Shiseido Research Center

Summary

Organization: Shiseido Research Center
Country: Japan

Top Publications

  1. doi Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis
    Mitsuhiro Denda
    Shiseido Innovative Science Research and Development Center, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 19:791-5. 2010
  2. ncbi Specific and rapid analysis of ubiquinones using Craven's reaction and HPLC with postcolumn derivatization
    Haruo Shimada
    Frontier Science Laboratories, H and BC Development Center, Shiseido Co, Ltd, Kanazawa, Yokohama 236 8643, Japan
    J Lipid Res 48:2079-85. 2007
  3. ncbi Rheology and UV-protecting properties of complex suspensions of titanium dioxides and zinc oxides
    Akio Nasu
    Material Science Research Center, Shiseido Co, Ltd 2 2 1, Hayabuchi, Tsuzuki ku, Yokohama shi 224 8558, Japan
    J Colloid Interface Sci 310:617-23. 2007
  4. ncbi Air-exposed keratinocytes exhibited intracellular calcium oscillation
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    Skin Res Technol 13:195-201. 2007
  5. ncbi Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption
    Kazuyuki Ikeyama
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:1713-9. 2007
  6. ncbi Sirc-cvs cytotoxicity test: an alternative for predicting rodent acute systemic toxicity
    Masato Kitagaki
    Shiseido Research Center, Quality Assurance Center, Kanazawa, Yokohama, Japan
    J Toxicol Sci 31:371-9. 2006
  7. ncbi In vivo measurement of water content of the fingernail and its seasonal change
    Mariko Egawa
    Shiseido Research Center Shin Yokohama, Tsuzuki, Yokohama 224 8558, Japan
    Skin Res Technol 12:126-32. 2006
  8. ncbi Carbonylation of cornified envelopes in the stratum corneum
    Tetsuji Hirao
    Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    FEBS Lett 579:6870-4. 2005
  9. ncbi Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process
    S Amano
    Skin Biology Research Laboratories, Shiseido Life Science Research Centre, Yokohama, Japan 236 8643
    Br J Dermatol 153:37-46. 2005
  10. ncbi Skin permeation of lidocaine from crystal suspended oily formulations
    Rakan Matsui
    H and BC Research Center, Shiseido Research Center, Yokohama, Japan
    Drug Dev Ind Pharm 31:729-38. 2005

Scientific Experts

Detail Information

Publications62

  1. doi Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis
    Mitsuhiro Denda
    Shiseido Innovative Science Research and Development Center, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 19:791-5. 2010
    ..Our results indicate that TRPM8 or a closely related protein in epidermal keratinocytes plays a role in epidermal permeability barrier homoeostasis and epidermal proliferation after barrier insult...
  2. ncbi Specific and rapid analysis of ubiquinones using Craven's reaction and HPLC with postcolumn derivatization
    Haruo Shimada
    Frontier Science Laboratories, H and BC Development Center, Shiseido Co, Ltd, Kanazawa, Yokohama 236 8643, Japan
    J Lipid Res 48:2079-85. 2007
    ..This method is thought to be widely and conveniently applicable for determining the level of ubiquinones because of its high selectivity for ubiquinone detection...
  3. ncbi Rheology and UV-protecting properties of complex suspensions of titanium dioxides and zinc oxides
    Akio Nasu
    Material Science Research Center, Shiseido Co, Ltd 2 2 1, Hayabuchi, Tsuzuki ku, Yokohama shi 224 8558, Japan
    J Colloid Interface Sci 310:617-23. 2007
    ....
  4. ncbi Air-exposed keratinocytes exhibited intracellular calcium oscillation
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    Skin Res Technol 13:195-201. 2007
    ..The ATP concentration also increased immediately after keratinocytes were exposed to air. We hypothesize that ATP is secreted from keratinocytes on exposure to air, and induces an increase of intracellular calcium concentration...
  5. ncbi Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption
    Kazuyuki Ikeyama
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:1713-9. 2007
    ..These results suggest that NO plays an important signaling role in cutaneous barrier homeostasis and in epidermal hyperplasia induced by barrier disruption...
  6. ncbi Sirc-cvs cytotoxicity test: an alternative for predicting rodent acute systemic toxicity
    Masato Kitagaki
    Shiseido Research Center, Quality Assurance Center, Kanazawa, Yokohama, Japan
    J Toxicol Sci 31:371-9. 2006
    ..8%. From this, it is concluded that this method could be used to predict the acute systemic toxicity potential of chemicals in rodents...
  7. ncbi In vivo measurement of water content of the fingernail and its seasonal change
    Mariko Egawa
    Shiseido Research Center Shin Yokohama, Tsuzuki, Yokohama 224 8558, Japan
    Skin Res Technol 12:126-32. 2006
    ..In this study, we applied Near infrared spectroscopy (NIR)-based prediction of water content of the cut nail plate to in vivo measurement to obtain information about the seasonal change of water in the fingernail...
  8. ncbi Carbonylation of cornified envelopes in the stratum corneum
    Tetsuji Hirao
    Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    FEBS Lett 579:6870-4. 2005
    ..Carbonylation of CEs did not depend on their maturity, as evaluated by loss of involucrin antigenicity during maturation process, suggesting that CEs are carbonylated regardless of their maturation stage...
  9. ncbi Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process
    S Amano
    Skin Biology Research Laboratories, Shiseido Life Science Research Centre, Yokohama, Japan 236 8643
    Br J Dermatol 153:37-46. 2005
    ..Although matrix metalloproteinases (MMPs) are believed to be involved in the BM damage, there is no good in vitro model for examining BM damage by MMPs or for exploring methods to protect the BM...
  10. ncbi Skin permeation of lidocaine from crystal suspended oily formulations
    Rakan Matsui
    H and BC Research Center, Shiseido Research Center, Yokohama, Japan
    Drug Dev Ind Pharm 31:729-38. 2005
    ..Finally, mathematical analysis was done to evaluate the effect of BO-2, and it was shown that BO-2 improved the LID solubility in stratum corneum lipids to efficiently enhance the LID permeation through skin...
  11. ncbi Expression profiling and cellular localization of genes associated with the hair cycle induced by wax depilation
    Yumiko Ishimatsu-Tsuji
    Shiseido Life Science Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 125:410-20. 2005
    ..These analyses will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents...
  12. ncbi A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin
    Masako Katsuyama
    Life Science Research Center, Shiseido Co Ltd, Tsuzuki ku, Yokohama, Japan
    J Dermatol Sci 38:207-13. 2005
    ..We found that xylitol (X) and farnesol (F) synergistically inhibited biofilm formation by SA and dissolved biofilm formed in vivo (Part 1)...
  13. ncbi A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics
    Masako Katsuyama
    Life Science Research Center, Shiseido Co Ltd, Tsuzuki ku, Yokohama, Japan
    J Dermatol Sci 38:197-205. 2005
    ..Staphylococcus epidermidis (SE) is a major constituent of skin microflora on healthy human skin, and provides protection against the growth of pathogenic bacteria...
  14. ncbi Odor, information and new cosmetics--the ripple effect on life by aromachology research
    Tsuneyuki Abe
    Institute of Beauty Sciences, Shiseido Co Ltd, Tokyo, Japan
    Chem Senses 30:i246-7. 2005
  15. ncbi In vivo assessment of pigmentary and vascular compartments changes in UVA exposed skin by reflectance-mode confocal microscopy
    Toyonobu Yamashita
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Exp Dermatol 16:905-11. 2007
    ..These in vivo studies confirmed that vascular change is an important factor for the development of the immediate pigment darkening and delayed tanning...
  16. doi Algorithm for in vitro Sun Protection Factor based on transmission spectrum measurement with concomitant evaluation of photostability
    Yoshimasa Miura
    Shiseido Research Center, Yokohama shi, Japan
    Photochem Photobiol 84:1569-75. 2008
    ..The values obtained showed an excellent correlation with in vivo SPF values, even for high-SPF sunscreens exceeding SPF 50. This method should be suitable as an in vitro SPF testing method for regulatory purposes...
  17. doi Protein carbonyls damage the water-holding capacity of the stratum corneum
    I Iwai
    Shiseido Life Science Research Center, Yokohama, Japan
    Skin Pharmacol Physiol 21:269-73. 2008
    ..As a hallmark of oxidatively damaged protein, protein carbonyl, including acrolein-protein adduct, has been observed in the skin. However, the influence of protein carbonylation on the stratum corneum (SC) has not yet been clarified...
  18. doi The evaluation of the amount of cis- and trans-urocanic acid in the stratum corneum by Raman spectroscopy
    Mariko Egawa
    Shiseido Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Photochem Photobiol Sci 9:730-3. 2010
    ..The results show this method can be used to measure cis- and trans-UCA levels in vivo...
  19. doi Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation
    Makiko Goto
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Cell Physiol 224:229-33. 2010
    ..These results suggest that differentiated keratinocytes are sensitive to external pressure and that TRP might be involved in the mechanism of their response...
  20. doi Grapefruit oil attenuates adipogenesis in cultured subcutaneous adipocytes
    Shinichiro Haze
    Shiseido Co, Ltd, Research Center, Yokohama shi, Japan
    Planta Med 76:950-5. 2010
    ..Our results demonstrate that grapefruit oil efficiently inhibits adipogenesis in cultured subcutaneous preadipocytes and adipocytes...
  21. doi Effects of metals on skin permeability barrier recovery
    Mitsuhiro Denda
    Shiseido Innovative Science Research and Development Center, Yokohama, Japan
    Exp Dermatol 19:e124-7. 2010
    ..There was a significant correlation between work function of each metal and barrier recovery rate. These results suggest that electron donation from outside accelerated the skin barrier recovery...
  22. doi Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation
    Kazuyuki Ikeyama
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 130:1158-66. 2010
    ..These results are consistent with the idea that NO generated by epidermal nNOS has a significant role in the cutaneous circulatory response to mechanical stimulation...
  23. doi Sagging of the cheek is related to skin elasticity, fat mass and mimetic muscle function
    T Ezure
    Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama shi, Kanagawa 224 8558, Japan
    Skin Res Technol 15:299-305. 2009
    ..The aim of this study was to investigate the mechanism of facial sagging by examining the relationship of sagging severity to changes of skin elasticity, fat mass and facial muscle function at the cheek...
  24. ncbi Distribution in skin of ceramide after oral administration to rats
    Osamu Ueda
    Functional Food Development Group, Functional Food Research and Development Center, Shiseido Co, Ltd, Kanagawa, Japan
    Drug Metab Pharmacokinet 24:180-4. 2009
    ..The results of the present study clearly demonstrate that some ceramide orally administered is distributed gradually in the dermis after gastrointestinal absorption, followed by transfer from the dermis to the epidermis...
  25. doi An innovative method to measure skin pigmentation
    Yuji Masuda
    Shiseido Research Center, Yokohama, Japan
    Skin Res Technol 15:224-9. 2009
    ..It is crucial to establish an accurate method for measuring skin pigmentation in cosmetic science and clinical dermatology. Here, we report a non-invasive precise method for measuring skin melanin content...
  26. doi Functional characteristics of the skin surface of children approaching puberty: age and seasonal influences
    Nobuko Akutsu
    Shiseido Life Science Research Center, Yokohama, Japan
    Acta Derm Venereol 89:21-7. 2009
    ..We conclude that, until puberty, most functional characteristics of the skin of children remain distinct from those of adults...
  27. ncbi Development of novel multifunctional cosmetic raw materials and their applications. IV. The effect of structure of polyoxyethylene/polyoxypropylene derivative on the self-organizing structures of surfactants
    Reiji Miyahara
    Shiseido Research Center Kanazawahakkei, Kanazawa Ku, Japan
    J Oleo Sci 58:65-73. 2009
    ..Thus, PEPTME (38/10) was considered to be most suited for preparing highly concentrated microemulsions...
  28. doi Function of oleic acid on epidermal barrier and calcium influx into keratinocytes is associated with N-methyl D-aspartate-type glutamate receptors
    Y Katsuta
    Shiseido Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Br J Dermatol 160:69-74. 2009
    ..Unsaturated fatty acids from sebum affect calcium dynamics in epidermal keratinocytes, disrupt the barrier function and induce abnormal keratinization. However, the mechanisms of these effects have not been clarified...
  29. ncbi Development of novel cosmetic base using sterol surfactant. I. Preparation of novel emulsified particles with sterol surfactant+
    Takashi Oka
    Shiseido Research Center, Yokohama shi, Japan
    J Oleo Sci 57:567-75. 2008
    ..The phase diagram analysis suggested that EPDME could form emulsified particles having lamellar structure on the surface of the particle with hydrophilic sterol surfactant in polar oils...
  30. doi Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines
    Michio Shibata
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 129:375-82. 2009
    ..acnes existing as normal resident flora plays an important role in the exacerbation of acne vulgaris as well as in possible induction of corticosteroid-induced acne or in that of rosacea-like dermatitis...
  31. ncbi Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1
    K Yano
    Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama, Kanagawa ken 224 8558, Japan
    Br J Dermatol 152:115-21. 2005
    ....
  32. ncbi Non-invasive visualization of melanin and melanocytes by reflectance-mode confocal microscopy
    Toyonobu Yamashita
    Shiseido Research Center Shin Yokohama, Yokohama, Japan
    J Invest Dermatol 124:235-40. 2005
    ..In conclusion, RCM successfully evidenced the difference in melanin distribution between the pigmented animals and humans, and the UV-induced pigmentation process in vivo as well...
  33. ncbi The evaluation of skin friction using a frictional feel analyzer
    Mariko Egawa
    Shisedo Research Center SHIN YOKOHAMA, Yokohama, Japan
    Skin Res Technol 8:41-51. 2002
    ..The objective here is to measure skin surface friction using these devices and examine the correlation with other physiological parameters in order to evaluate the potential of physical measurement of tactile sensation...
  34. ncbi Cultured human dermal papilla cells secrete a chemotactic factor for melanocytes
    Ritsuro Ideta
    Shiseido Research Center, Yokohama, Japan
    J Dermatol Sci 28:48-59. 2002
    ..This chemotactic signal between dermal papillae and melanocytes may control the localization and migration of hair melanocytes in vivo...
  35. ncbi Direct determination of pindolol enantiomers in human serum by column-switching LC-MS/MS using a phenylcarbamate-beta-cyclodextrin chiral column
    Akira Motoyama
    Pharmaceutical Research Center, Shiseido Co, Ltd, 2 12 1 Fukuura, Kanazawa Ku, Yokohama shi, Japan
    J Pharm Biomed Anal 28:97-106. 2002
    ..997. Recoveries from spiked serum and urine samples, estimated by the external standard method, were between 94.8 and 117.6% with a relative standard deviation (RSD) ranging from 2.1 to 18%...
  36. ncbi Immunoreactivity of VR1 on epidermal keratinocyte of human skin
    M Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Biochem Biophys Res Commun 285:1250-2. 2001
    ..RT-PCR assay of cultured human keratinocyte also showed expression of VR1 mRNA. These results suggest the existence of VR1-like protein in epidermal keratinocytes of human skin...
  37. ncbi Action of the novel antioxidants 4GBE43 and 2BBE43 against lipid peroxidation
    T Ezure
    Shiseido Pharmaceutical Research Laboratories, 2 12 1 Fukuura, Kanazawa Ku, 236 8643, Yokohama, Kanagawa, Japan
    Biochem Pharmacol 62:335-40. 2001
    ..However, 4GBE43 at 10(-4)-10(-5) M completely inhibited peroxidation, showing it to be more effective than alpha-tocopherol. These results suggest that 4GBE43 and 2BBE43 act as antioxidants by quenching the lipid peroxyl radical...
  38. ncbi Skin surface electric potential induced by ion-flux through epidermal cell layers
    M Denda
    Shiseido Reassert Center, 2 12 1, Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Biochem Biophys Res Commun 284:112-7. 2001
    ..These results suggest that the ion flux in the nucleated layer of the epidermis induce the skin surface potential and it is influenced by environmental and neuroendocrinological factors...
  39. ncbi 2-Nonenal newly found in human body odor tends to increase with aging
    S Haze
    Shiseido Co Ltd, Product Development Center, Yokohama, Japan
    J Invest Dermatol 116:520-4. 2001
    ..The results indicate that 2-nonenal is generated by the oxidative degradation of omega7 unsaturated fatty acids, and suggest that 2-nonenal may be involved in the age-related change of body odor...
  40. ncbi Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Invest Dermatol 116:261-5. 2001
    ..In conclusion, both the histamine H1 and H2 receptors in the epidermis are involved in skin barrier function and the cutaneous condition of epidermal hyperplasia...
  41. ncbi Influence of dry environment on epidermal function
    M Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, 236 8643, Yokohama, Japan
    J Dermatol Sci 24:S22-8. 2000
    ..Regulation of protease activity or ionic balance in the epidermis can accelerate barrier repair after injury. Improvement of the stratum corneum homeostasis can ameliorate skin damage induced by barrier disruption in a dry environment...
  42. ncbi Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery
    M Denda
    Shiseido Research Center 2, 2 12 1 Fukuura, Kanazwa ku, Yokohama, 236 8643, Japan
    Arch Dermatol Res 291:560-3. 1999
    ..These results suggest that the effects of these metal ions are different depending on the counter ion and/or the method of application...
  43. ncbi Characterization of the promoter region of the human melanocortin-1 receptor (MC1R) gene
    O Moro
    Shiseido Research Center, 1050 Nippa cho, Kohoku Ku, Yokohama shi, Kanagawa, 223 8553, Japan
    Biochem Biophys Res Commun 262:452-60. 1999
    ..In conclusion, the MC1R promoter shares the characteristics of many other GPCR promoters. These characteristics include GC-rich sequence, lack of a TATA box, and binding of SP-1...
  44. ncbi Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin
    M Denda
    Life Science Research Laboratories, Shiseido Research Center 2, Yokohama, Japan
    Br J Dermatol 138:780-5. 1998
    ..These animal models could be useful for objectively quantifying the influence of stress on the cutaneous function...
  45. pmc Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis
    S Denda
    Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143 0724, USA
    Mol Biol Cell 9:1425-35. 1998
    ..Together with a recent report that anti-OPN antibodies disrupt kidney morphogenesis, our results suggest that interactions between OPN and integrin alpha8 beta1 may help regulate kidney development and other morphogenetic processes...
  46. ncbi Effect of exposure of human skin to a dry environment
    Mariko Egawa
    Shiseido Research Center Shin Yokohama, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Skin Res Technol 8:212-8. 2002
    ..We have examined the effect of low humidity on healthy human skin by using noninvasive measurement devices...
  47. ncbi Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers
    T Ashikaga
    Shiseido Safety and Analytical Center, Safety Research Labs, 2 12 1 Fukuura, Kanazawa Ku, Yokohama shi, 236 8643, Japan
    Toxicol In Vitro 16:711-6. 2002
    ..The inducing effects of chemicals on the two phenotypical alterations were the same. These results suggest that these test systems can be used to predict contact-sensitizing ability of chemicals as an in vitro sensitization assay...
  48. ncbi gamma-Aminobutyric acid (A) receptor agonists accelerate cutaneous barrier recovery and prevent epidermal hyperplasia induced by barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 119:1041-7. 2002
    ..These results suggest that the gamma-aminobutyric acid (A)-like receptor is associated with skin barrier homeostasis and regulation of the receptor clinically effective for barrier dysfunctional or epidermal hyperproliferative diseases...
  49. ncbi Regulation of hyaluronan synthases in mouse uterine cervix
    Taro Uchiyama
    Shiseido Co Ltd, Pharmaceutical Development Center, Japan
    Biochem Biophys Res Commun 327:927-32. 2005
    ....
  50. ncbi Topical application of ionic polymers affects skin permeability barrier homeostasis
    M Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Skin Pharmacol Physiol 18:36-41. 2005
    ..Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis...
  51. ncbi Relation between asymmetry of prefrontal cortex activities and the autonomic nervous system during a mental arithmetic task: near infrared spectroscopy study
    Masahiro Tanida
    Bioengineering Research Laboratories, Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Neurosci Lett 369:69-74. 2004
    ....
  52. ncbi Direct determination of endogenous melatonin in human saliva by column-switching semi-microcolumn liquid chromatography/mass spectrometry with on-line analyte enrichment
    Akira Motoyama
    Pharmaceutical Research Center, Shiseido Co, Ltd, 2 12 1 Fukuura, Kanazawa Ku, Yokohama shi 236 8643, Japan
    Rapid Commun Mass Spectrom 18:1250-8. 2004
    ..3-20%. The method was successfully applied for the endogenous saliva MLT monitoring of two healthy subjects...
  53. ncbi Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression
    Kiichiro Yano
    Shiseido Life Science Research Center, Yokohama, Japan
    J Invest Dermatol 122:201-8. 2004
    ....
  54. ncbi Ratio of immature cornified envelopes does not correlate with parakeratosis in inflammatory skin disorders
    Tetsuji Hirao
    Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku Yokohama 236 8643, Japan
    Exp Dermatol 12:591-601. 2003
    ..These results obviously suggest that the maturation of CEs and disappearance of nuclei are differentially regulated in the epidermis...
  55. ncbi Dry environment increases mast cell number and histamine content in dermis in hairless mice
    Y Ashida
    Skin Biology Research Laboratories, Life Science Research Center, Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 149:240-7. 2003
    ..A variety of skin diseases, such as atopic dermatitis, senile xerosis or psoriasis tends to worsen during the dry winter season. These skin diseases are also characterized by itch sensation...
  56. ncbi Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 121:362-7. 2003
    ..These results suggest that, like the nervous system, influx of calcium and chloride ions into epidermal keratinocytes through ionotropic receptors plays a crucial role in cutaneous barrier homeostasis...
  57. ncbi Regulation of plasma substance P and skin mast cells by odorants
    Junichi Hosoi
    Shiseido Life Science Research Center, Yokohama 236 8643, Japan
    J Cutan Med Surg 7:287-91. 2003
    ..Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin...
  58. ncbi Auricular chondritis in young ear-tagged Crj:CD(SD)IGS rats
    M Kitagaki
    Safety Laboratories, Life Science Research Center, Shiseido Co Ltd, Japan
    Lab Anim 37:249-53. 2003
    ..The results suggest that the newly-formed cartilaginous nodules were due to interstitial proliferation of chondrocytes...
  59. ncbi Stress augmented ultraviolet-irradiation-induced pigmentation
    Kaori Inoue
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 121:165-71. 2003
    ..These results suggest that adrenocorticotropic hormone is at least partly responsible for the sensitivity of the pigmentary response after ultraviolet irradiation under stressful conditions...
  60. ncbi Beta2-adrenergic receptor antagonist accelerates skin barrier recovery and reduces epidermal hyperplasia induced by barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 121:142-8. 2003
    ..These results suggest that the beta2-adrenergic receptor is specifically associated with skin barrier homeostasis...
  61. ncbi New strategies to improve skin barrier homeostasis
    Mitsuhiro Denda
    Shiseido Life Science Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Adv Drug Deliv Rev 54:S123-30. 2002
    ..An external negative electric field accelerated the skin barrier recovery. These new methods to improve skin barrier homeostasis could be useful strategies to solve skin problems...
  62. ncbi The isolation and characterization of androgen-dependent genes in the flank organs of golden Syrian hamsters
    R Ideta
    Shiseido Life Science Research Laboratories, Yokohama, Japan
    Dermatology 196:47-50. 1998
    ..The SCD is a key enzyme in fatty acid biosynthesis and its expression is controlled by temperature, nutritional conditions and hormones. This is the first report that the mRNA expression of stearyl CoA is regulated by androgens...