Masao Ota

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. pmc Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients
    Kei Kitahara
    Department of Internal Medicine, Shinshu University School of Medicine, Asahi Matsumoto, Japan
    Dis Markers 25:175-80. 2008
  2. pmc Polymorphisms of the tissue inhibitor of metalloproteinase 3 gene are associated with resistance to high-altitude pulmonary edema (HAPE) in a Japanese population: a case control study using polymorphic microsatellite markers
    Nobumitsu Kobayashi
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    PLoS ONE 8:e71993. 2013
  3. pmc Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas
    Masayuki Hanaoka
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    PLoS ONE 7:e50566. 2012
  4. pmc Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Dis Markers 31:223-9. 2011
  5. doi Adaptation to high altitude in Sherpas: association with the insertion/deletion polymorphism in the Angiotensin-converting enzyme gene
    Yunden Droma
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Wilderness Environ Med 19:22-9. 2008
  6. ncbi Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Immunogenetics 59:45-52. 2007
  7. doi Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 70:742-6. 2009
  8. doi Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Gastroenterol 103:588-94. 2008
  9. ncbi Polymorphisms of renin-angiotensin system genes with high-altitude pulmonary edema in Japanese subjects
    Junichi Hotta
    Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Chest 126:825-30. 2004
  10. ncbi Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas
    Yunden Droma
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Aviat Space Environ Med 79:1056-60. 2008

Collaborators

Detail Information

Publications62

  1. pmc Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients
    Kei Kitahara
    Department of Internal Medicine, Shinshu University School of Medicine, Asahi Matsumoto, Japan
    Dis Markers 25:175-80. 2008
    ....
  2. pmc Polymorphisms of the tissue inhibitor of metalloproteinase 3 gene are associated with resistance to high-altitude pulmonary edema (HAPE) in a Japanese population: a case control study using polymorphic microsatellite markers
    Nobumitsu Kobayashi
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    PLoS ONE 8:e71993. 2013
    ..Genome-wide association analysis is necessary to better understand how genetics influence the outcome of HAPE...
  3. pmc Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas
    Masayuki Hanaoka
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    PLoS ONE 7:e50566. 2012
    ..Understanding of the mechanism of hypoxia tolerance in Tibetans is expected to provide lights to the therapeutic solutions of some hypoxia-related human diseases, such as cardiovascular disease and cancer...
  4. pmc Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Dis Markers 31:223-9. 2011
    ..Our findings provide the first evidence that KCNA3 is associated with AIP and suggest that KCNA3 may influence the risk for AIP...
  5. doi Adaptation to high altitude in Sherpas: association with the insertion/deletion polymorphism in the Angiotensin-converting enzyme gene
    Yunden Droma
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Wilderness Environ Med 19:22-9. 2008
    ..The objective of this study was to elucidate the genetic background underlying this characteristic among Sherpas with respect to the angiotension-converting enzyme (ACE) gene...
  6. ncbi Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Immunogenetics 59:45-52. 2007
    ..The two critical HLA regions for susceptibility to AIP are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1 proximal to C3-2-11, telomeric of HLA-E, in the class I regions...
  7. doi Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 70:742-6. 2009
    ..Analysis of allelic frequencies revealed no statistical association with either susceptibility or relapse of AIP. These data indicate that TLR4 polymorphisms do not play an important role in the development of AIP...
  8. doi Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Gastroenterol 103:588-94. 2008
    ..As cytotoxic T-lymphocyte antigen 4 (CTLA4) polymorphisms have recently been linked with several autoimmune diseases, we sought to determine if CTLA4 polymorphisms and serum sCTLA4 levels were associated with AIP as well...
  9. ncbi Polymorphisms of renin-angiotensin system genes with high-altitude pulmonary edema in Japanese subjects
    Junichi Hotta
    Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Chest 126:825-30. 2004
    ..Investigating the associations of the polymorphisms in the genes of RAS with HAPE is to elucidate the genetic background underlying this disease...
  10. ncbi Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas
    Yunden Droma
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Aviat Space Environ Med 79:1056-60. 2008
    ..We hypothesize that the two hypoxia sensor genes might associate with the occurrence of AMS symptoms in Sherpas at extremely high altitude...
  11. ncbi A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1
    Shuichi Yokosawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 45:384-90. 2007
    ..These results also suggested that the products of several genes interact to determine heritable susceptibility to AIH...
  12. pmc The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study
    Michiko Ito
    First Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Japan
    BMC Res Notes 5:36. 2012
    ..We investigated whether single nucleotide polymorphisms (SNPs) in the TLR4 gene were associated with the emphysema phenotype in Japanese subjects with chronic obstructive pulmonary disease (COPD)...
  13. doi Polymorphisms of human vascular endothelial growth factor gene in high-altitude pulmonary oedema susceptible subjects
    Masayuki Hanaoka
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Respirology 14:46-52. 2009
    ..Unfortunately, the results are inconsistent. Therefore, the association of VEGF gene single nucleotide polymorphisms (SNP) with being susceptible to HAPE was investigated...
  14. doi Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients
    Satoru Joshita
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Hepatol 53:537-41. 2010
    ....
  15. ncbi Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpas
    Yunden Droma
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    High Alt Med Biol 7:209-20. 2006
    ..The nitric oxide metabolites (NO( x )) in serum vary individually, thus it is not a reliable indicator for endogenous nitric oxide production...
  16. doi Long-term outcome of Japanese patients with type 1 autoimmune hepatitis
    Kaname Yoshizawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 56:668-76. 2012
    ..020) analyses. The development of liver malignancy was also a possibility among AIH patients with multiple relapses. Severe adverse effects of corticosteroids were rare, even in patients who underwent long-term treatment...
  17. doi Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
    Susumu Morita
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 74:219-22. 2013
    ..No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients...
  18. ncbi The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese
    Michiko Ito
    The First Department of Medicine, Shinshu University School of Medicine, Matsumoto
    Intern Med 47:1387-94. 2008
    ..We designed this study to investigate the association of single nucleotide polymorphisms (SNPs) of TGFB1 with the emphysema phenotype in the Japanese population...
  19. doi Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Antivir Ther 16:1073-80. 2011
    ..Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection...
  20. ncbi Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Clin Immunol 122:338-42. 2007
    ....
  21. ncbi Autoimmune pancreatitis and complement activation system
    Takashi Muraki
    Department of Medicine and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Pancreas 32:16-21. 2006
    ..Because this disease is occasionally associated with decreased levels of complements, we sought to clarify which complement activation system was operating in its active state...
  22. doi Development of multiplex assay with 16 SNPs on X chromosome for degraded samples
    Takahito Oki
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan
    Leg Med (Tokyo) 14:11-6. 2012
    ..Statistical analyses of the 16 SNPs indicated a high usefulness for the Japanese forensic practice. In addition, results of tests on degraded DNA confirm the usefulness of this technique in such samples...
  23. doi Association of serum cytokine levels with treatment response to pegylated interferon and ribavirin therapy in genotype 1 chronic hepatitis C patients
    Suguru Yoneda
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    J Infect Dis 203:1087-95. 2011
    ....
  24. ncbi Polymorphisms of the tyrosine hydroxylase gene in subjects susceptible to high-altitude pulmonary edema
    Masayuki Hanaoka
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Chest 123:54-8. 2003
    ..The association of constitutional susceptibility to HAPE regarding the blunted HVR aspect with polymorphisms of the TH gene was examined...
  25. ncbi Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independe
    Ryosuke Osada
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Hum Pathol 38:1310-20. 2007
    ..These results show that the HIF-alpha subunit represents an important biomarker in the evaluation of the prognosis of patients with ovarian carcinoma...
  26. doi Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 55:506-11. 2012
    ..0012; OR = 3.96). Furthermore, the frequency of serine at position 57 (P = 0.0000015; OR = 1.83) of the DRβchain differed the most in patients with PBC, compared with healthy subjects...
  27. doi Clinical significance of immunoglobulin G4-associated autoimmune hepatitis
    Takeji Umemura
    Division of Hepatology and Gastroenterology, Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 46:48-55. 2011
    ..However, the epidemiology and clinical features of IgG4-associated AIH remain uncertain. The aim of this study was to determine the prevalence and the clinical, serological, and histological characteristics of IgG4-associated AIH...
  28. ncbi Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema
    Yunden Droma
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Circulation 106:826-30. 2002
    ..Several polymorphisms have been identified in the gene encoding endothelial nitric oxide synthase (eNOS), which is a key enzyme responsible for NO synthesis, some of which were reported to be associated with vascular disorders...
  29. pmc STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis
    Satoru Joshita
    Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Dis Markers 2014:727393. 2014
    ..032, and rs10181656; P = 0.031) were associated with ANA status, but not with AMA positivity. Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population. ..
  30. ncbi Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis
    Kaname Yoshizawa
    Department of Medicine, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto 390 8621, Japan
    J Hepatol 42:578-84. 2005
    ..Genetic predisposition to type 1 autoimmune hepatitis (AIH) is linked mainly to HLA-class II genes. The aim of this study is to scan the HLA region for additional genes which may contribute to type 1 AIH susceptibility...
  31. pmc Human Leukocyte Antigen Class II Haplotypes Affect Clinical Characteristics and Progression of Type 1 Autoimmune Hepatitis in Japan
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    PLoS ONE 9:e100565. 2014
    ..Additional sequencing of the entire HLA region is required to more precisely identify the genetic components of AIH. ..
  32. pmc A novel immunoglobulin-immunoglobulin interaction in autoimmunity
    Shigeyuki Kawa
    Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan
    PLoS ONE 3:e1637. 2008
    ..In the future, the relevance of NRF, beyond autoimmune pancreatitis, in both diagnosis/prognosis as well as pathophysiology of autoimmune and other systemic diseases where IgG4's role seems paramount, needs to be systematically assessed...
  33. doi Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection
    Satoru Joshita
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 73:298-300. 2012
    ..2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection...
  34. ncbi Highly sensitive HLA-DNA typing from formalin-fixed and paraffin-embedded tissue samples
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Am J Forensic Med Pathol 27:347-51. 2006
    ....
  35. ncbi Allele frequencies for 15 STR loci in Tibetan populations from Nepal
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi 3 1 1, 390 8621 Matsumoto, Japan
    Forensic Sci Int 169:234-8. 2007
    ..Genetic parameters of forensic interest were calculated and genetic differentiation between the two populations tested...
  36. ncbi High prevalence of hypothyroidism in patients with autoimmune pancreatitis
    Kenichi Komatsu
    Department of Medicine, Gastroenterology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Dig Dis Sci 50:1052-7. 2005
    ....
  37. doi Serum chemokine levels are associated with the outcome of pegylated interferon and ribavirin therapy in patients with chronic hepatitis C
    Suguru Yoneda
    Departments of Medicine, Division of Hepatology and Gastroenterology Department of Legal Medicine, Shinshu University School of Medicine Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan
    Hepatol Res 41:587-93. 2011
    ..Conclusion:  Serum MIP-1β levels may predict the response to HCV treatment with pegylated interferon and ribavirin and are associated with amino acid substitutions in the ISDR...
  38. doi Restriction enzyme analysis of PCR products
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Methods Mol Biol 578:405-14. 2009
    ..The mutation is discriminated by the specific restriction endonuclease and is identified by gel electrophoresis followed by staining with ethidium bromide. This convenient and simple method is useful in a small basic research study...
  39. ncbi Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese
    Takeji Umemura
    Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatol Res 38:689-95. 2008
    ..Conclusion: These data suggest that the CTLA4 polymorphism is not associated with susceptibility to type 1 AIH in the Japanese population...
  40. doi A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
    Satoru Joshita
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 71:520-4. 2010
    ..This study showed a total of 11 candidate PBC susceptibility or resistance regions. In particular, the A2BP1 gene might play a pivotal role for susceptibility to PBC...
  41. ncbi HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population
    Shigeyuki Kawa
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Gastroenterology 122:1264-9. 2002
    ..Because of the close association between some autoimmune diseases and particular alleles of major histocompatibility complex genes, we investigated the association between HLA alleles and autoimmune pancreatitis...
  42. ncbi Two siblings with type 1 autoimmune pancreatitis
    Takayuki Watanabe
    Department of Gastroenterology, Shinshu University School of Medicine, Japan
    Intern Med 52:895-9. 2013
    ....
  43. pmc KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan
    Yuichi Nozawa
    Division of Hepatology and Gastroenterology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    PLoS ONE 8:e83381. 2013
    ..0067). In conclusion, combinations of KIR3DL1/HLA-Bw4, KIR2DL2/HLA-C1, and a genetic variant of the IL28B gene are predictive of the response to PEG-IFN and ribavirin therapy in Japanese patients infected with genotype 1b HCV. ..
  44. ncbi Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Nagano 390 8621, Japan
    Nat Protoc 2:2857-64. 2007
    ..This convenient and simple method is inexpensive and accurate for SNP genotyping and especially useful in small basic research studies of complex genetic diseases. The whole protocol takes only a day to carry out...
  45. doi Cytokine profiles affecting the pathogenesis of autoimmune hepatitis in Japanese patients
    Atsushi Kamijo
    Departments of Medicine Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatol Res 41:350-7. 2011
    ..Conclusion:  Our results suggest that a complex interplay of several cytokines, especially pro-inflammatory and T-helper 17 cytokines and regulatory T-cell suppression by IL-12p40 may play a pivotal role in the pathogenesis of AIH...
  46. doi De novo autoimmune hepatitis following living-donor liver transplantation for primary biliary cirrhosis
    Kaname Yoshizawa
    Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Transplant 22:385-90. 2008
    ..In conclusion, recipient immune cells attacked the allogeneic transplanted liver of the patient via de novo AIH, although the exact participation of autoimmune mechanisms is unclear...
  47. ncbi Hepatic portal venous gas on postmortem CT scan
    Hideki Asamura
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan
    Leg Med (Tokyo) 7:326-30. 2005
    ....
  48. ncbi Monozygotic twins concordant for intestinal Behçet's disease
    Taku Kobayashi
    Department of Internal Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan
    J Gastroenterol 40:421-5. 2005
    ..Both of the patients were diagnosed with intestinal Behçet's disease. Their monozygosity was confirmed by detailed genetic typing, and HLA-B51 was negative...
  49. ncbi Validation of sensitive human leukocyte antigen-sequence-specific primer and probe typing in forensic DNA examination
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Leg Med (Tokyo) 8:203-9. 2006
    ....
  50. ncbi Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene
    Norimoto Kobayashi
    Department of Pediatrics, School of Medicine, Shinshu University, Asahi 3 1 1, 390 8621, Matsumoto, Japan
    Clin Immunol 108:159-66. 2003
    ..These results indicate that highly restricted maternal T-cell clonotypes can markedly expand, possibly in response to tissue-specific antigens, in a MHC-identical recipient...
  51. ncbi Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea syndrome
    Masayuki Hanaoka
    First Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Chest 133:79-85. 2008
    ..There is growing evidence that leptin regulation is altered in obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the relation between polymorphisms of the leptin and leptin receptor (LEPR) genes and OSAS...
  52. doi Genetic background of autoimmune hepatitis in Japan
    Kaname Yoshizawa
    Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 46:42-7. 2011
    ....
  53. ncbi Lymphoproliferative disease of granular lymphocytes with T-cell receptor gamma delta-positive phenotype: restricted usage of T-cell receptor gamma and delta subunit genes
    Hideki Makishima
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Eur J Haematol 70:212-8. 2003
    ..Soluble Fas ligand in sera was significantly elevated in all patients. These findings suggest that gammadeltaT-LDGL qualifies as a distinct disease entity...
  54. ncbi Intestinal diffuse large B-cell lymphoma associated with celiac disease: a Japanese case
    Hideki Makishima
    The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Hematol 83:63-5. 2006
    ..This case suggests that the possibility of CD and its association with intestinal NHL should be kept in mind, even in Asian populations...
  55. ncbi Unusual characteristic patterns of postmortem injuries
    Hideki Asamura
    Department of Legal Medicine, Shinshu University School of Medicine
    J Forensic Sci 49:592-4. 2004
    ....
  56. ncbi Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies
    Satoshi Saito
    Department of Legal Medicine, Shinshu University School of Medicine, Matumoto, Japan
    Transfusion 43:908-17. 2003
    ..Cases in which NAIT has been caused by HLA antibodies are relatively rare. In this study, three cases of NAIT associated with HLA antibodies that occurred in a 1-year period are reported...
  57. doi Analysis of Y chromosome haplogroups in Japanese population using short amplicons and its application in forensic analysis
    Yuta Harayama
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan Electronic address
    Leg Med (Tokyo) 16:20-5. 2014
    ..Applying these systems, we classified the Japanese population into major haplogroups and confirmed the applicability of these systems in forensic DNA analysis...
  58. doi Unusual intracranial stab wounds inflicted with metal tent stakes for a case involving a family murder suicide
    Takahito Oki
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan
    Forensic Sci Int 202:e19-21. 2010
    ..87mgml(-1). The assailant, another family member with a history of major psychiatric disorders, apparently committed suicide by drowning following the attacks...
  59. ncbi Mitochondrial DNA diversity among three subpopulations of cynomolgus macaques (Macaca fascicularis) originating from the Indochinese region
    Takashi Shiina
    Department of Molecular Life Science, Tokai University School of Medicine, Nagano, Japan
    Exp Anim 59:567-78. 2010
    ..This will involve the selection of macaques and the monitoring of genetic heterogeneity among and within breeding facilities...
  60. doi Human amniotic mesenchymal cells differentiate into chondrocytes
    Jun Ping Wei
    Department of Organ Regeneration, The Institutes of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    Cloning Stem Cells 11:19-26. 2009
    ..These results showed that HAMc have the potential to differentiate into chondrocytes in vitro and in vivo, suggesting that they have therapeutic potential for the treatment of damaged or diseased cartilage...
  61. ncbi Case of shaken baby syndrome in Japan caused by shaking alone
    Hideki Asamura
    Department of Legal Medicine, Shinshu University School of Medicine, Nagano, Japan
    Pediatr Int 45:117-9. 2003
  62. ncbi Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognos
    Ryosuke Osada
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Hum Pathol 37:1414-25. 2006
    ..A high VEGF/SEMA ratio has adverse prognostic significance in patients with ovarian carcinoma...