Akihiro Sakurai

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. ncbi request reprint Clinical features of insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium of Japan
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Endocr J 59:859-66. 2012
  2. ncbi request reprint [Genetic information and future medicine]
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Rinsho Byori 60:1075-80. 2012
  3. doi request reprint Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare exceptions
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Endocrinol (Oxf) 78:248-54. 2013
  4. doi request reprint Multiple endocrine neoplasia type 1 in Japan: establishment and analysis of a multicentre database
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Endocrinol (Oxf) 76:533-9. 2012
  5. ncbi request reprint Facial angiofibroma as an initial manifestation in multiple endocrine neoplasia type 1
    Akihiro Sakurai
    Division of Clinical and Molecular Genetics, Shinshu University Hospital, Matsumoto
    Intern Med 47:1067-8. 2008
  6. ncbi request reprint Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Endocr J 56:887-95. 2009
  7. ncbi request reprint Delay in the diagnosis of multiple endocrine neoplasia type 1: typical symptoms are frequently overlooked
    Masanori Yamazaki
    Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Endocr J 59:797-807. 2012
  8. ncbi request reprint JunD-menin interaction regulates c-Jun-mediated AP-1 transactivation
    Yasuto Ikeo
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Endocr J 51:333-42. 2004
  9. ncbi request reprint Familial neuroendocrine tumor syndromes: from genetics to clinical practice
    Akihiro Sakurai
    Department of Preventive Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Pituitary 9:231-6. 2006
  10. ncbi request reprint Clinical and genetic features of patients with multiple endocrine tumors who have neither family history nor MEN1 germline mutations
    Akihiro Sakurai
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    Endocrine 23:45-9. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Clinical features of insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium of Japan
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Endocr J 59:859-66. 2012
    ..Also, clinicians should be aware that insulinoma can often be missed in middle-aged patients...
  2. ncbi request reprint [Genetic information and future medicine]
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Rinsho Byori 60:1075-80. 2012
    ..All medical professionals in Japan are expected to follow this guideline...
  3. doi request reprint Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare exceptions
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Endocrinol (Oxf) 78:248-54. 2013
    ..The objective of this study is to clarify the clinical features of MEN1 patients with Th-NET using database analysis...
  4. doi request reprint Multiple endocrine neoplasia type 1 in Japan: establishment and analysis of a multicentre database
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Endocrinol (Oxf) 76:533-9. 2012
    ..The clinical features and optimal management of MEN1 have yet to be clarified in Japan. The aim of this study was to clarify the clinical features of Japanese patients with MEN1...
  5. ncbi request reprint Facial angiofibroma as an initial manifestation in multiple endocrine neoplasia type 1
    Akihiro Sakurai
    Division of Clinical and Molecular Genetics, Shinshu University Hospital, Matsumoto
    Intern Med 47:1067-8. 2008
  6. ncbi request reprint Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Endocr J 56:887-95. 2009
    ..Expression of p27(Kip1) protein is not observed in tumor cells, either. These results confirmed the inactivation of the MEN1 gene as a genetic cause of an ectopically developed neuroendocrine tumor in a patient with MEN1...
  7. ncbi request reprint Delay in the diagnosis of multiple endocrine neoplasia type 1: typical symptoms are frequently overlooked
    Masanori Yamazaki
    Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Endocr J 59:797-807. 2012
    ..A greater understanding of MEN1 may assist medical practitioners to make earlier diagnoses, to share patients' medical information and to give family members sufficient disease information...
  8. ncbi request reprint JunD-menin interaction regulates c-Jun-mediated AP-1 transactivation
    Yasuto Ikeo
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Endocr J 51:333-42. 2004
    ....
  9. ncbi request reprint Familial neuroendocrine tumor syndromes: from genetics to clinical practice
    Akihiro Sakurai
    Department of Preventive Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Pituitary 9:231-6. 2006
    ..This review notes some points on genetic counseling before and after genetic testing for familial neuroendocrine tumor syndromes...
  10. ncbi request reprint Clinical and genetic features of patients with multiple endocrine tumors who have neither family history nor MEN1 germline mutations
    Akihiro Sakurai
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    Endocrine 23:45-9. 2004
    ..Phenotypic expression of such patients is variable, thus differentiation of familial MEN1 and MEN1 phenocopy cannot be made based on age and clinical phenotype alone...
  11. ncbi request reprint Novel 14 base-pair deletion of the MEN1 gene in a patient with recurrent primary hyperparathyroidism
    Miyuki Katai
    Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Jpn J Clin Oncol 36:395-7. 2006
    ..This deletional mutation has not previously been described elsewhere...
  12. ncbi request reprint Multiple endocrine neoplasia type 1 with unusual concomitance of various neoplastic disorders
    Yoshihiro Nishimura
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Endocr J 51:75-81. 2004
    ..Careful periodic screening of endocrine and other disorders for her siblings and children as well as for the patient is warranted...
  13. ncbi request reprint Octreotide as a rapid and effective painkiller for metastatic carcinoid tumor
    Miyuki Katai
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    Endocr J 52:277-80. 2005
    ..The use of octreotide may be a good option for controlling pain by metastatic bone disease and combination therapy of octreotide and interferon alpha-2b is worth to try for patients with inoperable metastatic carcinoid tumor...
  14. doi request reprint Follow-up nationwide survey on predictive genetic testing for late-onset hereditary neurological diseases in Japan
    Keiko Tanaka
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    J Hum Genet 58:560-3. 2013
    ..Institutional arrangements, such as revision of medical insurance system regarding genetic testing and counseling, might be necessary to resolve this issue. ..
  15. ncbi request reprint [Genetic medicine in the university hospital]
    Akihiro Sakurai
    Division of Molecular and Clinical Genetics, Shinshu University Hospital, Matsumoto, Japan
    Gan To Kagaku Ryoho 32:945-7. 2005
    ..However, in Japan, there is a shortage of clinical geneticists who are familiar with hereditary tumor syndromes. There are also many other problems such as the cost of genetic tests that should be solved...
  16. ncbi request reprint Current status of clinical care for familial endocrine tumor syndromes in Japan
    Akihiro Sakurai
    Division of Medical Genetics, Department of Preventive Medicine, Shinshu University School of Medicine, Matsumoto
    Endocr J 52:757-62. 2005
    ..Only 27.8% of respondents have read the guidelines and understood their concepts...
  17. pmc Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases
    Masayuki Mori
    Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Physiol 587:5577-84. 2009
    ..A better understanding of these issues should lead to more effective integration of exercise to optimize the treatment and management of individuals with lifestyle-related diseases...
  18. ncbi request reprint Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1
    Tsuyoshi Tanabe
    The First Department of Internal Medicine, Shinshu University School of Medicine, and Shinhu University Hospital, Matsumoto
    Intern Med 47:1615-9. 2008
    ..Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported. In addition, no etiological relationship between seminoma and MEN1 has yet been reported...
  19. ncbi request reprint Pituitary adenomas in adolescent patients with multiple endocrine neoplasia type 1
    Ako Oiwa
    Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Endocr J 49:635-40. 2002
    ..Medication with bromocriptine was started for both cases with good therapeutic responses. These cases emphasize relevance of early screening of endocrine disorders for members of families with MEN1...
  20. ncbi request reprint Mandibuloacral dysplasia and a novel LMNA mutation in a woman with severe progressive skeletal changes
    Tomoki Kosho
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 143:2598-603. 2007
    ..Treatment with bisphosphonates to inhibit osteoclast activity is likely to be beneficial...
  21. ncbi request reprint Nationwide survey on predictive genetic testing for late-onset, incurable neurological diseases in Japan
    Kunihiro Yoshida
    Department of Neurology and Rheumatology, Shinshu University Hospital, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Hum Genet 52:675-9. 2007
    ....
  22. ncbi request reprint Comprehensive genetics clinic for familial tumors: proposal for a suitable system in Japan
    Yoshimitsu Fukushima
    Division of Clinical and Molecular Genetics, Shinshu University Hospital, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    Int J Clin Oncol 9:304-7. 2004
    ..We introduce our activity at the Division of Clinical and Molecular Genetics, Shinshu University Hospital. Our system of a multidisciplinary approach to genetic counseling could be suitable for other hospitals in Japan...
  23. ncbi request reprint [The MEN consortium of Japan]
    Akihiro Sakurai
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Nihon Geka Gakkai Zasshi 113:351-5. 2012
    ..This is anticipated to promote clarification of the current status of MEN in Japan and improve future clinical management...
  24. ncbi request reprint Suppression of insulin-induced AP-1 transactivation by menin accompanies inhibition of c-Fos induction
    Wataru Yumita
    Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Cancer 103:738-44. 2003
    ..The molecular mechanism of inhibition of AP-1 function by menin needs further elucidation...
  25. ncbi request reprint [Presymptomatic testing and predictive testing]
    Akihiro Sakurai
    Division of Medical Genetics, Department of Preventive Medicine, Shinshu University School of Medicine
    Nihon Rinsho 63:93-8. 2005
  26. ncbi request reprint [Genetic test and genetic counseling of diabetes]
    Akihiro Sakurai
    Division of Molecular and Clinical Genetics, Shinshu University Hospital
    Nihon Rinsho 60:293-7. 2002
  27. ncbi request reprint Genetic analyses in patients with familial isolated hyperparathyroidism and hyperparathyroidism-jaw tumour syndrome
    Noriko Mizusawa
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Endocrinol (Oxf) 65:9-16. 2006
    ..AIM/PATIENTS AND METHODS: We investigated the involvement of the HRPT2, MEN1 and CASR genes in 11 provisional FIHP families and two HPT-JT families...
  28. ncbi request reprint [Genetic test for symptomatic patients]
    Akihiro Sakurai
    Division of Medical Genetics, Department of Preventive Medicine, Shinshu University School of Medicine
    Nihon Rinsho 63:87-91. 2005
  29. ncbi request reprint Long-term follow-up of patients with multiple endocrine neoplasia type 1
    Akihiro Sakurai
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Japan
    Endocr J 54:295-302. 2007
    ....
  30. ncbi request reprint [Genetic testing and counseling for familial tumor syndromes]
    Miyuki Katai
    Division of Molecular and Clinical Genetics, Shinshu University Hospital
    Gan To Kagaku Ryoho 29:502-7. 2002
    ..Genetic medicine is not sufficiently available at present in Japan. Establishment of genetic services that deal with genetic counseling, family support and ethical, social and legal issues is strongly desired...