T Suda

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. ncbi request reprint Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocr Rev 20:345-57. 1999
  2. ncbi request reprint Lessons from the space experiment SL-J/FMPT/L7: the effect of microgravity on chicken embryogenesis and bone formation
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Bone 22:73S-78S. 1998
  3. pmc Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors
    S Tanaka
    Department of Biochemistry, Showa University, School of Dentistry, Tokyo, Japan
    J Clin Invest 91:257-63. 1993
  4. ncbi request reprint Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    N Udagawa
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocrinology 141:3478-84. 2000
  5. ncbi request reprint Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF)
    Y H Gao
    Department of Oral Pathology, Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    Biochem Biophys Res Commun 252:697-702. 1998
  6. ncbi request reprint The molecular basis of osteoclast differentiation and activation
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo 142-8555, Japan
    Novartis Found Symp 232:235-47; discussion 247-50. 2001
  7. pmc Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha-hydroxylase gene in normocalcemic rats
    T Shinki
    Department of Biochemistry, School of Dentistry, Showa University, Hatanodai, Shinagawa ku, Tokyo 142 8555, USA
    Proc Natl Acad Sci U S A 96:8253-8. 1999
  8. ncbi request reprint Expression and antigenicity of human herpesvirus 8 encoded ORF59 protein in AIDS-associated Kaposi's sarcoma
    H Katano
    Department of Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Med Virol 59:346-55. 1999
  9. ncbi request reprint A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
    N Takahashi
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    Biochem Biophys Res Commun 256:449-55. 1999
  10. ncbi request reprint Activation of NF-kappaB is involved in the survival of osteoclasts promoted by interleukin-1
    E Jimi
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555 Japan
    J Biol Chem 273:8799-805. 1998

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocr Rev 20:345-57. 1999
    ....
  2. ncbi request reprint Lessons from the space experiment SL-J/FMPT/L7: the effect of microgravity on chicken embryogenesis and bone formation
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Bone 22:73S-78S. 1998
    ..No appreciable changes were recognized in these chicks. The reason for these unexpected results is not known. Further space experiments are needed to explain the failure of the effects of microgravity on chicken embryogenesis...
  3. pmc Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors
    S Tanaka
    Department of Biochemistry, Showa University, School of Dentistry, Tokyo, Japan
    J Clin Invest 91:257-63. 1993
    ..These results clearly indicate that M-CSF is indispensable for both proliferation of osteoclast progenitors and their differentiation into mature osteoclasts...
  4. ncbi request reprint Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    N Udagawa
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocrinology 141:3478-84. 2000
    ..These findings suggest that OPG produced by osteoblasts/stromal cells is a physiologically important regulator in osteoclast differentiation and function and that RANKL expressed by osteoblasts functions as a membrane-associated form...
  5. ncbi request reprint Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF)
    Y H Gao
    Department of Oral Pathology, Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    Biochem Biophys Res Commun 252:697-702. 1998
    ..These results suggested that Cbfa1 is somehow involved in osteoclastogenesis through regulation of ODF/OPGL...
  6. ncbi request reprint The molecular basis of osteoclast differentiation and activation
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo 142-8555, Japan
    Novartis Found Symp 232:235-47; discussion 247-50. 2001
    ..TNF alpha and IL-1 alpha may play an important role in pathological bone resorption due to inflammation...
  7. pmc Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha-hydroxylase gene in normocalcemic rats
    T Shinki
    Department of Biochemistry, School of Dentistry, Showa University, Hatanodai, Shinagawa ku, Tokyo 142 8555, USA
    Proc Natl Acad Sci U S A 96:8253-8. 1999
    ..These results suggest that CT plays an important role in the maintenance of serum 1alpha,25(OH)2D3 under normocalcemic physiological conditions, at least in rats...
  8. ncbi request reprint Expression and antigenicity of human herpesvirus 8 encoded ORF59 protein in AIDS-associated Kaposi's sarcoma
    H Katano
    Department of Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Med Virol 59:346-55. 1999
    ..1 mRNA in the same specimen. These data suggest that ORF59 is one of the HHV-8 encoded antigens in patients with AIDS-KS and also indicated that viral replication occurred in some of KS tumor cells...
  9. ncbi request reprint A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
    N Takahashi
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    Biochem Biophys Res Commun 256:449-55. 1999
    ..Activation of NF-kB and c-Jun N-terminal kinase through the RANK-mediated signaling system appears to be involved in differentiation and activation of osteoclasts...
  10. ncbi request reprint Activation of NF-kappaB is involved in the survival of osteoclasts promoted by interleukin-1
    E Jimi
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555 Japan
    J Biol Chem 273:8799-805. 1998
    ..These results indicate that IL-1 promotes the survival of osteoclasts through the activation of NF-kappaB...
  11. ncbi request reprint Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice
    I Nakamura
    Department of Biochemistry, School of Dentistry, Showa University, Shinagawa ku, Tokyo, Japan
    FEBS Lett 401:207-12. 1997
    ..Moreover, in renal proximal convoluted tubules of oc/oc mice, the basal striation did not form. These results suggest that osteosclerosis in oc/oc mice is possibly due to the dissociation of V-ATPase and cytoskeleton in osteoclasts...
  12. ncbi request reprint Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:19819-23. 2000
    ..These findings suggest that PGE(2) stimulates bone resorption by a cAMP-dependent mechanism via the EP4 receptor...
  13. ncbi request reprint Expression of mouse osteocalcin transcripts, OG1 and OG2, is differently regulated in bone tissues and osteoblast cultures
    T Yanai
    Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
    J Bone Miner Metab 19:345-51. 2001
    ..It is also suggested that the expression of OG1 and OG2 is regulated differently in bone tissues and osteoblast cultures...
  14. pmc Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA
    T Shinki
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Proc Natl Acad Sci U S A 94:12920-5. 1997
    ..In rats with the enhanced renal production of 1alpha,25-dihydroxyvitamin D3 (rats fed a low Ca diet), P4501alpha mRNA was greatly increased in the renal proximal convoluted tubules...
  15. ncbi request reprint Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene
    K Matsuzaki
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocrinology 140:925-32. 1999
    ..This coculture model will be useful for investigating the abnormalities ofosteoclast differentiation and function in human metabolic bone diseases...
  16. ncbi request reprint Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
    Y Ishimi
    Department of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    Endocrinology 140:1893-900. 1999
    ..Phytoestrogens may be useful for preventing bone loss caused by estrogen deficiency in females...
  17. doi request reprint c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis
    T Shimizu
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University, Tokyo, Japan
    Oncogene 29:5687-99. 2010
    ..Our findings indicate that differentiation potential has a key role in OS tumorigenic activity, and that the suppression of adipogenic ability is a critical factor for the development of OS...
  18. ncbi request reprint S 12911-2 inhibits osteoclastic bone resorption in vitro
    N Takahashi
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    J Bone Miner Res 18:1082-7. 2003
    ..This effect is directly linked to the presence of strontium, is effective on basal and stimulated resorption, and involves a decrease in ruffled border formation by osteoclasts...
  19. ncbi request reprint Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Osteoporos Int 3:111-3. 1993
  20. ncbi request reprint Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation
    H Tai
    Department of Biochemistry, School of Dentistry, Showa University, Shinagawa ku, Tokyo, Japan
    Endocrinology 138:2372-9. 1997
    ..The increased PGE2 synthesis by osteoblasts may play an important role in osteoclastogenesis induced by submaximal doses of IL-1 and IL-6...
  21. ncbi request reprint Osteoclasts are present in gp130-deficient mice
    K Kawasaki
    Department of Oral Pathology, School of Dentistry, Showa University, Tokyo, Japan
    Endocrinology 138:4959-65. 1997
    ..The osteoclastic bone resorption in gp130-deficient mice may be caused by the functional redundancy of bone-resorbing hormones and cytokines other than those of the IL-6 family...
  22. ncbi request reprint Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts
    I Nakamura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 273:11144-9. 1998
    ..These findings suggest that Src-dependent tyrosine phosphorylation of Cas is involved in the adhesion-induced actin organization associated with osteoclast activation...
  23. ncbi request reprint The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3
    T Sato
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    FEBS Lett 285:21-4. 1991
    ....
  24. pmc Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    Proc Natl Acad Sci U S A 94:9360-5. 1997
    ..We propose here that the increased B-lymphopoiesis due to estrogen deficiency is involved in the mechanism of stimulated bone resorption...
  25. ncbi request reprint Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells
    N Udagawa
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Biochem Biophys Res Commun 184:67-72. 1992
    ..These results indicate that the lack of bone resorption in oc/oc mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells...
  26. ncbi request reprint HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman's disease
    T Suda
    Department of Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Pathol Int 51:671-9. 2001
    ....
  27. doi request reprint Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells
    T Suda
    Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 24:384-9. 2009
    ..The purpose of this study was to examine the roles of beta-catenin and AP-1 in interleukin-1alpha (IL-1alpha) -induced OPG production in human gingival fibroblasts (hGFs) and periodontal ligament (PDL) cells...
  28. ncbi request reprint Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase
    T Monkawa
    School of Medicine, Keio University, Tokyo, Japan
    Biochem Biophys Res Commun 239:527-33. 1997
    ..This molecular cloning makes it possible to investigate the genetic mechanism of diseases related to calcium metabolism, including vitamin D-dependency rickets type I...
  29. ncbi request reprint A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts
    M Namiki
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo 142, Japan
    J Biol Chem 272:22046-52. 1997
    ..These results suggest that the BMP-2-induced signals, which inhibit myogenic differentiation and induce osteoblast differentiation, are transduced via BMPR-IA in C2C12 myoblasts...
  30. ncbi request reprint Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: diversification between the two species
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    Genes Immun 2:110-3. 2001
    ..Our results provide an important insight into the evolutionary processes that generated the major chemokine gene clusters and also valuable information in assigning the orthologues between human and mouse major cluster chemokines...
  31. ncbi request reprint Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice
    A Tachiiri
    Centre for the Development of Molecular Targets Drugs, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Genes Immun 4:153-9. 2003
    ..Thus, the expression of the functional IL-22 receptor in the liver is regulated at the gene transcription level...
  32. ncbi request reprint Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation
    H Nishio
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Biochim Biophys Acta 1444:283-90. 1999
    ..These results suggest that human Rab3D may play a specific role in granulocytes, for example in exocytosis of neutrophil-specific granules or in degranulation of both eosinophils and basophils...
  33. ncbi request reprint The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development
    K Ohta
    Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan
    Mech Dev 54:59-69. 1996
    ..The unique expression of Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons...
  34. ncbi request reprint Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
    T Suda
    Osaka Bioscience Institute, Japan
    Cell 75:1169-78. 1993
    ..Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis...
  35. ncbi request reprint Correlation between 25-hydroxyvitamin D3 1 alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis
    N Inui
    Department of Internal Medicine, Second Division, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med 110:687-93. 2001
    ..82, P <0.05). CONCLUSION: There is a correlation between 1 alpha-hydroxylase gene expression in alveolar macrophages with the activity of sarcoidosis and its associated disturbances in calcium metabolism...
  36. ncbi request reprint Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells
    D Ilic
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Biochem Biophys Res Commun 209:300-9. 1995
    ....
  37. ncbi request reprint Microgravity generated by space flight has little effect on the growth and development of chick embryonic bone
    K Kawashima
    Department of Physiological Chemistry, Teikyo University, Sagamiko, Japan
    Biol Sci Space 9:82-94. 1995
    ..Unlike the results of previous space flight experiments in which young growing mammals were used, these morphological and biochemical results indicate that microgravity has little effect on bone metabolism of the chick embryo...
  38. ncbi request reprint In vitro prevention of cell-mediated xeno-graft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells
    M Fujino
    Department of Experimental Surgery, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8509, Japan
    Xenotransplantation 8:115-24. 2001
    ....
  39. ncbi request reprint Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion
    M Ueno
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1, Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 287:501-6. 2001
    ..5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis...
  40. ncbi request reprint Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum
    S Hatakeyama
    Department of Structural Pathology, Institute of Nephrology, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 287:814-9. 2001
    ..The specific expression of AQP10 suggests its contribution to the water transport in the upper portion of small intestine...
  41. ncbi request reprint Expression and potential role of angiopoietins and Tie-2 in early development of the mouse metanephros
    M Kolatsi-Joannou
    Nephro Urology Unit, Institute of Child Health, London, United Kingdom
    Dev Dyn 222:120-6. 2001
    ....
  42. ncbi request reprint Enhanced expression of CD34 messenger RNA by developing endothelial cells of mice
    A Ito
    Department of Pathology, Osaka University Medical School, Japan
    Lab Invest 72:532-8. 1995
    ..Roles of CD34 for angiogenesis and its function as a homophilic adhesion molecule between endothelial and hematopoietic cells have been speculated...
  43. pmc Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders
    D Watanabe
    Osaka Bioscience Institute, Japan
    EMBO J 14:12-8. 1995
    ..Furthermore, the graft-versus host disease caused by transfer of lpr bone marrow to wild-type mice can be explained by the constitutive expression of the FasL in lpr-derived T cells...
  44. ncbi request reprint Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)
    S Sakano
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Oncogene 9:1155-61. 1994
    ..We named this gene, hematopoietic consensus tyrosine-lacking kinase, HYL. The HYL gene was assigned to chromosome 19 at band p13. It is suggested that HYL plays a significant role in the signal transduction of hematopoietic cells...
  45. ncbi request reprint Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice
    D A Long
    Nephro-Urology Unit, Institute of Child Health, University College London, London, United Kingdom
    J Am Soc Nephrol 12:2721-31. 2001
    ..In addition, Tie-2-expressing capillaries near damaged cortical tubules undergo proliferation. Further experiments are required to establish whether these events are functionally related...
  46. ncbi request reprint Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    T Takahashi
    Osaka Bioscience Institute, Japan
    Cell 76:969-76. 1994
    ..These results indicate that lpr and gld are mutations in Fas and Fasl, respectively, and suggest important roles of the Fas system in development of T cells as well as cytotoxic T lymphocyte-mediated cytotoxicity...
  47. ncbi request reprint Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner
    T Suda
    Department of Dermatology, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Br J Dermatol 152:887-95. 2005
    ..The drug has an outstanding therapeutic efficacy against many skin diseases characterized by neutrophil-rich infiltrates; however, mechanisms of its action are poorly understood...
  48. ncbi request reprint Diagnosis of a case of Gitelman's syndrome based on renal clearance studies and gene analysis of a novel mutation of the thiazide-sensitive Na-Cl cotransporter
    K Kageyama
    The Third Department of Internal Medicine, Hirosaki University Hospital, Aomori, Japan
    J Endocrinol Invest 28:822-6. 2005
    ..Renal clearance studies and TSC gene analysis by amplification and direct sequencing are useful diagnostic tools for confirming a diagnosis of Gitelman's syndrome...
  49. ncbi request reprint Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells
    M Hasegawa
    Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Oncogene 26:1748-56. 2007
    ..These results indicate that ASC, like death receptors, mediates two types of apoptosis depending on the cell type, in a manner involving caspase-8...
  50. ncbi request reprint Muramyl dipeptide-Lys stimulates the function of human dendritic cells
    A Todate
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    J Leukoc Biol 70:723-9. 2001
    ..These results suggested that the immunoadjuvant activity of MDP-Lys in vivo is mediated, in part, by its stimulation of DC function...
  51. ncbi request reprint Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells
    J Nakamura
    Department of Physiology, Hirosaki University School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan
    Cell Signal 13:199-205. 2001
    ..PKC-independent inhibition of electrical excitability by phorbol esters was also demonstrated...
  52. ncbi request reprint Human Fas ligand: gene structure, chromosomal location and species specificity
    T Takahashi
    Osaka Bioscience Institute, Japan
    Int Immunol 6:1567-74. 1994
    ..Several transcription cis-regulatory elements such as SP-1, NF-kappa B and IRF-1 were recognized in this region...
  53. ncbi request reprint Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells
    M Yano
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
    Blood 89:4317-26. 1997
    ....
  54. ncbi request reprint Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation
    Y Yamaguchi
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Blood 91:450-7. 1998
    ..These findings suggest that the upregulation of c-mpl induced by GATA-1 expression in M1 cells is closely associated with erythroid and megakaryocytic differentiation...
  55. pmc Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter
    H L Brenza
    Department of Biochemistry, University of Wisconsin Madison, 420 Henry Mall, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 95:1387-91. 1998
    ..These results indicate that parathyroid hormone stimulates 25-hydroxyvitamin D3-1alpha-hydroxylase by acting on the promoter of the 1alpha-hydroxylase gene...
  56. pmc Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets
    A Hirao
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Honjo, Japan
    EMBO J 16:2342-51. 1997
    ..These results suggest that Chk, but not Csk, may function as a translocation-controlled negative regulator of CD36-anchored Lyn in thrombin-induced platelet activation...
  57. pmc STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
    A Iwama
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    EMBO J 15:5866-75. 1996
    ..Our findings provide the first evidence for apoptosis via a receptor tyrosine kinase...
  58. ncbi request reprint Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system
    K Ohshiro
    Department of Cell Differentition, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 227:273-80. 1996
    ..Our findings reveal new possible roles of the MSP-STK/RON signaling pathway...
  59. ncbi request reprint The genomic organization of the human corticotropin-releasing factor type-1 receptor
    K Sakai
    Third Division, Department of Medicine, Hirosaki University School of Medicine, Hirosaki 036, Japan
    Gene 219:125-30. 1998
    ..Exon-intron boundaries are the same as that of the consensus sequence. Locations of introns in the coding sequence are similar to human CRF-R1, rat CRF-R1, human CRF-R2alpha and others belonging to the human glucagon receptor family...
  60. pmc Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
    Proc Natl Acad Sci U S A 95:3597-602. 1998
    ..ODF was found to be identical to TRANCE/RANKL, which enhances T-cell growth and dendritic-cell function. ODF seems to be an important regulator in not only osteoclastogenesis but also immune system...
  61. ncbi request reprint Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice
    I Hamaguchi
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 224:172-9. 1996
    ..CHK/HYL did not affect the activity of Src, Hck, and Fgr in cultured bone marrow cells, although CSK negatively regulates Src family kinases. These results suggest that CHK/HYL might not have the same function as CSK...
  62. ncbi request reprint Swapping between Fas and granulocyte colony-stimulating factor receptor
    T Takahashi
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Japan
    J Biol Chem 271:17555-60. 1996
    ....
  63. ncbi request reprint Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells
    M Hashiyama
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Blood 87:93-101. 1996
    ..Although its ligand has not been identified, TIE and its ligand may establish a novel regulatory pathway not only in early hematopoiesis, but also in the differentiation and/or proliferation of B cells...
  64. pmc IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    S Kotake
    The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Clin Invest 103:1345-52. 1999
    ....
  65. ncbi request reprint Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells
    A Iwama
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 195:301-9. 1993
    ..Both genes were expressed in a similar fashion in adult tissues and primitive hematopoietic cells, predominantly in the bone marrow HSCs...
  66. ncbi request reprint Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells
    A Iwama
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Blood 83:3160-9. 1994
    ..Characterization of these PTKs, including STK, will be helpful to elucidate the molecular mechanism of the growth regulation of hematopoietic stem cells...
  67. ncbi request reprint WECHE: a novel hematopoietic regulatory factor
    O Ohneda
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Immunity 12:141-50. 2000
    ..WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation...
  68. ncbi request reprint Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene
    Y Ohyama
    Graduate Department of Gene Science, Faculty of Science, Hiroshima University, Japan
    J Biol Chem 269:10545-50. 1994
    ....
  69. ncbi request reprint Novel mouse microsatellites: primer sequences and chromosomal location
    T Suda
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    DNA Res 1:169-74. 1994
    ..The microsatellites were distributed to most chromosomes except for chromosomes 16 and 19. These novel markers with defined locations are useful in linkage and genome mapping studies...
  70. ncbi request reprint Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis
    A O Hueber
    Imperial Cancer Research Fund ICRF Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 278:1305-9. 1997
    ..These findings link two apoptotic pathways previously thought to be independent and establish the dependency of Myc on CD95 signaling for its killing activity...