Minoru Takata

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. ncbi request reprint Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion
    M Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Br J Dermatol 156:1287-94. 2007
  2. ncbi request reprint Genetic alterations in melanocytic tumors
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Dermatol Sci 43:1-10. 2006
  3. ncbi request reprint Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPA): Its usefulness as an adjunctive diagnostic tool for melanocytic tumors
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    J Dermatol Sci 40:51-7. 2005
  4. ncbi request reprint Early cancers of the skin: clinical, histopathological, and molecular characteristics
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Clin Oncol 10:391-7. 2005
  5. ncbi request reprint Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Pigment Cell Melanoma Res 23:64-71. 2010
  6. pmc Polyclonality of BRAF mutations in acquired melanocytic nevi
    Jingrong Lin
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Natl Cancer Inst 101:1423-7. 2009
  7. ncbi request reprint Downregulated melanogenic paracrine cytokine linkages in hypopigmented palmoplantar skin
    Junichi Hasegawa
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan 2 School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan
    Pigment Cell Melanoma Res 21:687-99. 2008
  8. doi request reprint Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
    Atsuko Ashida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Cancer 124:862-8. 2009
  9. ncbi request reprint Establishment of a novel melanoma cell line SMYM-PRGP showing cytogenetic and biological characteristics of the radial growth phase of acral melanomas
    Hiroshi Murata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Cancer Sci 98:958-63. 2007
  10. doi request reprint Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma
    Hisashi Uhara
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    J Dermatol 39:336-8. 2012

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion
    M Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Br J Dermatol 156:1287-94. 2007
    ..The histopathological differentiation of malignant melanoma and Spitz naevus often presents diagnostic problems...
  2. ncbi request reprint Genetic alterations in melanocytic tumors
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Dermatol Sci 43:1-10. 2006
    ..The clear differences in genetic aberration patterns have significant clinical implications in the diagnosis and treatment of melanocytic tumors...
  3. ncbi request reprint Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPA): Its usefulness as an adjunctive diagnostic tool for melanocytic tumors
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    J Dermatol Sci 40:51-7. 2005
    ..The histopathology of melanocytic tumors sometimes presents diagnostic problems. Applicable parameters other than routine pathology are needed...
  4. ncbi request reprint Early cancers of the skin: clinical, histopathological, and molecular characteristics
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Clin Oncol 10:391-7. 2005
    ..Precise molecular analyses of early stages of skin cancers may have a strong impact on our understanding of in vivo development of cancers in other human organs...
  5. ncbi request reprint Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Pigment Cell Melanoma Res 23:64-71. 2010
    ..Based on these observations, we propose an alternative genetic progression model for melanoma...
  6. pmc Polyclonality of BRAF mutations in acquired melanocytic nevi
    Jingrong Lin
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Natl Cancer Inst 101:1423-7. 2009
    ..The polyclonality of BRAF mutations in acquired melanocytic nevi suggests that mutation of BRAF may not be an initial event in melanocyte transformation...
  7. ncbi request reprint Downregulated melanogenic paracrine cytokine linkages in hypopigmented palmoplantar skin
    Junichi Hasegawa
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan 2 School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan
    Pigment Cell Melanoma Res 21:687-99. 2008
    ..These findings suggest the possibility that downregulation of ET-1/SCF/receptor linkages is also associated with the decreased function of melanocytes in PP skin...
  8. doi request reprint Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
    Atsuko Ashida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Cancer 124:862-8. 2009
    ..These results show pathological activation of KIT in a substantial number of metastatic tumors of acral and mucosal melanomas, and suggest a potential therapeutic benefit of sunitinib for these melanomas...
  9. ncbi request reprint Establishment of a novel melanoma cell line SMYM-PRGP showing cytogenetic and biological characteristics of the radial growth phase of acral melanomas
    Hiroshi Murata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Cancer Sci 98:958-63. 2007
    ..SMYM-PRGP is an excellent tool for investigating the development and progression of acral melanoma...
  10. doi request reprint Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma
    Hisashi Uhara
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    J Dermatol 39:336-8. 2012
    ..Allergic reactions were not reported with any of the tracers. (99m)Tc-tin colloid, (99m)Tc-phytate, PBV and indocyanine green are useful tracers for SN mapping...
  11. ncbi request reprint Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Japan
    J Invest Dermatol 125:318-22. 2005
    ..This provides a rational basis to include acral melanomas into the clinical trials with MAPK inhibitors...
  12. ncbi request reprint Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels
    Naohito Hatta
    Department of Dermatology, Postgraduate School of Medicine, Kanazawa University, Kanazawa, Japan
    J Cutan Pathol 32:131-6. 2005
    ..Because the activation of hedgehog signals and the up-regulation of its critical transcriptional factor Gli1 are well documented in BCC, a molecular technique measuring Gli1 transcripts may aide the diagnosis...
  13. ncbi request reprint Histopathological characteristics of malignant melanoma affecting mucous membranes: a unifying concept of histogenesis
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Pathology 36:404-13. 2004
    ..Particular attention was paid to elucidation of morphological characteristics of early phases of mucosal melanoma in order to contribute to effective detection of this highly malignant neoplasm in the curable stages...
  14. doi request reprint A pilot study of human interferon beta gene therapy for patients with advanced melanoma by in vivo transduction using cationic liposomes
    Kazuhiko Matsumoto
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Jpn J Clin Oncol 38:849-56. 2008
    ..HuIFNbeta gene therapy showed much higher anti-tumor activity compared with the administration of HuIFNbeta protein for melanoma. These results suggest that HuIFNbeta gene therapy is an attractive strategy for the treatment of melanoma...
  15. ncbi request reprint High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi
    Nami Ichii-Nakato
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Invest Dermatol 126:2111-8. 2006
    ..Most of these nevi with wild-type BRAF had neroblastoma ras viral oncogene homolog mutations (9/14, 64.3%), suggesting different pathogenesis of medium-sized congenital nevi from acquired nevi and small congenital nevi...
  16. ncbi request reprint Sentinel lymph node biopsy in Japan
    Hisashi Uhara
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Clin Oncol 14:490-6. 2009
    ..0% (13/63); pT3, 34.0% (35/103); and pT4, 62.4% (63/101). The metastasis rate was also significantly related to ulceration of the primary tumor. Here, we discuss data from Japanese patients and the present status of SLNB in Japan...
  17. doi request reprint Tetracycline and niacinamide control bullous pemphigoid but not pemphigus foliaceus when these conditions coexist
    Junko Shiohara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    J Dermatol 37:657-61. 2010
    ..This case showed that tetracycline and niacinamide could control bullous pemphigoid, but could not control pemphigus foliaceus, and that prednisolone was effective for both conditions...
  18. doi request reprint NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression
    Maki Yamaura
    Department of Dermatology, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
    Cancer Res 69:2647-54. 2009
    ..The findings suggest that Nox4-generated ROS are required for transformation phenotype of melanoma cells and contribute to melanoma growth through regulation of G(2)-M cell cycle progression...
  19. ncbi request reprint Two cases of unusual acral melanocytic tumors: illustration of molecular cytogenetics as a diagnostic tool
    Minoru Takata
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Takara machi, Kanazawa, Japan
    Hum Pathol 34:89-92. 2003
    ..5 years of follow-up, whereas case 2 developed lymph node metastasis. We conclude that molecular techniques such as CGH can be of diagnostic help in the classification of histologically ambiguous lesions...
  20. ncbi request reprint Specific dermoscopy patterns and amplifications of the cyclin D1 gene to define histopathologically unrecognizable early lesions of acral melanoma in situ
    Maki Yamaura
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Arch Dermatol 141:1413-8. 2005
    ..To define early lesions of acral melanoma in situ that cannot be recognized histopathologically...
  21. doi request reprint Cutaneous angiosarcoma of the leg showing radiation sensitivity
    Atsuko Ohashi
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Australas J Dermatol 53:e51-3. 2012
    ..However, monotherapy with radiation may be effective in some cases of cutaneous angiosarcoma...
  22. doi request reprint A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation
    Yasutaka Tokuda
    Department of Dermatology, Matsumoto National Hospital, Matsumoto, Japan
    J Cutan Pathol 35:666-71. 2008
    ..Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern...
  23. ncbi request reprint Eccrine porocarcinoma: clinical and pathological studies of 12 cases
    Junko Shiohara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    J Dermatol 34:516-22. 2007
    ..Death was correlated with a pathological growth pattern and clinical lymph node metastasis. Sentinel lymph node biopsy was performed usefully in two patients...
  24. ncbi request reprint [A case of lepromatous type Hansen's disease]
    Fumiaki Shirasaki
    Kanazawa University Graduate School of Medical Science, Department of Dermatology, 15 1 Takara machi, Kanazawa 920 8641, Japan
    Nihon Hansenbyo Gakkai Zasshi 72:267-70. 2003
    ..Although a severe type 1 reaction developed after four months of treatment, he was treated with oral prednisolone at a dose of 40 mg/day...
  25. ncbi request reprint Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages
    Nahoko Komatsu
    Department of Dermatology, Graduate School of Medical Science, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Invest Dermatol 121:542-9. 2003
    ..Coexpression of various KLK and SPINK5 mRNA suggests that their proteins are the candidates to balance and maintain serine protease activities in both the skin and appendages...
  26. pmc Oculocutaneous albinism type 4 is one of the most common types of albinism in Japan
    Katsuhiko Inagaki
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Hum Genet 74:466-71. 2004
    ..We discuss the functional melanogenic activity of each mutant allele, judging from the relationship between the phenotypes and genotypes of the patients. This is the first report on a large group of patients with OCA4...
  27. ncbi request reprint Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides
    Nahoko Komatsu
    Department of Dermatology, School of Medicine, Kanazawa University, Kanazawa, Japan
    J Invest Dermatol 118:436-43. 2002
    ....
  28. pmc Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells
    Kazuhiko Yamamoto
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701 0192, Japan
    Mol Cell Biol 23:5421-30. 2003
    ..In addition, the efficiency of gene targeting is mildly decreased in FANCG-deficient cells, but depends on the specific locus. We conclude that FANCG is required for efficient HR-mediated repair of at least some types of DSBs...
  29. ncbi request reprint The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Okayama University, Okayama, Japan
    J Thorac Oncol 2:321-4. 2007
    ..However, our in vitro investigation did not explain the response observed in this particular patient. Further investigation is necessary to elucidate the mechanism of tumor sensitivity to EGFR tyrosine kinase inhibitors...
  30. ncbi request reprint Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP
    Steven F Goldberg
    Jake Gittlen Cancer Research Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Res 63:432-40. 2003
    ..Thus, we implicated a specific gene on chromosome 6 in the etiology of melanoma metastasis and identified potential up-stream regulators of KISS1 and TXNIP...
  31. ncbi request reprint 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis
    Kuniyoshi Iwabuchi
    Department of Biochemistry, Kanazawa Medical University, Daigaku 1 1, Uchinada, Kahoku gun, Ishikawa 920 0293, Japan
    Genes Cells 11:935-48. 2006
    ..These results demonstrate that the 53BP1-dependent repair pathway is important for survival of cells irradiated with IR during the G1 phase of the cell cycle...
  32. ncbi request reprint A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy
    Yasufumi Goto
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Cancer Res 66:4443-9. 2006
    ..These results showed that FABP7 is frequently expressed in melanoma, may be involved in cell proliferation and invasion, and may be a potential target for development of diagnostic and therapeutic methods...
  33. pmc Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates
    Eiichiro Sonoda
    CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    EMBO J 22:3188-97. 2003
    ..In conclusion, Rev3 plays critical roles in PRR, which accounts for survival on naturally occurring endogenous as well as induced damages during replication...
  34. ncbi request reprint Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
    Hiroshi Tauchi
    Department of Environmental Sciences, Faculty of Science, Ibaraki University, Bunkyo 2 1 1, Mito, Ibaraki 310 8512 Japan
    Nature 420:93-8. 2002
    ....
  35. ncbi request reprint Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage
    Takashi Okada
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Japan
    J Biol Chem 277:48690-5. 2002
    ..This implies functional redundancy between HR and Polkappa in maintaining chromosomal DNA. In conclusion, vertebrate Polkappa is involved in Rad18-independent TLS of UV damage and plays a role in maintaining genomic stability...
  36. ncbi request reprint Current topics in DNA double-strand break repair
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    J Radiat Res 49:93-103. 2008
    ..In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed...
  37. ncbi request reprint A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair
    Nobuko Matsushita
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701 0192, Japan
    Mol Cell 19:841-7. 2005
    ..These results define functional consequences of FancD2 monoubiquitination and reveal previously hidden functions for the FA protein core complex...
  38. pmc DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation
    Masamichi Ishiai
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    Mol Cell Biol 24:10733-41. 2004
    ..These results suggest that interaction between SNM1A and PIAS1 is required for ICL repair...
  39. ncbi request reprint Functional interplay between BRCA2/FancD1 and FancC in DNA repair
    Hiroyuki Kitao
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan
    J Biol Chem 281:21312-20. 2006
    ..These results provide insights into the functional interplay between the classical FA pathway and BRCA2...
  40. ncbi request reprint Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells
    Nobuko Matsushita
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    Genes Cells 10:321-32. 2005
    ..Our results indicate that SIRT1 and SIRT2 regulate stress-induced cell death pathways in a p53-independent manner...
  41. pmc Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM
    Seiki Hirano
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan
    EMBO J 24:418-27. 2005
    ..Our cell survival data suggest that the FA proteins serve to facilitate HR, but not global TLS, during crosslink repair...
  42. ncbi request reprint Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation
    Akiko Uchida
    Department of Hematology, Oncology and Respiratory Medicine, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Okayama 700 8558, Japan
    Cancer Sci 98:357-63. 2007
    ....
  43. ncbi request reprint Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies
    Takayuki Tabayashi
    Department of Medicine, University of Okayama, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Cancer Sci 98:182-8. 2007
    ..Our results suggest a critical role for Helios in the mechanism of leukemogenesis...
  44. ncbi request reprint RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates
    Samia Hamimes
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    J Biol Chem 280:9225-35. 2005
    ..Notably, RDM1 recognizes DNA distortions induced by cisplatin-DNA adducts in vitro. Finally, human RDM1 transcripts are abundant in the testis, suggesting a possible role during spermatogenesis...
  45. pmc Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination
    Kazuhiko Yamamoto
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    Mol Cell Biol 25:34-43. 2005
    ..Thus, we propose that FancD2 promotes a subpathway of HR that normally mediates gene conversion by a mechanism that avoids crossing over and hence SCEs...
  46. ncbi request reprint The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor
    Shinichi Toyooka
    Clin Cancer Res 13:3431; author reply 3431-2. 2007
  47. ncbi request reprint Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line
    Atsuko Ogino
    Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    Cancer Res 67:7807-14. 2007
    ..Thus, the balance of expression levels between gefitinib-sensitive or gefitinib-resistant EGFR may govern the response to gefitinib in lung cancer...
  48. ncbi request reprint Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde
    John R Ridpath
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 67:11117-22. 2007
    ....