Takashi Ashino

Summary

Affiliation: Showa University
Country: Japan

Publications

  1. doi request reprint Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Arterioscler Thromb Vasc Biol 33:760-8. 2013
  2. ncbi request reprint Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Mol Immunol 45:2106-15. 2008
  3. ncbi request reprint Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Toxicol Sci 36:635-43. 2011
  4. ncbi request reprint Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Tokyo, Japan
    Eur J Pharmacol 558:199-207. 2007
  5. ncbi request reprint Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Drug Metab Dispos 32:707-14. 2004
  6. ncbi request reprint Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
  7. pmc Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Redox Biol 2:284-8. 2014
  8. ncbi request reprint Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital
    Satoshi Numazawa
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    FEBS Lett 579:3560-4. 2005
  9. ncbi request reprint Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Toxicol Sci 28:181-9. 2003
  10. ncbi request reprint Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy
    J Toxicol Sci 39:815-20. 2014

Collaborators

Detail Information

Publications10

  1. doi request reprint Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Arterioscler Thromb Vasc Biol 33:760-8. 2013
    ..This study aimed to elucidate the role of Nrf2 in PDGF-mediated vascular smooth muscle cell migration and neointimal hyperplasia...
  2. ncbi request reprint Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Mol Immunol 45:2106-15. 2008
    ..The present findings suggest that HO-1 is induced via NO-induced nuclear translocation of Nrf2, and the enzymatic function of HO-1 inhibits the overproduction of NO in macrophages...
  3. ncbi request reprint Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Toxicol Sci 36:635-43. 2011
    ..The present findings suggest that auranofin is effective in preventing cocaine-induced hepatic injury, and HO-1 may contribute to protect against chemically-induced cytotoxicity...
  4. ncbi request reprint Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Tokyo, Japan
    Eur J Pharmacol 558:199-207. 2007
    ....
  5. ncbi request reprint Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Drug Metab Dispos 32:707-14. 2004
    ..This will be a possible reason for differential capability of P450 down-regulation between BCG and LPS...
  6. ncbi request reprint Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
    ..All of these findings indicate that TNFalpha is a major candidate to trigger HO-1 induction in response to LPS stimulation, and that its message is likely transduced through JNK and p38 pathways...
  7. pmc Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Redox Biol 2:284-8. 2014
    ..Nrf2(-⧸-) mice showed attenuated Cyp2b10 and Cyp2a5 induction by phenobarbital, a classical Cyp2b inducer. These findings suggest that the Nrf2 pathway is involved in Cyp2b10 and Cyp2a5 gene expression. ..
  8. ncbi request reprint Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital
    Satoshi Numazawa
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    FEBS Lett 579:3560-4. 2005
    ..These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR...
  9. ncbi request reprint Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Toxicol Sci 28:181-9. 2003
    ..These findings suggest that MMS induces HO-1 and/or MT-1/2 mRNA and its protein tissue-dependently, and the heme catabolites by HO-1 in the testis may contribute in some manner to its genotoxicity...
  10. ncbi request reprint Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes
    Takashi Ashino
    Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy
    J Toxicol Sci 39:815-20. 2014
    ..These results suggest that synthetic cannabinoids and their basic molecules are capable of inhibiting CYP1A enzymatic activity. ..