Tamotsu Tsukahara

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. pmc Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3295-307. 2011
  2. pmc PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan
    PLoS ONE 8:e58749. 2013
  3. doi request reprint Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan Electronic address
    Biochem Biophys Res Commun 433:281-5. 2013
  4. doi request reprint Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 424:524-9. 2012
  5. doi request reprint Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor γ
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Nagano, Japan
    Prostaglandins Other Lipid Mediat 93:126-33. 2010
  6. doi request reprint Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 404:109-14. 2011
  7. doi request reprint Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Mol Cell Biochem 352:57-63. 2011
  8. doi request reprint Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 406:558-63. 2011
  9. pmc Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3487-97. 2011
  10. pmc Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Sci Rep 2:687. 2012

Detail Information

Publications12

  1. pmc Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3295-307. 2011
    ..Thus, toxicity appears to depend on exposure time, even at low VGCF concentrations, because VGCF is biopersistent...
  2. pmc PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan
    PLoS ONE 8:e58749. 2013
    ..The PSF-PPARγ axis may play a role in the control of colorectal carcinogenesis. Taken together, this study is the first to describe the effects of PSF on cell proliferation, tumor growth, and cell signaling associated with PPARγ...
  3. doi request reprint Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan Electronic address
    Biochem Biophys Res Commun 433:281-5. 2013
    ..These findings suggest that alkyl-LPA activates PPARγ and stimulates glucose uptake in the absence of insulin in C2C12 cells. This may contribute to the plasma glucose-lowering effect in the treatment of insulin resistance...
  4. doi request reprint Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 424:524-9. 2012
    ..We observed a correlation between the level of PPARγ expression and the cells' sensitivity for proliferation...
  5. doi request reprint Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor γ
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Nagano, Japan
    Prostaglandins Other Lipid Mediat 93:126-33. 2010
    ..Our results identify PPARγ as a molecular mediator of cPA activity in HT-29 cells, and suggest that cPA and the PPARγ pathway might be therapeutic targets in the treatment of colon cancer...
  6. doi request reprint Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 404:109-14. 2011
    ..These findings contribute to the participation of cPA on the lipolytic activity in 3T3-L1 adipocytes. Our studies imply that cPA might be a therapeutic compound in the treatment of obesity and obesity-related diseases...
  7. doi request reprint Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Mol Cell Biochem 352:57-63. 2011
    ..However, the exposed cells showed no obvious intracellular ROS generation. These cellular and molecular findings suggest that HTT2800 could cause a potentially adverse inflammatory response in BEAS-2B cells...
  8. doi request reprint Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 406:558-63. 2011
    ..Taken together, these results suggest that HTT2800 specifically converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells...
  9. pmc Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3487-97. 2011
    ..Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs...
  10. pmc Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Sci Rep 2:687. 2012
    ..Thus, hydrogel microspheres are a potential system for stable and efficient delivery of bioactive lipids such as cPA and may offer a new strategy for targeted colon cancer treatment...
  11. doi request reprint Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
    Hisao Haniu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Electronic address
    Toxicol In Vitro 27:1679-85. 2013
    ..However, the culture medium composition may affect the proteins that are expressed on the cytoplasmic membrane, which may influence the biological response to MWCNTs. ..
  12. pmc DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:2689-95. 2011
    ..In the present study, we investigated whether DJ-1 could serve as a biomarker for assessing the biocompatibility of multiwalled carbon nanotubes (MWCNTs), using the highly purified carbon nanotube, HTT2800...