Toru Yamaguchi

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. ncbi request reprint [Calcium homeostasis and diabetes mellitus]
    Toru Yamaguchi
    Shimane University School of Medicine, Department of Internal Medicine I
    Clin Calcium 16:1270-75. 2006
  2. doi request reprint Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women
    Mika Yamauchi
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo City, Shimane 693 8501, Japan
    Clin Nutr 29:761-5. 2010
  3. ncbi request reprint Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes
    Toru Yamaguchi
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo shi, Shimane 693 8501, Japan
    Bone 45:174-9. 2009
  4. doi request reprint The calcium-sensing receptor in bone
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    J Bone Miner Metab 26:301-11. 2008
  5. doi request reprint Quantitative ultrasound and vertebral fractures in patients with type 2 diabetes
    Toru Yamaguchi
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    J Bone Miner Metab 29:626-32. 2011
  6. ncbi request reprint Bone metabolism and fracture risk in type 2 diabetes mellitus [Review]
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Endocr J 58:613-24. 2011
  7. doi request reprint Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Calcif Tissue Int 83:324-31. 2008
  8. doi request reprint Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Calcif Tissue Int 85:228-34. 2009
  9. doi request reprint BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: potential therapeutic targets for glucocorticoid-induced osteoporosis
    Kumi Hayashi
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Biochem Biophys Res Commun 379:261-6. 2009
  10. ncbi request reprint Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Japan
    J Clin Endocrinol Metab 94:3031-7. 2009

Collaborators

Detail Information

Publications70

  1. ncbi request reprint [Calcium homeostasis and diabetes mellitus]
    Toru Yamaguchi
    Shimane University School of Medicine, Department of Internal Medicine I
    Clin Calcium 16:1270-75. 2006
    ..Primary hyperparathyroidism induces glucose intolerance via insulin resistance due to elevated intracellular calcium in the targeted organ of insulin...
  2. doi request reprint Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women
    Mika Yamauchi
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo City, Shimane 693 8501, Japan
    Clin Nutr 29:761-5. 2010
    ..However, the relationship between ucOC and vitamin K intakes, bone mineral density (BMD) and bone biochemical markers is not clarified...
  3. ncbi request reprint Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes
    Toru Yamaguchi
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo shi, Shimane 693 8501, Japan
    Bone 45:174-9. 2009
    ..Visceral fat in men and hyperinsulinemia in women may protect against VFs independent of weight, L-BMD, diabetes duration, or therapies...
  4. doi request reprint The calcium-sensing receptor in bone
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    J Bone Miner Metab 26:301-11. 2008
  5. doi request reprint Quantitative ultrasound and vertebral fractures in patients with type 2 diabetes
    Toru Yamaguchi
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    J Bone Miner Metab 29:626-32. 2011
    ..It seems necessary to seek other imaging modalities or biochemical markers evaluating bone fragility and fracture risk in T2DM...
  6. ncbi request reprint Bone metabolism and fracture risk in type 2 diabetes mellitus [Review]
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Endocr J 58:613-24. 2011
    ..In practice, it is important for physicians to assess fracture risk in T2DM patients by evaluating prior VFs and fracture histories using spine X-ray and interview, respectively, until the usefulness of surrogate markers is established...
  7. doi request reprint Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Calcif Tissue Int 83:324-31. 2008
    ..056, 95% confidence interval [CI] 1.031-9.056, P = 0.0439, and OR = 5.415, 95% CI 1.126-26.040, P = 0.0350, respectively). Combination of obesity with hyperglycemia was a risk factor for VF despite sufficient BMD in diabetic men...
  8. doi request reprint Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Calcif Tissue Int 85:228-34. 2009
    ..The OC/BAP ratio could be clinically useful for assessing the risk of vertebral fractures independent of BMD in diabetic men...
  9. doi request reprint BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: potential therapeutic targets for glucocorticoid-induced osteoporosis
    Kumi Hayashi
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Biochem Biophys Res Commun 379:261-6. 2009
    ....
  10. ncbi request reprint Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Japan
    J Clin Endocrinol Metab 94:3031-7. 2009
    ..We monitored chronological changes in hyperglycemia, serum adiponectin, and bone markers during glycemic control in type 2 diabetes and analyzed relationships among these parameters...
  11. doi request reprint Decreased PTH levels accompanied by low bone formation are associated with vertebral fractures in postmenopausal women with type 2 diabetes
    Masahiro Yamamoto
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1, Enya cho, Izumo, Shimane 693 8501, Japan
    J Clin Endocrinol Metab 97:1277-84. 2012
    ..Patients with type 2 diabetes (T2DM) have an increased risk of vertebral fractures (VF) compared with non-T2DM controls due to poor bone quality. The aim of this study was to investigate the association between VF and bone turnover...
  12. ncbi request reprint A case of magnesium deficiency associated with insufficient parathyroid hormone action and severe osteoporosis
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane, Japan
    Endocr J 54:935-40. 2007
    ..These processes were probably linked to her severe osteoporosis, which was reversed by Mg supplementation...
  13. doi request reprint Association of n-3 polyunsaturated fatty acid intake with bone mineral density in postmenopausal women
    Kiyoko Nawata
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    Calcif Tissue Int 93:147-54. 2013
    ..In conclusion, n-3 fatty acid intake was positively associated with lumbar spine BMD independent of bone resorption and serum levels of cholesterol and triglycerides in postmenopausal women. ..
  14. pmc Low serum level of the endogenous secretory receptor for advanced glycation end products (esRAGE) is a risk factor for prevalent vertebral fractures independent of bone mineral density in patients with type 2 diabetes
    Masahiro Yamamoto
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane, Japan
    Diabetes Care 32:2263-8. 2009
    ..The involvement of the endogenous secretory receptor for AGEs (esRAGE) in VFs in those with type 2 diabetes, however, is still unknown...
  15. ncbi request reprint Advanced glycation end products (AGEs), but not high glucose, inhibit the osteoblastic differentiation of mouse stromal ST2 cells through the suppression of osterix expression, and inhibit cell growth and increasing cell apoptosis
    Kyoko Okazaki
    Department of Internal Medicine, Shimane University, Enya cho, Izumo, Shimane, Japan
    Calcif Tissue Int 91:286-96. 2012
    ....
  16. doi request reprint Fracture risk is increased by the complication of hypertension and treatment with calcium channel blockers in postmenopausal women with type 2 diabetes
    Shin Takaoka
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    J Bone Miner Metab 31:102-7. 2013
    ....
  17. doi request reprint Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression
    Ippei Kanazawa
    Dept of Internal Medicine 1, Shimane Univ Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Am J Physiol Endocrinol Metab 296:E139-46. 2009
    ..These agents could be candidate drugs that promote bone formation for the treatment of osteoporosis...
  18. doi request reprint Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    J Bone Miner Metab 28:554-60. 2010
    ....
  19. doi request reprint Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University School of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Eur J Endocrinol 160:265-73. 2009
    ..Although, adiponectin might be associated with bone metabolism, the relationships between serum adiponectin and bone mineral density (BMD) as well as vertebral fracture in type 2 diabetes are still unclear...
  20. doi request reprint Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University School of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    J Clin Endocrinol Metab 94:45-9. 2009
    ....
  21. ncbi request reprint Rosuvastatin increased serum osteocalcin levels independent of its serum cholesterol-lowering effect in patients with type 2 diabetes and hypercholesterolemia
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
    Intern Med 48:1869-73. 2009
    ..In the present study, we compared the effect of rosuvastatin with that of ezetimibe on bone turnover markers in patients with type 2 diabetes mellitus as well as hypercholesterolemia...
  22. doi request reprint Acute-onset hypomagnesemia-induced hypocalcemia caused by the refractoriness of bones and renal tubules to parathyroid hormone
    Masahiro Yamamoto
    Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    J Bone Miner Metab 29:752-5. 2011
    ....
  23. doi request reprint Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes
    Kumi Hayashi
    Endocrinology and Metabolism Division, Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane, Japan
    Diabetes Res Clin Pract 94:180-5. 2011
    ..We showed hippocampal and whole brain atrophies to be more frequent in elderly patients with type 2 diabetes than in non-diabetic controls. Their cognitive functions were significantly and negatively associated with hippocampal atrophy...
  24. pmc Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University School of Medicine, Japan
    BMC Cell Biol 8:51. 2007
    ..In this study, we investigated the effects of adiponectin on the proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells...
  25. ncbi request reprint Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
    Endocr J 57:415-21. 2010
    ....
  26. ncbi request reprint The uraemic toxin phenylacetic acid inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure
    Shozo Yano
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo City, Shimane 693 8501, Japan
    Nephrol Dial Transplant 22:3160-5. 2007
    ..Since phenylacetic acid (PAA) has been identified as one of the uraemic toxins in patients with CKD and has an inhibiting property of monocyte function, we examined if PAA might inhibit osteoblastic functions in vitro...
  27. doi request reprint Role of parathyroid hormone in bone fragility of postmenopausal women with vitamin D insufficiency
    Mika Yamauchi
    Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
    Calcif Tissue Int 88:362-9. 2011
    ..Functional hypoparathyroidism, rather than functional hyperparathyroidism, might be a risk factor for bone fragility in vitamin D insufficiency...
  28. ncbi request reprint Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693 8501, Japan
    Metabolism 60:1334-9. 2011
    ..05). Serum Ca level is positively associated with impaired glucose metabolism, independent of PTH or bone metabolism, in men with type 2 DM...
  29. doi request reprint Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693 8501, Japan
    Metabolism 59:1252-6. 2010
    ..Adiponectin might protect against BMD reduction in patients with type 2 diabetes mellitus...
  30. doi request reprint Advanced glycation end products suppress osteoblastic differentiation of stromal cells by activating endoplasmic reticulum stress
    Ken ichiro Tanaka
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
    Biochem Biophys Res Commun 438:463-7. 2013
    ..This process might accelerate AGEs-induced suppression of bone formation found in diabetes mellitus. ..
  31. doi request reprint Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications
    Masahiro Yamamoto
    Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    J Bone Miner Res 24:702-9. 2009
    ..T2DM patients may have an increased risk of VFs independent of BMD or diabetic complication status, suggesting that bone quality may define bone fragility in T2DM...
  32. doi request reprint Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Biochem Biophys Res Commun 375:414-9. 2008
    ....
  33. ncbi request reprint Effects of treatment with risedronate and alfacalcidol on progression of atherosclerosis in postmenopausal women with type 2 diabetes mellitus accompanied with osteoporosis
    Ippei Kanazawa
    Department of Internal Medicine, Shimane University, Izumo, Japan
    Am J Med Sci 339:519-24. 2010
    ..This study investigated the effects of treatment with risedronate and alfacalcidol on parameters of atherosclerosis in postmenopausal women with type 2 diabetes accompanied with osteoporosis...
  34. ncbi request reprint Serum DHEA-S level is associated with the presence of atherosclerosis in postmenopausal women with type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Endocr J 55:667-75. 2008
    ....
  35. doi request reprint Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, The Center for Community based Health Research and Education COHRE, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Japan
    Clin Endocrinol (Oxf) 74:467-72. 2011
    ....
  36. ncbi request reprint [Update on fracture risk in life style-related diseases]
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Clin Calcium 24:349-55. 2014
    ..Patients with diabetes or CKD who have no fracture could undergo drug treatments if their bone mineral density is osteopenic, considering the established link between these disorders and fracture risk. ..
  37. ncbi request reprint Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes
    Masahiro Yamamoto
    Internal Medicine 1, Shimane University Faculty of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    J Clin Endocrinol Metab 93:1013-9. 2008
    ..Recent studies have reported that increased bone content of pentosidine (PEN) is associated with its plasma concentration and bone fragility...
  38. ncbi request reprint Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion
    Masakazu Notsu
    Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693 8501, Japan
    Endocrinology 155:2402-10. 2014
    ..They also suggest that TGF-β adversely affects bone quality not only in primary osteoporosis but also in diabetes-related bone disorder. ..
  39. ncbi request reprint Hypercalcemia associated with eosinophilic myocarditis in a patient undergoing maintenance hemodialysis
    Ken ichiro Tanaka
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Intern Med 51:2913-6. 2012
    ..Since the serum 1,25(OH)(2)D level promptly and markedly decreased, the hypercalcemia complicated with HES was most likely caused by extrarenal production of 1,25(OH)(2)D...
  40. ncbi request reprint Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells
    Mika Yamauchi
    Dept of Endocrinology, Metabolism, and Hematological Oncology, Shimane Univ School of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Am J Physiol Endocrinol Metab 288:E608-16. 2005
    ..This suggests that the CaR may be involved in osteoblastic differentiation...
  41. doi request reprint Relationship between bone biochemical markers versus glucose/lipid metabolism and atherosclerosis; a longitudinal study in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Diabetes Res Clin Pract 92:393-9. 2011
    ....
  42. doi request reprint Elcatonin is effective for lower back pain and the symptoms of gastroesophageal reflux disease in elderly osteoporotic patients with kyphosis
    Yuko Yamane
    Yamane Hospital, Shimane, Japan
    Geriatr Gerontol Int 11:215-20. 2011
    ..We examine whether or not this drug would alleviate GERD symptoms as well as lower back pain in patients with osteoporosis...
  43. doi request reprint Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University School of Medicine, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    Bone 48:720-5. 2011
    ....
  44. doi request reprint Relationships between dimethylarginine and the presence of vertebral fractures in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan
    Clin Endocrinol (Oxf) 73:463-8. 2010
    ....
  45. doi request reprint Advanced glycation end products-induced reactive oxygen species generation is partly through NF-kappa B activation in human aortic endothelial cells
    Miwa Morita
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane, Japan
    J Diabetes Complications 27:11-5. 2013
    ....
  46. ncbi request reprint Primary pulmonary squamous cell carcinoma associated with elevated IL-6, leukocytosis, hypercalcemia, phagocytosis, reactive lymphadenopathy and glomerular mesangial cell proliferation via the production of PTH-rP and G-CSF
    Shin Takaoka
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
    Intern Med 47:275-9. 2008
    ..IL-6 also might have stimulated the proliferation of SCC and glomerular mesangial cells, and induced phagocytosis, reactive lymphadenopathy and hepatosplenomegaly by interacting with the mononuclear phagocytic system...
  47. doi request reprint [Bone metabolism in dyslipidemia and metabolic syndrome]
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine
    Clin Calcium 21:677-82. 2011
    ....
  48. doi request reprint Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cells
    Ken ichiro Tanaka
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, 693 8501, Japan
    Calcif Tissue Int 94:454-64. 2014
    ..Hence, BMP-2 stimulates ATF4 both dependently and independently of the PERK-eIF2α ER stress response pathway. ..
  49. doi request reprint [Secondary osteoporosis or secondary contributors to bone loss in fracture. Effects of oxidative stress on bone metabolism]
    Masakazu Notsu
    Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Clin Calcium 23:1285-92. 2013
    ..This report gives an outline of the effect of oxidative stress on bone metabolism in some conditions, such as diabetes mellitus, arteriosclerotic diseases, chronic kidney diseases and menopause. ..
  50. ncbi request reprint [Diabetes mellitus and osteoporosis. How to start drug therapy for osteoporosis in patients with diabetes mellitus]
    Toru Yamaguchi
    Internal Medicine 1, Shimane University Faculty of Medicine, Japan
    Clin Calcium 22:1403-9. 2012
    ..The criteria for starting drug treatment to prevent fragility fractures in DM patients, albeit tentative, are shown in this article...
  51. ncbi request reprint Partial improvement of anterior pituitary deficiency following steroid treatment in a patient with neurosarcoidosis accompanied by central diabetes insipidus
    Ken ichiro Tanaka
    Internal Medicine I, Shimane University Faculty of Medicine, Japan
    Intern Med 51:2175-9. 2012
    ..Pituitary endocrine functions can be rescued if steroid treatment is performed under conditions that maintain several hormonal axes...
  52. ncbi request reprint A case of membranous nephropathy associated with chronic sinusitis
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University School of Medicine, Shimane, Japan
    J Nephrol 22:289-94. 2009
    ..Thus, we suspect the pathogenetic link between membranous nephropathy and chronic sinusitis in this case, most probably through T-cell dysfunction...
  53. doi request reprint [New development in bisphosphonate treatment. When and how long should patients take bisphosphonates for osteoporosis?]
    Toru Yamaguchi
    Shimane University, Faculty of Medicine, Internal Medicine 1, Japan
    Clin Calcium 19:38-43. 2009
    ..Thus, alendronate treatment might be stopped for a while after 5 years to prevent SSBT and subsequent stress fractures...
  54. ncbi request reprint MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy
    Noriko Ogawa
    First Department of Internal Medicine, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    Clin Exp Nephrol 11:326-31. 2007
    ..This case suggests that an inflammation such as tonsillitis may be associated not only with the activity of IgA nephropathy but also with the production of MPO-ANCA...
  55. doi request reprint Phenylacetic acid stimulates reactive oxygen species generation and tumor necrosis factor-α secretion in vascular endothelial cells
    Miwa Morita
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
    Ther Apher Dial 15:147-50. 2011
    ..The plasma PAA level was reported to be approximately 3.5 mM in end-stage CKD patients, whereas it was <5 µM in healthy subjects; thus, PAA could be involved in the pathological changes of the vasculature in CKD...
  56. doi request reprint Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus
    Ippei Kanazawa
    Department of Internal Medicine, Shimane University, Japan
    Growth Horm IGF Res 21:268-71. 2011
    ....
  57. ncbi request reprint One-hour post-load hyperglycemia by 75g oral glucose tolerance test as a novel risk factor of atherosclerosis
    Ken ichiro Tanaka
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    Endocr J 61:329-34. 2014
    ..1mm) were 188 and 101 mg/dL, respectively (p<0.01). These findings show that early post-load hyperglycemia, particularly PG60 is a novel risk factor of atherosclerosis and useful to assess it. ..
  58. doi request reprint Osteosarcoma in a pregnant patient with McCune-Albright syndrome
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Bone 45:603-8. 2009
    ..We firstly reported a case of osteosarcoma in a patient with McCune-Albright syndrome, which rapidly progressed during pregnancy...
  59. doi request reprint [Osteoporosis secondary to various disorders]
    Toru Yamaguchi
    Internal Medicine 1, Faculty of Medicine, Shimane University, Japan
    Clin Calcium 22:813-8. 2012
    ..Fractures in type 2 diabetes and chronic kidney disease tend to result from the reduction in bone quality rather than that in bone mass...
  60. ncbi request reprint Acromegaly associated with monoclonal gammopathy of undetermined significance (MGUS)
    Ippei Kanazawa
    Department of Endocrinology Metabolism and Hematology Oncology, Shimane University Faculty of Medicine, Shimane, Japan
    Endocr J 53:687-91. 2006
    ..We suspect a pathogenetic link between acromegaly and MGUS in this case, because both GH and IGF-I are known to directly promote immunoglobulin production from plasma cells, thus inducing the proliferation of the cells in vitro...
  61. ncbi request reprint [Causes and treatment of hypomagnesemia]
    Masahiro Yamamoto
    Shimane University Faculty of Medicine, Department of Internal Medicine 1, Japan
    Clin Calcium 17:1241-8. 2007
    ..Mild and severe hypomagnesemia are treated with oral replacement such as magnesium oxide, as well as intravenous administration of magnesium sulfate...
  62. ncbi request reprint Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage
    Hideaki Sowa
    Division of Endocrinology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 278:21058-69. 2003
    ..Menin is important for both early differentiation of osteoblasts and inhibition of their later differentiation, and it might be crucial for intramembranous ossification...
  63. ncbi request reprint Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells
    Hideaki Sowa
    Third Department of Medicine, Kobe University School of Medicine, Japan
    J Bone Miner Res 17:1190-9. 2002
    ..We propose that Smad3 plays an important role in osteoblastic bone formation and might help to elucidate the transcriptional mechanism of bone formation and possibly lead to the development of bone-forming drugs...
  64. ncbi request reprint Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells
    Hideaki Sowa
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 277:36024-31. 2002
    ..The present study indicated that TGF-beta-responsive ERK1/2 and JNK cascades negatively regulate Smad3-induced transcriptional activity as well as ALP activity and mineralization in osteoblasts...
  65. ncbi request reprint The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation
    Toru Yamaguchi
    Department of Internal Medicine, Takatsuki General Hospital, 1 3 13 Kosobe cho, Takatsuki 569 1192, Japan
    Biochem Biophys Res Commun 299:532-8. 2002
    ..These processes may result in promoting further growth of the tumor and aggravating the associated bone disease...
  66. ncbi request reprint Familial hypocalciuric hypercalcemia caused by an R648stop mutation in the calcium-sensing receptor gene
    Mika Yamauchi
    Division of Endocrinology Metabolism, Neurology, and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Bone Miner Res 17:2174-82. 2002
    ..This report is the first to show that an R648stop CaR mutation yields a truncated receptor that is expressed on the cell surface but is devoid of biological activity, resulting in FHH...
  67. ncbi request reprint Trial to predict malignancy of affected parathyroid glands in primary hyperparathyroidism
    Qingxiang Chen
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Endocr J 50:527-34. 2003
    ..In conclusion, radial BMD was lower in malignant group compared to benign one in pHPT. Serum levels of calcium, ALP and mid PTH were useful to predict malignancy of affected parathyroid glands in pHPT patients...
  68. doi request reprint [Calcium homeostasis and osteoporosis in diabetes mellitus and the metabolic syndrome]
    Toru Yamaguchi
    Shimane University, Faculty of Medicine, Internal Medicine 1
    Clin Calcium 18:904-11. 2008
    ..Thus, converting fat into muscle tissue by regular exercise and healthy diet helps not only prevent hyperglycemia but also osteoporosis...
  69. ncbi request reprint [Impaired bone mineralization in calcium-sensing receptor (CaSR) knockout mice : the physiological action of CaSR in bone microenvironments]
    Toru Yamaguchi
    Shimane University, Faculty of Medicine, Internal Medicine 1
    Clin Calcium 17:1567-73. 2007
    ..These findings suggest that CaSR activation in chondrocytes and osteoblasts may stimulate bone remodeling in bone microenvironments...
  70. doi request reprint [Osteoporosis associated with the metabolic syndrome]
    Toru Yamaguchi
    Shimane University, Faculty of Medicine, Internal Medicine 1
    Clin Calcium 18:606-11. 2008
    ..Thus, BMD and fracture risk in patients with the metabolic syndrome may be determined by the balance between beneficial effects of obesity and dyslipidemia versus detrimental ones of hyperglycemia on bone...