M Jisaka

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. request reprint
    Jisaka M, Kim R, Boeglin W, Brash A. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J Biol Chem. 2000;275:1287-93 pubmed
    ..Thus, this positional determinant of the 8-LOX and 15-LOX-2 may have significance for other lipoxygenases. ..
  2. request reprint
    Jisaka M, Boeglin W, Kim R, Brash A. Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. Arch Biochem Biophys. 2001;386:136-42 pubmed
    ..We conclude that mouse 8-LOX is catalytically competent with only four amino acid iron ligands, and that Ser-558 of the wild-type enzyme does not play an essential role in catalysis. ..
  3. request reprint
    Jisaka M, Iwanaga C, Takahashi N, Goto T, Kawada T, Yamamoto T, et al. Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist. Biochem Biophys Res Commun. 2005;338:136-43 pubmed
    ..The present results suggest that 8S,15S-diH(P)ETE as well as 8S-H(P)ETE would contribute to the physiological function of 8-LOX and also that 8-LOX can function as a potential 15-LOX. ..