Takeki Uehara

Summary

Affiliation: Shionogi and Co
Country: Japan

Publications

  1. ncbi request reprint Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in rats
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    J Appl Toxicol 28:388-98. 2008
  2. ncbi request reprint Comparative analysis of gene expression between renal cortex and papilla in nedaplatin-induced nephrotoxicity in rats
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Hum Exp Toxicol 26:767-80. 2007
  3. doi request reprint The Japanese toxicogenomics project: application of toxicogenomics
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co, Ltd, Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Mol Nutr Food Res 54:218-27. 2010
  4. doi request reprint Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicol Appl Pharmacol 255:297-306. 2011
  5. doi request reprint Toxicogenomic biomarkers for renal papillary injury in rats
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 303:1-8. 2013
  6. doi request reprint A toxicogenomic approach for identifying biomarkers for myelosuppressive anemia in rats
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 282:139-45. 2011
  7. ncbi request reprint Identification of glutathione depletion-responsive genes using phorone-treated rat liver
    Naoki Kiyosawa
    Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, Japan
    J Toxicol Sci 32:469-86. 2007
  8. doi request reprint A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats
    Takeki Uehara
    Toxicogenomics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi, Ibaraki, Osaka 567 0085, Japan
    Toxicology 250:15-26. 2008
  9. doi request reprint Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats
    Yohsuke Minowa
    Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi Saito, Ibaraki, Osaka 567 0085, Japan
    Toxicology 297:47-56. 2012
  10. ncbi request reprint Gene expression profiling of methapyrilene-induced hepatotoxicity in rat
    Takeki Uehara
    Toxicogenomics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    J Toxicol Sci 33:37-50. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in rats
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    J Appl Toxicol 28:388-98. 2008
    ..The current results suggest that NDP has the potential risk to cause nephrotoxicity at a human therapeutic dose without hydration and that pre- and post-hydration at dosing can ameliorate this nephrotoxicity...
  2. ncbi request reprint Comparative analysis of gene expression between renal cortex and papilla in nedaplatin-induced nephrotoxicity in rats
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Hum Exp Toxicol 26:767-80. 2007
    ..Overall, the results contribute to understanding the renal molecular events of NDP-induced nephrotoxicity including novel potential biomarker genes encoding CKs 14 and 19 that may serve as indicators of renal papillary toxicity...
  3. doi request reprint The Japanese toxicogenomics project: application of toxicogenomics
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co, Ltd, Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Mol Nutr Food Res 54:218-27. 2010
    ..Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project...
  4. doi request reprint Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicol Appl Pharmacol 255:297-306. 2011
    ..Our toxicogenomic model might be useful for the prospective screening of hepatocarcinogenicity of compounds and prioritization of compounds for carcinogenicity testing...
  5. doi request reprint Toxicogenomic biomarkers for renal papillary injury in rats
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 303:1-8. 2013
    ....
  6. doi request reprint A toxicogenomic approach for identifying biomarkers for myelosuppressive anemia in rats
    Takeki Uehara
    Drug Developmental Research Laboratories, Shionogi and Co Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 282:139-45. 2011
    ..While further large-scale validation studies are needed, our results indicate that the genes we identified might be useful biomarkers for the sensitive detection of myelosuppressive anemia in rats...
  7. ncbi request reprint Identification of glutathione depletion-responsive genes using phorone-treated rat liver
    Naoki Kiyosawa
    Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, Japan
    J Toxicol Sci 32:469-86. 2007
    ..The identified GSH probe sets would be useful for detecting glutathione-depleting risk of chemicals from microarray data...
  8. doi request reprint A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats
    Takeki Uehara
    Toxicogenomics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi, Ibaraki, Osaka 567 0085, Japan
    Toxicology 250:15-26. 2008
    ....
  9. doi request reprint Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats
    Yohsuke Minowa
    Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, 7 6 8 Asagi Saito, Ibaraki, Osaka 567 0085, Japan
    Toxicology 297:47-56. 2012
    ..In summary, our toxicogenomic model is particularly useful for predicting the future onset of proximal tubular injury...
  10. ncbi request reprint Gene expression profiling of methapyrilene-induced hepatotoxicity in rat
    Takeki Uehara
    Toxicogenomics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    J Toxicol Sci 33:37-50. 2008
    ..We conclude that toxicogenomics would enable a more sensitive assessment at the earlier time point than classical toxicology evaluation...
  11. ncbi request reprint Gene expression profiling of rat liver treated with serum triglyceride-decreasing compounds
    Ko Omura
    Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, Japan
    J Toxicol Sci 32:387-99. 2007
    ..We conclude that these identified 218 probe sets could be a useful source of biomarkers for classification of plasma TG decrease, based on the mechanisms involving PPARalpha and CAR...
  12. ncbi request reprint Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database
    Chiaki Kondo
    Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1, Futaba cho, Toyonaka, Osaka, Japan
    Toxicology 265:15-26. 2009
    ..Our classifier has better prediction accuracy than any of the well-known biomarkers. Therefore, the toxicogenomics approach would be useful for concurrent diagnosis of renal tubular injury...
  13. ncbi request reprint Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin: a comparative study with cisplatin in rats
    Takeki Uehara
    Developmental Research Laboratories, Shionogi and Co Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Arch Toxicol 79:451-60. 2005
    ..Cortical lesions, indicated by slight tubular dilatation, were found only in the animals with papillary lesions. In summary, NDP is a promising second-generation platinum complex with reduced nephrotoxicity...
  14. ncbi request reprint Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies
    Yoko Nishimura
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka, 561 0825, Japan
    J Appl Toxicol 33:1120-30. 2013
    ..Our current results suggest that application of the model could potentially lead to the production of safer drugs...
  15. doi request reprint Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats
    Yutaka Tonomura
    Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 266:48-54. 2009
    ..Conversely, the rapid blood clearance of these markers should be taken into account when considering the use of these biomarkers...
  16. ncbi request reprint Predictive genomic biomarkers for drug-induced nephrotoxicity in mice
    Chiaki Kondo
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    J Toxicol Sci 37:723-37. 2012
    ..This study provides novel evidence that these nephrotoxicity biomarker genes identified are translatable to mice, and that they are useful for early and sensitive detection of nephrotoxicity...
  17. ncbi request reprint Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats
    Yutaka Tonomura
    Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co, Ltd, Toyonaka, Osaka, Japan
    Toxicology 273:53-9. 2010
    ..Therefore, combinatorial measurement of these biomarkers may be a powerful tool for highly effective screening of nephrotoxicity...
  18. ncbi request reprint Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity
    Rina Sakai
    Drug Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58 Rinkuu ourai Kita, Izumisano, Osaka 598 8531, Japan
    Toxicology 315:8-16. 2014
    ..In conclusion, CDKN1A may be a valuable biomarker for identifying DNA damage-inducing clastogens and as a follow-up assay for mammalian cytogenetic tests...
  19. doi request reprint Identification of potential genomic biomarkers for early detection of chemically induced cardiotoxicity in rats
    Yoko Mori
    Developmental Research Laboratories, Shionogi and Co, Ltd, 3 1 1 Futaba cho, Toyonaka, Osaka 561 0825, Japan
    Toxicology 271:36-44. 2010
    ....
  20. ncbi request reprint Utilization of a one-dimensional score for surveying chemical-induced changes in expression levels of multiple biomarker gene sets using a large-scale toxicogenomics database
    Naoki Kiyosawa
    Toxicogenomics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    J Toxicol Sci 31:433-48. 2006
    ....
  21. doi request reprint Decrease in urinary creatinine in acute kidney injury influences diagnostic value of urinary biomarker-to-creatinine ratio in rats
    Yutaka Tonomura
    Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Toxicology 290:241-8. 2011
    ..In conclusion, while Ucr-correction could overestimate the degree of AKI, it could also provide higher diagnostic power for AKI than UFR-correction. We should take into consideration of these backgrounds when using the Ucr-correction...