Ken ichiro Tanaka
Affiliation: Shimane University
Kanazawa I, Tanaka K, Takeo A, Notsu M, Miyake H, Sugimoto T. A scoring assessment tool for the risk of vertebral fractures in patients with type 2 diabetes mellitus. Bone. 2019;122:38-44 pubmed publisher
Kanazawa I, Takeno A, Tanaka K, Notsu M, Sugimoto T. Osteoblast AMP-activated protein kinase regulates glucose metabolism and bone mass in adult mice. Biochem Biophys Res Commun. 2018;503:1955-1961 pubmed publisher
..This is the first study to show that osteoblast AMPK plays an important roles in glucose metabolism and in maintaining trabecular bone volume, cortical thickness, and bone strength in adult mice. ..
Tanaka K, Yamaguchi T, Kanazawa I, Sugimoto T. Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells. Biochem Biophys Res Commun. 2015;461:193-9 pubmed publisher
..In addition, HG and AGEs may cause cortical bone deterioration by inducing osteocyte apoptosis. PTH may effectively treat these pathological processes and improve osteocyte function. ..
Tanaka K, Kanazawa I, Sugimoto T. Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus. Calcif Tissue Int. 2015;97:385-90 pubmed publisher
..05). In conclusion, reduction in endogenous insulin secretion is an independent risk factor of sarcopenia in men with T2DM. ..
Takeno A, Kanazawa I, Tanaka K, Notsu M, Yokomoto M, Yamaguchi T, et al
. Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expressions of NADPH oxidase 1 (Nox1) and Nox2. Bone. 2015;77:135-41 pubmed publisher
..Thus, AMPK activation may be a potent therapeutic candidate for preventing Hcy-induced osteocyte apoptosis and the resulting bone fragility. ..
Takeno A, Kanazawa I, Notsu M, Tanaka K, Sugimoto T. Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells. Int J Mol Sci. 2018;19: pubmed publisher
..The adipogenic effects of phloretin were independent of glucose uptake inhibition. Phloretin may affect energy metabolism by influencing adipogenesis and adiponectin expression. ..
Tanaka K, Kanazawa I, Sugimoto T. Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2016;122:141-147 pubmed publisher
..30, p=0.146 and ?=-0.30, p=0.085, respectively). Reduced muscle mass and increased visceral fat are independently associated with increased arterial stiffness in postmenopausal women with T2DM. ..
Tanaka K, Matsumoto E, Higashimaki Y, Sugimoto T, Seino S, Kaji H. FAM5C is a soluble osteoblast differentiation factor linking muscle to bone. Biochem Biophys Res Commun. 2012;418:134-9 pubmed publisher
..FAM5C might be an important humoral bone anabolic factor produced from muscle cells. ..
Tanaka K, Inoue Y, Hendy G, Canaff L, Katagiri T, Kitazawa R, et al
. Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells. Bone. 2012;51:158-67 pubmed publisher
..Tmem119 may play a critical role in the commitment of myoprogenitor cells to the osteoblast lineage. ..