Affiliation: Soka University
Nakajima K, Tohyama Y, Maeda S, Kohsaka S, Kurihara T. Neuronal regulation by which microglia enhance the production of neurotrophic factors for GABAergic, catecholaminergic, and cholinergic neurons. Neurochem Int. 2007;50:807-20 pubmed
..Taken together, neuronal stimulus was found to activate microglia to produce more neurotrophic factors as above, thereby changing microglia into more neurotrophic cells. ..
Nakajima K, Kanamatsu T, Takezawa Y, Kohsaka S. Up-regulation of glutamine synthesis in microglia activated with endotoxin. Neurosci Lett. 2015;591:99-104 pubmed publisher
..Microglia were thus, strongly suggested to metabolize Glu to Gln via GS activity when activated in the inflammatory/pathological state of the nervous system. ..
Sudo K, Takezawa Y, Kohsaka S, Nakajima K. Involvement of nitric oxide in the induction of interleukin-1 beta in microglia. Brain Res. 2015;1625:121-34 pubmed publisher
..Taken together, these results indicate that NO is an important signaling molecule for the ERK/JNK and NFÎºB activations, which are requisite to the induction of IL-1Î² in microglia. ..
Takezawa Y, Kohsaka S, Nakajima K. Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons. Brain Res. 2014;1586:34-45 pubmed publisher
..Taken together, these results demonstrated that the injured facial motoneurons transiently reduced glycogen synthase levels at around 1-2 weeks post-insult, but restored the levels at 4-5 weeks post-insult. ..
Nakajima K, Graeber M, Sonoda M, Tohyama Y, Kohsaka S, Kurihara T. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. J Neurosci Res. 2006;84:348-59 pubmed
..In summary, the microglia isolated from the axFN were found to be proliferative in an autocrine fashion and to have some cellular properties in common with those observed in vivo. ..
Nakajima K, Yamamoto S, Tohyama Y, Kohsaka S. Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro. Neurosci Lett. 2010;471:66-9 pubmed publisher
..In conclusion, p38 and JNK were shown to be the major MAPKs involved in the signaling cascade leading to PAI-1 induction in astrocytes stimulated with PLGn. ..
Nakajima K, Kanamatsu T, Koshimoto M, Kohsaka S. Microglia derived from the axotomized adult rat facial nucleus uptake glutamate and metabolize it to glutamine inÂ vitro. Neurochem Int. 2017;102:1-12 pubmed publisher
..Taken together, these results demonstrate that axoFN-microglia express functional GLT-1 and GS proteins, and are strongly suggested to serve as Glu scavengers inÂ vivo. ..
Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Ability of rat microglia to uptake extracellular glutamate. Neurosci Lett. 2001;307:171-4 pubmed
..All together, these results indicate that microglia can act as glutamate scavengers in vivo by expressing the glutamate transporter GLT-1...
Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia. Neurochem Int. 2004;44:205-14 pubmed