Michio Hashimoto

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. ncbi request reprint Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats
    Michio Hashimoto
    Department of Physiology, Shimane Medical University, Izumo, Japan
    J Neurochem 81:1084-91. 2002
  2. doi request reprint Differential effects of docoosahexaenoic and arachidonic acid on fatty acid composition and myosin heavy chain-related genes of slow- and fast-twitch skeletal muscle tissues
    Michio Hashimoto
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    Mol Cell Biochem 415:169-81. 2016
  3. doi request reprint The binding of Aβ1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan Electronic address
    Biochim Biophys Acta 1848:1402-9. 2015
  4. doi request reprint n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan Electronic address
    Biochim Biophys Acta 1851:203-9. 2015
  5. pmc Omega-3 polyunsaturated Fatty acids enhance neuronal differentiation in cultured rat neural stem cells
    Masanori Katakura
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Shimane Izumo, 693 8501, Japan
    Stem Cells Int 2013:490476. 2013
  6. pmc Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, 693 8501, Japan
    Neurochem Res 38:2124-35. 2013
  7. pmc Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats
    Sachiko Juman
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Nutrients 5:1949-61. 2013
  8. pmc Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney
    Masanori Katakura
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, 693 8501, Japan
    Med Gas Res 2:18. 2012
  9. ncbi request reprint Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    J Nutr 135:549-55. 2005
  10. doi request reprint The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40)
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    J Nutr Biochem 20:965-73. 2009

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats
    Michio Hashimoto
    Department of Physiology, Shimane Medical University, Izumo, Japan
    J Neurochem 81:1084-91. 2002
    ..Docosahexaenoic acid is thus a possible prophylactic means for preventing the learning deficiencies of Alzheimer's disease...
  2. doi request reprint Differential effects of docoosahexaenoic and arachidonic acid on fatty acid composition and myosin heavy chain-related genes of slow- and fast-twitch skeletal muscle tissues
    Michio Hashimoto
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    Mol Cell Biochem 415:169-81. 2016
    ..Our studies finally indicate that DHA and ARA differentially affect the regulation of contractile and metabolic properties of slow- and fast-twitch skeletal muscles. ..
  3. doi request reprint The binding of Aβ1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan Electronic address
    Biochim Biophys Acta 1848:1402-9. 2015
    ..DHA might help clearance of circulating Aβs by increased lipid raft-dependent degradation pathways and implicate to therapies in Alzheimer's disease. ..
  4. doi request reprint n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan Electronic address
    Biochim Biophys Acta 1851:203-9. 2015
    ..The findings of the present study suggest that long-term EPA+DHA administration may be a possible preventative strategy against age-related cognitive decline...
  5. pmc Omega-3 polyunsaturated Fatty acids enhance neuronal differentiation in cultured rat neural stem cells
    Masanori Katakura
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Shimane Izumo, 693 8501, Japan
    Stem Cells Int 2013:490476. 2013
    ..These results indicated that EPA could be involved in neuronal differentiation by mechanisms alternative to those of DHA, whereas AA did not affect neuronal differentiation in NSCs...
  6. pmc Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, 693 8501, Japan
    Neurochem Res 38:2124-35. 2013
    ..The present study suggests that long-term TAK-085 administration is a possible therapeutic strategy for protecting against metabolic syndrome-induced learning decline...
  7. pmc Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats
    Sachiko Juman
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Nutrients 5:1949-61. 2013
    ....
  8. pmc Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney
    Masanori Katakura
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, 693 8501, Japan
    Med Gas Res 2:18. 2012
    ..In this study, we investigated the effects of HRW on glucose- and α,β-dicarbonyl compound-induced ROS generation in vitro and in vivo...
  9. ncbi request reprint Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    J Nutr 135:549-55. 2005
    ..DHA is thus a possible therapeutic agent for ameliorating learning deficiencies due to Alzheimer's disease...
  10. doi request reprint The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40)
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    J Nutr Biochem 20:965-73. 2009
    ..Amyloid beta (Abeta) peptide (1-40) can cause cognitive impairment...
  11. ncbi request reprint Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University, Faculty of Medicine, Izumo, Japan
    Prostaglandins Leukot Essent Fatty Acids 73:475-83. 2005
    ..Therefore, decreases in PM fluidity, observed with age-dependent increased cholesterol and decreased USI, induce a decrease in 5'-ND activity, decrease extracellular adenosine levels, and might relate to hypertension in aged rats...
  12. ncbi request reprint Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    Biochim Biophys Acta 1738:91-8. 2005
    ..These results suggest that DHA-induced protection of memory deficits in AD-model rats is related to the interactions of cholesterol, palmitic acid or stearic acid with A beta peptides in DIFs where DHA ameliorates these interactions...
  13. ncbi request reprint Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University, Faculty of Medicine, Izumo, Japan
    Clin Exp Pharmacol Physiol 33:934-9. 2006
    ....
  14. ncbi request reprint Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity
    Michio Hashimoto
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane 693 8501, Japan
    Mol Cell Biochem 293:1-8. 2006
    ..These results suggest that DHA is a more potent membrane-fluidizer than EPA in withstanding cholesterol-induced decreases in platelet membrane fluidity and a stronger ameliorative modulator of platelet hyperaggregation...
  15. doi request reprint Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    J Neurochem 107:1634-46. 2008
    ..DHA concentration-dependently reduced the levels of oligomeric amyloid species, suggesting that dietary DHA-induced suppression of in vivo Abeta(1-40) aggregation occurs through the inhibitory effect of DHA on oligomeric amyloid species...
  16. doi request reprint Effects of docosahexaenoic acid on in vitro amyloid beta peptide 25-35 fibrillation
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Shimane, Japan
    Biochim Biophys Acta 1791:289-96. 2009
    ..These results suggest that DHA decreases the in vitro fibrillation of Abeta(25-35) by inhibiting the oligomeric amyloid species and, therefore, Abeta(25-35)-related neurotoxicity or behavioral impairment could be restrained by DHA...
  17. doi request reprint Docosahexaenoic acid withstands the Aβ(25-35)-induced neurotoxicity in SH-SY5Y cells
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    J Nutr Biochem 22:22-9. 2011
    ..Here, we have investigated whether DHA-induced inhibition of Amyloid β-peptide(25-35) (Aβ(25-35)) fibrillation limits or deteriorates the toxicity of the human neuroblastoma cells (SH-SY5Y)...
  18. ncbi request reprint Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Japan
    J Pharmacol Sci 116:150-62. 2011
    ..Therefore, it might be a useful therapeutic agent to prevent and/or delay cognitive impairment in mild cases of AD...
  19. doi request reprint Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, 693 8501, Japan
    Food Funct 2:386-94. 2011
    ..The present study suggests that long-term administration of TAK-085 is a possible therapeutic agent for protecting against Alzheimer's disease-induced learning deficiencies...
  20. pmc Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    Med Gas Res 1:26. 2011
    ..Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic syndrome rat model, SHR.Cg-Leprcp/NDmcr (SHR-cp)...
  21. doi request reprint Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats
    Abdul M Haque
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo City, Shimane, 693 8501, Japan
    J Nutr Biochem 19:619-26. 2008
    ..Our results suggest that long-term administration of green tea catechins provides effective prophylactic benefits against Abeta-induced cognitive impairment by increasing antioxidative defenses...
  22. ncbi request reprint Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus
    Yoko Tanabe
    Department of Environmental Physiology, Shimane University, Faculty of Medicine, Izumo, Japan
    Clin Exp Pharmacol Physiol 31:700-3. 2004
    ..These results suggest that the DHA-induced improvement in spatial cognition is associated with increased Fos expression in the CA1 hippocampus...
  23. doi request reprint Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells
    Shahdat Hossain
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
    J Neurochem 111:568-79. 2009
    ..Taken together, these data suggest that by restraining Abeta(1-42) toxic tri/tetrameric oligomers, DHA may limit amyloidogenic neurodegenerative diseases, Alzheimer's disease...
  24. ncbi request reprint Long-term administration of green tea catechins improves spatial cognition learning ability in rats
    Abdul M Haque
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    J Nutr 136:1043-7. 2006
    ..We suggest that this improvement in spatial cognitive learning ability is due to the antioxidative activity of green tea catechins...
  25. ncbi request reprint Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order
    Hossain Shahdat
    Department of Environmental Physiology, Shimane University School of Medicine, Izumo 693 8501, Japan
    Life Sci 74:3009-24. 2004
    ....
  26. doi request reprint Changes of noradrenaline-induced contractility and gene expression in aorta of rats acclimated to heat in two different modes
    Guang Hua Li
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Japan
    Eur J Appl Physiol 104:29-40. 2008
    ..The phases of the day when such changes occurred appear to be closely related to the periods when the animals were previously subjected to heat...
  27. ncbi request reprint Relationship between plasma and hippocampal lipid peroxidation in obese and hypertensive SHR/NDmcr-cp rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
    Clin Exp Pharmacol Physiol 31:S62-4. 2004
    ..5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor...
  28. ncbi request reprint [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid]
    Michio Hashimoto
    Department of Physiology, Shimane Medical University, Izumo 693 8501, Japan
    Nihon Yakurigaku Zasshi 120:54P-56P. 2002
    ....
  29. doi request reprint Effect of P2 receptor on the intracellular calcium increase by cancer cells in human umbilical vein endothelial cells
    Namie Nejime
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, 663 8179, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:429-36. 2008
    ..We previously reported that extracellular ATP increased [Ca2+]i and enhanced macromolecular permeability via the P2Y receptor. In tumor metastasis, cancer cells may exploit these regulatory mechanisms in the endothelial cell layer...
  30. doi request reprint Effects of nicorandil on sympathetic neurotransmission in rat caudal artery
    Ami Tei
    Department of Pharmacology and Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Clin Exp Pharmacol Physiol 37:619-23. 2010
    ..5. These findings suggest that nicorandil inhibits noradrenaline release via the K(ATP) channels of sympathetic nerves. These channels may be pharmacologically different from those of vascular smooth muscle...
  31. ncbi request reprint Contribution of the suprachiasmatic nucleus to the formation of a time memory for heat exposure in rats
    Megumi Maruyama
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, 693 8501 Japan
    J Physiol Sci 57:107-14. 2007
    ..These findings suggest that the SCN is crucial for establishing a time memory for heat stress, and it plays a minimal role in heat acclimation-induced changes in T(cor) in rats...
  32. doi request reprint Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model
    Masanori Katakura
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    Molecules 19:3247-63. 2014
    ..The results show that the use of combination therapy with DHA and EPA in SHRcp rats improved or prevented renal failure associate with metabolic syndrome with decreasing triglyceride levels and increasing ω-3 PUFA lipid mediators...
  33. doi request reprint Effects of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats
    Takayuki Inoue
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan Department of Developmental Biology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 91:119-27. 2014
    ..These results suggest that ARA deposition in the fast-twitch muscle of aged rats reduced cell volume with an increase in oxidative stress...
  34. doi request reprint Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells
    Toshiyuki Okui
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 85:163-9. 2011
    ..These results suggest that CLA promotes neuronal differentiation by increasing, in part, the expression of Hes6 mRNA and by activating p21(cip1) and p27(kip1) to arrest cell cycle...
  35. doi request reprint Proliferation of neuronal progenitor cells and neuronal differentiation in the hypothalamus are enhanced in heat-acclimated rats
    Kentaro Matsuzaki
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, 693 8501, Japan
    Pflugers Arch 458:661-73. 2009
    ....
  36. doi request reprint Effect of dietary n-3 fatty acids supplementation on fatty acid metabolism in atorvastatin-administered SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model
    Abdullah Al Mamun
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
    Biomed Pharmacother . 2016
    ....
  37. pmc Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats
    Masanori Katakura
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    PLoS ONE 10:e0140884. 2015
    ..These results indicate that there is a possibility of ARA administration having a reducing anti-inflammatory effect on the kidney. ..
  38. ncbi request reprint Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workers
    Akiko Nogi
    Department of Environmental and Preventive Medicine, Shimane University School of Medicine, Izumo City, Shimane, Japan
    J Occup Health 49:205-16. 2007
    ..In conclusion, an increase in n-3 PUFA was associated with HDL-C and TG in the Japanese and Mongolians, but these beneficial effects were not constant across the three Asian ethnic groups...
  39. doi request reprint Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    Geriatr Gerontol Int . 2016
    ....
  40. doi request reprint Aging attenuates acquired heat tolerance and hypothalamic neurogenesis in rats
    Kentaro Matsuzaki
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, 693 8501, Japan
    J Comp Neurol 523:1190-201. 2015
    ..Aging may interfere with heat exposure-induced hypothalamic neurogenesis and acquired heat tolerance in rats...
  41. ncbi request reprint Docosahexaenoic acid: one molecule diverse functions
    Michio Hashimoto
    a Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
    Crit Rev Biotechnol . 2016
    ..It reduces the brain amyloid burden and inhibits in vitro fibrillation and amyloid-induced neurotoxicity in cell-culture model. In this review, we discuss how DHA acts as a molecule with diverse functions...
  42. pmc Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking
    Shahdat Hossain
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, 693 8501, Japan
    BMC Complement Altern Med 15:118. 2015
    ..Identifying agents that inhibit amyloid beta peptide (Aβ) aggregation is the ultimate goal for slowing Alzheimer's disease (AD) progression. This study investigated whether the glycoside asiaticoside inhibits Aβ1-42 fibrillation in vitro...
  43. ncbi request reprint Alterations of calf venous and arterial compliance following acclimation to heat administered at a fixed daily time in humans
    Megumi Maruyama
    Department of Environmental Physiology, School of Medicine, Shimane University, Izumo, 693 8501, Japan
    Int J Biometeorol 50:269-74. 2006
    ..The results presented suggest that repeated heat exposure in humans, for 4 h at a fixed time daily, increases the calf CV and the CSA particularly during the period when the subjects were previously exposed to heat...
  44. doi request reprint Characterization of vasoconstrictor-induced relaxation in the cerebral basilar artery
    Budbazar Enkhjargal
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Eur J Pharmacol 637:118-23. 2010
    ....
  45. doi request reprint Possible participation of chloride ion channels in ATP release from cancer cells in suspension
    Namie Nejime
    Department of Pharmacology, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 36:278-82. 2009
    ..5. These findings indicate that Cl(-) channels play the most important role in ATP release from detached cancer cells and that gap junction hemichannels are also associated with ATP release...
  46. ncbi request reprint Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats
    Shahdat Hossain
    Department of Physiology, Shimane Medical University, Shimane, Japan
    Clin Exp Pharmacol Physiol 30:470-5. 2003
    ..5. The present study suggests that 5% P. ostreatus supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition...
  47. ncbi request reprint Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Japan
    J Pharmacol Sci 124:294-300. 2014
    ....
  48. ncbi request reprint Increased nitric oxide in proportion to the severity of heart failure in patients with dilated cardiomyopathy: close correlation of tumor necrosis factor-alpha with systemic and local production of nitric oxide
    Takashi Sugamori
    The Fourth Department of Internal Medicine, Shimane Medical University, Izumo, Japan
    Circ J 66:627-32. 2002
    ..The findings indicate that the concentrations of NO and TNF-alpha in patients with CHF increase in proportion to the severity of heart failure, and that TNF-alpha plays a role in the enhanced systemic and local production of NO...
  49. ncbi request reprint Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians
    Kuninori Shiwaku
    Department of Environmental and Preventive Medicine, Shimane University School of Medicine, Izumo, Japan
    J Lipid Res 45:914-22. 2004
    ..HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians...
  50. doi request reprint Maternal dietary n-6/n-3 fatty acid ratio affects type 1 diabetes development in the offspring of non-obese diabetic mice
    Yukiko Kagohashi
    Department of Health and Nutrition, The University of Shimane, Matsue, Shimane, Japan
    Congenit Anom (Kyoto) 50:212-20. 2010
    ..The present findings suggest that n-6/n-3 ratio of the maternal diet during gestation and lactation rather than that of offspring after weaning strongly affects the development of overt diabetes in NOD mice...
  51. ncbi request reprint Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats
    Kentaro Matsuzaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Neurosci Lett 400:230-4. 2006
    ..In the AD model rats, nobiletin showed protective effects on Abeta(1-40)-induced impairment of learning ability. These results suggest that nobiletin has the potential for becoming a novel lead compound for drug development for AD...
  52. ncbi request reprint Dysfunction of purinergic regulation of sympathetic neurotransmission in SHR/NDmcr-cp (SHR-cp) rat
    Naoko Tanaka
    First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan
    Clin Exp Pharmacol Physiol 31:S60-1. 2004
    ..This P1 dysfunction may play a role in the sympathetic hyperinnervation in metabolic syndrome...
  53. ncbi request reprint Characteristics of contractile activity in the renal artery of ovariectomized rats
    Budbazar Enkhjargal
    Division of Physiology, Department of Occupational Therapy, School of Nursing and Rehabilitation Sciences, Showa University, Japan
    J Smooth Muscle Res 44:17-28. 2008
    ..In conclusion, our results suggest that estrogen regulates contraction and relaxation in the renal artery via NO synthase activity and alteration of the Ca2+ transport systems...
  54. ncbi request reprint Effects of Hilsa ilisa fish oil on the atherogenic lipid profile and glycaemic status of streptozotocin-treated type 1 diabetic rats
    Ishtiaq Mahmud
    Department of Food Science and Nutrition, College of Agricultural and Marine Sciences CAMS, Sultan Qaboos University, Muscat, Oman
    Clin Exp Pharmacol Physiol 31:76-81. 2004
    ....
  55. ncbi request reprint Traditional Japanese dietary basics: a solution for modern health issues?
    Kuninori Shiwaku
    Lancet 363:1737-8. 2004
  56. ncbi request reprint [Safety issues in medical care: next step toward the safety standard]
    Michio Hashimoto
    Nihon Naika Gakkai Zasshi 95:1813-7. 2006
  57. ncbi request reprint Effects of shrimp (Macrobracium rosenbergii)-derived chitosan on plasma lipid profile and liver lipid peroxide levels in normo- and hypercholesterolaemic rats
    Shahdat Hossain
    Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh
    Clin Exp Pharmacol Physiol 34:170-6. 2007
    ..Liver LPO levels were positively correlated with the TUFA/TSFA molar ratio. 6. The present study suggests that dietary CS decreases the atherogenic lipid profiles of both NC and HC rats and reduces the bodyweight gain of HC rats...
  58. ncbi request reprint Measuring relative work values for home care nursing services in Japan
    Yasuko Ogata
    Department of Community Health Nursing, School of Nursing, Chiba University, Chiba shi, Japan
    Nurs Res 53:145-53. 2004
    ..To maintain the quality of services in home health nursing provided by Stations, reimbursement needs to account not only for the number of home visits, but also for the time and intensity of nursing services...
  59. ncbi request reprint ATP participates in the regulation of microvessel permeability
    Naoko Tanaka
    First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki 882 8508, Japan
    J Pharm Pharmacol 58:481-7. 2006
    ..Such purinergic regulation of endothelial permeability may function in physiological and pathophysiological conditions...
  60. ncbi request reprint [Safety management activities of Yokohama City University Hospital--safety management is the platform of quality improvement]
    Michio Hashimoto
    Department of Medical Risk Management, Yokohama City University Hospital, Yokohama, Japan
    Nihon Geka Gakkai Zasshi 104:35-9. 2003
    ..The next step will be to expand these activities into a movement for hospital-wide quality improvement and establishing clinical governance...
  61. ncbi request reprint Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats
    Tohru Yamakuni
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 298:793-7. 2002
    ..It is also suggested that V-1 expression is increased by hypertension in DS rat atrium...
  62. ncbi request reprint Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer
    Naoko Tanaka
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    J Pharm Pharmacol 57:335-40. 2005
    ..These results suggest that phosphorylation of the myosin light chain may play an important role in the purinergic regulation of macromolecular permeation through the vascular endothelium...
  63. ncbi request reprint P2Y-receptor regulates size of endothelial cells in an intracellular Ca2+ dependent manner
    Naoko Tanaka
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, 663 8179, Nishinomiya, Japan
    Life Sci 72:1445-53. 2003
    ..We concluded that the size of endothelial cells is regulated by P2Y receptors via intracelluar Ca(2+) derived from Ca(2+) stores...
  64. ncbi request reprint [Diverse physiological and pharmacological functions of fatty acids]
    Harumi Okuyama
    Nihon Yakurigaku Zasshi 131:259-67. 2008
  65. ncbi request reprint P2Y receptor-mediated enhancement of permeation requires Ca2+ signalling in vascular endothelial cells
    Naoko Tanaka
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Clin Exp Pharmacol Physiol 30:649-52. 2003
    ..4. These findings suggested that activation of the P2Y receptor enhances the passage of material in the endothelium, which is associated with Ca2+ signalling in endothelial cells...