Kohji Nishimura

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. ncbi request reprint Regulation of apoptosis through arachidonate cascade in mammalian cells
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Matsue, Japan
    Appl Biochem Biotechnol 102:239-50. 2002
  2. ncbi request reprint Control of life cycle of mouse adipogenic 3T3-L1 cells by dietary lipids and metabolic factors
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Matsue, 690 8504, Japan
    Appl Biochem Biotechnol 118:97-114. 2004
  3. doi request reprint 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes
    Abu Asad Chowdhury
    Department of Life Science and Biotechnology, Shimane University, Nishikawatsu cho, Matsue, Japan
    Prostaglandins Other Lipid Mediat 95:53-62. 2011
  4. doi request reprint A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes
    Pinky Karim Syeda
    Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane, Japan
    Hybridoma (Larchmt) 31:364-71. 2012
  5. doi request reprint Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids
    Mohammad Salim Hossain
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Exp Cell Res 318:408-15. 2012
  6. ncbi request reprint Endogenous prostaglandins E2 and F 2alpha serve as an anti-apoptotic factor against apoptosis induced by tumor necrosis factor-alpha in mouse 3T3-L1 preadipocytes
    Kohji Nishimura
    Department of Molecular and Functional Genomics, Center for Integrated Research in Science, Shimane University, Matsue, Shimane, Japan
    Biosci Biotechnol Biochem 70:2145-53. 2006
  7. doi request reprint Suppression of adipogenesis program in cultured preadipocytes transfected stably with cyclooxygenase isoforms
    Xiaoqing Chu
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Biochim Biophys Acta 1791:273-80. 2009
  8. ncbi request reprint Prostaglandin F(2alpha) is protective for apoptosis stimulated synergistically with 12-O-tetradecanoyl phorbol-beta-acetate and nordihydroguaiaretic acid in Madin-Darby canine kidney cells
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Biochim Biophys Acta 1682:102-11. 2004
  9. doi request reprint Up-regulation of adipogenesis in adipocytes expressing stably cyclooxygenase-2 in the antisense direction
    Xiaoqing Chu
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Prostaglandins Other Lipid Mediat 91:1-9. 2010
  10. ncbi request reprint Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes
    Mohammad Sharifur Rahman
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane, 690 8504, Japan
    Appl Biochem Biotechnol 171:128-44. 2013

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Regulation of apoptosis through arachidonate cascade in mammalian cells
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Matsue, Japan
    Appl Biochem Biotechnol 102:239-50. 2002
    ..We found that conjugated linolenic acid from bitter gourd was able to induce apoptosis in mouse preadipogenic 3T3-L1 cells. The findings provide the potential use of conjugated fatty acids to regulate obesity...
  2. ncbi request reprint Control of life cycle of mouse adipogenic 3T3-L1 cells by dietary lipids and metabolic factors
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Matsue, 690 8504, Japan
    Appl Biochem Biotechnol 118:97-114. 2004
    ..Therefore, dietary lipid factors are capable of controlling the life cycle of adipocytes together with metabolic factors...
  3. doi request reprint 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes
    Abu Asad Chowdhury
    Department of Life Science and Biotechnology, Shimane University, Nishikawatsu cho, Matsue, Japan
    Prostaglandins Other Lipid Mediat 95:53-62. 2011
    ..Taken together, 15d-PGJ(2) can interfere the COX pathway leading to the induced synthesis of endogenous PGs that contribute to negative regulation of adipogenesis program in preadipocytes...
  4. doi request reprint A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes
    Pinky Karim Syeda
    Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane, Japan
    Hybridoma (Larchmt) 31:364-71. 2012
    ..These results indicate the reliability and usefulness of our solid-phase ELISA for stable Δ(12)-PGJ(2), reflecting the biosynthesis of unstable PGD(2) in the culture system of adipocytes...
  5. doi request reprint Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids
    Mohammad Salim Hossain
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Exp Cell Res 318:408-15. 2012
    ....
  6. ncbi request reprint Endogenous prostaglandins E2 and F 2alpha serve as an anti-apoptotic factor against apoptosis induced by tumor necrosis factor-alpha in mouse 3T3-L1 preadipocytes
    Kohji Nishimura
    Department of Molecular and Functional Genomics, Center for Integrated Research in Science, Shimane University, Matsue, Shimane, Japan
    Biosci Biotechnol Biochem 70:2145-53. 2006
    ..These results indicate that endogenous PGE2 and PGF 2alpha synthesized by preadipocytes through the induction of COX-2 can serve as anti-apoptotic factors against apoptosis by TNF-alpha...
  7. doi request reprint Suppression of adipogenesis program in cultured preadipocytes transfected stably with cyclooxygenase isoforms
    Xiaoqing Chu
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Biochim Biophys Acta 1791:273-80. 2009
    ..Taken together, the results suggest that the sustained overexpression of either COX-1 or COX-2 resulted in the interference of adipogenesis program through a PG-independent mechanism with a different mode of action of COX isoforms...
  8. ncbi request reprint Prostaglandin F(2alpha) is protective for apoptosis stimulated synergistically with 12-O-tetradecanoyl phorbol-beta-acetate and nordihydroguaiaretic acid in Madin-Darby canine kidney cells
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Biochim Biophys Acta 1682:102-11. 2004
    ..Consistent with this indication, exogenous addition of PGF(2alpha), a predominant prostanoid in MDCK cells, was the most potent to protect the cells from the apoptosis induced by a mixture of TPA and NDGA...
  9. doi request reprint Up-regulation of adipogenesis in adipocytes expressing stably cyclooxygenase-2 in the antisense direction
    Xiaoqing Chu
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Prostaglandins Other Lipid Mediat 91:1-9. 2010
    ..These results suggest that COX-2 is more preferentially involved in the generation of endogenous anti-adipogenic prostanoids during the maturation phase of adipocytes...
  10. ncbi request reprint Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes
    Mohammad Sharifur Rahman
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane, 690 8504, Japan
    Appl Biochem Biotechnol 171:128-44. 2013
    ....
  11. ncbi request reprint Gene expression of isoformic enzymes in arachidonate cyclooxygenase pathway and the regulation by tumor necrosis factor alpha during life cycle of adipocytes
    Li Xu
    Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690 8504, Japan
    Prostaglandins Other Lipid Mediat 83:213-8. 2007
    ..The action of TNFalpha on preadipocytes can be modulated by the production of endogenous PGs through the induction of COX-2...
  12. doi request reprint Development of enzyme-linked immunosorbent assay for 8-iso-prostaglandin F2alpha, a biomarker of oxidative stress in vivo, and its application to the quantification in aged rats
    Xiaoqing Chu
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    J Pharm Biomed Anal 50:911-6. 2009
    ..These results indicate the utility and accuracy of our ELISA for 8-iso-PGF2alpha as a biomarker in vivo to assess systemic oxidative stress in animals or humans as well as oxidative injury at local sites...
  13. doi request reprint Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹⁴-prostaglandin J₂ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes
    Pinky Karim Syeda
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Appl Biochem Biotechnol 167:1107-18. 2012
    ..The results indicate the usefulness of our developed solid-phase ELISA with the monoclonal antibody for further studies on the endogenous synthesis of 15d-PGJ₂ and its roles in various cells and tissues...
  14. doi request reprint Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes
    Mohammad Salim Hossain
    Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690 8504, Japan
    Gene 502:138-41. 2012
    ..These findings suggest that the expression of MCP-1 involved in adipocyte inflammation could be positively regulated by the PGJ(2) series during adipogenesis in adipose tissue...
  15. ncbi request reprint Prostaglandin F2alpha protected cultured Madin-Darby canine kidney cells from the development of apoptosis induced by 12-o-tetradecanoyl phorbol-beta-acetate and stimulated synergistically with nordihydroguaiaretic acid
    Kohji Nishimura
    Department of Life Science and Biotechnology, Shimane University, Matsue, Japan
    Adv Exp Med Biol 525:177-80. 2003
  16. ncbi request reprint Development of enzyme-linked immunosorbent assay for prostaglandin D2 using the stable isosteric analogue as a hapten mimic and its application
    Md Abdul Mazid
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Prostaglandins Other Lipid Mediat 83:219-24. 2007
    ..The conversion became more evident after 6 h of the incubation. These findings indicate the importance of considering the optimal time for collecting the samples to be determined for PGD(2) before the conversion starts to occur...
  17. doi request reprint Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes
    Abu Asad Chowdhury
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Biochem Biophys Res Commun 411:287-92. 2011
    ..These results suggest that the stably reduced expression levels of L-PGDS regulates positively adipogenesis program in a cellular mechanism independent of pro-adipogenic action of PGJ(2) series...
  18. ncbi request reprint Regulation and role of arachidonate cascade during changes in life cycle of adipocytes
    Shan Lu
    Department of Life Science and Biotechnology, Shimane University, Matsue, 690 8504, Japan
    Appl Biochem Biotechnol 118:133-53. 2004
    ..These findings imply the specific roles of prostanoids produced by the mature adipocytes in the maintenance of terminal differentiation through an autocrine control mechanism...
  19. doi request reprint Development of enzyme-linked immunosorbent assay for Δ12-prostaglandin J2 and its application to the measurement of the endogenous product generated by cultured adipocytes during the maturation phase
    Mohammad Salim Hossain
    Department of Life Science and Biotechnology, Shimane University, 1060 Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Prostaglandins Other Lipid Mediat 94:73-80. 2011
    ....
  20. ncbi request reprint Gene expression of arachidonate cyclooxygenase pathway leading to the delayed synthesis of prostaglandins E2 and F2alpha in response to phorbol 12-myristate 13-acetate and action of these prostanoids during life cycle of adipocytes
    Li Xu
    Department of Life Science and Biotechnology, Shimane University, Nishikawatsu cho, Matsue, Shimane 690 8504, Japan
    Biochim Biophys Acta 1761:434-44. 2006
    ....
  21. ncbi request reprint Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage
    Md Abdul Mazid
    Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690 8504, Japan
    FEBS Lett 580:6885-90. 2006
    ..Further studies using cyclooxygenase inhibitors clarified the contribution of endogeous 15d-PGJ(2) produced by mature adipocytes to upregulation of fat storage in an autocrine manner...
  22. ncbi request reprint Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes
    Shan Lu
    Department of Life Science and Biotechnology, Shimane University, Matsue, Japan
    Adv Exp Med Biol 525:153-6. 2003
  23. ncbi request reprint Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist
    Mitsuo Jisaka
    Department of Life Science and Biotechnology, Shimane University, Matsue, Shimane 690 8504, Japan
    Biochem Biophys Res Commun 338:136-43. 2005
    ..The present results suggest that 8S,15S-diH(P)ETE as well as 8S-H(P)ETE would contribute to the physiological function of 8-LOX and also that 8-LOX can function as a potential 15-LOX...
  24. ncbi request reprint Molecular cloning, functional expression, and tissue distribution of a potato sprout allene oxide synthase involved in a 9-lipoxygenase pathway
    Darika Kongrit
    Division of Applied Resources Chemistry, Course of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan
    Biosci Biotechnol Biochem 70:2160-8. 2006
    ..Besides sprouts, the mRNA of this AOS was detected in buds, flowers, and stems, but not in leaves, tubers, or roots of mature plants, suggesting that this enzyme has a tissue-specific function...
  25. ncbi request reprint Arachidonate 12-lipoxygenases with reference to their selective inhibitors
    Shozo Yamamoto
    Department of Food and Nutrition, Faculty of Home Economics, Kyoto Women s University, Imakumano, Higashiyama ku, Kyoto 605 8501, Japan
    Biochem Biophys Res Commun 338:122-7. 2005
    ..14 microM. The compound was much less active with 12-lipoxygenase of leukocyte-type, 15-, 8-, and 5-lipoxygenases, and cyclooxygenases-1 and -2...
  26. ncbi request reprint Molecular cloning and functional expression of soybean allene oxide synthases
    Darika Kongrit
    Division of Applied Resources Chemistry, The United Graduate School of Agricultural Sciences, Tottori University, Koyama Minami, Tottori, Japan
    Biosci Biotechnol Biochem 71:491-8. 2007
    ..GmAOS1 and GmAOS2 were expressed in leaves, stems, and roots, suggesting broad distribution in a soybean plant...