Research Topics
Species | Tomoki KoshoSummaryAffiliation: Shinshu University Country: Japan Publications
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Detail Information
Publications
A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestationsTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 152:1333-46. 2010....
Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutationMasanori Yamazaki
Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 152:764-9. 2010..This is the first report of detailed longitudinal observation of a patient with CRLF1 abnormalities, compatible with the notion that CISS and CS may be a single clinical entity...
Neurodevelopmental features in 2q23.1 microdeletion syndrome: report of a new patient with intractable seizures and review of literatureMitsuo Motobayashi
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 158:861-8. 2012....
Myelodysplastic syndrome in a child with 15q24 deletion syndromeYoko Narumi
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 158:412-6. 2012..Further hematological investigation is recommended to be beneficial if physical and hematological examination results are suggestive of hematopoietic disturbance in patients with the syndrome...
Bilateral perisylvian polymicrogyria, periventricular nodular heterotopia, and left ventricular noncompaction in a girl with 10.5-11.1 Mb terminal deletion of 1p36Shoji Saito
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 146:2891-7. 2008..An atypically large deletion in this patient might be the basis for the development of these features and the severe clinical course...
Ehlers-Danlos syndrome type VIB with characteristic facies, decreased curvatures of the spinal column, and joint contractures in two unrelated girlsTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 138:282-7. 2005..They had constipation and recurrent cystitis with an enlarged bladder. In view of these findings, we propose that these two girls represent a clinically recognizable subgroup of EDS type VIB...
De-novo balanced translocation between 7q31 and 10p14 in a girl with central precocious puberty, moderate mental retardation, and severe speech impairmentTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Clin Dysmorphol 17:31-4. 2008..Speech impairment in the girl might be derived from dysfunction of FOXP2 by a position effect of the 7q31 translocation breakpoint...
Clinical consequences in truncating mutations in exon 34 of NOTCH2: report of six patients with Hajdu-Cheney syndrome and a patient with serpentine fibula polycystic kidney syndromeYoko Narumi
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 161:518-26. 2013..Acroosteolysis was observed in two patients with SFPKS and bowing fibulae were found in two patients with HCS. These clinical and molecular data would support the notion that HCS and SFPKS are a single disorder...
Care of children with trisomy 18 in JapanTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 146:1369-71. 2008
Mandibuloacral dysplasia and a novel LMNA mutation in a woman with severe progressive skeletal changesTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 143:2598-603. 2007..Treatment with bisphosphonates to inhibit osteoclast activity is likely to be beneficial...
Brothers with genu recurvatumNaoto Saito
Department of Applied Physical Therapy, Shinshu University School of Health Science, Matsumoto, Nagano, Japan
Knee 14:500-1. 2007..There was no history of trauma, or other orthopaedic or genetic disorders. These features strongly suggested involvement of heritable risk factors...
Genital abnormalities in Pallister-Hall syndrome: Report of two patients and review of the literatureYoko Narumi
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 152:3143-7. 2010..We recommend that clinical investigations of genital abnormalities are considered in patients with PHS, even those without hypopituitarism...
Successful pregnancy and lactation outcome in a patient with Gaucher disease receiving enzyme replacement therapy, and the subsequent distribution and excretion of imiglucerase in human breast milkYoshiki Sekijima
Clin Ther 32:2048-52. 2010..However, there have been no published reports regarding the excretion of imiglucerase into human breast milk and its effects on the nursing infant...
[Beckwith-Wiedemann syndrome]Tomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine
Nippon Rinsho . 2006
Neonatal management of trisomy 18: clinical details of 24 patients receiving intensive treatmentTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet A 140:937-44. 2006..These data of improved survival, through neonatal intensive treatment, are helpful for clinicians to offer the best information on treatment options to families of patients with trisomy 18...
