Shigeki Hongo

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. doi request reprint Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages
    Shigeki Hongo
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Am J Physiol Endocrinol Metab 297:E474-82. 2009
  2. ncbi request reprint Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation
    Shigeki Hongo
    Department of Biochemistry, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    J Cell Biochem 98:185-93. 2006
  3. doi request reprint Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice
    Masaharu Nagashima
    Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Atherosclerosis 212:70-7. 2010
  4. doi request reprint Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages
    Tomoko Kanome
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Hypertens Res 31:1801-10. 2008
  5. doi request reprint Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice
    Yuji Shiraishi
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Hypertens 26:1955-65. 2008
  6. doi request reprint Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Circulation 117:638-48. 2008
  7. doi request reprint Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    Gang Xu
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Circ Res 105:500-10. 2009
  8. ncbi request reprint Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells
    Takeshi Ohki
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Brain Res Dev Brain Res 135:55-63. 2002
  9. ncbi request reprint Human urotensin-II potentiates the mitogenic effect of mildly oxidized low-density lipoprotein on vascular smooth muscle cells: comparison with other vasoactive agents and hydrogen peroxide
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 29:821-31. 2006
  10. ncbi request reprint Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Curr Med Chem 16:550-63. 2009

Collaborators

Detail Information

Publications13

  1. doi request reprint Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages
    Shigeki Hongo
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Am J Physiol Endocrinol Metab 297:E474-82. 2009
    ..Thus, the results suggest that leptin accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux...
  2. ncbi request reprint Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation
    Shigeki Hongo
    Department of Biochemistry, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    J Cell Biochem 98:185-93. 2006
    ..Ndrg4 may play a role in supporting the activation of ERK and its target proteins needed for neuronal differentiation and in reducing the activation of Elk-1 implicated in cell growth...
  3. doi request reprint Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice
    Masaharu Nagashima
    Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Atherosclerosis 212:70-7. 2010
    ..Thus we investigated the effects of salusin-alpha and -beta on atherosclerotic plaque formation in vivo in apolipoprotein E-deficient (ApoE-/-) mice...
  4. doi request reprint Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages
    Tomoko Kanome
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Hypertens Res 31:1801-10. 2008
    ..These results suggested that Ang II enhances foam cell formation by upregulating ACAT1 expression predominantly through the actions of AT(1) receptor via the G protein/c-Src/PKC/MAPK pathway in human monocyte-macrophages...
  5. doi request reprint Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice
    Yuji Shiraishi
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Hypertens 26:1955-65. 2008
    ..In the present study, we investigated the enhancing effect of urotensin II on atherosclerosis in apolipoprotein E-knockout mice and its suppression by 4-aminoquinoline, an urotensin II receptor-selective antagonist...
  6. doi request reprint Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Circulation 117:638-48. 2008
    ....
  7. doi request reprint Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    Gang Xu
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Circ Res 105:500-10. 2009
    ..Macrophage foam cell formation, characterized by cholesterol ester accumulation, is modulated by scavenger receptor class A (SR-A), acyl-coenzyme A:cholesterol acyltransferase (ACAT)1, and ATP-binding cassette transporter (ABC)A1...
  8. ncbi request reprint Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells
    Takeshi Ohki
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Brain Res Dev Brain Res 135:55-63. 2002
    ..These results suggest that NDRG4 plays a role in neurite outgrowth and has an influence on an NGF-stimulated AP-1 activation by an undefined mechanism in PC12 cells...
  9. ncbi request reprint Human urotensin-II potentiates the mitogenic effect of mildly oxidized low-density lipoprotein on vascular smooth muscle cells: comparison with other vasoactive agents and hydrogen peroxide
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 29:821-31. 2006
    ..Activation of the G protein/c-Src/PKC/ERK and Rho kinase pathways by U-II together with the redox-sensitive JNK pathway by mox-LDL may explain the synergistic interaction between these agents...
  10. ncbi request reprint Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Curr Med Chem 16:550-63. 2009
    ..Here, we summarize the key roles of U-II in progression of hypertension and atherosclerotic cardiovascular diseases...
  11. ncbi request reprint Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo 142 8555, Japan
    Hypertension 46:738-44. 2005
    ....
  12. ncbi request reprint Genomic organization, expression, and comparative analysis of noncoding region of the rat Ndrg4 gene
    Akihiko Maeda
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    Gene 324:149-58. 2004
    ..6 centirays (cR) from the top. Comparison of the noncoding sequence of the rat Ndrg4 gene to those of the orthologous mouse and human genes suggests that the AP-1 binding site is a candidate regulatory element...
  13. ncbi request reprint Molecular characterization of NDRG4/Bdm1 protein isoforms that are differentially regulated during rat brain development
    Noriyuki Nakada
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Brain Res Dev Brain Res 135:45-53. 2002
    ..Differential expressions of NDRG4 protein isoforms may be a mechanism for modifying the NDRG4 function and for the formation of a functioning nervous system...