- Udagawa J, Hatta T, Hashimoto R, Otani H. Roles of leptin in prenatal and perinatal brain development. Congenit Anom (Kyoto). 2007;47:77-83 pubmed....
- Udagawa J, Hashimoto R, Suzuki H, Hatta T, Sotomaru Y, Hioki K, et al. The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology. 2006;147:647-58 pubmed..The neuropeptide Y mRNA level in the cortical plate was lower in ob/ob than the wild type at E16 and E18. These results suggest that leptin maintains neural progenitors and is related to glial and neuronal development in embryos. ..
- Udagawa J, Hashimoto R, Hioki K, Otani H. The role of leptin in the development of the cortical neuron in mouse embryos. Brain Res. 2006;1120:74-82 pubmed..These results suggest that leptin promotes the migration of neuronal lineage cells to CP and that the leptin-NPY axis in neurons works in the cerebral cortex on E16. ..
- Udagawa J, Ono A, Kawamoto M, Otani H. Leptin and its intracellular signaling pathway maintains the neurosphere. Neuroreport. 2010;21:1140-5 pubmed publisher..These results suggest that leptin maintains the self-renewal ability and EGF reactivity of immature neural lineage cells and the signal is mediated, at least in part, by the PI3 K pathway. ..