Affiliation: Shimane University
Hashimoto M, Shahdat H, Yamashita S, Katakura M, Tanabe Y, Fujiwara H, et al
. Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats. J Neurochem. 2008;107:1634-46 pubmed publisher
Hashimoto M, Katakura M, Hossain S, Rahman A, Shimada T, Shido O. Docosahexaenoic acid withstands the A?(25-35)-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2011;22:22-9 pubmed publisher
..This might be the basis of the DHA-induced amelioration of A?-induced neurodegeneration and related cognitive deficits. ..
Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Inoue T, Hossain S, et al
. n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats. Biochim Biophys Acta. 2015;1851:203-9 pubmed publisher
..The findings of the present study suggest that long-term EPA+DHA administration may be a possible preventative strategy against age-related cognitive decline. ..
Hashimoto M, Hossain S, Katakura M, Al Mamun A, Shido O. The binding of AÎ²1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease. Biochim Biophys Acta. 2015;1848:1402-9 pubmed publisher
..DHA might help clearance of circulating AÎ²s by increased lipid raft-dependent degradation pathways and implicate to therapies in Alzheimer's disease. ..
Hashimoto M, Hossain S, Shido O. Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. Mol Cell Biochem. 2006;293:1-8 pubmed
..These results suggest that DHA is a more potent membrane-fluidizer than EPA in withstanding cholesterol-induced decreases in platelet membrane fluidity and a stronger ameliorative modulator of platelet hyperaggregation. ..
Hashimoto M, Tozawa R, Katakura M, Shahdat H, Haque A, Tanabe Y, et al
. Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid ?-infused rats. Food Funct. 2011;2:386-94 pubmed publisher
..The present study suggests that long-term administration of TAK-085 is a possible therapeutic agent for protecting against Alzheimer's disease-induced learning deficiencies. ..
Hossain S, Hashimoto M, Katakura M, Al Mamun A, Shido O. Medicinal value of asiaticoside for Alzheimer's disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking. BMC Complement Altern Med. 2015;15:118 pubmed publisher
..Finally, asiaticoside prevents amyloidogenesis that precedes neurodegeneration in patients with Alzheimer's disease. ..
Hashimoto M, Inoue T, Katakura M, Hossain S, Mamun A, Matsuzaki K, et al
. Differential effects of docoosahexaenoic and arachidonic acid on fatty acid composition and myosin heavy chain-related genes of slow- and fast-twitch skeletal muscle tissues. Mol Cell Biochem. 2016;415:169-81 pubmed publisher
..Our studies finally indicate that DHA and ARA differentially affect the regulation of contractile and metabolic properties of slow- and fast-twitch skeletal muscles. ..
Hashimoto M, Hossain S, Katakura M, Mamun A, Shido O. Docosahexaenoic Acid Helps to Lessen Extinction Memory in Rats. Molecules. 2018;23: pubmed publisher
..DHA also increased the protein levels of GRP, BDNF, PSD-95, and VAChT, and the antioxidative potentials in the hippocampus. These results suggest the usefulness of DHA for treating stress disorders. ..