Kentaro Nakayama

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. doi request reprint Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, 6938501, Japan
    Gynecol Oncol 117:409-16. 2010
  2. pmc Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas
    M T Rahman
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Br J Cancer 107:300-7. 2012
  3. pmc EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target
    K Iida
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Br J Cancer 105:420-7. 2011
  4. pmc KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
    N Nakayama
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Br J Cancer 99:2020-8. 2008
  5. ncbi request reprint Surgical treatment outcomes of serious chronic tubo-ovarian abscess: a single-center series of 20 cases
    K Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Clin Exp Obstet Gynecol 40:377-80. 2013
  6. pmc KRAS and MAPK1 Gene Amplification in Type II Ovarian Carcinomas
    Mohammed Tanjimur Rahman
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Int J Mol Sci 14:13748-62. 2013
  7. pmc A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies
    Munmun Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan
    Int J Mol Sci 14:6067-73. 2013
  8. ncbi request reprint PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes
    Munmun Rahman
    Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane, 6938501, Japan
    Anticancer Res 33:113-8. 2013
  9. doi request reprint Uterine leiomyosarcoma producing granulocyte colony stimulating factor
    Kentaro Nakayama
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Int J Gynecol Pathol 31:172-177. 2012
  10. doi request reprint Prolonged long-term survival of low-grade endometrial stromal sarcoma patients with lung metastasis following treatment with medroxyprogesterone acetate
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89 1 Enyacho, Izumo 693 8501, Japan
    Int J Clin Oncol 15:179-83. 2010

Collaborators

Detail Information

Publications60

  1. doi request reprint Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, 6938501, Japan
    Gynecol Oncol 117:409-16. 2010
    ..The aim of this study was to clarify the functional role of Notch3 in human cervical carcinomas...
  2. pmc Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas
    M T Rahman
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Br J Cancer 107:300-7. 2012
    ....
  3. pmc EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target
    K Iida
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Br J Cancer 105:420-7. 2011
    ....
  4. pmc KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
    N Nakayama
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Br J Cancer 99:2020-8. 2008
    ..Furthermore, they suggest that the CI-1040-induced phenotypes depend on the mutational status of KRAS and BRAF in ovarian cancers. Therefore, ovarian cancer patients with KRAS or BRAF mutations may benefit from CI-1040 treatment...
  5. ncbi request reprint Surgical treatment outcomes of serious chronic tubo-ovarian abscess: a single-center series of 20 cases
    K Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Clin Exp Obstet Gynecol 40:377-80. 2013
    ..In addition, the chances for recurrence of inflammation can be lessened by thorough intraperitoneal irrigation and insertion of a drainage tube...
  6. pmc KRAS and MAPK1 Gene Amplification in Type II Ovarian Carcinomas
    Mohammed Tanjimur Rahman
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Int J Mol Sci 14:13748-62. 2013
    ..Additionally, RAS/RAF/MEK/ERK pathway-targeted therapy may benefit selected patients with type II ovarian carcinoma harboring KRAS/MAPK1 amplifications. ..
  7. pmc A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies
    Munmun Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan
    Int J Mol Sci 14:6067-73. 2013
    ..The present case suggests a role for targeted therapies in the treatment of OCCC and a need for the identification of biomarkers that will predict response to targeted therapies...
  8. ncbi request reprint PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes
    Munmun Rahman
    Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane, 6938501, Japan
    Anticancer Res 33:113-8. 2013
    ..This study indicates that the PPP2R1A mutation occurs at a lower frequency compared to other gynecological malignancies, irrespective of the histological subtype...
  9. doi request reprint Uterine leiomyosarcoma producing granulocyte colony stimulating factor
    Kentaro Nakayama
    Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Int J Gynecol Pathol 31:172-177. 2012
    ..tumor cells were distinctly positive for GCSF on immunohistochemistry. These findings confirmed the diagnosis of a GCSF-producting uterine leiomyosarcoma with a paraneoplastic leukocytosis...
  10. doi request reprint Prolonged long-term survival of low-grade endometrial stromal sarcoma patients with lung metastasis following treatment with medroxyprogesterone acetate
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89 1 Enyacho, Izumo 693 8501, Japan
    Int J Clin Oncol 15:179-83. 2010
    ..The aim of this study was to investigate the usefulness of medroxyprogesterone acetate (MPA) therapy for patients with metastatic low-grade endometrial stromal sarcoma (LGESS)...
  11. ncbi request reprint A comparative study between microwave endometrial ablation and conventional surgical procedures for treatment of menorrhagia
    K Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan
    Clin Exp Obstet Gynecol 38:33-7. 2011
    ..To compare microwave endometrial ablation (MEA) using a new curved applicator with conventional surgical procedures in 26 patients with menorrhagia...
  12. doi request reprint Microwave endometrial ablation is a highly efficacious way to emergently control life-threatening uterine hemorrhage
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane 6938501, Japan
    Arch Gynecol Obstet 283:1065-8. 2011
    ..To asses the effectiveness of microwave endometrial ablation (MEA) using a new curved applicator for the emergent control of uterine hemorrhage...
  13. doi request reprint Biological role and prognostic significance of NAC1 in ovarian cancer
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane, Japan
    Gynecol Oncol 119:469-78. 2010
    ..This study examined the biological and clinical significance of NAC1 expression in ovarian cancer and assessed whether NAC1 has the potential to be a therapeutic target...
  14. doi request reprint Concomitant postoperative radiation and chemotherapy following surgery was associated with improved overall survival in patients with FIGO stages III and IV endometrial cancer
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89 1 Enyacho, Izumo, 693 8501, Japan
    Int J Clin Oncol 15:440-6. 2010
    ..The aim of this study was to investigate the usefulness of concomitant postoperative radiation and chemotherapy in patients with the International Federation of Gynecology and Obstetrics (FIGO) stages III and IV endometrial cancer...
  15. doi request reprint Loss of MKK4 expression in ovarian cancer: a potential role for the epithelial to mesenchymal transition
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan
    Int J Cancer 128:94-104. 2011
    ..Our results suggest that MKK4 downregulation causes increased phosphorylation NF-κB. This promotes Twist over-expression, resulting in E-cadherin downregulation that induces EMT in ovarian cancer...
  16. ncbi request reprint Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer
    Mohammed Tanjimur Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Am J Clin Pathol 138:535-44. 2012
    ..Our findings suggest that Notch3 expression may be related to chemoresistance and that the Notch3 pathway may represent a novel therapeutic target for advanced stage chemoresistant ovarian cancer...
  17. doi request reprint Biological and clinical significance of NAC1 expression in cervical carcinomas: a comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane 6938501, Japan
    Hum Pathol 43:506-19. 2012
    ..Therefore, cervical carcinoma patients with NAC1 expression may benefit from a targeted therapy irrespective of histologic type...
  18. doi request reprint A BTB/POZ gene, NAC-1, a tumor recurrence-associated gene, as a potential target for Taxol resistance in ovarian cancer
    Masako Ishibashi
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Tohoku University, Sendai, Japan
    Clin Cancer Res 14:3149-55. 2008
    ..In the current study, we investigated further the relationship between NAC-1 expression and ovarian cancer...
  19. ncbi request reprint Evaluation of the antiangiogenic effect of Taxol in a human epithelial ovarian carcinoma cell line
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, 693 8501, Izumo, Japan
    Cancer Chemother Pharmacol 53:68-74. 2004
    ..In the present study, a human ovarian cancer cell line was used to investigate the possibility that Taxol might affect the expression of Ang-1, Ang-2, and VEGF...
  20. doi request reprint Is ATP7B a predictive marker in patients with ovarian carcinoma treated with platinum-taxane combination chemotherapy?
    Hiroshi Katagiri
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Int J Gynecol Cancer 23:60-4. 2013
    ..This study examined the prognostic significance of copper-transporting P-type adenosine triphosphatase (ATP7B) expression in patients with ovarian carcinoma treated with platinum-taxane combination chemotherapy...
  21. doi request reprint Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma
    Atsuko Katagiri
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Mod Pathol 25:282-8. 2012
    ..Measurement of ARID1A expression may be a method to predict resistance to platinum-based chemotherapy in patients with ovarian clear cell carcinoma...
  22. doi request reprint Functional and clinicopathological analysis of loss of MKK4 expression in endometrial cancer
    Masako Ishikawa
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Oncology 79:238-46. 2010
    ..In the current study, we investigated the mechanism relating downregulation of mitogen-activated protein kinase kinase-4 (MKK4) expression to the development of endometrial cancer...
  23. ncbi request reprint Induction of thymidine phosphorylase expression and enhancement of Furtulon sensitivity by Taxol in a human ovarian carcinoma cell line
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693 8501, Japan
    Anticancer Res 23:2665-9. 2003
    ..The aim of this study was to determine whether Paclitaxel (Taxol) induces TP expression and whether increased TP expression is further sensitized to Furtulon, using a human ovarian carcinoma cell line...
  24. ncbi request reprint NAC1, a potential stem cell pluripotency factor expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma
    Masako Ishikawa
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane 693 8501, Japan
    Int J Oncol 36:1097-103. 2010
    ..Endometrial carcinomas with NAC1 overexpression are clinically aggressive, high-grade carcinomas. Therefore, detection of NAC1 overexpression in endometrial cancers may identify patients who will benefit from NAC1 targeted therapy...
  25. doi request reprint Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer
    Mohammed Tanjimur Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Oncology 84:166-73. 2013
    ..In the current study we investigated the clinicopathological significance of fatty acid synthase (FASN) expression and its relationship with estrogen receptor (ER) and progesterone receptor (PR) in endometrioid endometrial cancer...
  26. doi request reprint Expression of the bric-a-brac tramtrack broad complex protein NAC-1 in cervical carcinomas seems to correlate with poorer prognosis
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan
    Clin Cancer Res 14:1686-91. 2008
    ..The aim of this study was to clarify the functional role of NAC-1 in human cervical carcinomas...
  27. doi request reprint Clinicopathologic analysis of loss of AT-rich interactive domain 1A expression in endometrial cancer
    Munmun Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, 6938501, Japan
    Hum Pathol 44:103-9. 2013
    ..No significant differences between positive and negative cases of AT-rich interactive domain 1A were observed with respect to any clinicopathologic features or patient survival...
  28. ncbi request reprint Gene amplification of ZNF217 located at chr20q13.2 is associated with lymph node metastasis in ovarian clear cell carcinoma
    Mohammed Tanjimur Rahman
    Department of Obstetrics, Shimane University School of Medicine, Shimane, Japan
    Anticancer Res 32:3091-5. 2012
    ..This study sought to determine the mechanism by which ZNF217 amplification affects patient survival...
  29. ncbi request reprint NAC1, a BTB/POZ protein overexpressed in uterine sarcomas
    Mohammed Tanjimur Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan
    Anticancer Res 32:3841-5. 2012
    ..The purpose of this study was to investigate the role of Nucleus accumbens-associated 1 (NAC1) in the development of uterine sarcomas...
  30. doi request reprint MKK4 acts as a potential tumor suppressor in ovarian cancer
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane, 6938501, Japan
    Tumour Biol 32:661-70. 2011
    ..Similar results were produced in tumor xenografts in nude mice. These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer...
  31. ncbi request reprint [Paclitaxel + carboplatin (TC)-resistant stage Ic squamous cell carcinomas arising in mature cystic teratomas of the ovary]
    Masako Ishikawa
    Department of Obstetrics and Gynecology, Shimane University School of Medicine
    Gan To Kagaku Ryoho 37:747-52. 2010
    ..However, her breast cancer recurrence was exacerbated and she died. The results of TAE, however, showed that it may be an effective second-line therapy for recurrent squamous cell carcinoma arising from a mature cystic teratoma...
  32. ncbi request reprint Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer
    Kohkichi Hata
    Department of Obstetrics and Gynecology, University School of Medicine, Izumo 693 8501, Japan
    Gynecol Oncol 93:215-22. 2004
    ..The aim was to evaluate whether angiopoietin/Tie2 system with VEFG affects prognosis in patients of epithelial ovarian cancer...
  33. doi request reprint Expression of a BTB/POZ protein, NAC1, is essential for the proliferation of normal cyclic endometrial glandular cells and is up-regulated by estrogen
    Masako Ishibashi
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan
    Clin Cancer Res 15:804-11. 2009
    ..The purpose of this study was to investigate the expression and localization of NAC1, a member of the BTB/POZ gene family in the human cyclic endometrium...
  34. ncbi request reprint ESR1 gene amplification in endometrial carcinomas: a clinicopathological analysis
    Mohammed Tanjimur Rahman
    Shimane University School of Medicine, Enyacho 89 1, Izumo, Shimane, 6938501 Japan
    Anticancer Res 33:3775-81. 2013
    ....
  35. doi request reprint Frequent loss of tumor suppressor ARID1A protein expression in adenocarcinomas/adenosquamous carcinomas of the uterine cervix
    Atsuko Katagiri
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan
    Int J Gynecol Cancer 22:208-12. 2012
    ..This study investigated whether ARID1A expression was also lost in cervical squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas...
  36. ncbi request reprint Dihydropyrimidine dehydrogenase in normal and malignant endometrium: relationship with cell proliferation and thymidine phosphorylase
    Ritsuto Fujiwaki
    Department of Obstetrics and Gynecology, Shimane Medical University, 693 8501, Izumo, Japan
    Virchows Arch 443:672-7. 2003
    ..DPD may act cooperatively with TP to affect cell function by maintaining the pyrimidine nucleotide pool balance in normal and malignant endometrium...
  37. doi request reprint Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma
    Munmun Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693 8501, Japan
    Hum Pathol 43:2197-206. 2012
    ..Although PIK3CA mutations were associated with a more favorable prognosis, they did not predict the sensitivity of ovarian clear cell carcinoma cells to PI3K/AKT/mTOR inhibitors...
  38. doi request reprint Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma
    Mohammed Tanjimur Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Cancer 118:2846-57. 2012
    ..The goal of this study was to examine the clinical significance of ZNF217 amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian clear cell carcinoma (OCCC)...
  39. pmc Microwave endometrial ablation as an alternative to hysterectomy for the emergent control of uterine bleeding in patients who are poor surgical candidates
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane, Japan
    Arch Gynecol Obstet 280:279-82. 2009
    ..Microwave endometrial ablation is a new, minimally invasive treatment option for menorrhagia. Its popularity in many countries is increasing due to its safety and simplicity...
  40. ncbi request reprint [A case of stage IVb cervical carcinoma in which survival was prolonged by two different chemotherapies and CCRT]
    Masako Ishikawa
    Dept of Obstetrics and Gynecology, Shimane University School of Medicine, Japan
    Gan To Kagaku Ryoho 39:451-5. 2012
    ..A lung biopsy at that time showed no evidence of malignancy, and the patient has remained without any evidence of disease for the past six years...
  41. ncbi request reprint Induction of thymidine phosphorylase expression by Taxol does not enhance Furtulon sensitivity in a cisplatin-resistant human ovarian carcinoma cell line
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693 8501, Japan
    Anticancer Res 23:1525-31. 2003
    ..Next, if lower TP expression correlated with decreased sensitivity to Furtulon, we planned to investigate the possibility that increased TP expression induced by Paclitaxel (Taxol) exposure might increase the sensitivity to Furtulon...
  42. doi request reprint Sister Mary Joseph's nodule associated with rare endometrial squamous cell carcinoma
    Mohammed Tanjimur Rahman
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89 1 Enyacho, Izumo, Shimane, 6938501, Japan
    Arch Gynecol Obstet 286:711-5. 2012
    ..Here, we present a case of Sister Mary Joseph's (SMJN) nodule originating from a primary squamous cell carcinoma of the endometrium, a rare histological subtype...
  43. ncbi request reprint The proliferative activity of ovarian tumors of low malignant potential differs from that of ovarian carcinoma
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane Medical University, Enyacho 89 1, Izumo 693 8501, Japan
    Anticancer Res 23:4657-62. 2003
    ..In contrast, the similar associations of proliferative activity with tumor size in the serous subtype of LMP and OC suggest that serous LMPs may be precursors of serous OCs...
  44. ncbi request reprint Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer
    Naomi Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Cancer 116:2621-34. 2010
    ..This study examined the clinical significance of CCNE1 (Cyclin E1) amplification and assessed whether CCNE1 is a potential therapeutic target in ovarian cancer...
  45. doi request reprint Low expression of nucleus accumbens-associated protein 1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma
    Takeshi Nishi
    Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Japan
    Pathol Int 62:802-10. 2012
    ..These results indicate that the gene(s) regulated by NAC1 vary depending on the types of carcinoma or originating tissue, and that low expression of NAC1 predicts poor prognosis for patients with PDA...
  46. ncbi request reprint Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy
    Kentaro Nakayama
    Department of Obstetrics, Shimane Medical University, Izumo, Japan
    Clin Cancer Res 10:2804-11. 2004
    ..Our goal was to investigate ATP7B expression in ovarian carcinoma and whether its expression correlates with prognosis and reduced responsiveness to cisplatin treatment...
  47. ncbi request reprint Genetic classification of ovarian carcinoma based on microsatellite analysis: relationship to clinicopathological features and patient survival
    Zhang Huan
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693 8501, P R China
    Oncol Rep 19:775-81. 2008
    ....
  48. ncbi request reprint [A case of postoperative rapid brain metastasis originating from stage II a cervical adenosquamous cell carcinoma]
    Masako Ishikawa
    Dept of Obstetrics and Gynecology, Shimane University School of Medicine, Japan
    Gan To Kagaku Ryoho 38:133-7. 2011
    ..The extremely rapid progression of this patient's disease is unusual. To our knowledge, this is one of the most aggressive cases of cervical adenosquamous cell carcinoma documented...
  49. ncbi request reprint Allelotypes as potential prognostic markers in ovarian carcinoma treated with cisplatin-based chemotherapy
    Satoru Nakayama
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Int J Mol Med 11:621-5. 2003
    ..Furthermore, the association of FAL value with therapy response indicated that ovarian carcinomas with high levels of chromosomal alteration may be more resistant to this type of chemotherapy...
  50. ncbi request reprint Clinical significance of interleukin-1 receptor antagonist in patients with cervical carcinoma
    Ritsuto Fujiwaki
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693 8501, Japan
    Gynecol Oncol 89:77-83. 2003
    ..Our purpose was to determine the clinical significance of interleukin-1 receptor antagonist (IL-1ra), which is an endogenous inhibitor cytokine of IL-1, in patients with cervical carcinoma...
  51. doi request reprint Microwave endometrial ablation at a frequency of 2.45 GHz for menorrhagia: analysis of treatment results at a single facility
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    J Obstet Gynaecol Res 40:224-9. 2014
    ..45 GHz in women with menorrhagia. This method has been attracting attention as an alternative to hysterectomy in the treatment of functional and organic menorrhagia...
  52. ncbi request reprint Serum endostatin levels in patients with epithelial ovarian cancer
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693 8501, Japan
    Anticancer Res 23:1907-12. 2003
    ..The aim of this study was to assess the prognostic potentials of serum endostatin levels in epithelial ovarian cancer...
  53. doi request reprint Primary osteosarcoma of ovary
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89 1 Enyacho, Izumo, Shimane, 693 8501, Japan
    Int J Clin Oncol 14:163-6. 2009
    ..Early diagnosis provides hope of a complete surgical resection, which is currently the only promising treatment...
  54. doi request reprint Nuclear localization signal in a cancer-related transcriptional regulator protein NAC1
    Kosuke Okazaki
    Department of Biochemistry, Shimane University School of Medicine, Izumo, Japan
    Carcinogenesis 33:1854-62. 2012
    ..The identification of an NAC1 NLS thus clarifies the mechanism through which NAC1 translocates to the nucleus to regulate the transcription of genes involved in oncogenicity and pluripotency...
  55. ncbi request reprint Prognostic value of overexpression of p53 in human ovarian carcinoma patients receiving cisplatin
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Cancer Lett 192:227-35. 2003
    ..Therefore, detection of p53 overexpression using the DO7 antibody may be considered as a predictive marker of chemoresistance for cisplatin in patients with ovarian carcinoma...
  56. ncbi request reprint Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Oncology 62:340-8. 2002
    ..Ang1 and Ang2 bind with similar affinity to the endothelial cell tyrosine kinase receptor Tie2. Our purpose was to assess the potential role of the Ang/Tie2 system in physiological and pathological angiogenesis in the ovary...
  57. doi request reprint A case of bilateral pelvic lymph node involvement in stage 1a1 squamous cell carcinoma of cervix and a review of the literature
    Shamima Yeasmin
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Int J Clin Oncol 14:564-7. 2009
    ..While stage 1a1 cases may still be managed conservatively, physicians must consider the possibility of lymph node metastasis, particularly in patients with positive LVSI, and counsel patients accordingly...
  58. pmc Mechanisms of ovarian cancer metastasis: biochemical pathways
    Kentaro Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693 8501, Japan E Mails H K K M
    Int J Mol Sci 13:11705-17. 2012
    ..Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed...
  59. ncbi request reprint Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes
    Ritsuto Fujiwaki
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Int J Cancer 99:328-35. 2002
    ..Combination therapy including TK inhibitor is a possible therapeutic intervention in patients with epithelial ovarian cancer...