Affiliation: Showa University
Nakatani Y, Kudo I. [Enzymes involved in arachidonic acid metabolism]. Arerugi. 2004;53:1057-61 pubmed
Nakatani Y, Chin Y, Hara S, Kudo I. Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation. Biochem Biophys Res Commun. 2007;354:676-80 pubmed
..These results suggest that PGE(2) generated by the stimulation of AVP probably modulates the physiological effects of AVP. ..
Nakatani Y, Hokonohara Y, Tajima Y, Kudo I, Hara S. Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. Prostaglandins Other Lipid Mediat. 2011;94:112-7 pubmed publisher
..Furthermore, forcible expression of cPGES/p23 in 3Y1 cells resulted in facilitation of 15-PGDH promoter activity. These results suggest that the PGE(2)-inactivating pathway is controlled by the PGE(2) biosynthetic enzyme, cPGES/p23. ..
Nakatani Y, Hokonohara Y, Kakuta S, Sudo K, Iwakura Y, Kudo I. Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochem Biophys Res Commun. 2007;362:387-92 pubmed
..Moreover, the PGE(2) content in the lungs of cPGES/p23-null embryos was lower than that of the wild type. These results indicate that cPGES-derived PGES is involved in the normal development of mouse embryonic lung. ..