Michio Hashimoto


Affiliation: Shimane University
Country: Japan


  1. Hashimoto M, Shahdat H, Yamashita S, Katakura M, Tanabe Y, Fujiwara H, et al. Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats. J Neurochem. 2008;107:1634-46 pubmed publisher
  2. Hashimoto M, Katakura M, Hossain S, Rahman A, Shimada T, Shido O. Docosahexaenoic acid withstands the A?(25-35)-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2011;22:22-9 pubmed publisher
    ..This might be the basis of the DHA-induced amelioration of A?-induced neurodegeneration and related cognitive deficits. ..
  3. Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Inoue T, Hossain S, et al. n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats. Biochim Biophys Acta. 2015;1851:203-9 pubmed publisher
    ..The findings of the present study suggest that long-term EPA+DHA administration may be a possible preventative strategy against age-related cognitive decline. ..
  4. Hashimoto M, Hossain S, Katakura M, Al Mamun A, Shido O. The binding of Aβ1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease. Biochim Biophys Acta. 2015;1848:1402-9 pubmed publisher
    ..DHA might help clearance of circulating Aβs by increased lipid raft-dependent degradation pathways and implicate to therapies in Alzheimer's disease. ..
  5. request reprint
    Hashimoto M, Hossain S, Shido O. Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. Mol Cell Biochem. 2006;293:1-8 pubmed
    ..These results suggest that DHA is a more potent membrane-fluidizer than EPA in withstanding cholesterol-induced decreases in platelet membrane fluidity and a stronger ameliorative modulator of platelet hyperaggregation. ..
  6. Hashimoto M, Tozawa R, Katakura M, Shahdat H, Haque A, Tanabe Y, et al. Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid ?-infused rats. Food Funct. 2011;2:386-94 pubmed publisher
    ..The present study suggests that long-term administration of TAK-085 is a possible therapeutic agent for protecting against Alzheimer's disease-induced learning deficiencies. ..
  7. Hossain S, Hashimoto M, Katakura M, Al Mamun A, Shido O. Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking. BMC Complement Altern Med. 2015;15:118 pubmed publisher
    ..Finally, asiaticoside prevents amyloidogenesis that precedes neurodegeneration in patients with Alzheimer's disease. ..
  8. Hashimoto M, Inoue T, Katakura M, Hossain S, Mamun A, Matsuzaki K, et al. Differential effects of docoosahexaenoic and arachidonic acid on fatty acid composition and myosin heavy chain-related genes of slow- and fast-twitch skeletal muscle tissues. Mol Cell Biochem. 2016;415:169-81 pubmed publisher
    ..Our studies finally indicate that DHA and ARA differentially affect the regulation of contractile and metabolic properties of slow- and fast-twitch skeletal muscles. ..
  9. Hashimoto M, Hossain S, Katakura M, Mamun A, Shido O. Docosahexaenoic Acid Helps to Lessen Extinction Memory in Rats. Molecules. 2018;23: pubmed publisher
    ..DHA also increased the protein levels of GRP, BDNF, PSD-95, and VAChT, and the antioxidative potentials in the hippocampus. These results suggest the usefulness of DHA for treating stress disorders. ..

More Information


  1. Al Mamun A, Hashimoto M, Katakura M, Tanabe Y, Tsuchikura S, Hossain S, et al. Effect of dietary n-3 fatty acids supplementation on fatty acid metabolism in atorvastatin-administered SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model. Biomed Pharmacother. 2017;85:372-379 pubmed publisher
  2. Okuda M, Fujita Y, Katsube T, Tabata H, Yoshino K, Hashimoto M, et al. Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain. BMC Complement Altern Med. 2018;18:110 pubmed publisher
    ..HPBR ameliorated cognitive dysfunction and reduced the levels of amyloid-β, which is a major protein responsible for AD, in the brain. These results suggest that HPBR is effective for preventing AD. ..