Hisao Haniu

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. doi request reprint Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
    Hisao Haniu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Toxicol In Vitro 27:1679-85. 2013
  2. doi request reprint Toxicoproteomic evaluation of carbon nanomaterials in vitro
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Department of Orthopaedic Surgery, School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Proteomics 74:2703-12. 2011
  3. pmc DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:2689-95. 2011
  4. pmc Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3487-97. 2011
  5. pmc Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3295-307. 2011
  6. doi request reprint Proteomics-based safety evaluation of multi-walled carbon nanotubes
    Hisao Haniu
    Institute of Carbon Science and Technology, School of Medicine, Shinshu University, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Toxicol Appl Pharmacol 242:256-62. 2010
  7. pmc Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
    Seiji Takanashi
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan
    Sci Rep 2:498. 2012
  8. doi request reprint Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes
    Nobuhide Ogihara
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Japan
    Nanomedicine (Lond) 7:981-93. 2012
  9. pmc Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
    Hisao Haniu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano, Japan Insutitute for Biomedical Sciences, Shinshu University, Nagano, Japan
    Int J Nanomedicine 9:1979-90. 2014
  10. doi request reprint Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts
    Masayuki Shimizu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Adv Mater 24:2176-85. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
    Hisao Haniu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Toxicol In Vitro 27:1679-85. 2013
    ..However, the culture medium composition may affect the proteins that are expressed on the cytoplasmic membrane, which may influence the biological response to MWCNTs. ..
  2. doi request reprint Toxicoproteomic evaluation of carbon nanomaterials in vitro
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Department of Orthopaedic Surgery, School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Proteomics 74:2703-12. 2011
    ..In this review, we discuss the basic concept of our approach, the results, the problems, and the possibility of a long-term safety assessment for carbon nanomaterials using the toxicoproteomic approach...
  3. pmc DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:2689-95. 2011
    ..In the present study, we investigated whether DJ-1 could serve as a biomarker for assessing the biocompatibility of multiwalled carbon nanotubes (MWCNTs), using the highly purified carbon nanotube, HTT2800...
  4. pmc Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3487-97. 2011
    ..Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs...
  5. pmc Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
    Hisao Haniu
    Institute of Carbon Science and Technology, Shinshu University, Matsumoto, Nagano, Japan
    Int J Nanomedicine 6:3295-307. 2011
    ..Thus, toxicity appears to depend on exposure time, even at low VGCF concentrations, because VGCF is biopersistent...
  6. doi request reprint Proteomics-based safety evaluation of multi-walled carbon nanotubes
    Hisao Haniu
    Institute of Carbon Science and Technology, School of Medicine, Shinshu University, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Toxicol Appl Pharmacol 242:256-62. 2010
    ..Our proteomics-based approach for detecting biological responses to nanomaterials is a promising new method for detailed safety evaluations...
  7. pmc Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
    Seiji Takanashi
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Nagano 390 8621, Japan
    Sci Rep 2:498. 2012
    ..Such evaluations should facilitate the clinical application and development of CNTs for use in important medical fields...
  8. doi request reprint Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes
    Nobuhide Ogihara
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Japan
    Nanomedicine (Lond) 7:981-93. 2012
    ..Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials...
  9. pmc Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
    Hisao Haniu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano, Japan Insutitute for Biomedical Sciences, Shinshu University, Nagano, Japan
    Int J Nanomedicine 9:1979-90. 2014
    ....
  10. doi request reprint Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts
    Masayuki Shimizu
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Adv Mater 24:2176-85. 2012
    ..Transmission electron microscopy shows needle-like crystals around the MWCNTs, and diffraction patterns reveal that the peak of the crystals almost coincides with the known peak of HA...
  11. pmc PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan
    PLoS ONE 8:e58749. 2013
    ..The PSF-PPARγ axis may play a role in the control of colorectal carcinogenesis. Taken together, this study is the first to describe the effects of PSF on cell proliferation, tumor growth, and cell signaling associated with PPARγ...
  12. doi request reprint Application of carbon fibers to biomaterials: a new era of nano-level control of carbon fibers after 30-years of development
    Naoto Saito
    Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Asahi 3 1 1, Matsumoto, Nagano, 390 8621, Japan
    Chem Soc Rev 40:3824-34. 2011
    ..In this critical review, we summarize the history of carbon fiber application to the biomaterials and describe future perspectives in the new age of nano-level control of carbon fibers (122 references)...
  13. doi request reprint Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Biochem Biophys Res Commun 433:281-5. 2013
    ..These findings suggest that alkyl-LPA activates PPARγ and stimulates glucose uptake in the absence of insulin in C2C12 cells. This may contribute to the plasma glucose-lowering effect in the treatment of insulin resistance...
  14. ncbi request reprint Medical application of carbon-nanotube-filled nanocomposites: the microcatheter
    Shozo Koyama
    Department of Integrative Physiology and Bio System Control, Department of Neurosurgery, School of Medicine, Shinshu University, Matsumoto 390 8621, Japan
    Small 2:1406-11. 2006
    ..g., toxic properties) of carbon nanotubes is discussed. In addition, critical issues that must be clarified for the full utilization of current carbon-nanotube science and technology in biomedical fields are discussed...
  15. doi request reprint Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 424:524-9. 2012
    ..We observed a correlation between the level of PPARγ expression and the cells' sensitivity for proliferation...
  16. doi request reprint Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Mol Cell Biochem 352:57-63. 2011
    ..However, the exposed cells showed no obvious intracellular ROS generation. These cellular and molecular findings suggest that HTT2800 could cause a potentially adverse inflammatory response in BEAS-2B cells...
  17. doi request reprint Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 406:558-63. 2011
    ..Taken together, these results suggest that HTT2800 specifically converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells...