Kohji Shirai

Summary

Country: Japan

Publications

  1. ncbi request reprint The effects of partial use of formula diet on weight reduction and metabolic variables in obese type 2 diabetic patients--multicenter trial
    Kohji Shirai
    Toho University Sakura Hospital, Sakura, Japan Electronic
    Obes Res Clin Pract 7:e43-54. 2013
  2. pmc Evaluation of blood pressure control using a new arterial stiffness parameter, cardio-ankle vascular index (CAVI)
    Kohji Shirai
    Department of Vascular Function, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    Curr Hypertens Rev 9:66-75. 2013
  3. pmc Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study
    Tamio Teramoto
    Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Cardiovasc Diabetol 11:29. 2012
  4. ncbi request reprint Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives
    Kohji Shirai
    Internal Medicine, Sakura Hospital, School of Medicine, Toho University
    J Atheroscler Thromb 18:924-38. 2011
  5. pmc Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study
    Tsukasa Namekata
    Pacific Rim Disease Prevention Center, P O Box 25444, Seattle, WA 98165 2344, USA
    BMC Cardiovasc Disord 11:51. 2011
  6. ncbi request reprint A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI)
    Kohji Shirai
    Internal Medicine, Sakura Hospital, Medical Center, Toho University, 564 1 Shimoshizu, Sakura shi, Chiba 285 8741, Japan
    J Atheroscler Thromb 13:101-7. 2006
  7. ncbi request reprint Contradictory effects of β1- and α1- aderenergic receptor blockers on cardio-ankle vascular stiffness index (CAVI)--CAVI independent of blood pressure
    Kohji Shirai
    Internal Medicine, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 18:49-55. 2011
  8. ncbi request reprint Effects of olmesartan, an angiotensin II receptor blocker, and amlodipine, a calcium channel blocker, on Cardio-Ankle Vascular Index (CAVI) in type 2 diabetic patients with hypertension
    Yoh Miyashita
    Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Japan
    J Atheroscler Thromb 16:621-6. 2009
  9. ncbi request reprint Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy
    Hidehisa Sasaki
    Departments of Pharmacy, Sakura Medical Center, School of Medicine, Toho University, Japan
    J Atheroscler Thromb 16:568-75. 2009
  10. ncbi request reprint Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients
    Masahiro Ohira
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    Diabetes Res Clin Pract 78:34-41. 2007

Collaborators

Detail Information

Publications78

  1. ncbi request reprint The effects of partial use of formula diet on weight reduction and metabolic variables in obese type 2 diabetic patients--multicenter trial
    Kohji Shirai
    Toho University Sakura Hospital, Sakura, Japan Electronic
    Obes Res Clin Pract 7:e43-54. 2013
    ....
  2. pmc Evaluation of blood pressure control using a new arterial stiffness parameter, cardio-ankle vascular index (CAVI)
    Kohji Shirai
    Department of Vascular Function, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    Curr Hypertens Rev 9:66-75. 2013
    ..This paper reviewed the principle and rationale of CAVI, and the possibilities of clinical applications, especially in the studies of hypertension. ..
  3. pmc Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study
    Tamio Teramoto
    Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Cardiovasc Diabetol 11:29. 2012
    ..We investigated glycemic control, relationship between lipid metabolism and HbA1c, and safety in diabetic patients treated with bezafibrate...
  4. ncbi request reprint Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives
    Kohji Shirai
    Internal Medicine, Sakura Hospital, School of Medicine, Toho University
    J Atheroscler Thromb 18:924-38. 2011
    ..This review covers the principles of CAVI and our current knowledge about CAVI, focusing on its roles and future outlook...
  5. pmc Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study
    Tsukasa Namekata
    Pacific Rim Disease Prevention Center, P O Box 25444, Seattle, WA 98165 2344, USA
    BMC Cardiovasc Disord 11:51. 2011
    ....
  6. ncbi request reprint A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI)
    Kohji Shirai
    Internal Medicine, Sakura Hospital, Medical Center, Toho University, 564 1 Shimoshizu, Sakura shi, Chiba 285 8741, Japan
    J Atheroscler Thromb 13:101-7. 2006
    ..002 vs. NA). CAVI in the patients with all three complications was 8.9 +/- 0.35 (p < 0.001 vs. NA). These results suggested that CAVI could reflect arteriosclerosis of the aorta, femoral artery and tibial artery quantitatively...
  7. ncbi request reprint Contradictory effects of β1- and α1- aderenergic receptor blockers on cardio-ankle vascular stiffness index (CAVI)--CAVI independent of blood pressure
    Kohji Shirai
    Internal Medicine, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 18:49-55. 2011
    ..But, it has not been experimentally proved yet. For confirmation, pharmacological studies were performed comparing with brachial-ankle pulse wave velocity (baPWV)...
  8. ncbi request reprint Effects of olmesartan, an angiotensin II receptor blocker, and amlodipine, a calcium channel blocker, on Cardio-Ankle Vascular Index (CAVI) in type 2 diabetic patients with hypertension
    Yoh Miyashita
    Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Japan
    J Atheroscler Thromb 16:621-6. 2009
    ..In this study, we evaluated the effect of angiotensin II receptor blocker (ARB) and calcium channel (Ca) blocker on CAVI in type 2 diabetic patients with hypertension...
  9. ncbi request reprint Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy
    Hidehisa Sasaki
    Departments of Pharmacy, Sakura Medical Center, School of Medicine, Toho University, Japan
    J Atheroscler Thromb 16:568-75. 2009
    ..In the present study, we evaluated the effects of two CCBs, efonidipine and amlodipine, on renal function and arterial stiffness...
  10. ncbi request reprint Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients
    Masahiro Ohira
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    Diabetes Res Clin Pract 78:34-41. 2007
    ..These results suggest that metformin may increase LPL production, thereby increasing LDL particle size. These effects might be independent of the hypoglycemic effect of metformin...
  11. doi request reprint Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Sakura City, Chiba 285 8741, Japan
    Metabolism 58:708-13. 2009
    ..260, P = .0683), which is a marker of insulin sensitivity. Plasma Ang II is associated with body weight, decreases during weight loss, and is associated with markers of insulin resistance in obese subjects with T2D...
  12. ncbi request reprint Effect of ezetimibe monotherapy on lipid metabolism and arterial stiffness assessed by cardio-ankle vascular index in type 2 diabetic patients
    Yoh Miyashita
    Departments of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, 564 1 Shimoshizu, Chiba, Japan
    J Atheroscler Thromb 17:1070-6. 2010
    ..High cholesterol absorption in the small intestine has been proposed to be a risk factor of atherosclerosis. In this study, we evaluated the effect of ezetimibe monotherapy on arterial stiffness in type 2 diabetic patients...
  13. ncbi request reprint Effects of body weight reduction on cardio-ankle vascular index (CAVI)
    Daiji Nagayama
    Center of Diabetes, Endocrine and Metabolism, Toho University Medical Center Sakura Hospital, Chiba 285 8741, Japan
    Obes Res Clin Pract 7:e139-e145. 2013
    ..We hypothesized that CAVI may be a candidate marker of increased vascular stiffness in obese patients. The aim of this study is to investigate the effect of weight reduction on CAVI...
  14. ncbi request reprint Atorvastatin and pravastatin elevated pre-heparin lipoprotein lipase mass of type 2 diabetes with hypercholesterolemia
    Kei Endo
    The Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, Toho University School of Medicine, 564 1 Shimoshizu, Sakura, Chiba 285 0841, Japan
    J Atheroscler Thromb 11:341-7. 2004
    ..Especially, its effect was remarkable in patients who showed low preheparin LPL mass...
  15. ncbi request reprint Pioglitazone decreases plasma angiotensin II concentration in type 2 diabetes
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba 285 8741, Japan
    J Atheroscler Thromb 17:651-7. 2010
    ..Plasma angiotensin II (AII) is a putative marker of adipocyte RAS production. The aim of this study was to investigate the effect of pioglitazone on plasma AII in type 2 diabetes (T2D)...
  16. ncbi request reprint [A relationship between insulin resistance and reduction in oxidative stress in vivo by atorvastatin]
    Takashi Hitsumoto
    Department of Cardiovascular Center, Sakura Hospital, Toho University School of Medicine, Chiba
    J Cardiol 44:233-42. 2004
    ..To examine the relationship between insulin resistance (IR) and the reduction of oxidative stress in vivo by the statin atorvastatin...
  17. ncbi request reprint Effects of pitavastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardio-ankle vascular index in type 2 diabetic patients
    Yoh Miyashita
    Departments of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Japan
    J Atheroscler Thromb 16:539-45. 2009
    ..A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients...
  18. ncbi request reprint [Relationship between insulin resistance and oxidative stress in vivo]
    Takashi Hitsumoto
    Department of Cardiovascular Center, Sakura Hospital, Toho University School of Medicine, Shimoshizu 564 1, Sakura, Chiba 285 0841
    J Cardiol 42:119-27. 2003
    ..The relationship between oxidative stress in vivo and insulin resistance was examined...
  19. ncbi request reprint The angiotensin II receptor antagonist valsartan enhances lipoprotein lipase mass in preheparin serum in type 2 diabetes with hypertension
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 8741, Japan
    Diabetes Res Clin Pract 74:242-8. 2006
    ..The results of this study suggest that valsartan may enhance LPL production in adipocytes, resulting in enlarged LDL particle size...
  20. ncbi request reprint Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus
    Hidehisa Sasaki
    Department of Pharmacy, Toho University, Sakura Hospital, School of Medicine, Chiba, Japan
    J Atheroscler Thromb 13:149-57. 2006
    ..These findings suggest that combination therapy with benidipine hydrochloride and candesartan cilexetil may contribute to the suppression of arteriosclerosis and may be useful for elderly hypertensive patients with diabetes mellitus...
  21. ncbi request reprint Enhancement of serum lipoprotein lipase mass levels by intensive insulin therapy
    Yoh Miyashita
    Department of Internal Medicine, Sakura Hospital, School of Medicine, Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 0841, Japan
    Diabetes Res Clin Pract 72:61-7. 2006
    ..Similar changes were observed in the iso-dose group. These results suggest that BBI therapy enhances preheparin LPL mass, accompanied by antiatherogenic changes in glucose and lipid metabolism...
  22. ncbi request reprint Formula diet is effective for the reduction and differentiation of visceral adipose tissue in Zucker fatty rats
    Takashi Yamaguchi
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan
    J Atheroscler Thromb 19:127-36. 2012
    ..Formula diet (FD), which is used as a tool for calorie restriction, has beneficial effects on metabolic disorders in obese patients; however, the molecular mechanism is not fully understood...
  23. doi request reprint Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase
    Masahiro Ohira
    Center for Diabetes, Metabolism and Endocrinology, Sakura Hospital, Toho University Medical Center, 564 1 Shimoshizu, Sakura City, Chiba 285 0841, Japan
    Metabolism 61:1452-60. 2012
    ..These results suggest that atorvastatin and pitavastatin increase LPL activity, protein levels and LPL mRNA expression by activating AMPK in skeletal muscle cells...
  24. ncbi request reprint Effect of acarbose, an alpha-glucosidase inhibitor, on serum lipoprotein lipase mass levels and common carotid artery intima-media thickness in type 2 diabetes mellitus treated by sulfonylurea
    Tomokazu Oyama
    Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 15:154-9. 2008
    ..The aim of this study was to examine the effects of combination therapy of sulfonylurea and acarbose on LPL mass and CCA-IMT...
  25. doi request reprint Suppression of lipoprotein lipase expression in 3T3-L1 cells by inhibition of adipogenic differentiation through activation of the renin-angiotensin system
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba 285 8741, Japan
    Metabolism 57:1093-100. 2008
    ..These results suggest that LPL expression may be suppressed by inhibition of adipogenic differentiation through activation of endogenous RAS in 3T3-L1 cells angiotensin type 1 receptor...
  26. doi request reprint Improvement of postprandial hyperglycemia and arterial stiffness upon switching from premixed human insulin 30/70 to biphasic insulin aspart 30/70
    Masahiro Ohira
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285 0841, Japan
    Metabolism 60:78-85. 2011
    ..These results suggest that switching biphasic insulin from BHI30 to BIAsp30 improves arterial stiffness, and the improvement of arterial stiffness may be associated with improvement of postprandial hyperglycemia...
  27. ncbi request reprint Preheparin serum lipoprotein lipase mass might be a biomarker of metabolic syndrome
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 8741, Japan
    Diabetes Res Clin Pract 76:93-101. 2007
    ..562. A negative correlation between preheparin LPL mass and urinary 8-OHdG was observed. These results suggest that low preheparin LPL mass may reflect systemic oxidative stress and also a biomarker of the severity of metabolic syndrome...
  28. ncbi request reprint Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes
    Atsuhito Saiki
    Center of Diabetes, Endocrinology and Metabolism, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 12:163-8. 2005
    ..Statins, especially pitavastatin, increased the expression of LPL in 3T3-L1 preadipocytes. The TG-lowering effect of pitavastatin might be mediated by enhancement of LPL production in adipocytes...
  29. ncbi request reprint Beneficial effect of low carbohydrate in low calorie diets on visceral fat reduction in type 2 diabetic patients with obesity
    Yoh Miyashita
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine, Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 0841, Japan
    Diabetes Res Clin Pract 65:235-41. 2004
    ....
  30. doi request reprint Metformin promotes induction of lipoprotein lipase in skeletal muscle through activation of adenosine monophosphate-activated protein kinase
    Masahiro Ohira
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, Medical Center, Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 0841, Japan
    Metabolism 58:1408-14. 2009
    ..These results suggest that metformin increases LPL activity, LPL protein expression, and LPL mRNA expression through activation of AMPK in skeletal muscle cells but not in adipocytes...
  31. ncbi request reprint Effect of the angiotensin II receptor antagonist telmisartan on lipoprotein lipase mass in preheparin serum
    Takashi Hitsumoto
    Department of Internal Medicine, Sakura Hospital, Toho University School of Medicine, Chiba, Japan
    J Atheroscler Thromb 15:138-45. 2008
    ....
  32. ncbi request reprint Changes in cardio-ankle vascular index in smoking cessation
    Hirofumi Noike
    Department of Cardiovascular Center, Sakura Medical Center, School of Medicine, Toho University, 561 4 Shimoshizu, Sakura City, Chiba, Japan
    J Atheroscler Thromb 17:517-25. 2010
    ..To investigate the effect of smoking and smoking cessation on cardio-ankle vascular index (CAVI)...
  33. doi request reprint Stroke and cardio-ankle vascular stiffness index
    Jun Suzuki
    Clinical Physiology Unit, Sakura Medical Center, Toho University, Sakura, Japan
    J Stroke Cerebrovasc Dis 22:171-5. 2013
    ..We investigated the relationship between stroke and cardio-ankle vascular stiffness index (CAVI), a novel noninvasive measure of vascular stiffness...
  34. ncbi request reprint Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin
    Yoh Miyashita
    Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University School of Medicine, Chiba, Japan
    J Atheroscler Thromb 9:65-71. 2002
    ..These effects of pravastatin were inhibited by mevalonate. The results suggest that 7-ketocholesterol-induced apoptosis of vascular smooth muscle cells is inhibited by pravastatin, and mevalonate acts as a trigger of the apoptosis...
  35. ncbi request reprint Association between preheparin serum lipoprotein lipase mass and acute myocardial infarction in Japanese men
    Takashi Hitsumoto
    Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University, Sakura City, Chiba, Japan
    J Atheroscler Thromb 9:163-9. 2002
    ..1, 2.4). The result indicates that a low pre-LPL mass may be an important risk factor for AMI and stable organic angina pectoris...
  36. ncbi request reprint Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy
    Tomoaki Shiba
    Department of Ophthalmology, Toho University Sakura Medical Center, 564 1 Shimoshizu, Sakura, Chiba, 285 8741, Japan
    Graefes Arch Clin Exp Ophthalmol 251:2689-95. 2013
    ....
  37. ncbi request reprint A case of obstructive jaundice with severe hypercholesterolemia probably due to lipoprotein-Y
    Takeyoshi Murano
    Department of Research and Development, Toho University Sakura Medical Center, Chiba, Japan
    J Atheroscler Thromb 15:276-80. 2008
    ..We analyzed the lipoproteins of a patient with pancreatic cancer causing obstructive jaundice, with marked hypercholesterolemia...
  38. ncbi request reprint Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats
    Yoh Miyashita
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, Toho University School of Medicine, 564 Shimoshizu, Sakura shi, Chiba 285 8741, Japan
    J Atheroscler Thromb 12:92-7. 2005
    ..These results suggest that apoptosis of SMC induced by 7-ketocholesterol may be accelerated when SMC acquire a high proliferative potential by prolonged exposure to diabetic condition...
  39. ncbi request reprint Relationship between preheparin lipoprotein lipase mass concentration in serum and bare metal stent restenosis
    Takashi Hitsumoto
    Division of Internal Medicine, Sakura Hospital, Toho University School of Medicine, Chiba
    J Cardiol 48:65-73. 2006
    ..This study examined the relationship between preheparin lipoprotein lipase protein (preheparin LpL mass) concentration in serum and bare-metal stent restenosis...
  40. ncbi request reprint Effects of pioglitazone hydrochloride on Japanese patients with type 2 diabetes mellitus
    Tamio Teramoto
    Department of Internal Medicine, School of Medicine, Teikyo University, Kaga, Tokyo, Japan
    J Atheroscler Thromb 14:86-93. 2007
    ..The effects of pioglitazone hydrochloride monotherapy on abnormal lipid control were evaluated in Japanese patients with type 2 diabetes mellitus, comparing with glibenclamide monotherapy...
  41. doi request reprint Enhanced circulating soluble LR11 in patients with diabetic retinopathy
    Mao Takahashi
    Cardiovascular Center, Sakura Hospital Medical Center, Toho University, Chiba, Japan
    Am J Ophthalmol 154:187-92. 2012
    ..To investigate the relationship of circulating levels of soluble form of LR11 (sLR11; also called SorLA or SORL1), with the progression of proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes mellitus...
  42. ncbi request reprint Relationship between two AMI risk factors: low serum lipoprotein lipase mass and hypoadiponectinemia
    Takashi Hitsumoto
    The Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Sakura City, Chiba, Japan
    J Atheroscler Thromb 18:148-56. 2011
    ..The aim of this study was to elucidate the relationship between low s-LpL and hypoadiponectinemia, both of which are risk factors for AMI...
  43. ncbi request reprint Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis
    Takashi Hitsumoto
    The Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 16:363-70. 2009
    ..The aim of this study was to clarify the clinical significance of serum 7-ketocholesterol concentrations (s-7KCHO) in the progression of coronary atherosclerosis...
  44. ncbi request reprint Enhanced circulating soluble LR11 in patients with coronary organic stenosis
    Mao Takahashi
    Department of Cardiovascular Center, Sakura Hospital, Medical Center, Toho University, Chiba, Japan
    Atherosclerosis 210:581-4. 2010
    ..01). These results suggest that the circulating sLR11 might reflect coronary organic stenosis, and that hyperglycemic condition might be promoting factor for expression of LR11 in intimal smooth muscle cells...
  45. ncbi request reprint [Overview: Atherogenic lipoproteins and their clinical significance]
    Kohji Shirai
    Internal Medicine, Sakura Hospital, Toho University
    Nihon Rinsho 62:5-9. 2004
  46. ncbi request reprint The recovery of dysfunctional lipoprotein lipase (Asp204-Glu) activity by modification of substrate
    Takeyoshi Murano
    Department of Clinical Laboratory Medicine, Sakura General Hospital, Toho University, 564 1 Shimoshizu, Sakura shi, Chiba Prefecture 285, Japan
    Atherosclerosis 183:101-7. 2005
    ..The expressed LPL (Asp204-Glu) also showed the same properties. These results suggested that the LPL (Asp204-Glu) is a functional deficiency, and the activity could be recovered by using acidic phospholipids as an emulsifier...
  47. ncbi request reprint Effects of serotonin on expression of the LDL receptor family member LR11 and 7-ketocholesterol-induced apoptosis in human vascular smooth muscle cells
    Daiji Nagayama
    Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center, 564 1, Shimoshizu, Sakura City, Chiba 285 8741, Japan
    Biochem Biophys Res Commun 446:906-10. 2014
    ..Furthermore, 5-HT suppressed the 7KCHO-induced apoptosis of VSMCs via caspase-3/7-dependent pathway. These findings provide new insights on the changes in the differentiation stage of VSMCs mediated by 5-HT. ..
  48. ncbi request reprint Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis
    Keijiro Nakamura
    Department of Cardiovascular Center, Sakura Medical Center, School of Medicine, Toho University, Japan
    Circ J 72:598-604. 2008
    ....
  49. ncbi request reprint Association between cardio-ankle vascular index and serum cystatin C levels in patients with cardiovascular risk factor
    Keijiro Nakamura
    Department of Cardiovascular Center, Sakura Medical Center, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 16:371-9. 2009
    ..The aim of this study was to clarify the relationship between CAVI and serum cystatin C levels to understand the role of arterial stiffness in the presence of renal insufficiency...
  50. ncbi request reprint Usefulness of preheparin lipoprotein lipase mass as a parameter for predicting the efficacy of colestimide
    Hidehisa Sasaki
    Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 12:218-24. 2005
    ..These results suggest that baseline preheparin LPL mass may be a marker of the response to colestimide...
  51. ncbi request reprint Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin
    Hiroshi Ozaki
    Department of Internal Medicine, Sakura Hospital, Toho University School of Medicine, Chiba, Japan
    J Atheroscler Thromb 12:308-14. 2005
    ..These results suggest that 7-KCHO activates macrophage and enhances MMP-9 activity, and its effects may be inhibited by fluvastatin...
  52. ncbi request reprint Parkinson's disease and the cardio-ankle vascular stiffness index
    Jun Suzuki
    Clinical Physiology Unit, Sakura Medical Center, Toho University, Japan
    Intern Med 53:421-6. 2014
    ..To investigate the relationship between Parkinson's disease (PD) and the cardio-ankle vascular stiffness index (CAVI), a novel non-invasive measurement of vascular stiffness...
  53. ncbi request reprint [Remnant lipoprotein cholesterol level measured by homogeneous assay reflects the quantity of intermediate-density lipoprotein]
    Takeyoshi Murano
    Departmen of Research and development, Toho University Medical Center, Sakura Hospital, Sakura
    Rinsho Byori 56:367-72. 2008
    ..Since RemL-C measurement can be run on an automated clinical analyzer permitting quick and high throughput measurement, RemL-C levels may be useful in the screening of hyperlipidemia...
  54. ncbi request reprint Effect of rosuvastatin 5-20mg on triglycerides and other lipid parameters in Japanese patients with hypertriglyceridemia
    Yasushi Saito
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Atherosclerosis 194:505-11. 2007
    ..The current study does not suggest a dose-related effect of rosuvastatin in lowering TG in hypertriglyceridemic Japanese patients, although dose-related improvements in other elements of the atherogenic lipid profile were observed...
  55. ncbi request reprint Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells
    Masaki Ohtsuka
    Department of Internal Medicine, Sakura Hospital, Medical Center of Toho University, 564 Shimoshizu, Sakura, Chiba 285 8741, Japan
    J Atheroscler Thromb 13:256-62. 2006
    ..These results suggest that lipids deposited in human atheromatous lesions may induce apoptosis of SMC and that oxysterols may be important factor contributing to induce apoptosis among deposited lipids...
  56. ncbi request reprint Relationship between metabolic syndrome and early stage coronary atherosclerosis
    Takashi Hitsumoto
    The Department of Internal Medicine, Sakura Hospital, Toho University School of Medicine, Chiba, Japan
    J Atheroscler Thromb 14:294-302. 2007
    ..The aim of this study is to clarify relationship between metabolic syndrome and early stage coronary atherosclerosis using a 3-dimensional intra-vascular ultrasound...
  57. ncbi request reprint Complications in adults with growth hormone deficiency--a survey study in Japan
    Minoru Irie
    Toho University, Tokyo, Japan
    Endocr J 51:479-85. 2004
    ..2.9%). These results indicated that GH deficiency have an increased prevalence of cardiovascular risk factors in Japanese similar to Western countries, and suggested that GH supplement therapy may be needed to reduce those complications...
  58. ncbi request reprint Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine
    Hidehisa Sasaki
    Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, Chiba 285 8741, Japan
    Metabolism 56:357-62. 2007
    ..These results suggest that 7KCHO-induced apoptosis of SMCs is inhibited by calcium channel blockade, and that Ca2+ influx into cells mediated by 7KCHO plays an important role in 7KCHO-induced apoptosis...
  59. ncbi request reprint Reduction of visceral adiposity after operation in a subject with insulinoma
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine Toho University, Chiba, Japan
    J Atheroscler Thromb 11:209-14. 2004
    ..An OGTT showed a non-diabetic pattern after the operation. These results suggest that hyperinsulinemia might be one of the factors that enhance visceral adiposity and insulin resistance...
  60. ncbi request reprint Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells
    Tomokazu Oyama
    Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University School of Medicine, Chiba, Japan
    J Atheroscler Thromb 9:109-13. 2002
    ..Both inhibited migration, whereas the free cholesterol and cholesterol ester did not. Oxysterols generated in the lipid pool might inhibit the migration of smooth muscle cells...
  61. doi request reprint Aseptic meningitis as the sole manifestation of Behçet's disease
    Ryuji Sakakibara
    Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, 564 1 Shimoshizu, Sakura, 285 8741, Japan
    Neurol Sci 30:405-7. 2009
    ..Behçet's disease should be listed as a differential diagnosis of acute aseptic meningitis because, in acute aseptic meningitis caused by Behçet's disease, early treatment with corticosteroids could ameliorate this disorder...
  62. ncbi request reprint The level of pre-heparin serum lipoprotein lipase mass at different stages of pregnancy
    Toshihiko Kinoshita
    Department of Obstetrics and Gynecology, Sakura Hospital, Toho University School of Medicine, 564 1 Shimoshizu, Sakura City, Chiba 285 8741, Japan
    Clin Chim Acta 337:153-6. 2003
    ..To clarify the dynamics of pre-heparin LPL mass during pregnancy, we studied the relationship between pre-heparin LPL mass and lipids in normal pregnant women...
  63. ncbi request reprint Acute decrease of cardio-ankle vascular index with the administration of beraprost sodium
    Mao Takahashi
    Department of Internal Medicine, Sakura Hospital, Medical Center, Toho University, Chiba, Japan
    J Atheroscler Thromb 19:479-84. 2012
    ....
  64. ncbi request reprint Obesity as the core of the metabolic syndrome and the management of coronary heart disease
    Kohji Shirai
    Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Shimoshizu, Japan
    Curr Med Res Opin 20:295-304. 2004
    ..Combining these new treatments with lifestyle changes and drug therapies for managing other CHD risk factors, as part of a multifaceted approach to treatment, will have benefits for CHD prevention...
  65. ncbi request reprint Low lipoprotein lipase mass in preheparin serum of type 2 diabetes mellitus patients and its recovery with insulin therapy
    Yoh Miyashita
    Department of Internal Medicine, Sakura Hospital, School of Medicine, Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 0841, Japan
    Diabetes Res Clin Pract 56:181-7. 2002
    ..Fifteen patients started to take insulin therapy. Preheparin LPL mass increased significantly at 4th week, when fasting blood glucose decreased. These results suggested that preheparin LPL mass was greatly regulated by insulin action...
  66. ncbi request reprint The role of polyol pathway in high glucose-induced endothelial cell damages
    Tomokazu Oyama
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine, Toho University, 564 1 Shimoshizu, Sakura City, Chiba, Japan
    Diabetes Res Clin Pract 73:227-34. 2006
    ..These results suggest that high glucose-induced endothelial cell damages may be mediated by activation of the polyol pathway accompanied by augmented oxidative stress...
  67. ncbi request reprint A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin
    Chikako Ishikawa
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan
    J Hum Genet 49:582-5. 2004
    ..No nucleotide variation in the exons of CYP3A4 was identified. To our knowledge, this is the first report showing that the adverse effect of cerivastatin might be caused by the genetic variant of CYP2C8...
  68. doi request reprint Occult hepatitis B virus infection in Japanese chronic hemodialysis patients
    Osamu Nagakawa
    Mihama Sakura Clinic, 602 1 Shimosizu, Sakura, Chiba 285 0841, Japan
    Ther Apher Dial 17:289-92. 2013
    ..Of 212 HBsAg-negative and anti-HBc-positive patients, three were positive for HBV DNA. Our study showed that the prevalence of occult HBV infection in chronic hemodialysis patients from eastern Japan was 0.3%...
  69. ncbi request reprint [Analysis of lipoproteins]
    Masahiro Ohira
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, Medical Center, Toho University
    Nihon Rinsho 65:147-52. 2007
  70. ncbi request reprint [Establishment and effect of the drug safety management monitoring system]
    Hidehisa Sasaki
    Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, 564 1 Shimoshizu, Sakura City 285 8741, Japan
    Yakugaku Zasshi 123:893-900. 2003
    ..Two of these 14 cases were reported to the Ministry of Health, Labour and Welfare because they were serious. Therefore, it was concluded that this system was useful for early detection of adverse reactions...
  71. ncbi request reprint Prognosis of hypercholesterolemic patients taking pravastatin for five years: the Chiba Lipid Intervention Program (CLIP) Study
    Yasushi Saito
    Second Department of Internal Medicine, School of Medicine, Chiba University, Japan
    J Atheroscler Thromb 9:99-108. 2002
    ..2) Pravastatin administration might reduce the mortality rate and myocardial infarction. 3) The combination of multiple risks is a strong factor for a cardiac event in addition to hypercholesterolemia...
  72. doi request reprint Prevalence and mechanism of bladder dysfunction in Guillain-Barré Syndrome
    Ryuji Sakakibara
    Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan
    Neurourol Urodyn 28:432-7. 2009
    ..To examine the prevalence and mechanism of urinary dysfunction in GBS...
  73. ncbi request reprint [Clinical significance of preheparin serum lipoprotein lipase mass in normocholesterolemic patients with coronary artery disease]
    Takashi Hitsumoto
    Department of Cardiovascular Center, Sakura Hospital, Toho University School of Medicine, Shimoshizu 564 1, Sakura, Chiba 285 0841
    J Cardiol 40:1-9. 2002
    ..Some normocholesterolemic patients have coronary artery disease (CAD) in Japan. This study evaluated the clinical significance of preheparin lipoprotein lipase mass as a risk factor for normocholesterolemic patients with CAD...
  74. ncbi request reprint [Practical method of formula diet for metabolic syndrome]
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center
    Nihon Rinsho 64:569-73. 2006
  75. ncbi request reprint Phosphate overload accelerates vascular calcium deposition in end-stage renal disease patients
    Takashi Shigematsu
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Japan
    Nephrol Dial Transplant 18:iii86-9. 2003
    ..These results suggest that the control of phosphate excess is important for prevention of calcium deposition on arteriole walls in ESRD patients...
  76. ncbi request reprint [The lipid metabolism in obesity]
    Nobukiyo Koide
    Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine Toho University
    Nihon Rinsho 65:379-84. 2007
  77. ncbi request reprint The role of pitavastatin-enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes
    Atsuhito Saiki
    J Atheroscler Thromb 13:122. 2006
  78. ncbi request reprint [Hypolipidemia in malabsorption syndrome]
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center
    Nihon Rinsho 65:621-6. 2007