Toshiaki Shimizu

Summary

Country: Japan

Publications

  1. ncbi request reprint The relationship between the concentration of dextran sodium sulfate and the degree of induced experimental colitis in weanling rats
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:481-6. 2003
  2. ncbi request reprint Enhanced production of interferon-gamma as a possible cause of protein-losing enteropathy after modified Fontan operation
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:504-7. 2003
  3. ncbi request reprint Effects of highly purified eicosapentaenoic acid on erythrocyte fatty acid composition and leukocyte and colonic mucosa leukotriene B4 production in children with ulcerative colitis
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:581-5. 2003
  4. ncbi request reprint Effects of alpha-linolenic acid on colonic secretion in rats with experimental colitis
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, Japan
    J Gastroenterol 42:129-34. 2007
  5. doi request reprint Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 54:528-31. 2012
  6. ncbi request reprint Octreotide prevents L-asparaginase-induced pancreatic injury in rats
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Exp Hematol 36:172-80. 2008
  7. doi request reprint Estimation of postoperative fat absorption using the 13C mixed-triglyceride breath test in children with choledochal cyst
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Eur J Pediatr 168:35-8. 2009
  8. doi request reprint Urinary sulfated bile acid analysis for the early detection of biliary atresia in infants
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 53:497-500. 2011
  9. doi request reprint ω-3 fatty acids attenuate mucosal inflammation in premature rat pups
    Yoshikazu Ohtsuka
    Department of Pediatrics and Adolescence Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Pediatr Surg 46:489-95. 2011
  10. doi request reprint Lissencephaly with marked ventricular dilation, agenesis of corpus callosum, and cerebellar hypoplasia caused by TUBA1A mutation
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, Japan
    Brain Dev 35:274-9. 2013

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint The relationship between the concentration of dextran sodium sulfate and the degree of induced experimental colitis in weanling rats
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:481-6. 2003
    ..We examined differences in the severity of DSS-induced colitis as a function of the concentration of DSS administered and sought to establish a DSS-induced colitis model in young rats...
  2. ncbi request reprint Enhanced production of interferon-gamma as a possible cause of protein-losing enteropathy after modified Fontan operation
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:504-7. 2003
  3. ncbi request reprint Effects of highly purified eicosapentaenoic acid on erythrocyte fatty acid composition and leukocyte and colonic mucosa leukotriene B4 production in children with ulcerative colitis
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:581-5. 2003
    ..Therefore, the authors investigated the effects of eicosapentaenoic acid (EPA) on fatty acid composition and leukotriene (LT) production in children with UC...
  4. ncbi request reprint Effects of alpha-linolenic acid on colonic secretion in rats with experimental colitis
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, Japan
    J Gastroenterol 42:129-34. 2007
    ..The aim of this study was to examine the contribution of prostaglandins (PGs) and leukotrienes (LTs) to mucosal secretion in intestines with UC and to evaluate the effect of dietary n-3 PUFAs on diarrhea in UC...
  5. doi request reprint Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 54:528-31. 2012
    ..The aim of this study was to evaluate the prophylactic effects of oral eicosapentaenoic acid (EPA) supplementation on ribavirin-induced hemolytic anemia in pediatric and young adult patients...
  6. ncbi request reprint Octreotide prevents L-asparaginase-induced pancreatic injury in rats
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Exp Hematol 36:172-80. 2008
    ..We assessed the effect of ASNase on pancreatic acinar cells and then investigated the preventive effects of octreotide against ASNase-induced pancreatic injury in rats...
  7. doi request reprint Estimation of postoperative fat absorption using the 13C mixed-triglyceride breath test in children with choledochal cyst
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Eur J Pediatr 168:35-8. 2009
    ..Conclusion. Occult fat malabsorption occurs in patients with CC after RYHJ, even in the absence of clinical symptoms or abnormal laboratory data...
  8. doi request reprint Urinary sulfated bile acid analysis for the early detection of biliary atresia in infants
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 53:497-500. 2011
    ..Measurement of urinary sulfated bile acid (USBA) is a non-invasive method to detect bile congestion. Our aim was to evaluate the feasibility of USBA analysis for the early detection of biliary atresia (BA)...
  9. doi request reprint ω-3 fatty acids attenuate mucosal inflammation in premature rat pups
    Yoshikazu Ohtsuka
    Department of Pediatrics and Adolescence Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Pediatr Surg 46:489-95. 2011
    ..Necrotizing enterocolitis (NEC) is a devastating intestinal disease of premature infants. Although ω-3 fatty acids are known to have antiinflammatory effects, their effect against NEC remains unclear...
  10. doi request reprint Lissencephaly with marked ventricular dilation, agenesis of corpus callosum, and cerebellar hypoplasia caused by TUBA1A mutation
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, Japan
    Brain Dev 35:274-9. 2013
    ..These findings are consistent with previous reports and will be a clue to diagnosis of TUBA1A mutation...
  11. doi request reprint Peroxisome proliferator-activated receptor γ 2 mutation may cause a subset of ulcerative colitis
    Yo Aoyagi
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 52:729-34. 2010
    ..We attempted to demonstrate whether the functional imbalance between TLRs and PPARγ could lead to the onset and some polymorphisms of those genes could contribute to susceptibility to IBD...
  12. pmc Efficacy of bacterial ribosomal RNA-targeted reverse transcription-quantitative PCR for detecting neonatal sepsis: a case control study
    Makoto Fujimori
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    BMC Pediatr 10:53. 2010
    ..Since BrRNA-RT-qPCR targets bacterial ribosomal RNA, detection rates using this approach may exceed those using conventional PCR...
  13. ncbi request reprint Bifidobacterium breve enhances transforming growth factor beta1 signaling by regulating Smad7 expression in preterm infants
    Tohru Fujii
    Department of Pediatrics and Adolescence Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 43:83-8. 2006
    ..The present study examined the effect of probiotics on the immunologic system of preterm infants in relation to TGF-beta signaling...
  14. doi request reprint Leukocytapheresis in pediatric patients with ulcerative colitis
    Takeshi Tomomasa
    Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan
    J Pediatr Gastroenterol Nutr 53:34-9. 2011
    ..Leukocytapheresis (LCAP) is a nonpharmacologic therapy that has recently been used to treat ulcerative colitis (UC). This multicenter open-label study prospectively assessed the efficacy and safety of LCAP in pediatric patients with UC...
  15. doi request reprint Non-invasive assessment of liver fibrosis in patients after the Fontan operation
    Takeshi Furukawa
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 53:980-4. 2011
    ..This study analyzed the change in liver fibrosis markers after the Fontan operation and investigated their clinical usefulness as an index of congestive liver fibrosis...
  16. doi request reprint Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine
    Yoshikazu Ohtsuka
    Department of Pediatrics and Adolescence Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Pediatr Res 71:46-53. 2012
    ..breve) was administered to rat pups during the newborn or weaning period, and the expression of inflammatory genes was investigated using a cDNA microarray and real-time PCR...
  17. doi request reprint Pulse steroids as induction therapy for children with ulcerative colitis
    Takahiro Kudo
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 53:974-9. 2011
    ..We have therefore retrospectively compared induction therapy using pulse steroids with conventional steroid treatment for children and adolescents with moderate-to-severe UC...
  18. doi request reprint Clustered subclinical seizures in a patient with acute encephalopathy with biphasic seizures and late reduced diffusion
    Mitsutaka Komatsu
    Department of Pediatrics, Urayasu Ichikawa Municipal Hospital, Urayasu, Japan
    Brain Dev 32:472-6. 2010
    ..aEEG is useful for continuous monitoring in children with acute encephalopathy, may disclose subclinical seizures, and can contribute to an objective evaluation of the efficacy of antiepileptic drugs...
  19. doi request reprint Imbalance of peroxisome proliferator-activated receptor gamma and adiponectin predisposes Kawasaki disease patients to developing atherosclerosis
    Hideo Fukunaga
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 52:795-800. 2010
    ....
  20. doi request reprint Human osteoblasts support hematopoietic cell development in vitro
    Yusuke Shiozawa
    Department of Developmental Biology, National Research Institute for Child Health and Development, Tokyo, Japan
    Acta Haematol 120:134-45. 2008
    ..The ability of human osteoblasts to support early hematopoiesis was investigated...
  21. doi request reprint Effect of dietary Lorenzo's oil and docosahexaenoic acid treatment for Zellweger syndrome
    Yasuhiro Arai
    Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan
    Congenit Anom (Kyoto) 48:180-2. 2008
    ..DHA levels in the brains and livers of treated patients were higher than in untreated patients. Early initiation of Lorenzo's oil and the long-term administration of DHA may be useful for patients with Zellweger syndrome...
  22. doi request reprint Changes in the presence of urine Helicobacter pylori antibody in Japanese children in three different age groups
    Yukiko Naito
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 50:291-4. 2008
    ..To determine these rates in children living in an urban region of Japan, the levels of urine H. pylori antibodies in children of three different age groups were measured...
  23. doi request reprint Anti-infectious activity of synbiotics in a novel mouse model of methicillin-resistant Staphylococcus aureus infection
    Enkhtuya Lkhagvadorj
    Division of Laboratory for Probiotic Research, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Microbiol Immunol 54:265-75. 2010
    ..B. breve in combination with GOS is demonstrated to have valuable preventive and curative effects against even fatal MRSA infections...
  24. doi request reprint Nutritional state, maturational delay on electroencephalogram, and developmental outcome in extremely low birth weight infants
    Akihisa Okumura
    Department of Pediatrics, Juntendo University, School of Medicine, Bunkyo ku, Tokyo, Japan
    Brain Dev 32:613-8. 2010
    ..Among infants with undernutrition, developmental outcome was relatively worse in those with persistent dysmature patterns than those without...
  25. doi request reprint Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease
    Yoshikazu Ohtsuka
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Gastroenterol Hepatol 25:1626-30. 2010
    ..However, proper 6-thioguanine nucleotide (6-TGN) concentrations in Japanese children with IBD have not been reported...
  26. doi request reprint Analysis of arterial function in adults with a history of Kawasaki disease
    Hisako Tobayama
    Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    J Cardiol 61:330-5. 2013
    ..The purpose of the present study was to assess endothelial function and arterial stiffness as markers of the early onset of atherosclerosis in adult patients with a history of KD...
  27. pmc GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression
    Yosuke Baba
    Atopy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 287:32689-96. 2012
    ..These results indicate that GATA2 and GATA1 positively and negatively control human ST2 gene transcription, respectively...
  28. doi request reprint Phenotypic overlapping of trisomy 12p and Pallister-Killian syndrome
    Eisuke Inage
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Med Genet 53:159-61. 2010
    ..The microblepharon identified in our patient is a characteristic feature of 12p trisomy. Further patients are needed to establish the phenotypic difference between trisomy 12p and Pallister-Killian syndrome...
  29. doi request reprint Association between iron status and neurodevelopmental outcomes among VLBW infants
    Noriko Kon
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Brain Dev 32:849-54. 2010
    ..Our purpose was to evaluate iron status and neurodevelopmental outcomes in infants with and without extrauterine growth restriction (EUGR)...
  30. doi request reprint Acute encephalopathy with biphasic seizures and late reduced diffusion associated with hemophagocytic syndrome
    Rieko Tadokoro
    Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan
    Brain Dev 32:477-81. 2010
    ..These facts suggested that hypercytokinemia will be related to the pathogenesis of acute encephalopathy of our patient...
  31. pmc Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei
    Yukihide Chiba
    Department of Pediatrics, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Immunology 130:352-62. 2010
    ..These data show probiotic L. casei to have considerable potential to induce IL-12 production and promote Th1 cell development, but the secretion of proinflammatory cytokines such as IL-12 and IL-17 may be well controlled in PP cells...
  32. doi request reprint False positive of an immunochromatography kit for detection of norovirus in neonatal feces
    Takahiro Niizuma
    Department of Pediatrics, Koshigaya Municipal Hospital, 10 47 1 Higashikoshigaya, Koshigaya, Saitama, 343 8577, Japan
    J Infect Chemother 19:171-3. 2013
    ..Since the false positive rate of ICG in the diagnosis of norovirus infection in neonates and early infancy is high, ICG is not an appropriate method, and it is necessary to confirm the results using reliable methods like RT-PCR...
  33. doi request reprint Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Virol 56:25-30. 2013
    ..Every year, an estimated 200-500 children in Japan develop influenza-associated encephalopathy (IAE), and 10-30% of these children die...
  34. doi request reprint Pulmonary artery size as an indication for thoracoscopic repair of congenital diaphragmatic hernia in neonates
    Tadaharu Okazaki
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Surg Int 28:883-6. 2012
    ..We reviewed 24 consecutive cases of prenatally or immediately postnatally diagnosed left-sided congenital diaphragmatic hernia (CDH) to evaluate pulmonary artery (PA) size as an indication for thoracoscopic repair (TR)...
  35. doi request reprint Microarray analysis of gastric mucosa among children with Helicobacter pylori infection
    Tamaki Ikuse
    Department of Pediatric and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Pediatr Int 54:319-24. 2012
    ..pylori is not clear. The aim of the present study was to evaluate immune responses in the H. pylori-infected gastric mucosa of children using microarray and real-time polymerase chain reaction (PCR) analysis of pediatric gastric samples...
  36. doi request reprint Serum indoxyl sulfate as an early marker for detecting chronic cyclosporine nephrotoxicity
    Daisuke Umino
    Department of Pediatric and Adolescent Medicine, Juntendo University School of Medicine, 3 1 3 hongou, Bunkyou ku, Tokyo 113 8431, Japan
    Pediatr Int 52:257-61. 2010
    ..The purpose of the present study was therefore to detect early change of CsA nephropathy (CsAN) using blood samples...
  37. doi request reprint Immunological investigation of the hepatic tissue from infants with biliary atresia
    Haruna Baba
    Department of Pediatrics and Adolescence Medicine, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Pediatr Surg Int 25:157-62. 2009
    ..The objective of this study was to evaluate the expression of MMP-3 and -9, and TIMP-1, -2, and -3 and their relationship to liver fibrosis in infants with biliary atresia...
  38. doi request reprint Pulmonary artery size has prognostic value in low birth weight infants with congenital diaphragmatic hernia
    Toshiaki Takahashi
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Pediatr Surg Int 27:847-50. 2011
    ..The aim of this study was to examine the relationship between birth weight, pulmonary artery (PA) size, and outcome in congenital diaphragmatic hernia (CDH) to establish if PA size has prognostic value...
  39. doi request reprint Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis
    Kiyotaka Ohtani
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 52:584-9. 2010
    ....
  40. pmc Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease
    Satoru Nagata
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 128:511-20. 2009
    ..All bacteria identified in this study were antibiotic resistant. These data suggest that sAg and hsps produced by gut bacteria might be involved in KD...
  41. pmc Bacterial rRNA-targeted reverse transcription-PCR used to identify pathogens responsible for fever with neutropenia
    Sachi Sakaguchi
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Microbiol 48:1624-8. 2010
    ..Our findings also indicate that anaerobic intestinal bacteria, which are difficult to detect by standard culture techniques, may be responsible for some cases of febrile neutropenia...
  42. doi request reprint Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies
    Mariko Wada
    Department of Laboratory for Probiotics Research, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Support Care Cancer 18:751-9. 2010
    ....
  43. doi request reprint Norovirus encephalopathy in a previously healthy child
    Kaoru Obinata
    Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan
    Pediatr Infect Dis J 29:1057-9. 2010
    ..The encephalopathy in our patient may be related to hypercytokinemia rather than to direct viral invasion...
  44. doi request reprint Studies of anti-inflammatory effects of Rooibos tea in rats
    Haruna Baba
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 51:700-4. 2009
    ..As oxidative stress can induce inflammation, the anti-inflammatory effects of Rooibos tea were investigated using a rat colitis model...
  45. doi request reprint Antioxidative properties of human milk and spermine are not related to expression of Hsp 70
    Hiromichi Shoji
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Acta Paediatr 97:81-4. 2008
    ..We hypothesized that the antioxidative property of SPM is related to the expression of Hsp and examined this relationship in an intestinal epithelial cell (IEC) line...
  46. doi request reprint Management of pulmonary hypertension in congenital diaphragmatic hernia: nitric oxide with prostaglandin-E1 versus nitric oxide alone
    Satoko Shiyanagi
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Pediatr Surg Int 24:1101-4. 2008
    ..The aim of this study was to investigate the role of PGE1 for treating PH in CDH...
  47. ncbi request reprint Effects of oral administration of bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants
    Chongxin Wang
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 44:252-7. 2007
    ..Our objective was to investigate the effects of the oral administration of Bifidobacterium breve M-16V (B breve) on fecal lactic acid and SCFAs in low birth weight (LBW) infants...
  48. doi request reprint Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats
    Hiroki Suganuma
    Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
    Ann Nutr Metab 62:123-8. 2013
    ..The aim of this study was to investigate alterations in brain fatty acid composition during development and in response to hypoxic-ischemic insults in neonatal rats...
  49. doi request reprint Amplitude spectral analyses of disorganized patterns on electroencephalograms in preterm infants
    Masako Saito
    Department of Pediatrics, Juntendo University, Faculty of Medicine, Bunkyo ku, Tokyo, Japan
    Brain Dev 35:38-44. 2013
    ..Amplitude spectral analyses will contribute to objective evaluation of disorganized patterns...
  50. doi request reprint A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, Bunkyo ku, Tokyo, Japan
    Brain Dev 34:881-5. 2012
    ..The unusual constellation of brain malformations of our patient will widen the spectrum of epidermal nevus syndrome...
  51. doi request reprint Glucose metabolism soon after birth in very premature infants with small- and appropriate-for-gestational-age birth weights
    Mayuko Tsubahara
    Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
    Early Hum Dev 88:735-8. 2012
    ..01), the serum insulin level (p<0.05) and the CPR level (p<0.05) in all 52 infants. Conclusion: In very premature infants, poor foetal growth may impair foetal insulin secretion and affect the QUICKI at birth...
  52. pmc L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels
    Kei Minowa
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Drugs R D 12:49-55. 2012
    ..However, severe pancreatitis sometimes occurs in patients receiving ASNase, because of an unknown mechanism...
  53. doi request reprint Efficacy and safety of pulse steroid therapy in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease
    Satoru Nagata
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Digestion 81:188-92. 2010
    ..We have evaluated the therapeutic efficacy and safety of pulse steroid therapy for ulcerative colitis (UC) in a Japanese pediatric population by means of a survey...
  54. doi request reprint Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures
    Akihisa Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Brain Dev 33:77-82. 2011
    ..Continuous seizure monitoring with amplitude-integrated EEG will contribute to correct estimation of seizure burden and efficacy of antiepileptic drugs in children with acute encephalopathy with refractory, repetitive partial seizures...
  55. doi request reprint Neurodevelopment in the offspring of Japanese systemic lupus erythematosus patients
    Naomi Yoshikawa
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Brain Dev 32:390-5. 2010
    ..To evaluate pregnancy outcome of systemic lupus erythematosus (SLE) and the neuropsychological outcomes in offspring of SLE mothers...
  56. doi request reprint Maternal docosahexaenoic acid-enriched diet prevents neonatal brain injury
    Hiroki Suganuma
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Neuropathology 30:597-605. 2010
    ..Dietary supplementation of DHA during pregnancy may thus be beneficial in preventing neonatal brain injury...
  57. pmc Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants
    Hiromichi Shoji
    Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan
    Acta Paediatr 100:972-6. 2011
    ..We investigated the relationship between blood DHA and AA status in 27 very-low-birth-weight (VLBW) infants with or without parenteral lipid emulsion...
  58. doi request reprint Indications for thoracoscopic repair of congenital diaphragmatic hernia in neonates
    Tadaharu Okazaki
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Bunkyo Ku, Tokyo, Japan
    Pediatr Surg Int 27:35-8. 2011
    ..We reviewed 26 consecutive cases of congenital diaphragmatic hernia (CDH) prospectively to establish selection criteria for successful thoracoscopic CDH repair (TR)...
  59. pmc Effects of leukotriene receptor antagonists on peripheral eosinophil counts and serum IgE levels in children with food allergy
    Yoko Yamakawa
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Drugs R D 10:147-54. 2010
    ..Although the efficacy of leukotriene receptor antagonists (LTRAs) for bronchial asthma is already established, their effect on food allergy remains unclear...
  60. ncbi request reprint Neonatal transient eosinophilic colitis causes lower gastrointestinal bleeding in early infancy
    Yoshikazu Ohtsuka
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 44:501-5. 2007
    ....
  61. doi request reprint Overfeeding can cause NEC-like enterocolitis in premature rat pups
    Kyo Okada
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Neonatology 97:218-24. 2010
    ..The mortality rate associated with NEC is quite high and in most reports ranges from 20 to 30%. Despite extensive studies, the pathogenesis of NEC remains poorly understood...
  62. doi request reprint Effects of ghrelin on growth and cardiac function in infants with congenital heart disease
    Tomohiro Kitamura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 52:358-61. 2010
    ..The purpose of the present study was therefore to investigate the relationship between ghrelin level and growth and cardiac function in CHD infants...
  63. ncbi request reprint Factors involved in the regulation of plasma leptin levels in children and adolescents with anorexia nervosa
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo 113 0033, Japan
    Pediatr Int 47:154-8. 2005
    ..The effects of changes in body mass index (BMI) and other factors on plasma leptin levels in children and adolescents with anorexia nervosa (AN) were examined...
  64. ncbi request reprint Serum and urine Helicobacter pylori antibody titer after intravenous gamma-globulin treatment for Kawasaki disease and its clearance
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo 113 0033, Japan
    Pediatr Int 47:172-4. 2005
    ..pylori) antibodies, although the therapy can cause false-positive results in those assays...
  65. ncbi request reprint Effects of iron-unsaturated human lactoferrin on hydrogen peroxide-induced oxidative damage in intestinal epithelial cells
    Hiromichi Shoji
    Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, 113 0033 Tokyo, Japan
    Pediatr Res 61:89-92. 2007
    ..Our study indicates that apo-hLf alleviates H2O2-induced oxidative damage in intestinal cells due to the iron-chelating capacity. Therefore, Lf in HM may act as an antioxidant in the gastrointestinal tract (GIT)...
  66. doi request reprint A boy with a severe phenotype of succinic semialdehyde dehydrogenase deficiency
    Yoko Yamakawa
    Department of Pediatrics, Juntendo University, Urayasu Hospital, Japan
    Brain Dev 34:107-12. 2012
    ..The clinical manifestation of our patient indicates the wide variety of SSADH deficiency phenotypes...
  67. ncbi request reprint Polarized production of T-helper cell type 1 cells in Peyer's patches in Crohn's disease
    Takahiro Kudo
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Digestion 70:214-25. 2004
    ..To examine the immunological events in PPs, we performed functional and phenotypical studies on PP cells, the lamina propria cells in the colonic mucosa and peripheral blood mononuclear cells (PBMC) in inflammatory bowel disease...
  68. doi request reprint Protective effects of Mizoribine on Cyclosporine A nephropathy in rats
    Satoshi Hara
    Department of Pediatrics, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Pediatr Res 66:524-7. 2009
    ..On the basis of these findings, we suggest MZR effectively attenuates renal macrophage accumulation and the progression of interstitial fibrosis...
  69. ncbi request reprint Effects of human milk and spermine on hydrogen peroxide-induced oxidative damage in IEC-6 cells
    Hiromichi Shoji
    Department of Pediatrics, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 41:460-5. 2005
    ..Human milk (HM) contains various bioactive substances, some of which are known as antioxidants, including polyamines such as spermine (SPM). We examined the antioxidative properties of HM and SPM in an intestinal epithelial cell line...
  70. ncbi request reprint Early dietary treatments with Lorenzo's oil and docosahexaenoic acid for neurological development in a case with Zellweger syndrome
    Kyoko Tanaka
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, 113 8421 Tokyo, Japan
    Brain Dev 29:586-9. 2007
    ..Our findings suggest that the dietary treatment with combination of MCT milk, DHA, Lorenzo's oil, and Lunaria oil in the patients with Zellweger syndrome bring some benefits for neurological development...
  71. ncbi request reprint Fecal alpha1-antitrypsin concentrations as a measure of enteric protein loss after modified fontan operations
    Tohru Fujii
    Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 37:577-80. 2003
    ..The authors examined the possibility of using fecal alpha1-antitrypsin concentration measurements for the early detection of postoperative PLE and in longer term postoperative monitoring of these patients...
  72. doi request reprint Drug-eluting stents ameliorate pulmonary vein stenotic changes in pigs in vivo
    Takeshi Furukawa
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Pediatr Cardiol 31:773-9. 2010
    ..Because of the small sample size and the considerable variation in injury scores and balloon-to-vein ratios, future studies with larger samples are necessary...
  73. doi request reprint Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD
    Junya Fujimura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Transplant 14:540-8. 2010
    ....
  74. doi request reprint Effects of early enteral feeding on fecal elastase 1 and plasma secretin
    Noritsugu Kaneko
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 52:607-10. 2010
    ..The aim of the present study was to examine the effects of extremely early enteral feedings on the development in very low-birthweight (VLBW) infants...
  75. doi request reprint Expression of COX-1, COX-2, and PPAR-gamma in the gastric mucosa of children with Helicobacter pylori infection
    Hidenori Haruna
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 50:1-6. 2008
    ..The present study examined the effects of cyclo-oxygenase (COX)-1, -2, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on gastric mucosal injury in children with H. pylori infection...
  76. doi request reprint Altered gene expression in umbilical cord mononuclear cells in preterm infants with periventricular leukomalacia
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, Japan
    Early Hum Dev 86:665-7. 2010
    ..The aim of this study is to examine the difference in mRNA expression in umbilical cord blood according to the presence or absence of PVL...
  77. ncbi request reprint Effects of extremely early enteral feeding on plasma glicentin levels in very-low-birthweight infants
    Toshiaki Shimizu
    Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan
    J Paediatr Child Health 42:636-9. 2006
    ..We examined the effects of extremely early enteral feedings on the postnatal and postprandial changes in plasma glicentin levels in very-low-birthweight (VLBW) infants...
  78. doi request reprint Acute encephalopathy in children with Dravet syndrome
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, Bunkyo ku, Tokyo, Japan
    Epilepsia 53:79-86. 2012
    ..The occurrence of acute encephalopathy in children with Dravet syndrome has been reported sporadically. This study clarified the features of acute encephalopathy in children with Dravet syndrome...
  79. doi request reprint Refractory neonatal epilepsy with a de novo duplication of chromosome 2q24.2q24.3
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Epilepsia 52:e66-9. 2011
    ..3-Mb duplication of 2q24.2q24.3, where at least 22 genes including a cluster of voltage-gated sodium channel genes (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A) and one noncoding RNA are located...
  80. doi request reprint Complete resection of hepatoblastoma originating in the caudate lobe: case report and literature review
    Hiroyuki Koga
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, 113 8421, Japan
    Pediatr Surg Int 25:1017-20. 2009
    ..Total blood loss was 10 mL, and the operation lasted 9 h. His postoperative course was uneventful. Preoperative chemotherapy facilitated complete resection by left hepatic lobectomy with total excision of the caudate lobe...
  81. doi request reprint Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma
    Keiko Onda
    Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, 157 8535, Japan
    Int J Hematol 91:808-19. 2010
    ..The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies...
  82. ncbi request reprint Usefulness of nonbreath-hold 1-shot magnetic resonance cholangiopancreatography for the evaluation of choledochal cyst in children
    Mitsuyoshi Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Gastroenterol Nutr 42:539-44. 2006
    ..The aim of this study was to clarify the usefulness of magnetic resonance cholangiopancreatography (MRCP) for the evaluation of choledochal cyst in children...
  83. doi request reprint Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography
    Mariko Sekigawa
    Department of Pediatrics, Juntendo Nerima Hospital, Tokyo, Japan
    J Pediatr 156:158-60. 2010
    ..PET scanning may be useful in the diagnosis of autoimmune encephalitis...
  84. doi request reprint Intracellular magnesium and tolerance against hypoxia in immature rat heart
    Tomoyuki Sato
    Department of Pediatrics, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Pediatr Int 52:773-7. 2010
    ..In immature rat hearts, we examined the association between high tolerance for hypoxia and the kinetics of magnesium (Mg), which has myocardial protective effects in adult hearts...
  85. ncbi request reprint Comparison of the phospholipid classes in human milk in Japanese mothers of term and preterm infants
    Hiromichi Shoji
    Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Acta Paediatr 95:996-1000. 2006
    ..Phospholipids (PLs) play an essential role in the growth and brain development of infants...
  86. doi request reprint Fatty acid composition of the brain of intrauterine growth retardation rats and the effect of maternal docosahexaenoic acid enriched diet
    Mitsuru Ikeno
    Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo, 113 8421 Japan
    Early Hum Dev 85:733-5. 2009
    ..Additionally, we evaluated the effect of maternal docosahexaenoic acid (DHA)-enriched diet...
  87. doi request reprint Kernicterus in preterm infants
    Akihisa Okumura
    Department of Pediatrics, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Pediatrics 123:e1052-8. 2009
    ..We sought to clarify the features of kernicterus in preterm infants...
  88. ncbi request reprint Evaluation of psychosomatic stress in children by measuring salivary chromogranin A
    Tsubasa Lee
    Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Acta Paediatr 95:935-9. 2006
    ..To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction on the suppression of stress in children...
  89. doi request reprint Pancreaticoduodenectomy for pancreatoblastoma: a case report and literature review
    Rumi Ohata
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Pediatr Surg Int 26:447-50. 2010
    ..The liver metastases were resected. Postoperative recovery was uneventful. Here, we present this case and review the literature focusing on management of PB...
  90. ncbi request reprint Detection of abnormal union of pancreaticobiliary junction by magnetic resonance cholangiopancreatography in a girl with acute pancreatitis
    Ryuyo Suzuki
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 44:183-5. 2002
  91. ncbi request reprint Serum free T4 and thyroid stimulating hormone levels in preterm infants and relationship between these levels and respiratory distress syndrome
    Kyoko Tanaka
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 49:447-51. 2007
    ..The present study sought to determine the serum levels of free T4 (fT4) and TSH in ELBW infants and to examine the relationship between these levels and the development of RDS...
  92. ncbi request reprint Guidelines for treatment of ulcerative colitis in children
    Takeshi Tomomasa
    Department of Pediatrics, Gunma University Graduate School, Japan
    Pediatr Int 46:494-6. 2004
    ..3) Pulsed steroid therapy, selective removal of blood cells, and intravenous infusion of cyclosporin should be included in the therapeutic option for severe and fluminant cases...
  93. ncbi request reprint Diagnostic accuracy of the 13C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study
    Seiichi Kato
    Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan
    Am J Gastroenterol 97:1668-73. 2002
    ..The primary purpose of this study was to evaluate diagnostic accuracy of the 13C-UBT for children and to determine its optimum cutoff value...
  94. doi request reprint Effect of hypoxic-ischemic injury on serine palmitoyltransferase activity in the developing rat brain
    Masaki Daigo
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pathobiology 75:330-4. 2008
    ....
  95. ncbi request reprint Anomalous pancreatic duct anatomy, ectopic distal location of the papilla of Vater and congenital biliary dilatation: a new developmental triad?
    Long Li
    Department of Pediatric Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421 Tokyo, Japan
    Pediatr Surg Int 19:180-5. 2003
    ....
  96. ncbi request reprint Characterization of monocyte-macrophage-lineage cells induced from CD34+ bone marrow cells in vitro
    Kyoko Suzuki
    Department of Developmental Biology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int J Hematol 85:384-9. 2007
    ..Monocyte-macrophage-lineage cells induced in vitro should provide an ideal model for functional analysis of monocyte-macrophage cells...
  97. doi request reprint Retherapy using L-asparaginase with octreotide in a patient recovering from L-asparaginase-induced pancreatitis
    Mitsuyoshi Suzuki
    Exp Hematol 36:253-4. 2008
  98. ncbi request reprint [Adjunctive immunotherapy of mycobacterial infections]
    Haruaki Tomioka
    Department of Microbiology and Immunology, Shimane University, School of Medicine, Izumo, Shimane, Japan
    Nihon Saikingaku Zasshi 60:445-52. 2005
  99. doi request reprint Scoring system for the severity of acute pancreatitis in children
    Mitsuyoshi Suzuki
    Pancreas 37:222-3. 2008
  100. ncbi request reprint Effects of type II alveolar epithelial cells on T cell mitogenic responses to concanavalin A and purified protein derivatives
    Katsumasa Sato
    Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Japan
    Microbiol Immunol 49:885-90. 2005
    ..Therefore, it appears that A-549 cells suppress T cell mitogenesis by producing some unknown humoral suppressor factors...
  101. ncbi request reprint Combined effects of ATP on the therapeutic efficacy of antimicrobial drug regimens against Mycobacterium avium complex infection in mice and roles of cytosolic phospholipase A2-dependent mechanisms in the ATP-mediated potentiation of antimycobacterial hos
    Haruaki Tomioka
    Department of Microbiology and Immunology, Shimane University School of Medicine, Shimane, Japan
    J Immunol 175:6741-9. 2005
    ....