Yoshihito Nakatani

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. doi request reprint Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Prostaglandins Other Lipid Mediat 94:112-7. 2011
  2. ncbi request reprint [Enzymes involved in arachidonic acid metabolism]
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University
    Arerugi 53:1057-61. 2004
  3. ncbi request reprint Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 354:676-80. 2007
  4. ncbi request reprint Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagaw ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 362:387-92. 2007
  5. ncbi request reprint [Prostaglandin E2 synthases]
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Nihon Yakurigaku Zasshi 120:373-8. 2002
  6. ncbi request reprint Coupling between cyclooxygenases and prostaglandin F(2alpha) synthase. Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F(2alpha)-synthetic activity
    Karin Nakashima
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    Biochim Biophys Acta 1633:96-105. 2003
  7. ncbi request reprint Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1
    Daisuke Kamei
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 279:33684-95. 2004
  8. pmc Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
    Daisuke Kamei
    The Department of Health Chemistry, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem J 425:361-71. 2009
  9. doi request reprint Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35
    Yukiko Kuroki
    Department of Health Chemistry, School of Pharmacy, Showa University, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 424:409-13. 2012
  10. ncbi request reprint A novel role of group VIB calcium-independent phospholipase A2 (iPLA2gamma) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells
    Hiroshi Kuwata
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555
    J Biol Chem 282:20124-32. 2007

Collaborators

Detail Information

Publications25

  1. doi request reprint Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Prostaglandins Other Lipid Mediat 94:112-7. 2011
    ..Furthermore, forcible expression of cPGES/p23 in 3Y1 cells resulted in facilitation of 15-PGDH promoter activity. These results suggest that the PGE(2)-inactivating pathway is controlled by the PGE(2) biosynthetic enzyme, cPGES/p23...
  2. ncbi request reprint [Enzymes involved in arachidonic acid metabolism]
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University
    Arerugi 53:1057-61. 2004
  3. ncbi request reprint Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 354:676-80. 2007
    ..These results suggest that PGE(2) generated by the stimulation of AVP probably modulates the physiological effects of AVP...
  4. ncbi request reprint Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagaw ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 362:387-92. 2007
    ..Moreover, the PGE(2) content in the lungs of cPGES/p23-null embryos was lower than that of the wild type. These results indicate that cPGES-derived PGES is involved in the normal development of mouse embryonic lung...
  5. ncbi request reprint [Prostaglandin E2 synthases]
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Nihon Yakurigaku Zasshi 120:373-8. 2002
    ..Most recently, glutathione-nonspecific mPGES-2, homologous to glutaredoxin and thioredoxin, was identified. These PGESs seem to be a potential novel target for drug development...
  6. ncbi request reprint Coupling between cyclooxygenases and prostaglandin F(2alpha) synthase. Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F(2alpha)-synthetic activity
    Karin Nakashima
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    Biochim Biophys Acta 1633:96-105. 2003
    ..Taken together, our results suggest the presence of a novel, membrane-associated form of PGFS that is stimulus-inducible and is likely to be preferentially coupled with COX-2...
  7. ncbi request reprint Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1
    Daisuke Kamei
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 279:33684-95. 2004
    ..Collectively, our present results provide unequivocal evidence that mPGES-1 contributes to the formation of PGE2 involved in pain hypersensitivity and inflammation...
  8. pmc Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
    Daisuke Kamei
    The Department of Health Chemistry, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem J 425:361-71. 2009
    ..Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1-dependent PGE2 biosynthetic pathway in both cancer cells and host microenvironments in tumour growth and metastasis...
  9. doi request reprint Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35
    Yukiko Kuroki
    Department of Health Chemistry, School of Pharmacy, Showa University, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 424:409-13. 2012
    ..These results indicated that mPGES-1 is induced during Aβ-mediated neuronal cell death and is involved in Aβ-induced neurotoxicity associated with AD pathology...
  10. ncbi request reprint A novel role of group VIB calcium-independent phospholipase A2 (iPLA2gamma) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells
    Hiroshi Kuwata
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555
    J Biol Chem 282:20124-32. 2007
    ..Moreover, lipopolysaccharide-stimulated sPLA(2)-IIA expression was also abolished by knockdown of iPLA(2)gamma. These findings open new insight into a novel regulatory role of iPLA(2)gamma in stimulus-coupled sPLA(2)-IIA expression...
  11. pmc Regulation of cytosolic prostaglandin E synthase by phosphorylation
    Tsuyoshi Kobayashi
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem J 381:59-69. 2004
    ..Taken together, the results of the present study have provided the first evidence that the cellular function of this eicosanoid-biosynthetic enzyme is under the control of a molecular chaperone and its client protein kinase...
  12. ncbi request reprint Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 280:14028-41. 2005
    ....
  13. doi request reprint Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts
    Hiroshi Kuwata
    Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan Electronic address
    Biochim Biophys Acta 1841:44-53. 2014
    ....
  14. doi request reprint Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
    Shuntaro Hara
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochimie 92:651-9. 2010
    ..In this review, we summarize the current understanding of the in vivo roles of PGES enzymes by knockout mouse studies and provide an overview of their biochemical properties...
  15. pmc Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice
    Emiko Yoda
    Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Shinagawa ku, Tokyo, Japan
    PLoS ONE 9:e109409. 2014
    ..These results suggest that iPLA2γ is an additional, long-sought-after PLA2 that hydrolyzes platelet membranes and facilitates platelet aggregation in response to ADP. ..
  16. ncbi request reprint Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein
    Toshihiro Tanioka
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 303:1018-23. 2003
    ..These results suggest that the regulation of cPGES activity in cells depends on its association with Hsp90 and provide the first line of evidence that eicosanoid biosynthesis is under the control of the molecular chaperone...
  17. ncbi request reprint Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis
    Daisuke Kamei
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 278:19396-405. 2003
    ..These results collectively suggest that aberrant expression of mPGES-1 in combination with COX-2 can contribute to tumorigenesis...
  18. pmc Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1
    Yuka Sasaki
    Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo 142 8555, Japan
    Sci Rep 5:17376. 2015
    ..These results indicate that PGIS and mPGES-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis, and that PGIS-derived PGI2 has anti-carcinogenic effects. ..
  19. pmc Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2gamma-deficient mice
    Emiko Yoda
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Lipid Res 51:3003-15. 2010
    ..Thus, in addition to maintenance of homeostasis of the mitochondrial membrane, iPLA(2)γ may contribute to modulation of lipid mediator production in vivo...
  20. ncbi request reprint Cytosolic phospholipase A2 alpha interacts with microtubules
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    Adv Exp Med Biol 507:21-4. 2002
  21. ncbi request reprint Type IIA secretory PLA2-mediated delayed PGE2 biosynthesis is regulated by the products of the cytosolic PLA2
    Hiroshi Kuwata
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Adv Exp Med Biol 507:9-13. 2002
  22. ncbi request reprint Subcellular localization and regulation of hypoxia-inducible factor-2alpha in vascular endothelial cells
    Ryo Takahashi
    Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biochem Biophys Res Commun 317:84-91. 2004
    ..CHF2 might be one of the key regulators of HIF-2alpha-mediated gene expression in normoxic EC...
  23. ncbi request reprint Prostaglandin E synthase
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Japan
    Prostaglandins Other Lipid Mediat 68:383-99. 2002
    ..Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development...
  24. doi request reprint Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis
    Yuka Sasaki
    Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan
    Prostaglandins Other Lipid Mediat 121:42-5. 2015
    ..In this review, we summarize the current understanding of the roles of mPGES-1, a PGE2-inactivating enzyme (15-hydroxyprostagladin dehydrogenase), and PGE2 specific receptors (EPs) in colon carcinogenesis. ..
  25. ncbi request reprint Contribution of membrane-associated prostaglandin E2 synthase to bone resorption
    Masatomo Saegusa
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Cell Physiol 197:348-56. 2003
    ..We therefore conclude that mPGES, which is induced by and mediates the effects of bone resorptive stimuli, may make a target molecule for the treatment of bone resorptive disorders...