H Onimaru

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. request reprint
    Onimaru H, Kumagawa Y, Homma I. Respiration-related rhythmic activity in the rostral medulla of newborn rats. J Neurophysiol. 2006;96:55-61 pubmed
    ..These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I-like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations. ..
  2. Onimaru H, Ikeda K, Kawakami K. Phox2b expressing neurons in the most rostral medulla of newborn rats. Adv Exp Med Biol. 2010;669:87-90 pubmed publisher
    ..Here, we briefly review these recent findings. We also show a unique distribution of Phox2b expressing cells in the most rostral medulla, which could be an interesting target for neurophysiological analysis. ..
  3. Onimaru H, Ikeda K, Kawakami K. Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats. Neuroscience. 2012;212:131-9 pubmed publisher
    ..Our findings suggested that the location of Phox2b-ir neurons, including preinspiratory neurons of the pFRG, matched their role as sensors of blood CO(2) concentration. ..
  4. Iigaya K, Okazaki S, Minoura Y, Onimaru H. Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system. Neuroscience. 2017;343:213-221 pubmed publisher
    ..We hypothesize that the VMH oscillation might be involved in low-frequency modulation of the SNA. ..
  5. Oyama Y, Iigaya K, Minoura Y, Okabe T, Izumizaki M, Onimaru H. An in vitro experimental model for analysis of central control of sympathetic nerve activity. J Physiol Sci. 2017;67:629-635 pubmed publisher
    ..This preparation allows analysis of the central control of the SNA in vitro. ..
  6. Ikeda K, Kawakami K, Onimaru H, Okada Y, Yokota S, Koshiya N, et al. The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology. J Physiol Sci. 2017;67:45-62 pubmed
    ..In this review, we focus on the recent findings and attempt to elucidate the anatomical and functional mechanisms underlying respiratory control in the lower brainstem and spinal cord. ..
  7. Tani M, Kotani S, Hayakawa C, Lin S, Irie S, Ikeda K, et al. Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Pflugers Arch. 2017;469:327-338 pubmed publisher
    ..Our results also suggested a minor contribution of the TRPV1 channels to central chemoreception. ..
  8. Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T. Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region. Brain Res Bull. 2018;139:16-20 pubmed publisher
    ..We found that more than 60% of the EYFP/Phox2b-positive cells showed Pre-I neuron-like rhythmic burst activity in the parafacial region of newborn rat. ..
  9. request reprint
    Onimaru H, Arata A, Arata S, Shirasawa S, Cleary M. In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla. Brain Res Dev Brain Res. 2004;153:275-9 pubmed
    ..Such an activity pattern was not clearly detected in Pbx3-/- mouse preparations. The difference in the spatio-temporal pattern between Tlx3-/- and Pbx3-/- suggests different levels of functional disorder of the respiratory center. ..
  10. request reprint
    Onimaru H, Homma I. Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal. J Appl Physiol (1985). 2006;100:2094-5 pubmed

Locale

Detail Information

Publications15

  1. request reprint
    Onimaru H, Kumagawa Y, Homma I. Respiration-related rhythmic activity in the rostral medulla of newborn rats. J Neurophysiol. 2006;96:55-61 pubmed
    ..These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I-like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations. ..
  2. Onimaru H, Ikeda K, Kawakami K. Phox2b expressing neurons in the most rostral medulla of newborn rats. Adv Exp Med Biol. 2010;669:87-90 pubmed publisher
    ..Here, we briefly review these recent findings. We also show a unique distribution of Phox2b expressing cells in the most rostral medulla, which could be an interesting target for neurophysiological analysis. ..
  3. Onimaru H, Ikeda K, Kawakami K. Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats. Neuroscience. 2012;212:131-9 pubmed publisher
    ..Our findings suggested that the location of Phox2b-ir neurons, including preinspiratory neurons of the pFRG, matched their role as sensors of blood CO(2) concentration. ..
  4. Iigaya K, Okazaki S, Minoura Y, Onimaru H. Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system. Neuroscience. 2017;343:213-221 pubmed publisher
    ..We hypothesize that the VMH oscillation might be involved in low-frequency modulation of the SNA. ..
  5. Oyama Y, Iigaya K, Minoura Y, Okabe T, Izumizaki M, Onimaru H. An in vitro experimental model for analysis of central control of sympathetic nerve activity. J Physiol Sci. 2017;67:629-635 pubmed publisher
    ..This preparation allows analysis of the central control of the SNA in vitro. ..
  6. Ikeda K, Kawakami K, Onimaru H, Okada Y, Yokota S, Koshiya N, et al. The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology. J Physiol Sci. 2017;67:45-62 pubmed
    ..In this review, we focus on the recent findings and attempt to elucidate the anatomical and functional mechanisms underlying respiratory control in the lower brainstem and spinal cord. ..
  7. Tani M, Kotani S, Hayakawa C, Lin S, Irie S, Ikeda K, et al. Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Pflugers Arch. 2017;469:327-338 pubmed publisher
    ..Our results also suggested a minor contribution of the TRPV1 channels to central chemoreception. ..
  8. Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T. Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region. Brain Res Bull. 2018;139:16-20 pubmed publisher
    ..We found that more than 60% of the EYFP/Phox2b-positive cells showed Pre-I neuron-like rhythmic burst activity in the parafacial region of newborn rat. ..
  9. request reprint
    Onimaru H, Arata A, Arata S, Shirasawa S, Cleary M. In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla. Brain Res Dev Brain Res. 2004;153:275-9 pubmed
    ..Such an activity pattern was not clearly detected in Pbx3-/- mouse preparations. The difference in the spatio-temporal pattern between Tlx3-/- and Pbx3-/- suggests different levels of functional disorder of the respiratory center. ..
  10. request reprint
    Onimaru H, Homma I. Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal. J Appl Physiol (1985). 2006;100:2094-5 pubmed
  11. Lin S, Ohbayashi M, Yamamoto T, Onimaru H, Kogo M. Effects of riluzole on spinal seizure-like activity in the brainstem-spinal cord preparation of newborn rat. Neurosci Res. 2017;: pubmed publisher
    ..Riluzole at the optimal dose could be a potential treatment to protect drug-induced epileptic brain tissue from excitotoxic damage without inducing respiratory suppression. ..
  12. Kotani S, Irie S, Izumizaki M, Onimaru H. Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations. Pflugers Arch. 2018;470:385-394 pubmed publisher
    ..These results suggest that changes in both membrane excitability and synaptic connections are involved in the shortening of respiratory neuron bursts by eugenol. ..
  13. Onimaru H, Ikeda K, Kawakami K. Defective interaction between dual oscillators for respiratory rhythm generation in Na+,K+-ATPase {alpha}2 subunit-deficient mice. J Physiol. 2007;584:271-84 pubmed
    ..Coupling was partially restored by repeated activation of the neurons within the networks, suggesting the involvement of an activity-dependent process in the prenatal development of this coupling. ..
  14. Onimaru H, Ikeda K, Kawakami K. CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat. J Neurosci. 2008;28:12845-50 pubmed publisher
    ..Our findings suggest that Phox2b-expressing parafacial neurons play a role in respiratory rhythm generation as well as central chemoreception and thus are essential for postnatal survival. ..