Tsutomu Hirano

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. pmc Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
    M Nagashima
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Diabetologia 54:2649-59. 2011
  2. ncbi request reprint Lipoprotein abnormalities in diabetic nephropathy
    T Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Kidney Int Suppl 71:S22-4. 1999
  3. ncbi request reprint Ezetimibe decreases serum amyloid A levels in HDL3 in hemodialysis patients
    T Hirano
    Department of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Tokyo, Japan
    Clin Nephrol 74:282-7. 2010
  4. ncbi request reprint A novel and simple method for quantification of small, dense LDL
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Lipid Res 44:2193-201. 2003
  5. ncbi request reprint Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Kidney Int 63:2171-7. 2003
  6. ncbi request reprint Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Hatanodai, Tokyo, Japan
    J Hypertens 24:103-8. 2006
  7. doi request reprint Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    Gang Xu
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Circ Res 105:500-10. 2009
  8. ncbi request reprint Measurement of small dense low-density lipoprotein particles
    Tsutomu Hirano
    Division of Diabetes and Metabolism, First Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hattanodai, Shinagawa ku, Tokyo 142 8666, Japan
    J Atheroscler Thromb 12:67-72. 2005
  9. doi request reprint Small dense LDL-cholesterol determined by a simple precipitation assay for screening familial combined hyperlipidemia
    Tsutomu Hirano
    Department of Diabetes, Metabolism, and Endocrinology, Showa University, Tokyo, Japan
    Atherosclerosis 205:603-7. 2009
  10. doi request reprint A simple and precise method for measuring HDL-cholesterol subfractions by a single precipitation followed by homogenous HDL-cholesterol assay
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University, School of Medicine, Tokyo, Japan
    J Lipid Res 49:1130-6. 2008

Collaborators

Detail Information

Publications81

  1. pmc Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
    M Nagashima
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Diabetologia 54:2649-59. 2011
    ..We investigated the possibility that glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can prevent the development of atherosclerosis in Apoe (-/-) mice...
  2. ncbi request reprint Lipoprotein abnormalities in diabetic nephropathy
    T Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Kidney Int Suppl 71:S22-4. 1999
    ..This study included: middle-aged to older type 2 diabetic patients with normoalbuminuria, microalbuminuria, and overt albuminuria; nondiabetic patients with primary renal disease; and normal control subjects...
  3. ncbi request reprint Ezetimibe decreases serum amyloid A levels in HDL3 in hemodialysis patients
    T Hirano
    Department of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Tokyo, Japan
    Clin Nephrol 74:282-7. 2010
    ....
  4. ncbi request reprint A novel and simple method for quantification of small, dense LDL
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Lipid Res 44:2193-201. 2003
    ..94). Sd LDL value was related to triglyceride, apoB, and LDL-cholesterol, but not to the buoyant LDL level. These results suggest that this precipitation method is a simple and rapid method for the measurement of sd LDL concentration...
  5. ncbi request reprint Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Kidney Int 63:2171-7. 2003
    ....
  6. ncbi request reprint Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Hatanodai, Tokyo, Japan
    J Hypertens 24:103-8. 2006
    ..We examined the roles of AII type 1 and type 2 receptors (AT1R and AT2R) in cholesterol metabolism in rats fed either normal chow or high-fructose diets...
  7. doi request reprint Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    Gang Xu
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Circ Res 105:500-10. 2009
    ..Macrophage foam cell formation, characterized by cholesterol ester accumulation, is modulated by scavenger receptor class A (SR-A), acyl-coenzyme A:cholesterol acyltransferase (ACAT)1, and ATP-binding cassette transporter (ABC)A1...
  8. ncbi request reprint Measurement of small dense low-density lipoprotein particles
    Tsutomu Hirano
    Division of Diabetes and Metabolism, First Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hattanodai, Shinagawa ku, Tokyo 142 8666, Japan
    J Atheroscler Thromb 12:67-72. 2005
    ..We recently established a simple precipitation method for the quantification of sd LDL. This method is applicable to routine clinical use and allows the rapid measurement of a large number of samples...
  9. doi request reprint Small dense LDL-cholesterol determined by a simple precipitation assay for screening familial combined hyperlipidemia
    Tsutomu Hirano
    Department of Diabetes, Metabolism, and Endocrinology, Showa University, Tokyo, Japan
    Atherosclerosis 205:603-7. 2009
    ..However, the number of females included in the study is small, making it difficult to draw conclusions especially in females...
  10. doi request reprint A simple and precise method for measuring HDL-cholesterol subfractions by a single precipitation followed by homogenous HDL-cholesterol assay
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University, School of Medicine, Tokyo, Japan
    J Lipid Res 49:1130-6. 2008
    ..Our method is far simpler and more precise than the classical dual precipitation method for HDL-C subfractions, and it can be easily performed in a routine chemical laboratory...
  11. ncbi request reprint Vascular endothelial markers, von Willebrand factor and thrombomodulin index, are specifically elevated in type 2 diabetic patients with nephropathy: comparison of primary renal disease
    T Hirano
    First Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Clin Chim Acta 299:65-75. 2000
    ..These results suggest that generalized vascular endothelial damage occurs in diabetic nephropathy including the microalbuminuric stage, which is not attributed to kidney damage per se...
  12. ncbi request reprint Doxazosin reduces prevalence of small dense low density lipoprotein and remnant-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients
    T Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Am J Hypertens 14:908-13. 2001
    ..These results suggest that doxazosin may help to prevent coronary artery disease by reducing atherogenic lipoproteins, including small dense LDL and remnant lipoproteins, in hypertensive patients, regardless of the presence of diabetes...
  13. ncbi request reprint Clinical significance of small dense low-density lipoprotein cholesterol levels determined by the simple precipitation method
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Arterioscler Thromb Vasc Biol 24:558-63. 2004
    ..The small dense LDL-C level was identical to cholesterol in the denser LDL fraction with a density of 1.044 to 1.063 g/mL. The aim of this study was to examine clinical significance of this precipitation method for small dense LDL-C...
  14. ncbi request reprint Marked decrease of apolipoprotein A-V in both diabetic and nondiabetic patients with end-stage renal disease
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, and Department of Nephrology, Yokohama Daiichi Hospital, Japan
    Metabolism 56:462-3. 2007
    ..These results suggest that reduced apo A-V levels do not necessarily lead to hyper-TG in ESRD, but we are unable to exclude the possibility that low apo A-V plays a role in raising the TG level in diabetic ESRD...
  15. doi request reprint Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice
    Masaharu Nagashima
    Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Atherosclerosis 212:70-7. 2010
    ..Thus we investigated the effects of salusin-alpha and -beta on atherosclerotic plaque formation in vivo in apolipoprotein E-deficient (ApoE-/-) mice...
  16. ncbi request reprint Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance
    Jianmin Ran
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, Japan
    Metabolism 55:478-88. 2006
    ..Plasma adiponectin levels were substantially correlated with SI (r = 0.61, P < .0001). These results suggest that AII suppresses adiponectin production via AII type 1 receptor, resulting in impaired insulin sensitivity...
  17. ncbi request reprint Small dense LDL phenotype is associated with postprandial increases of large VLDL and remnant-like particles in patients with acute myocardial infarction
    Shinji Koba
    Third Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Atherosclerosis 170:131-40. 2003
    ..The aim of this study was to investigate the relationships among LDL phenotype, very-low-density lipoprotein (VLDL) subclasses, and postprandial lipoprotein metabolism in CHD patients...
  18. ncbi request reprint Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats
    Kenta Okada
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 27:293-9. 2004
    ..Olmesartan ameliorates insulin resistance and overproduction of TG in fructose-fed rats, and these effects appear to be independent of its hypotensive action...
  19. ncbi request reprint Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo 142 8555, Japan
    Hypertension 46:738-44. 2005
    ....
  20. ncbi request reprint Effects of atorvastatin on triglyceride-rich lipoproteins, low-density lipoprotein subclass, and C-reactive protein in hemodialysis patients
    Ayako Ikejiri
    First Department of Internal Medicine, Showa University School of Medicine, Tokkyo, Japan
    Metabolism 53:1113-7. 2004
    ..These results suggest that atorvastatin is safe and effective for the management of dyslipidemia in patients with CFR who are receiving HD, which may help to suppress the development of atherosclerosis...
  21. ncbi request reprint Significant increase of apolipoprotein B48 levels by a standard test meal in type 2 diabetic patients with nephropathy
    Takeshi Yamamoto
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 15:199-205. 2008
    ..We investigated postprandial changes of apolipoprotein (apo) B48 in type 2 diabetics at different stages of diabetic nephropathy in order to explore non-traditional lipid abnormalities in diabetic nephropathy...
  22. ncbi request reprint Lipoprotein lipase mRNA in white adipose tissue but not in skeletal muscle is increased by pioglitazone through PPAR-gamma
    Haruaki Kageyama
    First Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Biochem Biophys Res Commun 305:22-7. 2003
    ..Since pioglitazone does not affect LPL production in SM, this would contribute to prevent the development of insulin resistance due to lipotoxicity...
  23. doi request reprint Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes
    Toshiaki Suguro
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, Japan
    Clin Sci (Lond) 115:327-34. 2008
    ..In conclusion, the results of the present study provide the first evidence that increased plasma U-II levels may be associated with the progression of diabetic retinopathy and carotid atherosclerosis in patients with Type 2 diabetes...
  24. doi request reprint Serum salusin-alpha levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 31:463-8. 2008
    ..Our results suggest that the decrease in serum salusin-alpha, an anti-atherogenic peptide, may be associated with carotid atherosclerosis in hypertensive patients...
  25. ncbi request reprint Decreased peroxisome proliferator-activated receptor alpha gene expression is associated with dyslipidemia in a rat model of chronic renal failure
    Yusaku Mori
    First Department of Internal Medicine, Showa University, School of Medicine, Tokyo, Japan
    Metabolism 56:1714-8. 2007
    ..Our results indicate that PPAR-alpha mRNA expression is down-regulated in the liver of CRF rats and that this down-regulation may play a crucial role in the development of dyslipidemia...
  26. doi request reprint Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice
    Yuji Shiraishi
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Hypertens 26:1955-65. 2008
    ..In the present study, we investigated the enhancing effect of urotensin II on atherosclerosis in apolipoprotein E-knockout mice and its suppression by 4-aminoquinoline, an urotensin II receptor-selective antagonist...
  27. doi request reprint Chronic insulin infusion normalizes blood pressure and the gene expressions of angiotensin II type 1 receptor in fructose-fed rats
    Tomoyasu Fukui
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 31:127-33. 2008
    ....
  28. ncbi request reprint The effects of statin and fibrate on lowering small dense LDL- cholesterol in hyperlipidemic patients with type 2 diabetes
    Anna Tokuno
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 14:128-32. 2007
    ..We studied the effects of representative lipid-lowering agents (statin and fibrate) on sd-LDL-cholesterol (C) in patients with type 2 diabetes...
  29. ncbi request reprint Angiotensin II type 1 receptor blocker ameliorates overproduction and accumulation of triglyceride in the liver of Zucker fatty rats
    Jianmin Ran
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, Japan
    Am J Physiol Endocrinol Metab 287:E227-32. 2004
    ..Taken in sum, ARB improves the overproduction and accumulation of TG in the liver associated with insulin resistance, and it does so through mechanisms independent of its hypotensive action...
  30. ncbi request reprint Association between small dense low-density lipoprotein and postprandial accumulation of triglyceride-rich remnant-like particles in normotriglyceridemic patients with myocardial infarction
    Fumiyoshi Tsunoda
    Third Department of Internal Medicine, Showa University School of Medicine, Hatanodai, Shinagawa ku, Tokyo, Japan
    Circ J 68:1165-72. 2004
    ..This study was aimed to investigate the relationship between the low-density lipoprotein (LDL) phenotype and postprandial hyperlipemia (PPL) in MI patients...
  31. ncbi request reprint Angiotensin II infusion increases hepatic triglyceride production via its type 2 receptor in rats
    Jianmin Ran
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Hypertens 23:1525-30. 2005
    ..To explore this mechanism, we examined the roles of AII type 1 and type 2 receptors in TG metabolism in the same rat model...
  32. ncbi request reprint Significance of small dense low-density lipoproteins and other risk factors in patients with various types of coronary heart disease
    Shinji Koba
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Am Heart J 144:1026-35. 2002
    ..5 nm) is associated with various types of coronary heart disease (CHD) in Japanese patients, an ethnic group with lower serum cholesterol levels and less massive obesity compared with Western populations...
  33. ncbi request reprint Remarkably high prevalence of small dense low-density lipoprotein in Japanese men with coronary artery disease, irrespective of the presence of diabetes
    Shinji Koba
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Atherosclerosis 160:249-56. 2002
    ..Type 2 diabetes shows a greater capacity to reduce LDL size, which may contribute to the high incidence of CAD in the diabetic population...
  34. pmc Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population
    Yoshiyuki Ban
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
    PLoS ONE 7:e37501. 2012
    ..Recent studies have demonstrated an association between thyroglobulin (Tg) polymorphisms and AITD in Caucasians, suggesting that Tg is a susceptibility gene on 8q24...
  35. ncbi request reprint Low-dose candesartan cilexetil prevents early kidney damage in type 2 diabetic patients with mildly elevated blood pressure
    Satoru Murayama
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 26:453-8. 2003
    ..In conclusion, low-dose candesartan can prevent early kidney damage in type 2 diabetic patients with mildly higher blood pressure independently of its hypotensive action...
  36. ncbi request reprint An increased number of very-low-density lipoprotein particles is strongly associated with coronary heart disease in Japanese men, independently of intermediate-density lipoprotein or low-density lipoprotein
    Shinji Koba
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Coron Artery Dis 13:255-62. 2002
    ..Japanese patients with coronary heart disease (CHD) usually have slightly elevated triglyceride levels but virtually normal low-density lipoprotein (LDL)-cholesterol levels...
  37. ncbi request reprint Significance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseases
    Shinji Koba
    The Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Atherosclerosis 189:206-14. 2006
    ..The sd-LDL mass plays a more important role in the progression of CHD than the LDL size, and the sd-LDL-C concentration serves as a powerful surrogate marker for the prevention of CHD...
  38. ncbi request reprint Small LDL-cholesterol is superior to LDL-cholesterol for determining severe coronary atherosclerosis
    Shinji Koba
    Department of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 15:250-60. 2008
    ..This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is superior to LDL-C as a biomarker of coronary heart disease (CHD)...
  39. doi request reprint Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice
    Michishige Terasaki
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Metabolism 61:974-7. 2012
    ..Foam cell formation was suppressed by 40% in the exudate peritoneal macrophages obtained from the PKF-treated mice. The DPP-4 inhibitor prevents the development of atherosclerotic lesions by suppressing macrophage foam cell formation...
  40. doi request reprint Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population
    Yoshiyuki Ban
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Thyroid 20:893-9. 2010
    ..Previous investigations have also demonstrated that two intronic SNPs (rs706778 and rs3118470) in the interleukin-2 receptor-alpha (IL2RA) gene were associated with type 1 diabetes in the Japanese population...
  41. ncbi request reprint Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure
    Tsutomu Kazumi
    Department of Medicine, Hyogo Rehabilitation Center Hospital, Kobe, Japan
    Diabetes Care 25:971-6. 2002
    ..BP can be classified into three categories: optimal, normal, and high-normal. The present study examined whether those with high-normal BP have any of these three conditions as compared with those with optimal BP in young healthy men...
  42. doi request reprint Smaller low-density lipoprotein size as a possible risk factor for the prevalence of coronary artery diseases in haemodialysis patients: associations of cholesteryl ester transfer protein and the hepatic lipase gene polymorphism with low-density lipoprote
    Hideki Kimura
    Division of Nephrology, Department of General Medicine, School of Medicine, University of Fukui, Fukui, Japan
    Nephrology (Carlton) 16:558-66. 2011
    ..However, little is known about LDL size status and its relationship with CAD prevalence in haemodialysis (HD) patients who are at high risk for atherosclerosis...
  43. ncbi request reprint Apolipoprotein CIII deficiency prevents the development of hypertriglyceridemia in streptozotocin-induced diabetic mice
    Toshihiro Takahashi
    Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Metabolism 52:1354-9. 2003
    ..These results suggest that apo CIII deficiency prevents the development of hypertriglyceridemia associated with diabetes by stimulating TG removal, possibly by promoting the interaction of VLDL with the TG removal system...
  44. ncbi request reprint Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia
    Yoshiyuki Ban
    Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Tokyo 142 8555, Japan
    J Atheroscler Thromb 16:179-87. 2009
    ..The expression of UII and its receptor (UT) mRNA is detected at high levels in the brain. We evaluated the relationship between plasma UII levels and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease...
  45. ncbi request reprint Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension
    Toshiaki Suguro
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Am J Hypertens 20:211-7. 2007
    ..In this study, we demonstrated a correlation between plasma U-II level and progression of atherosclerosis in hypertensive patients...
  46. pmc Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice
    Yukinori Nogi
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e35683. 2012
    ..GIP receptors (GIPRs) are found to be severely down-regulated in diabetic animals. We examined whether GIP can exert anti-atherogenic effects in diabetes...
  47. doi request reprint Ezetimibe alone or in combination with pitavastatin prevents kidney dysfunction in 5/6 nephrectomized rats fed high-cholesterol
    Yusaku Mori
    Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan
    Metabolism 61:379-88. 2012
    ....
  48. ncbi request reprint Distinct role of adiposity and insulin resistance in glucose intolerance: studies in ventromedial hypothalamic-lesioned obese rats
    Asako Kageyama
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Metabolism 51:716-23. 2002
    ..Insulin resistance or increased adiposity alone is not sufficient to impair glucose tolerance, but increased adiposity plays an important role in the development of glucose intolerance in an insulin-resistant state...
  49. ncbi request reprint Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats
    Jianmin Ran
    First Dept of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 666, Japan
    Am J Physiol Endocrinol Metab 287:E955-61. 2004
    ..Our results may suggest a new mechanism for the intimate association between hypertension and dyslipidemia...
  50. ncbi request reprint Remnant lipoprotein cholesterol homogenous assay (RemL-C) is closely associated with very-low-density lipoprotein remnants: comparison with the immunoseparation assay
    Masaharu Nagashima
    Department of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8666, Japan
    Rinsho Byori 56:973-9. 2008
    ..We examined the characteristics of the homogeneous assay for reacting with VLDL remnants...
  51. ncbi request reprint Fasting increases gene expressions of uncoupling proteins and peroxisome proliferator-activated receptor-gamma in brown adipose tissue of ventromedial hypothalamus-lesioned rats
    Haruaki Kageyama
    Division of Geriatric Health and Nutrition, National Institute of Health and Nutrition, 162 8636, Tokyo, Japan
    Life Sci 72:3035-46. 2003
    ..These results suggest that VMH-lesions enhance the gene expression of UCPs in BAT under long-term fasting as a defensive reaction to inhibit the reduction of body temperature through an increase in PPAR-gamma activity...
  52. ncbi request reprint Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes
    Soushou Lee
    Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Endocr J 57:119-26. 2010
    ..We concluded that intact GLP-1 levels are comparable between non-diabetics and T2DM, suggesting that impaired insulin secretion in Japanese T2DM is not attributable to defect in GLP-1 secretion...
  53. ncbi request reprint Remarkable increase of apolipoprotein B48 level in diabetic patients with end-stage renal disease
    Toshiyuki Hayashi
    First Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Atherosclerosis 197:154-8. 2008
    ..The remarkably high level of apoB48 in diabetic ESRD seems to be attributable to dyslipidemia induced by both diabetic nephropathy and ESRD...
  54. doi request reprint Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population
    Yoshiyuki Ban
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan
    Autoimmunity 42:126-30. 2009
    ..The other three SNPs were not associated with GD or GO or HT in our Japanese population. These results suggest that the IL-23R gene is associated with AITDs only in a specific ethnic group...
  55. ncbi request reprint Intensive insulin therapy reduces small dense low-density lipoprotein particles in patients with type 2 diabetes mellitus: relationship to triglyceride-rich lipoprotein subspecies
    Toshiyuki Hayashi
    First Department of Internal Medicine, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8666, Japan
    Metabolism 55:879-84. 2006
    ..These results suggest that intensive insulin therapy decreases atherogenic sd-LDL particles by reducing TG in TG-rich lipoproteins. We did not find any specific relationship between VLDL1 and sd-LDL during insulin treatment...
  56. ncbi request reprint Atherogenic lipoproteins and diabetes mellitus
    Gen Yoshino
    Department of Laboratory Medicine, Toho University School of Medicine, Ohmori Nishi, Ohta ku, 143 0015, Tokyo, Japan
    J Diabetes Complications 16:29-34. 2002
    ..Finally, strict diet control and treatment of diabetics with dyslipidemias by acarbose, troglitazone, fibrates and/or statins were all successful in increasing LDL size...
  57. pmc Endogenous bioactive peptides as potential biomarkers for atherosclerotic coronary heart disease
    Takuya Watanabe
    Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    Sensors (Basel) 12:4974-85. 2012
    ..Therefore, salusin-α, heregulin-β(1), adiponectin, and/or GLP-1, alone or in various combinations, may be useful as biomarkers for atherosclerotic CAD...
  58. doi request reprint The roles of salusins in atherosclerosis and related cardiovascular diseases
    Takuya Watanabe
    Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    J Am Soc Hypertens 5:359-65. 2011
    ..Therefore, salusin-α could be a candidate biomarker for atherosclerosis and may be therapeutically useful for prevention of atherosclerotic cardiovascular diseases...
  59. ncbi request reprint [Small dense LDL concentration is closely associated with serum apolipoprotein B, comparisons of non-LDL cholesterol or LDL cholesterol]
    Toshiyuki Hayashi
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo
    Rinsho Byori 54:569-75. 2006
    ..These results suggest that apo B is superior to non-HDL-C in reflecting a potent atherogenic lipoprotein, sd-LDL, which may explain a potent predictive power of apo B for CHD...
  60. ncbi request reprint Treatment of small dense LDL
    Gen Yoshino
    Department of Laboratory Medicine, Toho University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 9:266-75. 2002
    ....
  61. pmc Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin's actions in nondiabetic and diabetic apolipoprotein E-null mice
    Michishige Terasaki
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa ku, Tokyo, Japan
    PLoS ONE 8:e70933. 2013
    ..It remains to be seen, however, whether this effect stems from increased levels of the two active incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)...
  62. ncbi request reprint Measurement of the serum lipoprotein lipase concentration is useful for studying triglyceride metabolism: Comparison with postheparin plasma
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Metabolism 53:526-31. 2004
    ..Delta LPL mass did not show a closer association with triglyceride metabolism than postheparin LPL or preheparin LPL. In conclusion, serum LPL measurement is simple and seems to be useful for studying triglyceride metabolism...
  63. ncbi request reprint [Measurement of lipoprotein size]
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine
    Nihon Rinsho 65:224-7. 2007
  64. ncbi request reprint [Metabolic syndrome and small, dense LDL]
    Gen Yoshino
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine
    Nihon Rinsho 64:391-9. 2006
  65. ncbi request reprint [Dyslipidemia and atherosclerosis]
    Shinji Koba
    Division of Cardiology, Metabolism and Endocrinology, Showa University School of Medicine
    Nihon Rinsho 69:138-43. 2011
    ..Dysfunction of HDL is an independent pro-atherogenic factor. In addition, decreased HDL-cholesterol is a feature of the metabolic dyslipidemia...
  66. ncbi request reprint Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages
    Toshiaki Suguro
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, Japan
    Atherosclerosis 186:275-81. 2006
    ....
  67. ncbi request reprint Fluvastatin increases LDL particle size and reduces oxidative stress in patients with hyperlipidemia
    Gen Yoshino
    Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 10:343-7. 2003
    ..The results imply that fluvastatin, with its unique antioxidant property among statins, reduces oxidative stress and increases LDL particle size simultaneously in hyperlipidemic patients...
  68. pmc Proteomic profiling of thyroid papillary carcinoma
    Yoshiyuki Ban
    Division of Diabetes, Metabolism and Endocrinology, Department of Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    J Thyroid Res 2012:815079. 2012
    ..Furthermore, IHC confirmed the overexpression of both those markers in PTCs compared with normal surrounding tissues. Our protein data suggest that NPNT and MLEC could be a characteristic marker for PTC...
  69. ncbi request reprint Serum concentration of small dense low-density lipoprotein-cholesterol during oral glucose tolerance test and oral fat tolerance test
    Kyoko Ogita
    Department of Vascular Medicine and Geriatrics, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Chim Acta 387:36-41. 2008
    ..Using this assay, we reported a unique circadian rhythm of sdLDLC. We determined whether a glucose intake and/or a fat intake affects on serum sdLDLC concentration and determined the modulators of serum sdLDLC concentration...
  70. doi request reprint Periostin, discovered by nano-flow liquid chromatography and mass spectrometry, is a novel marker of diabetic retinopathy
    Michiya Takada
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 399:221-6. 2010
    ..Proteomic analysis by LC/MS/MS, which permits accurate quantitative comparison, was useful in identifying new candidates such as periostin potentially involved in the pathogenesis of PDR...
  71. ncbi request reprint [Metabolic syndrome and small dense LDL-cholesterol]
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8666
    Rinsho Byori 55:434-8. 2007
    ..These results suggest that measurement of sdLDL-C is useful to evaluate overall atherogenic risks associated with metabolic syndrome and may be applicable to routine clinical examination...
  72. ncbi request reprint [Measurements of oxidized LDL and small dense LDL]
    Tsutomu Hirano
    First Department of Internal Medicine, Showa University School of Medicine
    Nihon Rinsho 65:178-81. 2007
  73. ncbi request reprint Small dense low-density lipoprotein cholesterol is a useful marker of metabolic syndrome in patients with coronary artery disease
    Tsuyoshi Nozue
    Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, Japan
    J Atheroscler Thromb 14:202-7. 2007
    ..An evaluation of the relation between small dense low-density lipoprotein cholesterol (sd-LDL-C) levels measured by the heparin-magnesium precipitation method and metabolic syndrome (MetS)...
  74. ncbi request reprint C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    Tsutomu Kazumi
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women s University, Health Science Center, Nishonomiya, Japan
    Metabolism 52:1113-6. 2003
    ..Although low-grade inflammation was associated with long QTc interval and low HDL-cholesterol, the mechanism underlying these associations is an important question to be addressed...
  75. ncbi request reprint [New simple method for small, dense LDL: development of a new quantification method and clinical significance]
    Yasuki Ito
    Research and Development Department, Denka Seiken Co, Ltd, Chuo Ku, Tokyo 103 0025
    Rinsho Byori 52:406-13. 2004
    ..0 +/- 9.9 in the control). Our findings suggest that this method can measure S LDL reliably with a simple procedure and that the analysis of S LDL-C can give a better index for the risk assessment of CHD than total LDL-C...
  76. ncbi request reprint Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men
    Tsutomu Kazumi
    Department of Food Sciences and Nutrition, Mukogawa Women s University, Hyogo, Japan
    Metabolism 53:589-93. 2004
    ..HOMA IR did not emerge as a determinant of adiponectin in both models. These findings suggest that in young healthy men hypoadiponectinemia is more closely related to adiposity and dyslipidemia than IR...
  77. ncbi request reprint NAD (P) H oxidase p22 phox C242T polymorphism affects LDL particle size and insulin resistance in Japanese subjects
    Rieko Hayaishi-Okano
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    J Atheroscler Thromb 9:200-5. 2002
    ..Our data demonstrate that variation in the small NAD(P)H oxidase subunit p22 phox gene substantially influences LDL particle size and may also reflect differences in the insulin sensitivity of non-diabetic subjects...
  78. ncbi request reprint Circadian rhythm of serum concentration of small dense low-density lipoprotein cholesterol
    Kyoko Ogita
    Department of Vascular Medicine and Geriatrics, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519 Japan
    Clin Chim Acta 376:96-100. 2007
    ..Using this method, we observed the circadian rhythm of sdLDLC to determine the adequacy of fasting measurement of it and to seek the modulator of the atherogenic lipoprotein...
  79. ncbi request reprint [Remnant hyperlipoproteinemia]
    Katsuyuki Nakajima
    Otsuka Pharmaceutical Co, Ltd
    Nihon Rinsho 65:354-9. 2007
  80. ncbi request reprint [Treatment of lipid metabolism abnormalities with consideration given to renal protection]
    Tsutomu Hirano
    Nihon Naika Gakkai Zasshi 96:2812-8. 2007
  81. ncbi request reprint Effects of statin on small dense low-density lipoprotein cholesterol and remnant-like particle cholesterol in heterozygous familial hypercholesterolemia
    Tsuyoshi Nozue
    Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, Yokhohama, Japan
    J Atheroscler Thromb 15:146-53. 2008
    ..This study aimed to clarify the effects of statin on sd-LDL-C and RLP-C levels in heterozygous FH...