Takeshi Itoh

Summary

Affiliation: Shionogi and Co
Country: Japan

Publications

  1. ncbi request reprint Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
    Shunji Hayashidani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H1229-35. 2003
  2. ncbi request reprint Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    T Itoh
    Shionogi Institute for Medical Science, Shionogi and Co, Ltd, Osaka, Japan
    Cancer Res 58:1048-51. 1998
  3. ncbi request reprint Experimental metastasis is suppressed in MMP-9-deficient mice
    T Itoh
    Shionogi Institute for Medical Science, Shionogi and Co, Ltd, Osaka, Japan
    Clin Exp Metastasis 17:177-81. 1999
  4. ncbi request reprint The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis
    Takeshi Itoh
    Discovery Research Laboratories, Shionogi and Co, Ltd, Toyonaka City, Osaka, Japan
    J Immunol 169:2643-7. 2002
  5. ncbi request reprint Matrix metalloproteinase-9 in macrophages induces thymic neovascularization following thymocyte apoptosis
    Chikako Odaka
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
    J Immunol 174:846-53. 2005
  6. pmc Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
    Veronique Masson
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    FASEB J 19:234-6. 2005
  7. ncbi request reprint Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
    Junseo Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 23:5041-8. 2004
  8. ncbi request reprint Reduced retinal angiogenesis in MMP-2-deficient mice
    Kyoko Ohno-Matsui
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113, Japan
    Invest Ophthalmol Vis Sci 44:5370-5. 2003
  9. ncbi request reprint MMP-2 and MMP-9 synergize in promoting choroidal neovascularization
    Vincent Lambert
    Laboratory of Tumor and Development Biology, University of Liege, Belgium
    FASEB J 17:2290-2. 2003
  10. ncbi request reprint Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia
    Masafumi Kuzuya
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Toyonaka, Nagoya 466 8550, Japan
    Circulation 108:1375-81. 2003

Collaborators

  • Motoharu Seiki
  • T Yoshioka
  • R Suzuki
  • Shigeru Kanda
  • Vincent Lambert
  • Jean Marie Rakic
  • Kyoko Imanaka-Yoshida
  • Makoto Noda
  • Masafumi Kuzuya
  • Masaubmi Shibuya
  • Hiroyuki Tsutsui
  • S M Krane
  • C Odaka
  • Hideaki Matsuda
  • Masayuki Satoh
  • Keiichi Inoue
  • Shigeyoshi Itohara
  • Veronique Masson
  • Junseo Oh
  • Kyoko Ohno-Matsui
  • Shunji Hayashidani
  • Sachie Hiratsuka
  • Junko Ono
  • Keizo Anzai
  • Nobuhide Matsuoka
  • Seiyo Ikeda
  • Masahiko Nakano
  • Masaru Taniguchi
  • Tomoyuki Nitta
  • Yohichi Yasunami
  • Yuko Mikuni-Takagaki
  • Masaki Inada
  • Kaoru Oikawa
  • Takanori Noguchi
  • Jin Sung Park
  • Takashi Onodera
  • Khalid Bajou
  • Carine Munaut
  • Claude Libert
  • Silvia Blacher
  • Agnes Noel
  • Jean Michel Foidart
  • Catherine Maillard
  • Shige Itohara
  • Maud Jost
  • Zena Werb
  • Laura Rodriguez de la Ballina
  • Ben Wielockx
  • Shinobu Kuratomi
  • Akinori Noma
  • Akiko Okada
  • Eijiro Adachi
  • Hirotoshi Motoda
  • Rei Takahashi
  • Shunya Kondo
  • David B Alexander
  • Chiaki Takahashi
  • Toru Kubota
  • Ikuo Morita
  • Hidenori Matsusaka
  • Tetsuya Shiomi
  • Manabu Mochizuki
  • Takeshi Yoshida
  • Tomoko Uetama
  • Masaki Ikeuchi
  • Akira Takeshita
  • Masato Hayano
  • Hiroshi Kijima
  • Masato Murakami
  • Robert M Senior
  • Kazuhiro Nakamura
  • Shinobu Iwai
  • J Michael Shipley

Detail Information

Publications13

  1. ncbi request reprint Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
    Shunji Hayashidani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H1229-35. 2003
    ..The inhibition of MMP-2 activation may therefore be a potentially useful therapeutic strategy to manage post-MI hearts...
  2. ncbi request reprint Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    T Itoh
    Shionogi Institute for Medical Science, Shionogi and Co, Ltd, Osaka, Japan
    Cancer Res 58:1048-51. 1998
    ..014 and P < 0.0015, respectively). These results indicated that host-derived gelatinase A plays an important role in angiogenesis and tumor progression, suggesting the usefulness of gelatinase A inhibitors for anticancer chemotherapy...
  3. ncbi request reprint Experimental metastasis is suppressed in MMP-9-deficient mice
    T Itoh
    Shionogi Institute for Medical Science, Shionogi and Co, Ltd, Osaka, Japan
    Clin Exp Metastasis 17:177-81. 1999
    ..These results indicated that host-derived MMP-9 plays an important role in the process of tumor metastasis...
  4. ncbi request reprint The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis
    Takeshi Itoh
    Discovery Research Laboratories, Shionogi and Co, Ltd, Toyonaka City, Osaka, Japan
    J Immunol 169:2643-7. 2002
    ..These results indicated a suppressive role of MMP-2 and a pivotal role of MMP-9 in the development of inflammatory joint disease...
  5. ncbi request reprint Matrix metalloproteinase-9 in macrophages induces thymic neovascularization following thymocyte apoptosis
    Chikako Odaka
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
    J Immunol 174:846-53. 2005
    ..These studies demonstrate a potential role of macrophage MMP-9 in the remodeling of thymic extracellular matrix following thymocyte apoptosis...
  6. pmc Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
    Veronique Masson
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    FASEB J 19:234-6. 2005
    ..Our data demonstrate for the first time in an experimental model that MMP-2 and MMP-9 cooperate in promoting the in vivo invasive and angiogenic phenotype of malignant keratinocytes...
  7. ncbi request reprint Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
    Junseo Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 23:5041-8. 2004
    ..In the absence of MMP-2 and MT1-MMP, myoblast fusion in vitro is also significantly retarded. These findings suggest functional overlap in mice between the two MMPs with distinct molecular natures...
  8. ncbi request reprint Reduced retinal angiogenesis in MMP-2-deficient mice
    Kyoko Ohno-Matsui
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113, Japan
    Invest Ophthalmol Vis Sci 44:5370-5. 2003
    ....
  9. ncbi request reprint MMP-2 and MMP-9 synergize in promoting choroidal neovascularization
    Vincent Lambert
    Laboratory of Tumor and Development Biology, University of Liege, Belgium
    FASEB J 17:2290-2. 2003
    ..These findings suggest that MMP-2 and MMP-9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization...
  10. ncbi request reprint Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia
    Masafumi Kuzuya
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Toyonaka, Nagoya 466 8550, Japan
    Circulation 108:1375-81. 2003
    ..To define the role of MMP-2 in arterial remodeling, we evaluated the influence of the targeted deletion of the MMP-2 gene on vascular remodeling after flow cessation in the murine carotid arteries...
  11. ncbi request reprint MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
    Sachie Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Cancer Cell 2:289-300. 2002
    ..Thus, a block of MMP9 induction via VEGFR-1 inhibition could be useful for the prevention of tumor metastasis in lung...
  12. ncbi request reprint A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism
    Keiichi Inoue
    Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biol Chem 281:33814-24. 2006
    ..Our results indicate that MMP-2 plays a crucial role in forming and maintaining the osteocytic canalicular network, and we propose that osteocytic network formation is a determinant of bone remodeling and mineralization...
  13. ncbi request reprint Successful islet transplantation to two recipients from a single donor by targeting proinflammatory cytokines in mice
    Masayuki Satoh
    Department of Surgery, Fukuoka University, Fukuoka, Japan
    Transplantation 83:1085-92. 2007
    ..We herein determined whether this limitation could be overcome by targeting pro-inflammatory cytokines with the prevention of immediate islet graft loss in association with engraftment in mice...