Research Topics
Genomes and GenesSpecies | Takeki UeharaSummaryAffiliation: Shionogi and Co Country: Japan Publications
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Detail Information
Publications
Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in ratsTakeki Uehara
Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
J Appl Toxicol 28:388-98. 2008..The current results suggest that NDP has the potential risk to cause nephrotoxicity at a human therapeutic dose without hydration and that pre- and post-hydration at dosing can ameliorate this nephrotoxicity...- Comparative analysis of gene expression between renal cortex and papilla in nedaplatin-induced nephrotoxicity in ratsTakeki Uehara
Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
Hum Exp Toxicol 26:767-80. 2007..Overall, the results contribute to understanding the renal molecular events of NDP-induced nephrotoxicity including novel potential biomarker genes encoding CKs 14 and 19 that may serve as indicators of renal papillary toxicity... 
The Japanese toxicogenomics project: application of toxicogenomicsTakeki Uehara
Developmental Research Laboratories, Shionogi and Co, Ltd, Futaba cho, Toyonaka, Osaka 561 0825, Japan
Mol Nutr Food Res 54:218-27. 2010..Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project...- Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics databaseTakeki Uehara
Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
Toxicol Appl Pharmacol 255:297-306. 2011..Our toxicogenomic model might be useful for the prospective screening of hepatocarcinogenicity of compounds and prioritization of compounds for carcinogenicity testing... - Toxicogenomic biomarkers for renal papillary injury in ratsTakeki Uehara
Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi, Ibaraki, Osaka 567 0085, Japan Department of Veterinary Pathology, Graduate School of Agriculture and Biological Science, Osaka Prefecture University, 1 58 Rinkuu ourai Kita, Izumisano, Osaka 598 8531, Japan Electronic address
Toxicology 303:1-8. 2013.... - A toxicogenomic approach for identifying biomarkers for myelosuppressive anemia in ratsTakeki Uehara
Drug Developmental Research Laboratories, Shionogi and Co Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
Toxicology 282:139-45. 2011..While further large-scale validation studies are needed, our results indicate that the genes we identified might be useful biomarkers for the sensitive detection of myelosuppressive anemia in rats... - Identification of glutathione depletion-responsive genes using phorone-treated rat liverNaoki Kiyosawa
Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, Japan
J Toxicol Sci 32:469-86. 2007..The identified GSH probe sets would be useful for detecting glutathione-depleting risk of chemicals from microarray data... - A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in ratsTakeki Uehara
Toxicogenomics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi, Ibaraki, Osaka 567 0085, Japan
Toxicology 250:15-26. 2008.... - Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in ratsYohsuke Minowa
Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi Saito, Ibaraki, Osaka 567 0085, Japan
Toxicology 297:47-56. 2012..In summary, our toxicogenomic model is particularly useful for predicting the future onset of proximal tubular injury... - Gene expression profiling of methapyrilene-induced hepatotoxicity in ratTakeki Uehara
Toxicogenomics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
J Toxicol Sci 33:37-50. 2008..We conclude that toxicogenomics would enable a more sensitive assessment at the earlier time point than classical toxicology evaluation... - Gene expression profiling of rat liver treated with serum triglyceride-decreasing compoundsKo Omura
Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, Japan
J Toxicol Sci 32:387-99. 2007..We conclude that these identified 218 probe sets could be a useful source of biomarkers for classification of plasma TG decrease, based on the mechanisms involving PPARalpha and CAR... - Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics databaseChiaki Kondo
Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1, Futaba cho, Toyonaka, Osaka, Japan
Toxicology 265:15-26. 2009..Our classifier has better prediction accuracy than any of the well-known biomarkers. Therefore, the toxicogenomics approach would be useful for concurrent diagnosis of renal tubular injury... - Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin: a comparative study with cisplatin in ratsTakeki Uehara
Developmental Research Laboratories, Shionogi and Co Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
Arch Toxicol 79:451-60. 2005..Cortical lesions, indicated by slight tubular dilatation, were found only in the animals with papillary lesions. In summary, NDP is a promising second-generation platinum complex with reduced nephrotoxicity... - Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in ratsYutaka Tonomura
Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
Toxicology 266:48-54. 2009..Conversely, the rapid blood clearance of these markers should be taken into account when considering the use of these biomarkers... - Predictive genomic biomarkers for drug-induced nephrotoxicity in miceChiaki Kondo
Drug Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
J Toxicol Sci 37:723-37. 2012..This study provides novel evidence that these nephrotoxicity biomarker genes identified are translatable to mice, and that they are useful for early and sensitive detection of nephrotoxicity... - Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in ratsYutaka Tonomura
Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co, Ltd, Toyonaka, Osaka, Japan
Toxicology 273:53-9. 2010..Therefore, combinatorial measurement of these biomarkers may be a powerful tool for highly effective screening of nephrotoxicity... - Identification of potential genomic biomarkers for early detection of chemically induced cardiotoxicity in ratsYoko Mori
Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
Toxicology 271:36-44. 2010.... - Utilization of a one-dimensional score for surveying chemical-induced changes in expression levels of multiple biomarker gene sets using a large-scale toxicogenomics databaseNaoki Kiyosawa
Toxicogenomics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
J Toxicol Sci 31:433-48. 2006.... - Decrease in urinary creatinine in acute kidney injury influences diagnostic value of urinary biomarker-to-creatinine ratio in ratsYutaka Tonomura
Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
Toxicology 290:241-8. 2011..In conclusion, while Ucr-correction could overestimate the degree of AKI, it could also provide higher diagnostic power for AKI than UFR-correction. We should take into consideration of these backgrounds when using the Ucr-correction...