H Onimaru

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. ncbi request reprint Respiration-related rhythmic activity in the rostral medulla of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Neurophysiol 96:55-61. 2006
  2. doi request reprint Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats
    H Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuroscience 212:131-9. 2012
  3. pmc Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Physiol 590:1615-24. 2012
  4. ncbi request reprint Spontaneous oscillatory burst activity in the piriform-amygdala region and its relation to in vitro respiratory activity in newborn rats
    H Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuroscience 144:387-94. 2007
  5. pmc Defective interaction between dual oscillators for respiratory rhythm generation in Na+,K+-ATPase {alpha}2 subunit-deficient mice
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Physiol 584:271-84. 2007
  6. ncbi request reprint Two modes of respiratory rhythm generation in the newborn rat brainstem-spinal cord preparation
    Hiroshi Onimaru
    Showa University School of Medicine, Department of Physiology
    Adv Exp Med Biol 605:104-8. 2008
  7. doi request reprint CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Neurosci 28:12845-50. 2008
  8. doi request reprint Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    Respir Physiol Neurobiol 168:13-8. 2009
  9. doi request reprint Phox2b expressing neurons in the most rostral medulla of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Shinagawa ku, Tokyo 142, Japan
    Adv Exp Med Biol 669:87-90. 2010
  10. doi request reprint Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparations in vitro
    T Fujii
    Department of Physiology, Showa University School of Medicine, Shinagawa ku, Tokyo 142, Japan
    Adv Exp Med Biol 669:333-6. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Respiration-related rhythmic activity in the rostral medulla of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Neurophysiol 96:55-61. 2006
    ..These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I-like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations...
  2. doi request reprint Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats
    H Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuroscience 212:131-9. 2012
    ..Our findings suggested that the location of Phox2b-ir neurons, including preinspiratory neurons of the pFRG, matched their role as sensors of blood CO(2) concentration...
  3. pmc Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Physiol 590:1615-24. 2012
    ..These neurons were predominantly Phox2b immunoreactive. Our findings suggest that the response of pFRG/RTN neurons to hypercapnia is induced by direct action on the postsynaptic membrane via closing of K(+) channels...
  4. ncbi request reprint Spontaneous oscillatory burst activity in the piriform-amygdala region and its relation to in vitro respiratory activity in newborn rats
    H Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuroscience 144:387-94. 2007
    ..This rhythmic burst activity may be involved in the development of neuronal circuits that process information related to olfaction, emotion, and respiration...
  5. pmc Defective interaction between dual oscillators for respiratory rhythm generation in Na+,K+-ATPase {alpha}2 subunit-deficient mice
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Physiol 584:271-84. 2007
    ..Coupling was partially restored by repeated activation of the neurons within the networks, suggesting the involvement of an activity-dependent process in the prenatal development of this coupling...
  6. ncbi request reprint Two modes of respiratory rhythm generation in the newborn rat brainstem-spinal cord preparation
    Hiroshi Onimaru
    Showa University School of Medicine, Department of Physiology
    Adv Exp Med Biol 605:104-8. 2008
    ..We show two different modes of respiratory rhythm generation in the brainstem-spinal cord preparation that depends on the background stimulation level...
  7. doi request reprint CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Neurosci 28:12845-50. 2008
    ..Our findings suggest that Phox2b-expressing parafacial neurons play a role in respiratory rhythm generation as well as central chemoreception and thus are essential for postnatal survival...
  8. doi request reprint Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    Respir Physiol Neurobiol 168:13-8. 2009
    ..In this brief review, we focused on these recent findings and discuss the functional role of pFRG/Pre-I neurons...
  9. doi request reprint Phox2b expressing neurons in the most rostral medulla of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Shinagawa ku, Tokyo 142, Japan
    Adv Exp Med Biol 669:87-90. 2010
    ..Here, we briefly review these recent findings. We also show a unique distribution of Phox2b expressing cells in the most rostral medulla, which could be an interesting target for neurophysiological analysis...
  10. doi request reprint Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparations in vitro
    T Fujii
    Department of Physiology, Showa University School of Medicine, Shinagawa ku, Tokyo 142, Japan
    Adv Exp Med Biol 669:333-6. 2010
    ....
  11. doi request reprint Calcium imaging of neuronal activity in the most rostral parafacial respiratory group of the newborn rat
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Shinagawa ku, Tokyo, Japan
    J Physiol Sci 62:71-7. 2012
    ..We show that usage of calcium imaging would be very useful for analysis of neuronal activity over different time scales, and discuss the advantages and disadvantages of this method...
  12. ncbi request reprint Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    J Appl Physiol 100:2094-5. 2006
  13. ncbi request reprint Development of the rat respiratory neuron network during the late fetal period
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neurosci Res 42:209-18. 2002
    ..Potentiation of synaptic interaction between respiratory neurons, causing developmental changes in the burst pattern, might be involved in the maturation process during late fetal stages...
  14. ncbi request reprint A novel functional neuron group for respiratory rhythm generation in the ventral medulla
    Hiroshi Onimaru
    Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    J Neurosci 23:1478-86. 2003
    ..Our findings suggest that the pFRG comprises a neuronal population that is involved in the primary respiratory rhythm generation in the rostrocaudally extending respiratory neuron network of the medulla...
  15. ncbi request reprint In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Toyo 142 8555, Japan
    Brain Res Dev Brain Res 153:275-9. 2004
    ..Such an activity pattern was not clearly detected in Pbx3-/- mouse preparations. The difference in the spatio-temporal pattern between Tlx3-/- and Pbx3-/- suggests different levels of functional disorder of the respiratory center...
  16. ncbi request reprint Developmental changes in the spatio-temporal pattern of respiratory neuron activity in the medulla of late fetal rat
    H Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neuroscience 131:969-77. 2005
    ..We suggest that the pre-inspiratory neuron network of the para-facial region in the rostral ventrolateral medulla functions as the rhythm generator after E19/20...
  17. ncbi request reprint Optical imaging of respiratory neuron activity from the dorsal view of the lower brainstem
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Pharmacol Physiol 32:297-301. 2005
    ..This method is very useful for analysis of pharmacological properties, as well as the spatio-temporal pattern of respiratory-related network activity in the brainstem...
  18. ncbi request reprint Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column
    Kamon Iigaya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R927-36. 2007
    ..The increase in EPSPs of the IML neurons in response to glutamate application suggests that the CeVLM participates in the regulation of sympathetic nerve activity and blood pressure and may correspond to the caudal pressor area...
  19. pmc Mechanisms of CO2/H+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro
    Akira Kawai
    Department of Physiology, Showa University, School of Medicine, Tokyo, Japan
    J Physiol 572:525-37. 2006
    ..Thus, pre-inspiratory neurons might play an important role in modulation of respiratory rhythm by central chemoreception in the brainstem-spinal cord preparation...
  20. ncbi request reprint Rostral ventrolateral medulla neurons of neonatal Wistar-Kyoto and spontaneously hypertensive rats
    Tomokazu Matsuura
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Hypertension 40:560-5. 2002
    ..These differences in RVLM neurons suggest a mechanism that possibly leads to elevation in blood pressure...
  21. ncbi request reprint Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats
    Shusuke Koda
    Department of Anesthesiology and Intensive Care, Nippon Medical School, Tokyo, Japan
    Biomed Res 26:241-7. 2005
    ..9+/- 4.0 sec vs. 4.7+/- 2.1 sec, P> 0.01). Our results suggest that administration of an appropriate dose of cannabinoid receptor agonist WIN 55,212-2 has an anticonvulsant effect but does not cause respiratory depression...
  22. pmc Contribution of Ca2+-dependent conductances to membrane potential fluctuations of medullary respiratory neurons of newborn rats in vitro
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Physiol 552:727-41. 2003
    ..We hypothesize that modulation of spontaneous activity of pre-inspiratory neurons via N-, L- and P/Q-type Ca2+ channels is important for respiratory rhythm or pattern generation...
  23. ncbi request reprint Facilitation of respiratory rhythm by a mu-opioid agonist in newborn rat pons-medulla-spinal cord preparations
    Ayaka Tanabe
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neurosci Lett 375:19-22. 2005
    ..Our findings also suggest the existence of a pontine excitatory system, which is depressed by the pontine inhibitory system under control conditions...
  24. pmc Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat
    Wiktor A Janczewski
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, 10833 Le Conte Avenue, Los Angeles, CA 90095 1763, USA
    J Physiol 545:1017-26. 2002
    ..We propose that the same pathway is responsible for rhythmic activation of the abdominal muscles during opioid-induced apnoea in the newborn rat...
  25. ncbi request reprint Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II 1a receptor knockout mice
    Tomokazu Matsuura
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Hypertension 46:349-54. 2005
    ..These results suggest that the angiotensin II type 2 receptor in rostral ventrolateral medulla plays an antagonistic role against the angiotensin II type 1a receptor in controlling the neuronal activity of rostral ventrolateral medulla...
  26. ncbi request reprint Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    Leping Cheng
    The Dana Farber Cancer Institute, and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:510-7. 2004
    ..Finally, excess GABA-mediated inhibition caused dysfunction of central respiratory circuits in Tlx3 mutant mice...
  27. pmc Pbx3 deficiency results in central hypoventilation
    Joon Whan Rhee
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Pathol 165:1343-50. 2004
    ..Pbx3-deficient mice provide a model for congenital central hypoventilation syndrome and suggest that Pbx3 mutations may promote the pathogenesis of this disorder...
  28. doi request reprint Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings
    Naoki Oshima
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 31:1445-54. 2008
    ..The results explain the mechanism by which Ang II in the RVLM area increases peripheral sympathetic activity and blood pressure...
  29. ncbi request reprint Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical School, Kawachi, Tochigi 329 0498, Japan
    J Neurosci 24:10693-701. 2004
    ..Based on these results, we propose a model for functional coupling between the Na+, K+-ATPase alpha2 subunit and KCC2, which excludes Cl- from the cytosol in respiratory center neurons...
  30. ncbi request reprint [Novel function of sodium pump]
    Keiko Ikeda
    Tanpakushitsu Kakusan Koso 50:434-9. 2005