, Graeber M, Sonoda M, Tohyama Y, Kohsaka S, Kurihara T. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. J Neurosci Res. 2006;84:348-59 pubmed
    ..In summary, the microglia isolated from the axFN were found to be proliferative in an autocrine fashion and to have some cellular properties in common with those observed in vivo. ..
  2. Nakajima K, Yamamoto S, Tohyama Y, Kohsaka S. Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro. Neurosci Lett. 2010;471:66-9 pubmed publisher
    ..In conclusion, p38 and JNK were shown to be the major MAPKs involved in the signaling cascade leading to PAI-1 induction in astrocytes stimulated with PLGn. ..
  3. Nakajima K, Kanamatsu T, Koshimoto M, Kohsaka S. Microglia derived from the axotomized adult rat facial nucleus uptake glutamate and metabolize it to glutamine in vitro. Neurochem Int. 2017;102:1-12 pubmed publisher
    ..Taken together, these results demonstrate that axoFN-microglia express functional GLT-1 and GS proteins, and are strongly suggested to serve as Glu scavengers in vivo. ..
  4. request reprint
    Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Ability of rat microglia to uptake extracellular glutamate. Neurosci Lett. 2001;307:171-4 pubmed
    ..All together, these results indicate that microglia can act as glutamate scavengers in vivo by expressing the glutamate transporter GLT-1...
  5. request reprint
    Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia. Neurochem Int. 2004;44:205-14 pubmed
    ....
  6. request reprint
    Nakajima K, Matsushita Y, Tohyama Y, Kohsaka S, Kurihara T. Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia. Neurosci Lett. 2006;401:199-202 pubmed
    ..Taken together, these results suggest that the induction of IL-1beta and TNFalpha in endotoxin-stimulated microglia is differentially regulated at the level of NFkappaB activation. ..

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Publications6

  1. request reprint
    Nakajima K, Graeber M, Sonoda M, Tohyama Y, Kohsaka S, Kurihara T. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. J Neurosci Res. 2006;84:348-59 pubmed
    ..In summary, the microglia isolated from the axFN were found to be proliferative in an autocrine fashion and to have some cellular properties in common with those observed in vivo. ..
  2. Nakajima K, Yamamoto S, Tohyama Y, Kohsaka S. Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro. Neurosci Lett. 2010;471:66-9 pubmed publisher
    ..In conclusion, p38 and JNK were shown to be the major MAPKs involved in the signaling cascade leading to PAI-1 induction in astrocytes stimulated with PLGn. ..
  3. Nakajima K, Kanamatsu T, Koshimoto M, Kohsaka S. Microglia derived from the axotomized adult rat facial nucleus uptake glutamate and metabolize it to glutamine in vitro. Neurochem Int. 2017;102:1-12 pubmed publisher
    ..Taken together, these results demonstrate that axoFN-microglia express functional GLT-1 and GS proteins, and are strongly suggested to serve as Glu scavengers in vivo. ..
  4. request reprint
    Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Ability of rat microglia to uptake extracellular glutamate. Neurosci Lett. 2001;307:171-4 pubmed
    ..All together, these results indicate that microglia can act as glutamate scavengers in vivo by expressing the glutamate transporter GLT-1...
  5. request reprint
    Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia. Neurochem Int. 2004;44:205-14 pubmed
    ....
  6. request reprint
    Nakajima K, Matsushita Y, Tohyama Y, Kohsaka S, Kurihara T. Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia. Neurosci Lett. 2006;401:199-202 pubmed
    ..Taken together, these results suggest that the induction of IL-1beta and TNFalpha in endotoxin-stimulated microglia is differentially regulated at the level of NFkappaB activation. ..