Takashi Ashino

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. doi request reprint Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Arterioscler Thromb Vasc Biol 33:760-8. 2013
  2. ncbi request reprint Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Tokyo, Japan
    Eur J Pharmacol 558:199-207. 2007
  3. ncbi request reprint Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Mol Immunol 45:2106-15. 2008
  4. ncbi request reprint Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Toxicol Sci 36:635-43. 2011
  5. ncbi request reprint Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Drug Metab Dispos 32:707-14. 2004
  6. ncbi request reprint Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
  7. ncbi request reprint Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Toxicol Sci 28:181-9. 2003
  8. ncbi request reprint Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital
    Satoshi Numazawa
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    FEBS Lett 579:3560-4. 2005

Collaborators

Detail Information

Publications8

  1. doi request reprint Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Arterioscler Thromb Vasc Biol 33:760-8. 2013
    ..This study aimed to elucidate the role of Nrf2 in PDGF-mediated vascular smooth muscle cell migration and neointimal hyperplasia...
  2. ncbi request reprint Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Tokyo, Japan
    Eur J Pharmacol 558:199-207. 2007
    ....
  3. ncbi request reprint Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Mol Immunol 45:2106-15. 2008
    ..The present findings suggest that HO-1 is induced via NO-induced nuclear translocation of Nrf2, and the enzymatic function of HO-1 inhibits the overproduction of NO in macrophages...
  4. ncbi request reprint Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Toxicol Sci 36:635-43. 2011
    ..The present findings suggest that auranofin is effective in preventing cocaine-induced hepatic injury, and HO-1 may contribute to protect against chemically-induced cytotoxicity...
  5. ncbi request reprint Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Drug Metab Dispos 32:707-14. 2004
    ..This will be a possible reason for differential capability of P450 down-regulation between BCG and LPS...
  6. ncbi request reprint Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
    ..All of these findings indicate that TNFalpha is a major candidate to trigger HO-1 induction in response to LPS stimulation, and that its message is likely transduced through JNK and p38 pathways...
  7. ncbi request reprint Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Toxicol Sci 28:181-9. 2003
    ..These findings suggest that MMS induces HO-1 and/or MT-1/2 mRNA and its protein tissue-dependently, and the heme catabolites by HO-1 in the testis may contribute in some manner to its genotoxicity...
  8. ncbi request reprint Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital
    Satoshi Numazawa
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    FEBS Lett 579:3560-4. 2005
    ..These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR...