Toshitsugu Sugimoto

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. Kanazawa I, Tanaka K, Takeo A, Notsu M, Miyake H, Sugimoto T. A scoring assessment tool for the risk of vertebral fractures in patients with type 2 diabetes mellitus. Bone. 2019;122:38-44 pubmed publisher
  2. Kanazawa I, Takeno A, Tanaka K, Notsu M, Sugimoto T. Osteoblast AMP-activated protein kinase regulates glucose metabolism and bone mass in adult mice. Biochem Biophys Res Commun. 2018;503:1955-1961 pubmed publisher
    ..This is the first study to show that osteoblast AMPK plays an important roles in glucose metabolism and in maintaining trabecular bone volume, cortical thickness, and bone strength in adult mice. ..
  3. Miyake H, Kanazawa I, Sugimoto T. Albuminuria Increases All-Cause Mortality in Japanese Patients with Type 2 Diabetes Mellitus. J Clin Med. 2018;7: pubmed publisher
    ..73 m²). However, because of several limitations, further large-scale longitudinal studies are necessary to confirm the present study. ..
  4. Tanaka K, Yamaguchi T, Kanazawa I, Sugimoto T. Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells. Biochem Biophys Res Commun. 2015;461:193-9 pubmed publisher
    ..In addition, HG and AGEs may cause cortical bone deterioration by inducing osteocyte apoptosis. PTH may effectively treat these pathological processes and improve osteocyte function. ..
  5. Tanaka K, Kanazawa I, Sugimoto T. Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus. Calcif Tissue Int. 2015;97:385-90 pubmed publisher
    ..05). In conclusion, reduction in endogenous insulin secretion is an independent risk factor of sarcopenia in men with T2DM. ..
  6. Takeno A, Kanazawa I, Tanaka K, Notsu M, Yokomoto M, Yamaguchi T, et al. Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expressions of NADPH oxidase 1 (Nox1) and Nox2. Bone. 2015;77:135-41 pubmed publisher
    ..Thus, AMPK activation may be a potent therapeutic candidate for preventing Hcy-induced osteocyte apoptosis and the resulting bone fragility. ..
  7. Takeno A, Kanazawa I, Notsu M, Tanaka K, Sugimoto T. Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..The adipogenic effects of phloretin were independent of glucose uptake inhibition. Phloretin may affect energy metabolism by influencing adipogenesis and adiponectin expression. ..
  8. Tanaka S, Kanazawa I, Notsu M, Sugimoto T. Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2016;116:1-6 pubmed publisher
    ..09-2.88 per SD increase, p=0.02, respectively]. The present study showed that serum DPP-4 level was positively and specifically associated with accumulation of visceral fat and the presence of metabolic syndrome in men with T2DM. ..
  9. Koike S, Yano S, Tanaka S, Sheikh A, Nagai A, Sugimoto T. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17: pubmed publisher
    ..These findings might be important to understand the pathogenesis of vascular calcification in diabetes and CKD. ..

More Information

Publications14

  1. Tanaka K, Kanazawa I, Sugimoto T. Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2016;122:141-147 pubmed publisher
    ..30, p=0.146 and ?=-0.30, p=0.085, respectively). Reduced muscle mass and increased visceral fat are independently associated with increased arterial stiffness in postmenopausal women with T2DM. ..
  2. Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T. Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol. 2007;8:51 pubmed
    ..Taken together, this study suggests that adiponectin stimulates the proliferation, differentiation, and mineralization of osteoblasts via the AdipoR1 and AMP kinase signaling pathways in autocrine and/or paracrine fashions. ..
  3. Yokomoto Umakoshi M, Kanazawa I, Takeno A, Tanaka K, Notsu M, Sugimoto T. Activation of AMP-activated protein kinase decreases receptor activator of NF-κB ligand expression and increases sclerostin expression by inhibiting the mevalonate pathway in osteocytic MLO-Y4 cells. Biochem Biophys Res Commun. 2016;469:791-6 pubmed publisher
    ..These findings indicated that AMPK regulated RANKL and sclerostin expression through the mevalonate pathway in osteocytes. ..
  4. Tanaka K, Kanazawa I, Kaji H, Sugimoto T. Association of osteoglycin and FAM5C with bone turnover markers, bone mineral density, and vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Bone. 2017;95:5-10 pubmed publisher
    ..The present study showed for the first time that higher serum OGN levels were associated with decreased BMD and increased risk of vertebral fractures in postmenopausal women with T2DM. ..
  5. Sugimoto T, Shiraki M, Fukunaga M, Hagino H, Sone T, Nakano T, et al. 24-Month Open-Label Teriparatide Once-Weekly Efficacy Research Trial Examining Bone Mineral Density in Subjects with Primary Osteoporosis and High Fracture Risk. Adv Ther. 2017;34:1727-1740 pubmed publisher
    ..The limitation of this study is that this was an open-label, single-arm study. Asahi Kasei Pharma Corporation. JapicCTI-132276. ..