Shun Ichiro Taniguchi

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. ncbi request reprint Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cells
    S Taniguchi
    Department of Molecular Oncology and Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Cancer Res 61:7627-34. 2001
  2. ncbi request reprint Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC
    Shun Ichiro Taniguchi
    Department of Molecular Oncology, Institute on Aging and Adaptation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan
    Semin Immunopathol 29:231-8. 2007
  3. ncbi request reprint Suppression of cancer phenotypes through a multifunctional actin-binding protein, calponin, that attacks cancer cells and simultaneously protects the host from invasion
    Shun Ichiro Taniguchi
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Cancer Sci 96:738-46. 2005
  4. ncbi request reprint Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer
    Taro Yokoyama
    Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Nagano, Matsumoto 390 8621, Japan
    Cancer Lett 202:101-8. 2003
  5. ncbi request reprint Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors
    Toshiyuki Nakamura
    Department of Surgery, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Biosci Biotechnol Biochem 66:2362-6. 2002
  6. ncbi request reprint Suppression of peritoneal dissemination through protecting mesothelial cells from retraction by cancer cells
    Shigenari Hashimoto
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Int J Cancer 107:557-63. 2003
  7. doi request reprint Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization
    Nobutaka Kobayashi
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano, Japan
    Cancer Res 70:7073-83. 2010
  8. pmc Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilatation in calponin knockout mice
    Shizue Masuki
    Department of Sports Medical Sciences, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    J Physiol 553:203-12. 2003
  9. ncbi request reprint Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats
    Takayuki Sasaki
    Department of Surgery, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Cancer Sci 97:649-57. 2006
  10. ncbi request reprint ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma
    Xin Guan
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
    Int J Cancer 107:202-8. 2003

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cells
    S Taniguchi
    Department of Molecular Oncology and Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Cancer Res 61:7627-34. 2001
    ..The CN(-/-) mice, which exhibit fragile blood vessels and peritoneum, could serve as sensitive and useful host models to investigate cancer metastasis...
  2. ncbi request reprint Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC
    Shun Ichiro Taniguchi
    Department of Molecular Oncology, Institute on Aging and Adaptation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan
    Semin Immunopathol 29:231-8. 2007
    ....
  3. ncbi request reprint Suppression of cancer phenotypes through a multifunctional actin-binding protein, calponin, that attacks cancer cells and simultaneously protects the host from invasion
    Shun Ichiro Taniguchi
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Cancer Sci 96:738-46. 2005
    ..Thus, we believe that if we use adequate multifunctional molecules for therapy, it is possible to simultaneously suppress cancer phenotypes and protect normal cells from the attack of cancer cells...
  4. ncbi request reprint Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer
    Taro Yokoyama
    Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Nagano, Matsumoto 390 8621, Japan
    Cancer Lett 202:101-8. 2003
    ..The biological significance of ASC methylation inducible ASC suppression in colorectal cancer will be discussed...
  5. ncbi request reprint Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors
    Toshiyuki Nakamura
    Department of Surgery, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Biosci Biotechnol Biochem 66:2362-6. 2002
    ..longum produced cytosine deaminase. In addition, transfected B. longum produced cytosine deaminase that converted 5-fluorocytosine into 5-fluorouracil. B. longum could be useful for enzyme/pro-drug therapy of hypoxic solid tumors...
  6. ncbi request reprint Suppression of peritoneal dissemination through protecting mesothelial cells from retraction by cancer cells
    Shigenari Hashimoto
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Int J Cancer 107:557-63. 2003
    ..Peritoneal dissemination was prominently suppressed in AdGFP-CN-infected CN(-/-) mice, and the survival of those mice was significantly prolonged. Thus, calponin h1 functioned to protect host MS cells from the invasion of F10 cells...
  7. doi request reprint Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization
    Nobutaka Kobayashi
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano, Japan
    Cancer Res 70:7073-83. 2010
    ..Taken together, our results suggest that stromal HA serves as a microenvironmental signal for the recruitment of TAMs, which are key regulatory cells involved in tumor neovascularization...
  8. pmc Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilatation in calponin knockout mice
    Shizue Masuki
    Department of Sports Medical Sciences, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    J Physiol 553:203-12. 2003
    ..Thus, impaired MAP regulation in KO mice during exercise was caused by a blunted muscle vascular alpha-adrenergic contractile response and by the attenuated HR response to spontaneous change in MAP due to reduced baroreflex sensitivity...
  9. ncbi request reprint Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats
    Takayuki Sasaki
    Department of Surgery, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Cancer Sci 97:649-57. 2006
    ..Thus, we proposed that anaerobic bacteria of the genus B. longum were an attractive and safe tumor-targeting vector and transfected B. longum was a potential anticancer agent that could effectively and specifically treat solid tumors...
  10. ncbi request reprint ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma
    Xin Guan
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
    Int J Cancer 107:202-8. 2003
    ..Our study shows that ASC is downregulated in melanoma, and that its suppression is partially mediated by aberrant methylation...
  11. pmc Crucial role of hyaluronan in neointimal formation after vascular injury
    Yuichiro Kashima
    Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    PLoS ONE 8:e58760. 2013
    ....
  12. pmc Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment
    Hiroshi Koyama
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano 390 8621, Japan
    Am J Pathol 172:179-93. 2008
    ..These findings underline the significance of tumor-associated stroma in the promotion of intratumoral lymphangiogenesis and suggest a pivotal role for the hyaluronan-rich tumor microenvironment...
  13. ncbi request reprint Calponin h1-S175T point mutation enhances resistance to actin cytoskeleton perturbation in human cancer cells
    Akemi Sugaya
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Anticancer Res 30:1071-8. 2010
    ..This result indicates that S175T may be an effective target for new cancer treatments...
  14. doi request reprint Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages
    Andrea J McCoy
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    Eur J Immunol 40:2797-803. 2010
    ..hydrophila. Our results indicated that the NLRP3 inflammasome senses A. hydrophila infection through the action of bacterial cytotoxins...
  15. ncbi request reprint Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice
    Noriyuki Yajima
    Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Circulation 117:3079-87. 2008
    ..Here, we investigated the contribution of ASC to neointimal formation after vascular injury in ASC-deficient (ASC(-/-)) mice...
  16. ncbi request reprint Dihydropyrimidine dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma
    Hiroichi Kobayashi
    Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Japan
    Oral Oncol 41:38-47. 2005
    ..Expression of DPD is an independent predictor for clinical outcome. Furthermore, heterogeneity of DPD expression may be a clue for predicting sensitivity to 5-Fu in patients with OSCC...
  17. ncbi request reprint ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
    Masatatsu Yamamoto
    Department of Molecular Oncology Division of Molecular and Cellular Biology Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Genes Cells 9:1055-67. 2004
    ..These results demonstrate critical roles for ASC in the release of IL-1beta/IL-18 via activation of caspase-1 and provide new insights into the inflammatory responses for host defence and diseases...
  18. doi request reprint Clinical significance of apoptosis-associated speck-like protein containing a caspase recruitment domain in oral squamous cell carcinoma
    Tetsu Shimane
    Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol 115:799-809. 2013
    ..To assess apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) expression in oral squamous cell carcinoma (OSCC) and analyze its clinical and pathological significance...
  19. doi request reprint ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis
    Hideshi Yamazaki
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, 390 8621, Japan
    Rheumatol Int 32:1625-32. 2012
    ..Taken together, we can conclude that ASC is involved in the development of CIA and plays a role in the priming phase of the immune response to type II collagen...
  20. pmc Role of ASC in the mouse model of Helicobacter pylori infection
    Bekale N Benoit
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Histochem Cytochem 57:327-38. 2009
    ..pylori colonization...
  21. pmc A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC
    Kazuhiko Matsushita
    Department of Molecular Oncology, Institute on Aging and Adaptation, Graduate School of Medicine, Shinshu University, Negano 390 8621, Japan
    Mediators Inflamm 2009:287387. 2009
    ..These results suggest that although the PGR domain is dispensable for procaspase-1 activation, it plays an important role in the regulation of the molecular structure and activity of ASC...
  22. doi request reprint Targeting solid tumors with non-pathogenic obligate anaerobic bacteria
    Shun Ichiro Taniguchi
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Tokyo, Japan
    Cancer Sci 101:1925-32. 2010
    ....
  23. ncbi request reprint Strong enhancement of recombinant cytosine deaminase activity in Bifidobacterium longum for tumor-targeting enzyme/prodrug therapy
    Yoshinori Hamaji
    Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Biosci Biotechnol Biochem 71:874-83. 2007
    ..longum produces mutant CD and strongly increased (by 10-fold) its 5-FC to 5-FU enzymatic activity. The use of B. longum harboring the new shuttle-plasmid increases the effectiveness of our enzyme/prodrug strategy...
  24. ncbi request reprint Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma
    Hiroichi Kobayashi
    Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Clin Cancer Res 10:572-80. 2004
    ..The aim of the present study was to elucidate the clinical significance of expression patterns of moesin in patients with oral squamous cell carcinoma (OSCC)...
  25. ncbi request reprint Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis
    Miwako Kaneko
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Jpn J Cancer Res 93:935-43. 2002
    ..These results suggest that CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by decreasing VEGF expression and angiogenesis in vivo and partially through reducing cellular proliferative potential and cell motility...
  26. doi request reprint Upregulation of the apoptosis-related inflammasome in cardiac allograft rejection
    Tatsuichiro Seto
    Department of Surgery II, School of Medicine, Shinshu University, Matsumoto, Japan
    J Heart Lung Transplant 29:352-9. 2010
    ..The aim of the present study was to determine how ASC is associated with the development of cardiac allograft rejection...
  27. ncbi request reprint Enhanced baroreflex sensitivity in free-moving calponin knockout mice
    Shizue Masuki
    Department of Sports Medicine, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Am J Physiol Heart Circ Physiol 284:H939-46. 2003
    ....
  28. pmc Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M
    Hiroshi Koyama
    Department of Molecular Oncology, Division of Molecular and Cellular Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
    Am J Pathol 170:1086-99. 2007
    ..Taken together, these results suggest that hyaluronan overproduction accelerates tumor angiogenesis through stromal reaction, notably in the presence of versican...
  29. ncbi request reprint Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure
    Junji Sagara
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Biol Chem 278:45611-9. 2003
    ..These results suggest that scapinin is a putative regulatory subunit of PP1 and is involved in transformed or immature phenotypes of HL-60 cells. We also describe the presence of scapinin family proteins from worm to human...
  30. ncbi request reprint Shifts in cellular localization of moesin in normal oral epithelium, oral epithelial dysplasia, verrucous carcinoma and oral squamous cell carcinoma
    Hiroichi Kobayashi
    Department of Dentistry and Oral Surgery, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Asahi 3 11, Matsumoto 390 8621, Japan
    J Oral Pathol Med 32:344-9. 2003
    ..The purpose of the study is to assess the shifts in cellular distribution of moesin in normal oral epithelium, oral epithelial dysplasia (OED), verrucous carcinoma (VC), and oral squamous cell carcinoma (OSCC)...
  31. pmc Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton
    Junji Sagara
    Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Nagano, Japan
    PLoS ONE 4:e4247. 2009
    ..These results suggest that scapinin enhances cell spreading and motility through direct interaction with actin and that PP1 plays a regulatory role in scapinin-induced morphological changes...
  32. ncbi request reprint Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC
    Mie Moriya
    Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, 390 8621, Japan
    Biochemistry 44:575-83. 2005
    ..These data identify a coherent interaction surface, establishing a molecular model of PYD-PYD complexes with an important role for charge-charge interactions...
  33. ncbi request reprint Translocation of heparanase into nucleus results in cell differentiation
    Tetsuji Nobuhisa
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Cancer Sci 98:535-40. 2007
    ..Our results suggest that a novel function of heparanase upon cell differentiation would raise a potential new strategy for cancer therapy of promyeloid leukemia and other types of cancer...
  34. ncbi request reprint ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils
    Masaaki Shiohara
    Department of Pediatrics, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Biochem Biophys Res Commun 293:1314-8. 2002
    ..These findings suggest that up-regulation of ASC is closely associated with inflammation and apoptosis in neutrophils...
  35. ncbi request reprint Inhibition of urokinase-type plasminogen activator delays expression of c-jun, activated transforming growth factor beta 1, and matrix metalloproteinase 2 during post-hepatectomy liver regeneration in mice
    Kazuhiko Nomura
    First Department of Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Nagano, Matsumoto 390 8621, Japan
    J Hepatol 36:637-44. 2002
    ..In the present study, we investigated the effect of u-PA on liver regeneration after hepatectomy...
  36. ncbi request reprint [ASC and PYRIN family: novel players regulating innate immunity and apoptosis]
    Junji Sagara
    School of Health Sciences, Shinshu University, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Seikagaku 78:483-91. 2006
  37. ncbi request reprint Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development
    Junya Masumoto
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 278:4268-76. 2003
    ..These studies suggest that zAsc mediates the activation of Caspy, a caspase that plays an important role in the morphogenesis of the jaw and gill-bearing arches...
  38. ncbi request reprint ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis
    Junya Masumoto
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 303:69-73. 2003
    ..These findings suggest that ASC is a mediator of NF-kappa B activation and Caspase-8-dependent apoptosis in an Ipaf signaling pathway...
  39. pmc The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
    Christian Stehlik
    The Burnham Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 196:1605-15. 2002
    ..Our findings suggest that ASC modulates diverse NF-kappaB induction pathways by acting upon the IKK complex, implying a broad role for this and similar proteins containing PAAD domains in regulation of inflammatory responses...
  40. ncbi request reprint Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation
    Christian Stehlik
    Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 171:6154-63. 2003
    ....
  41. ncbi request reprint ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
    Takao Ohtsuka
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 6:121-8. 2004
    ..Our findings demonstrate that ASC has an essential role in the intrinsic mitochondrial pathway of apoptosis through a p53-Bax network...
  42. ncbi request reprint Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
    Akihiro Fujisawa
    Department of Dermatology, Kyoto University Graduate School of Medicine, Japan
    Blood 109:2903-11. 2007
    ..These results indicated that monocytes undergo rapid cell death in a cathepsin B-dependent manner upon activation of cryopyrin, which is also a specific phenomenon induced by disease-associated mutation of CIAS1...