Y Todoroki

Summary

Affiliation: Shizuoka University
Country: Japan

Publications

  1. ncbi request reprint Development of specific inhibitors of CYP707A, a key enzyme in the catabolism of abscisic acid
    Y Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    Curr Med Chem 17:3230-44. 2010
  2. ncbi request reprint 3'-Azidoabscisic acid as a photoaffinity reagent for abscisic acid binding proteins
    Y Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 11:2381-4. 2001
  3. doi request reprint Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 16:3141-52. 2008
  4. doi request reprint Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8'-hydroxylase CYP707A
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 19:5782-6. 2009
  5. doi request reprint Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 20:5506-9. 2010
  6. ncbi request reprint Metabolism of 5'alpha,8'-cycloabscisic acid, a highly potent and long-lasting abscisic acid analogue, in radish seedlings
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 12:363-70. 2004
  7. doi request reprint Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8'-hydroxylase CYP707A with no growth-retardant effect
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 17:6620-30. 2009
  8. ncbi request reprint Differences between the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity
    Kotomi Ueno
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 13:3359-70. 2005
  9. ncbi request reprint Effect of the minor ABA metabolite 7'-hydroxy-ABA on Arabidopsis ABA 8'-hydroxylase CYP707A3
    Hajime Shimomura
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    Bioorg Med Chem Lett 17:4977-81. 2007
  10. ncbi request reprint A new non-azole inhibitor of ABA 8'-hydroxylase: effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring
    Yoshiharu Araki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 16:3302-5. 2006

Collaborators

  • Masaharu Mizutani
  • N Hirai
  • Shigeo Yoshida
  • Tadao Asami
  • Kotomi Ueno
  • Kanzo Sakata
  • Shigeki Saito
  • Yoshiharu Araki
  • Katsuhiko Sekimata
  • Hajime Shimomura
  • Hidetaka Yoneyama
  • Koichi Yoneyama
  • Sun young Han
  • Toshiyuki Ohnishi
  • Yasutomo Takeuchi
  • Suguru Takatsuto
  • Jun Uzawa
  • Shozo Fujioka
  • Hideo Etoh
  • Shoko Shinoda
  • Tetsuo Kushiro
  • Yuji Kamiya
  • Arisa Miyawaki
  • Tomokazu Koshiba
  • Masanori Okamoto
  • Tomoyuki Miyashita
  • Eiji Nambara

Detail Information

Publications15

  1. ncbi request reprint Development of specific inhibitors of CYP707A, a key enzyme in the catabolism of abscisic acid
    Y Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    Curr Med Chem 17:3230-44. 2010
    ....
  2. ncbi request reprint 3'-Azidoabscisic acid as a photoaffinity reagent for abscisic acid binding proteins
    Y Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 11:2381-4. 2001
    ..This compound was stable in organic and aqueous solutions in the dark, but was decomposed by UV irradiation. Its biological activity was equivalent to that of abscisic acid, suggesting that it may be an effective photoaffinity reagent...
  3. doi request reprint Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 16:3141-52. 2008
    ..These findings should be useful for designing potent azole-containing specific inhibitors of ABA 8'-hydroxylase...
  4. doi request reprint Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8'-hydroxylase CYP707A
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 19:5782-6. 2009
    ....
  5. doi request reprint Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 20:5506-9. 2010
    ..DSI-505ME and DSI-505MZ, which have an imidazolyl group with a methyl 5-acrylate, strongly inhibited recombinant CYP707A3, with no growth-retardant effect...
  6. ncbi request reprint Metabolism of 5'alpha,8'-cycloabscisic acid, a highly potent and long-lasting abscisic acid analogue, in radish seedlings
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 12:363-70. 2004
    ..The present results suggest that the highly potent and long-lasting activity of CycloABA is caused by resistance to ABA 8'-hydroxylase, and that CycloABA is partially metabolized to the glucose conjugate by ABA glucosyltransferase...
  7. doi request reprint Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8'-hydroxylase CYP707A with no growth-retardant effect
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 17:6620-30. 2009
    ..This compound, abscinazole-F1, induced drought tolerance in apple seedlings upon spray treatment with a 10 microM solution...
  8. ncbi request reprint Differences between the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity
    Kotomi Ueno
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem 13:3359-70. 2005
    ..In particular, 8',8'-difluoro-ABA and 9',9'-difluoro-ABA yielded no enzyme reaction products and strongly inhibited the enzyme (K(I) = 0.16 and 0.25 microM, respectively)...
  9. ncbi request reprint Effect of the minor ABA metabolite 7'-hydroxy-ABA on Arabidopsis ABA 8'-hydroxylase CYP707A3
    Hajime Shimomura
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    Bioorg Med Chem Lett 17:4977-81. 2007
    ..The result of enzyme inhibition assay suggests that the local polarity at C-7', neither steric bulkiness nor overall molecular hydrophilicity, would be the major reason why (+)-7'-hydroxy-ABA is not a potent inhibitor of CYP707A3...
  10. ncbi request reprint A new non-azole inhibitor of ABA 8'-hydroxylase: effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring
    Yoshiharu Araki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Bioorg Med Chem Lett 16:3302-5. 2006
    ..This finding should assist in the design of more effective, non-azole ABA 8'-hydroxylase inhibitors...
  11. doi request reprint Synthesis and biological activity of amino acid conjugates of abscisic acid
    Yasushi Todoroki
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    Bioorg Med Chem 19:1743-50. 2011
    ..Because our study indicates the possibility that different plants have hydrolyzing activity toward different ABA-amino acids, an ABA-amino acid may function as a species-selective pro-hormone of ABA...
  12. ncbi request reprint Brz220 interacts with DWF4, a cytochrome P450 monooxygenase in brassinosteroid biosynthesis, and exerts biological activity
    Katsuhiko Sekimata
    Discovery Research Institute, RIKEN, Wako, Saitama, Japan
    Biosci Biotechnol Biochem 72:7-12. 2008
    ..In this context, we concluded that DWF4 is the target site of Brz220 in Arabidopsis...
  13. ncbi request reprint A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis
    Shigeki Saito
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biosci Biotechnol Biochem 70:1731-9. 2006
    ..Thus uniconazole-P effectively inhibits ABA catabolism in Arabidopsis plants. We also discuss the structure-activity relationship of the azole-type compounds on ABA 8'-hydroxylase inhibitory activity...
  14. ncbi request reprint A lead compound for the development of ABA 8'-hydroxylase inhibitors
    Kotomi Ueno
    The United Graduate School of Agricultural Science, Gifu University, Gifu 501 1193, Japan
    Bioorg Med Chem Lett 15:5226-9. 2005
    ..Compound 4 resisted 8'-hydroxylation, but inhibited ABA 8'-hydroxylation as effectively as 2. These results suggest that compound 2 is a useful lead compound for the future design and development of an ideal ABA 8'-hydroxylase inhibitor...
  15. ncbi request reprint Asymmetrical ligand binding by abscisic acid 8'-hydroxylase
    Kotomi Ueno
    The United Graduate School of Agricultural Science, Gifu University, Gifu 501 1193, Japan
    Bioorg Med Chem 15:6311-22. 2007
    ..These findings suggest that the C4'-oxo moiety coupled with the C2',C3'-double bond is the significant key functional group by which ABA 8'-hydroxylase distinguishes (1'S)-(+)-ABA from (1'R)-(-)-ABA...