M Denda

Summary

Affiliation: Shiseido Research Center
Country: Japan

Publications

  1. ncbi request reprint Association of cyclic adenosine monophosphate with permeability barrier homeostasis of murine skin
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 122:140-6. 2004
  2. ncbi request reprint Expression of voltage-gated calcium channel subunit alpha1C in epidermal keratinocytes and effects of agonist and antagonists of the channel on skin barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 15:455-60. 2006
  3. ncbi request reprint Epidermal keratinocytes as the forefront of the sensory system
    Mitsuhiro Denda
    Shiseido Life Science Research Center, Yokohama, Japan
    Exp Dermatol 16:157-61. 2007
  4. ncbi request reprint Possible role of epidermal keratinocytes in the construction of acupuncture meridians
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology CREST, Tokyo, Japan Electronic address
    J Acupunct Meridian Stud 7:92-4. 2014
  5. doi request reprint How does epidermal pathology interact with mental state?
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    Med Hypotheses 80:194-6. 2013
  6. ncbi request reprint Potassium channel openers accelerate epidermal barrier recovery
    M Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 157:888-93. 2007
  7. ncbi request reprint Air-exposed keratinocytes exhibited intracellular calcium oscillation
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    Skin Res Technol 13:195-201. 2007
  8. ncbi request reprint gamma-Aminobutyric acid (A) receptor agonists accelerate cutaneous barrier recovery and prevent epidermal hyperplasia induced by barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 119:1041-7. 2002
  9. ncbi request reprint Effects of skin surface temperature on epidermal permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:654-9. 2007
  10. ncbi request reprint New strategies to improve skin barrier homeostasis
    Mitsuhiro Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Adv Drug Deliv Rev 54:S123-30. 2002

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Association of cyclic adenosine monophosphate with permeability barrier homeostasis of murine skin
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 122:140-6. 2004
    ..These results suggest that intracellular cAMP in the epidermis is involved in skin barrier homeostasis...
  2. ncbi request reprint Expression of voltage-gated calcium channel subunit alpha1C in epidermal keratinocytes and effects of agonist and antagonists of the channel on skin barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 15:455-60. 2006
    ..These results suggest that the VGCC exists on epidermal keratinocytes and plays an important role in skin barrier homeostasis...
  3. ncbi request reprint Epidermal keratinocytes as the forefront of the sensory system
    Mitsuhiro Denda
    Shiseido Life Science Research Center, Yokohama, Japan
    Exp Dermatol 16:157-61. 2007
    ..e. first, keratinocytes recognize various environmental factors, and then the information is processed and conveyed to the nervous system...
  4. ncbi request reprint Possible role of epidermal keratinocytes in the construction of acupuncture meridians
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology CREST, Tokyo, Japan Electronic address
    J Acupunct Meridian Stud 7:92-4. 2014
    ....
  5. doi request reprint How does epidermal pathology interact with mental state?
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    Med Hypotheses 80:194-6. 2013
    ..Thus, there are multiple plausible pathways through which changes in skin can affect emotional state...
  6. ncbi request reprint Potassium channel openers accelerate epidermal barrier recovery
    M Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 157:888-93. 2007
    ..Although alterations in external K+ levels also regulate barrier recovery after acute insults, the mechanisms whereby K+ regulates barrier function remain unknown...
  7. ncbi request reprint Air-exposed keratinocytes exhibited intracellular calcium oscillation
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    Skin Res Technol 13:195-201. 2007
    ..The ATP concentration also increased immediately after keratinocytes were exposed to air. We hypothesize that ATP is secreted from keratinocytes on exposure to air, and induces an increase of intracellular calcium concentration...
  8. ncbi request reprint gamma-Aminobutyric acid (A) receptor agonists accelerate cutaneous barrier recovery and prevent epidermal hyperplasia induced by barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 119:1041-7. 2002
    ..These results suggest that the gamma-aminobutyric acid (A)-like receptor is associated with skin barrier homeostasis and regulation of the receptor clinically effective for barrier dysfunctional or epidermal hyperproliferative diseases...
  9. ncbi request reprint Effects of skin surface temperature on epidermal permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:654-9. 2007
    ..Previous reports suggest the existence of a water flux sensor in the epidermis, and as TRPV4 is known to be activated by osmotic pressure, our results indicate that it might be this sensor...
  10. ncbi request reprint New strategies to improve skin barrier homeostasis
    Mitsuhiro Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Adv Drug Deliv Rev 54:S123-30. 2002
    ..An external negative electric field accelerated the skin barrier recovery. These new methods to improve skin barrier homeostasis could be useful strategies to solve skin problems...
  11. ncbi request reprint Topical application of ionic polymers affects skin permeability barrier homeostasis
    M Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Skin Pharmacol Physiol 18:36-41. 2005
    ..Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis...
  12. ncbi request reprint Beta2-adrenergic receptor antagonist accelerates skin barrier recovery and reduces epidermal hyperplasia induced by barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 121:142-8. 2003
    ..These results suggest that the beta2-adrenergic receptor is specifically associated with skin barrier homeostasis...
  13. ncbi request reprint Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 121:362-7. 2003
    ..These results suggest that, like the nervous system, influx of calcium and chloride ions into epidermal keratinocytes through ionotropic receptors plays a crucial role in cutaneous barrier homeostasis...
  14. ncbi request reprint Negative electric potential induces alteration of ion gradient and lamellar body secretion in the epidermis, and accelerates skin barrier recovery after barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 118:65-72. 2002
    ..These results suggest that the external electric potential affects the ionic gradients in the epidermis and also influences the skin barrier homeostasis...
  15. ncbi request reprint Epidermal proliferative response induced by sodium dodecyl sulphate varies with environmental humidity
    M Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 145:252-7. 2001
    ..Previous studies have suggested that susceptibility of skin to external agents increases in the dry winter season...
  16. ncbi request reprint Immunoreactivity of VR1 on epidermal keratinocyte of human skin
    M Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Biochem Biophys Res Commun 285:1250-2. 2001
    ..RT-PCR assay of cultured human keratinocyte also showed expression of VR1 mRNA. These results suggest the existence of VR1-like protein in epidermal keratinocytes of human skin...
  17. doi request reprint Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Kanagawa 236 8643, Japan
    Adv Exp Med Biol 704:847-60. 2011
    ..The present review deals with the potential roles of TRP channels expressed in epidermal keratinocytes and focuses on the concept of the epidermis as an active interface between the body and the environment...
  18. ncbi request reprint Barrier recovery rate varies time-dependently in human skin
    M Denda
    Shiseido Research Center 2 2 12 1 Fukuura, Kanazawa Ku, Yokohama, 236 8643 Japan
    Br J Dermatol 142:881-4. 2000
    ..8 pmol mL-1). These results suggest significant time-dependent variation in cutaneous barrier repair independent of changes in skin temperature and cortisol level...
  19. ncbi request reprint Odorant inhalation affects skin barrier homeostasis in mice and humans
    M Denda
    Shiseido Research Center 2, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 142:1007-10. 2000
    ..Odorants with a sedative effect prevented the delay of skin barrier recovery induced by stress after acute barrier disruption. Other odorants did not show this effect...
  20. doi request reprint Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis
    Mitsuhiro Denda
    Shiseido Innovative Science Research and Development Center, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 19:791-5. 2010
    ..Our results indicate that TRPM8 or a closely related protein in epidermal keratinocytes plays a role in epidermal permeability barrier homoeostasis and epidermal proliferation after barrier insult...
  21. ncbi request reprint Influence of dry environment on epidermal function
    M Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, 236 8643, Yokohama, Japan
    J Dermatol Sci 24:S22-8. 2000
    ..Regulation of protease activity or ionic balance in the epidermis can accelerate barrier repair after injury. Improvement of the stratum corneum homeostasis can ameliorate skin damage induced by barrier disruption in a dry environment...
  22. doi request reprint Methodology to improve epidermal barrier homeostasis: how to accelerate the barrier recovery?
    M Denda
    Shiseido Research Center, Shiseido Co, Ltd, Yokohama, Japan
    Int J Cosmet Sci 31:79-86. 2009
    ..In this review, I will describe our recent findings and show how they provide the basis for a new perspective for clinical dermatology...
  23. doi request reprint Effects of metals on skin permeability barrier recovery
    Mitsuhiro Denda
    Shiseido Innovative Science Research and Development Center, Yokohama, Japan
    Exp Dermatol 19:e124-7. 2010
    ..There was a significant correlation between work function of each metal and barrier recovery rate. These results suggest that electron donation from outside accelerated the skin barrier recovery...
  24. doi request reprint Acceleration of permeability barrier recovery by exposure of skin to 10-30 kHz sound
    M Denda
    Shiseido Innovative Science Research and Development Center, Yokohama 236 8643, Japan
    Br J Dermatol 162:503-7. 2010
    ..Previous reports show that ultrasound can influence human brain electrical activity and systemic hormone levels in various parts of the body, other than the ear, so there may be an unknown ultrasound-responsive system in humans...
  25. ncbi request reprint Skin surface electric potential induced by ion-flux through epidermal cell layers
    M Denda
    Shiseido Reassert Center, 2 12 1, Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Biochem Biophys Res Commun 284:112-7. 2001
    ..These results suggest that the ion flux in the nucleated layer of the epidermis induce the skin surface potential and it is influenced by environmental and neuroendocrinological factors...
  26. ncbi request reprint Barium sulphate with a negative zeta potential accelerates skin permeability barrier recovery and prevents epidermal hyperplasia induced by barrier disruption
    S Fuziwara
    Shiseido Research Centre, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 151:557-64. 2004
    ....
  27. ncbi request reprint Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin
    M Denda
    Life Science Research Laboratories, Shiseido Research Center 2, Yokohama, Japan
    Br J Dermatol 138:780-5. 1998
    ..These animal models could be useful for objectively quantifying the influence of stress on the cutaneous function...
  28. ncbi request reprint Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Invest Dermatol 116:261-5. 2001
    ..In conclusion, both the histamine H1 and H2 receptors in the epidermis are involved in skin barrier function and the cutaneous condition of epidermal hyperplasia...
  29. ncbi request reprint Dry environment increases mast cell number and histamine content in dermis in hairless mice
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 149:240-7. 2003
    ..A variety of skin diseases, such as atopic dermatitis, senile xerosis or psoriasis tends to worsen during the dry winter season. These skin diseases are also characterized by itch sensation...
  30. ncbi request reprint Stress alters cutaneous permeability barrier homeostasis
    M Denda
    Shiseido Research Center, Yokohama, 236 8643 Japan
    Am J Physiol Regul Integr Comp Physiol 278:R367-72. 2000
    ..These results suggest that psychological stress stimulates increased production of glucocorticoids, which, in turn, adversely affects permeability barrier homeostasis...
  31. ncbi request reprint Paradoxical effects of beta-estradiol on epidermal permeability barrier homeostasis
    M Tsutsumi
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 157:776-9. 2007
    ....
  32. doi request reprint Mechanical-stimulation-evoked calcium waves in proliferating and differentiated human keratinocytes
    Moe Tsutsumi
    Shiseido Research Center, 2 12 1, Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Cell Tissue Res 338:99-106. 2009
    ..Thus, signaling via gap junctions might be involved in the induction of calcium waves in response to mechanical stress at the upper layer of the epidermis...
  33. ncbi request reprint Dopamine D2-like receptor agonists accelerate barrier repair and inhibit the epidermal hyperplasia induced by barrier disruption
    Shigeyoshi Fuziwara
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 125:783-9. 2005
    ..These results suggest that dopaminergic receptors are involved in epidermal barrier homeostasis...
  34. ncbi request reprint Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis
    Junko Sato
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 119:900-4. 2002
    ..The present study demonstrates that sudden changes from a high to a low humidity environment results in abnormal barrier function, which could adversely influence the incidence and/or severity of skin disorders...
  35. ncbi request reprint Epidermal interleukin-1 alpha generation is amplified at low humidity: implications for the pathogenesis of inflammatory dermatoses
    Y Ashida
    Shiseido Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan
    Br J Dermatol 144:238-43. 2001
    ..CONCLUSIONS: These results suggest that IL-1 alpha is an important factor in mediating the relationship between environmental humidity and epidermal pathology...
  36. doi request reprint Calcium ion gradients and dynamics in cultured skin slices of rat hindpaw in response to stimulation with ATP
    Moe Tsutsumi
    Shiseido Research Center, Shiseido Co, Ltd, Yokohama, Japan
    J Invest Dermatol 129:584-9. 2009
    ..These results suggest that the response to stimulation of keratinocytes in cultured skin slices varies depending upon the location (depth) within the epidermis...
  37. ncbi request reprint Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis
    Yuji Katsuta
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 124:1008-13. 2005
    ..These results suggest that unsaturated fatty acids in sebum alter the calcium dynamics in epidermal keratinocytes and induce abnormal follicular keratinization...
  38. ncbi request reprint Identification of immature cornified envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components
    T Hirao
    Shiseido Life Science Research Center, Yokohama, Japan
    Exp Dermatol 10:35-44. 2001
    ..These results suggest that involucrin-positive, fragile CEs are immature and less hydrophobic, and that their occurrence is closely related to impairment of the barrier function of the skin...
  39. ncbi request reprint Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery
    M Denda
    Shiseido Research Center 2, 2 12 1 Fukuura, Kanazwa ku, Yokohama, 236 8643, Japan
    Arch Dermatol Res 291:560-3. 1999
    ..These results suggest that the effects of these metal ions are different depending on the counter ion and/or the method of application...
  40. doi request reprint Function of oleic acid on epidermal barrier and calcium influx into keratinocytes is associated with N-methyl D-aspartate-type glutamate receptors
    Y Katsuta
    Shiseido Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Br J Dermatol 160:69-74. 2009
    ..Unsaturated fatty acids from sebum affect calcium dynamics in epidermal keratinocytes, disrupt the barrier function and induce abnormal keratinization. However, the mechanisms of these effects have not been clarified...
  41. doi request reprint Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation
    Kazuyuki Ikeyama
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 130:1158-66. 2010
    ..These results are consistent with the idea that NO generated by epidermal nNOS has a significant role in the cutaneous circulatory response to mechanical stimulation...
  42. ncbi request reprint Characterization of multiple P2X receptors in cultured normal human epidermal keratinocytes
    Kaori Inoue
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 124:756-63. 2005
    ..Changes in the expression levels and cation influx via multiple P2X receptors might be involved in the regulation of differentiation and one of the epidermal external sensors...
  43. doi request reprint Mathematical analysis of intercellular calcium propagation induced by adenosine triphosphate
    Moe Tsutsumi
    Shiseido Research Center, Yokohama, Japan
    Skin Res Technol 16:146-50. 2010
    ..The feature of the calcium wave propagation appeared to be different between differentiated cells and proliferating cells, and so the mechanisms involved might be different...
  44. ncbi request reprint Functional vanilloid receptors in cultured normal human epidermal keratinocytes
    Kaori Inoue
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Biochem Biophys Res Commun 291:124-9. 2002
    ..These findings suggest that functional VR1-like protein is present and functions as a sensor against noxious chemical stimuli, such as capsaicin or acidification, in epidermal keratinocytes...
  45. doi request reprint Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation
    Makiko Goto
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Cell Physiol 224:229-33. 2010
    ..These results suggest that differentiated keratinocytes are sensitive to external pressure and that TRP might be involved in the mechanism of their response...
  46. ncbi request reprint Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes
    Kaori Inoue
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:362-71. 2007
    ..Furthermore, in UVB-radiated cells, we note the possibility that P2 receptor antagonists may reduce skin inflammation...
  47. ncbi request reprint Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption
    Kazuyuki Ikeyama
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:1713-9. 2007
    ..These results suggest that NO plays an important signaling role in cutaneous barrier homeostasis and in epidermal hyperplasia induced by barrier disruption...
  48. ncbi request reprint P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 119:1034-40. 2002
    ..These results suggest that cutaneous barrier homeostasis can be regulated by cation flux through a P2X3-like ATP receptor...
  49. doi request reprint Effect of endothelial nitric oxide synthase on epidermal permeability barrier recovery after disruption
    K Ikeyama
    Shiseido Innovative Science Research and Development Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 163:915-9. 2010
    ..We previously demonstrated that neuronal nitric oxide synthase (nNOS) in epidermal keratinocytes is associated with epidermal permeability barrier homeostasis...
  50. doi request reprint Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation
    Sumiko Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Dermatol Sci 57:108-13. 2010
    ..Its therapeutic effect includes acceleration of epidermal turnover without apparent inflammation, and its action is pH-dependent. However, little is known about the molecular mechanism of GA-induced peeling...
  51. doi request reprint Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition
    Eriko Kawai
    Shiseido Research Center, Yokohama, Japan
    Exp Dermatol 17:688-92. 2008
    ..These results suggest that the skin surface electric potential may be an indicator of the pathophysiology of the living layer of epidermis, and thus may be useful as a new parameter to evaluate skin condition...
  52. doi request reprint Expressions of rod and cone photoreceptor-like proteins in human epidermis
    Moe Tsutsumi
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 18:567-70. 2009
    ..PCR analysis confirmed the expression of rhodopsin-like and opsin-like genes in human retina and the skin. These results suggest that a series of proteins, which play a crucial role in visual perception, are expressed in human epidermis...
  53. ncbi request reprint Water content and thickness of the stratum corneum contribute to skin surface morphology
    J Sato
    Skin Biology Research Laboratories, Shiseido Research Center, Yokohama, Japan
    Arch Dermatol Res 292:412-7. 2000
    ..A significant correlation between skin roughness and stratum corneum thickness was also observed. These results suggest that skin surface morphology is associated with both water content and thickness of the stratum corneum...
  54. ncbi request reprint Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice
    Chika Katagiri
    Shiseido Life Science Research Center, Yokohama, Japan
    J Dermatol Sci 31:29-35. 2003
    ..Seasonal changes affect the condition of skin and may trigger various cutaneous disorders...
  55. doi request reprint Sex difference in human fingertip recognition of micron-level randomness as unpleasant
    M Nakatani
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, Japan
    Int J Cosmet Sci 33:346-50. 2011
    ..Possible physical and perceptual mechanisms involved are discussed...
  56. ncbi request reprint NMDA-type glutamate receptor is associated with cutaneous barrier homeostasis
    Shigeyoshi Fuziwara
    Shisedo Research Center, Fukuura Kanazawa ku, Yokohoma, Japan
    J Invest Dermatol 120:1023-9. 2003
    ..These results suggest that glutamate plays an important role as a signal of cutaneous barrier homeostasis and epidermal hyperplasia induced by barrier disruption...
  57. ncbi request reprint Modulations in epidermal calcium regulate the expression of differentiation-specific markers
    Peter M Elias
    Dermatology and Medical Services, Veterans Administration Medical Center, University of California School of Medicine, San Francisco 94121, USA
    J Invest Dermatol 119:1128-36. 2002
    ....
  58. ncbi request reprint Visible radiation affects epidermal permeability barrier recovery: selective effects of red and blue light
    Mitsuhiro Denda
    J Invest Dermatol 128:1335-6. 2008
  59. ncbi request reprint Altered distribution of calcium in facial epidermis of aged adults
    Mitsuhiro Denda
    J Invest Dermatol 121:1557-8. 2003