T Imai

Summary

Affiliation: Shionogi and Co
Country: Japan

Publications

  1. ncbi request reprint Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka 566 0022, Kinki University School of Medicine, Osaka 589 8511, Japan
    J Biol Chem 274:27975-80. 1999
  2. ncbi request reprint The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
    T Imai
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:15036-42. 1997
  3. ncbi request reprint Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
    M Baba
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:14893-8. 1997
  4. ncbi request reprint Identification of single C motif-1/lymphotactin receptor XCR1
    T Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566 0022, Japan
    J Biol Chem 273:16551-4. 1998
  5. ncbi request reprint Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 458:37-40. 1999
  6. ncbi request reprint Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7
    R Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:13803-9. 1997
  7. ncbi request reprint Structure and expression of two highly related genes encoding SCM-1/human lymphotactin
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 395:82-8. 1996
  8. ncbi request reprint Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7
    R Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 273:7118-22. 1998
  9. ncbi request reprint Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13
    M Nagira
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:19518-24. 1997
  10. ncbi request reprint Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector
    T Imai
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 271:21514-21. 1996

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka 566 0022, Kinki University School of Medicine, Osaka 589 8511, Japan
    J Biol Chem 274:27975-80. 1999
    ..The strategy used in this study may also be applicable to identification of other unknown chemokine genes...
  2. ncbi request reprint The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
    T Imai
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:15036-42. 1997
    ..Taken together, TARC is a specific functional ligand for CCR4, and CCR4 is the specific receptor for TARC selectively expressed on T cells...
  3. ncbi request reprint Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
    M Baba
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:14893-8. 1997
    ..Taken together, GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-CY4. We propose GPR-CY4 to be designated as CCR6...
  4. ncbi request reprint Identification of single C motif-1/lymphotactin receptor XCR1
    T Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566 0022, Japan
    J Biol Chem 273:16551-4. 1998
    ..Following the set rule for the chemokine receptor nomenclature, we propose to designate GPR5 as XCR1 from XC chemokine receptor-1...
  5. ncbi request reprint Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 458:37-40. 1999
    ..In spleen, CD8+ cells and NK1.1+ cells were found to express mXCR1. Identification of mXCR1 will now allow us to study the role of this unique cytokine system in the mouse models of inflammation and immunity...
  6. ncbi request reprint Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7
    R Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:13803-9. 1997
    ..ELC and EBI1 may thus play roles in migration and homing of normal lymphocytes, as well as in pathophysiology of lymphocytes infected with these herpesviruses. We propose EBI1 to be designated as CCR7...
  7. ncbi request reprint Structure and expression of two highly related genes encoding SCM-1/human lymphotactin
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 395:82-8. 1996
    ..The biological activities of SCM-1alpha and SCM-1beta, which have two amino acid differences at positions 7 and 8 in the mature proteins, remain to be compared...
  8. ncbi request reprint Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7
    R Yoshida
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 273:7118-22. 1998
    ..Thus, SLC and ELC, even though sharing only 32% amino acid identity, constitute a genetically and functionally highly related subgroup of CC chemokines...
  9. ncbi request reprint Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13
    M Nagira
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:19518-24. 1997
    ..Collectively, SLC is a novel CC chemokine specific for lymphocytes and, together with ELC, constitutes a new group of chemokines localized at chromosome 9p13...
  10. ncbi request reprint Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector
    T Imai
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 271:21514-21. 1996
    ..TARC may a factor playing important roles in T cell development in thymus as well as in trafficking and activation of mature T cells...
  11. ncbi request reprint Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
    T Imai
    Shionogi Institute for Medical Science, Settsu, Japan
    Cell 91:521-30. 1997
    ..Thus, fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions...
  12. ncbi request reprint Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus
    I Ishikawa-Mochizuki
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 460:544-8. 1999
    ..Furthermore, ILC is strongly and selectively expressed in the skin where infection of MCV also takes place. Thus, ILC is likely to be the original chemokine of MC148R...
  13. ncbi request reprint Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression
    M Nagira
    Shionogi Institute for Medical Science, Osaka, Japan
    Cell Immunol 157:144-57. 1994
    ..These results together with the comparison of the structures of 5' flanking sequences of these genes indicate distinct regulations of gene expression for these four members of TM4SF...
  14. ncbi request reprint Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82
    T Imai
    Shionogi Institute for Medical Science, Osaka, Japan
    J Immunol 155:1229-39. 1995
    ..It is, therefore, suggested that CD4 exists at least in two physical states, one associated with p56lck and another associated with CD81 and CD82 in the absence or uncoupling of p56lck...
  15. ncbi request reprint Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
    ....
  16. ncbi request reprint Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans
    Y Tanaka
    Shionogi Institute for Medical Science, Osaka, Osaka Sayama, Japan
    Eur J Immunol 29:633-42. 1999
    ..Thus, in both humans and mice, LARC may be physiologically involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells toward epithelial cells...
  17. ncbi request reprint Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily
    S Takagi
    Shionogi Institute for Medical Science, Osaka, Japan
    Int J Cancer 61:706-15. 1995
    ..Like ME491, CO-029 and L6, TALLA-1 may be another TM4SF member behaving as a potential tumor-associated antigen...
  18. pmc Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells
    K Fukudome
    Shionogi Institute for Medical Science, Osaka, Japan
    J Virol 66:1394-401. 1992
    ..Therefore, C33 antigen has only N-linked carbohydrates, the modification of which appears to be substantially altered in the presence of the HTLV-1 genome...
  19. ncbi request reprint Molecular cloning of a novel C or gamma type chemokine, SCM-1
    T Yoshida
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 360:155-9. 1995
    ..SCM-1 and lymphotactin may thus represent the human and murine prototypes of a novel C or gamma type chemokine family...
  20. ncbi request reprint C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63
    T Imai
    Shionogi Institute for Medical Science, Osaka, Japan
    J Immunol 149:2879-86. 1992
    ..PHA stimulation also induced the dramatic size changes in the N-linked sugars previously shown to accompany human T cell leukemia virus type 1-induced transformation of CD4+ T cells...
  21. ncbi request reprint C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells
    T Imai
    Shionogi Institute for Medical Science, Osaka, Japan
    J Immunol 151:6470-81. 1993
    ..Furthermore, the regular association of C33 Ag and M38 Ag (TAPA-1) with CD4 or CD8 might indicate that they play a role in expression and/or function of the CD4/CD8 co-receptor complex...
  22. ncbi request reprint Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Kumamoto, Japan
    Cytogenet Cell Genet 81:10-1. 1998
  23. ncbi request reprint Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes
    Y Tasaki
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    Genomics 55:353-7. 1999
    ..This evidence provides a new model, duplication and fusion, of the molecular basis for diversity within a gene family...
  24. ncbi request reprint Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4
    T Imai
    ICOS Corporation, Bothell, Washington 98021, USA
    J Biol Chem 273:1764-8. 1998
    ..Since MDC and TARC are both expressed in the thymus, one role for these chemokines may be to attract CCR4-bearing thymocytes in the process of T cell education and differentiation...
  25. ncbi request reprint Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system
    H Mori
    Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Neurosci Res 64:132-43. 2001
    ..Taken together, these observations raise the possibility that mIMP3 represses neuronal differentiation through the regulation of igf2 mRNA expression...
  26. ncbi request reprint Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion
    J K Harrison
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 0267, USA
    J Biol Chem 276:21632-41. 2001
    ..These data identify specific structural features of the FKN-CD that are important in interactions with CX3CR1 including steady state binding, signaling, and firm adhesion of CX3CR1-expressing cells...
  27. ncbi request reprint A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes
    K Hieshima
    Department of Biochemistry, Kumamoto University Medical School, Japan
    J Immunol 159:1140-9. 1997
    ..9 nM and 590 sites/cell. Thus, PARC is a novel CC chemokine with a close phylogenic relationship with MIP-1 alpha/LD78 alpha, but with a highly selective activity on lymphocytes...
  28. ncbi request reprint Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 40:211-3. 1997
  29. ncbi request reprint Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
    K Hieshima
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860, Japan
    J Biol Chem 272:5846-53. 1997
    ..4 nM and 2100 sites/cell. Collectively, LARC is a novel CC chemokine, which may represent a new group of CC chemokines localized on chromosome 2...
  30. ncbi request reprint Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family
    J Sawada
    Research Function for Biotechnology, Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 274:35475-82. 1999
    ....
  31. ncbi request reprint Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice
    S Kawasaki
    Department of Respiratory Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 166:2055-62. 2001
    ..This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine...
  32. ncbi request reprint A model for membrane bioreactor process based on the concept of formation and degradation of soluble microbial products
    S G Lu
    Department of Civil Engineering, Yamaguchi University, Ube, Yamaguchi 755-8611, Japan
    Water Res 35:2038-48. 2001
    ..The present study demonstrated that SMPs contributed most to the organic matter in the effluent, and the results coincided well with the observations of many other researchers...
  33. ncbi request reprint Somatic gene alteration of AIB1 gene in patients with breast cancer
    A Shibata
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Japan
    Endocr J 48:199-204. 2001
    ..Taken together, both LOH and amplification of AIB1 gene were identified in breast cancer patients, raising the possibility that AIB1 have oncogenic as well as antioncogenic potential for the pathogenesis of breast cancer...
  34. pmc Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
    T Imai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, BP 163, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 98:224-8. 2001
    ....
  35. ncbi request reprint Modulation of bronchial epithelial cells by IL-17
    M Kawaguchi
    Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 108:804-9. 2001
    ..CONCLUSION: These findings suggest that IL-17, alone or in combination with other cytokines, modulates airway inflammation via-in part-the expression of epithelial IL-6, IL-8, and ICAM-1...
  36. ncbi request reprint The human homolog of Diminuto/Dwarf1 gene (hDiminuto): a novel ACTH-responsive gene overexpressed in benign cortisol-producing adrenocortical adenomas
    D Sarkar
    Department of Endocrinology and Metabolism, and Genetics Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    J Clin Endocrinol Metab 86:5130-7. 2001
    ..We, therefore, hypothesize that hDiminuto might be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth...
  37. ncbi request reprint Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle
    T Imai
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama, Funabashi City, Chiba, Japan
    Acta Physiol Scand 176:57-63. 2002
    ..In addition, the present study provides evidence that UBSM spontaneous mechanical activity is also attributable to the mechanism(s) other than the generation of Ca2+ spike...
  38. ncbi request reprint Iron lactate induction of pancreatic and endometrial proliferative lesions and a lack of increased tumors in a 104-week carcinogenicity study in F344 rats
    T Imai
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Food Chem Toxicol 40:1441-8. 2002
    ..Results in both cases were negative. Further investigations are needed to elucidate the mechanisms of induction of pancreatic and endometrial proliferative lesions by iron lactate...
  39. ncbi request reprint In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells
    T Imai
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Cell Endocrinol 214:107-15. 2004
    ..These results suggest that GATA-4 plays an important role in the regulation of Sertoli cell function, and is exactly regulated in these cells...
  40. ncbi request reprint Diagnosis of candidemia by polymerase chain reaction and blood culture: prospective study in a high-risk population and identification of variables associated with development of candidemia
    M S Moreira-Oliveira
    Infectious Diseases Division, Department of Internal Medicine, Rua Alexandre Fleming, 40 Cidade Universitária Zeferino Vaz, 13081 970, Campinas, Sao Paulo, Brazil
    Eur J Clin Microbiol Infect Dis 24:721-6. 2005
    ..04), and an indwelling urinary catheter (p = 0.02) were significant variables associated with the development of candidemia. The PCR technique in conjunction with DNA sequencing was a helpful tool in the diagnosis of candidemia...
  41. ncbi request reprint A 13-week subchronic toxicity study of dietary administered morin in F344 rats
    Y M Cho
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 44:891-7. 2006
    ..0% females. Based on the above findings, the no-observed-adverse-effect level (NOAEL) for both sexes was estimated to be 0.625% (299 and 356 mg/kg b.w./day for males and females, respectively)...
  42. ncbi request reprint Recycling mineral nutrients to farmland via compost application
    Y Y Liu
    Department of Civil and Environmental Engineering, Yamaguchi University, Tokiwadai 2 16 1, Ube, Yamaguchi 755 8611, Japan
    Water Sci Technol 53:111-8. 2006
    ..The controlled composting process and farmland uses are believed necessary for reducing the heavy metal accumulation in agricultural plants...
  43. doi request reprint Evaluation of toxicity of green tea catechins with 90-day dietary administration to F344 rats
    S Takami
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:2224-9. 2008
    ..Based on above findings, the no observed adverse effect level (NOAEL) of GTC was estimated to be 1.25% (764mg/kg body weight/day for males and 820mg/kg body weight/day for females)...
  44. ncbi request reprint Fractalkine-mediated endothelial cell injury by NK cells
    O Yoneda
    Department of Internal Medicine, Department of Periodontology, Osaka Dental University, Osaka, Japan
    J Immunol 164:4055-62. 2000
    ..Our results suggest that fractalkine plays an important role not only in the binding of NK cells to endothelial cells, but also in NK cell-mediated endothelium damage, which may result in vascular injury...
  45. ncbi request reprint ATM mutations in patients with ataxia telangiectasia screened by a hierarchical strategy
    T Sasaki
    Division of Genome Analysis, Institute of Genetic Information, Kyushu University, Fukuoka, Japan
    Hum Mutat 12:186-95. 1998
    ..Overall, mutations were found in at least 75% of the different ATM alleles examined. Possible reasons for the inability to detect mutations in some patients are discussed...
  46. ncbi request reprint Fifty sequenced-tagged sites on human chromosome 11
    T Miwa
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genomics 17:211-4. 1993
    ..These STSs can serve as new reagents for investigating human DNA in somatic cell hybrids and for isolating yeast artificial chromosomes to anchor large DNA contigs and fine-scale physical maps of chromosome 11...
  47. ncbi request reprint Epidermal growth factor promotes adipogenesis of 3T3-L1 cell in vitro
    H Adachi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Endocrinology 135:1824-30. 1994
    ..These results suggest that EGF shows biphasic effects on adipocytes: although EGF inhibits preadipocytes differentiation into mature adipocytes, it promotes adipogenesis in the differentiated adipocytes...
  48. ncbi request reprint Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)
    T Toda
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 3:465-70. 1994
    ..These data suggest that ZFM1 might be a candidate for mutations that cause MEN1...
  49. ncbi request reprint Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster
    Y Matsuda
    Genome Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, 263, Japan
    Genomics 34:347-52. 1996
    ..This type of inversion appeared to be conserved in the three rodent species, mouse, rat, and Syrian hamster, using additional comparative mapping data with the Rck gene...
  50. ncbi request reprint Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC
    K Shoudai
    Department of Biochemistry, Kumamoto University Medical School, Kumamoto, Japan
    Biochim Biophys Acta 1396:273-7. 1998
    ..The short and long transcripts are expressed highly selectively in the liver at nearly equivalent levels. There seems to be one copy of the gene per haploid genome. We now designate NCC-4 as LEC from liver-expressed chemokine...
  51. ncbi request reprint Cyclic adenosine 3',5'-monophosphate stimulation of placental proliferin and proliferin-related protein secretion
    M Yamaguchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Endocrinology 136:2040-6. 1995
    ..These data suggest that cAMP levels can regulate trophoblast giant cell differentiation and, consequently, the amount of PLF and PRP secretion...
  52. ncbi request reprint Changes in epidermal growth factor receptor and the levels of its ligands during menstrual cycle in human endometrium
    T Imai
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Biol Reprod 52:928-38. 1995
    ....
  53. ncbi request reprint The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 51:311-2. 1998
  54. pmc Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice
    H Yoneyama
    Department of Molecular Preventive Medicine, School of Medicine, and CREST, The University of Tokyo, Tokyo 113, Japan
    J Clin Invest 102:1933-41. 1998
    ..These results suggest that recruitment of IL-4-producing CCR4(+) CD4(+) T cells by granuloma-derived TARC into the liver parenchyma may be a key cause of massive liver injury after systemic LPS administration...
  55. ncbi request reprint Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 49:339-40. 1998
  56. ncbi request reprint Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice
    M Tanaka
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, 8 1 Kawadacho, Tokyo, Shinjuku ku, 162 8666, Japan
    Biochem Biophys Res Commun 258:194-8. 1999
    ....
  57. pmc Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion
    M Yamaguchi
    Department of Biology, University of California, Santa Cruz 95064, USA
    Proc Natl Acad Sci U S A 92:2830-4. 1995
    ..The data suggest that TGF-alpha and EGF do not regulate the production of mPL-I and mPL-II in a similar manner...
  58. ncbi request reprint Canadian Mennonites and individuals residing in the Friesland region of The Netherlands share the same molecular basis of 17 alpha-hydroxylase deficiency
    T Imai
    Department of Biochemistry, Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235
    Hum Genet 89:95-6. 1992
    ..The Mennonite Churches derive their name from Menno Simons, an early leader of the sect in Friesland. Presumably this 4-base duplication appeared within the Friesian population prior to emigration of the Mennonites from the Netherlands...
  59. ncbi request reprint The role of human MBF1 as a transcriptional coactivator
    Y Kabe
    Faculty of Bioscience, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 274:34196-202. 1999
    ..hMBF1 also bound to ATF1, a member of the basic leucine zipper protein family, and mediated its activity as a transcriptional activator. These data establish that the coactivator MBF1 is functionally conserved in eukaryotes...
  60. ncbi request reprint Mutant GTP cyclohydrolase I mRNA levels contribute to dopa-responsive dystonia onset
    M Hirano
    Department of Medical Genetics, Nara Medical University, Japan
    Ann Neurol 40:796-8. 1996
    ..These results demonstrate the importance of mutant mRNA levels for phenotypic variability among cases with the same mutation...