- Nakatani Y, Kudo I. [Enzymes involved in arachidonic acid metabolism]. Arerugi. 2004;53:1057-61 pubmed
- Nakatani Y, Chin Y, Hara S, Kudo I. Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation. Biochem Biophys Res Commun. 2007;354:676-80 pubmed..These results suggest that PGE(2) generated by the stimulation of AVP probably modulates the physiological effects of AVP. ..
- Nakatani Y, Hokonohara Y, Tajima Y, Kudo I, Hara S. Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. Prostaglandins Other Lipid Mediat. 2011;94:112-7 pubmed publisher..Furthermore, forcible expression of cPGES/p23 in 3Y1 cells resulted in facilitation of 15-PGDH promoter activity. These results suggest that the PGE(2)-inactivating pathway is controlled by the PGE(2) biosynthetic enzyme, cPGES/p23. ..
- Nakatani Y, Hokonohara Y, Kakuta S, Sudo K, Iwakura Y, Kudo I. Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochem Biophys Res Commun. 2007;362:387-92 pubmed..Moreover, the PGE(2) content in the lungs of cPGES/p23-null embryos was lower than that of the wild type. These results indicate that cPGES-derived PGES is involved in the normal development of mouse embryonic lung. ..