M Jisaka


Affiliation: Shimane University
Country: Japan


  1. request reprint
    Jisaka M, Kim R, Boeglin W, Brash A. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J Biol Chem. 2000;275:1287-93 pubmed
    ..Thus, this positional determinant of the 8-LOX and 15-LOX-2 may have significance for other lipoxygenases. ..
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    Jisaka M, Boeglin W, Kim R, Brash A. Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. Arch Biochem Biophys. 2001;386:136-42 pubmed
    ..We conclude that mouse 8-LOX is catalytically competent with only four amino acid iron ligands, and that Ser-558 of the wild-type enzyme does not play an essential role in catalysis. ..
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    Jisaka M, Iwanaga C, Takahashi N, Goto T, Kawada T, Yamamoto T, et al. Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist. Biochem Biophys Res Commun. 2005;338:136-43 pubmed
    ..The present results suggest that 8S,15S-diH(P)ETE as well as 8S-H(P)ETE would contribute to the physiological function of 8-LOX and also that 8-LOX can function as a potential 15-LOX. ..