Takayoshi Tsutamoto

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi request reprint Beneficial effect of perindopril on cardiac sympathetic nerve activity and brain natriuretic peptide in patients with chronic heart failure: comparison with enalapril
    Takayoshi Tsutamoto
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 72:740-6. 2008
  2. ncbi request reprint Relationship between renal function and plasma brain natriuretic peptide in patients with heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    J Am Coll Cardiol 47:582-6. 2006
  3. ncbi request reprint Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and N-terminal proBNP and prognosis in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 71:1873-8. 2007
  4. ncbi request reprint Effect of atorvastatin vs. rosuvastatin on cardiac sympathetic nerve activity in non-diabetic patients with dilated cardiomyopathy
    Takayoshi Tsutamoto
    Toyosato Hospital, Shiga, Japan
    Circ J 75:2160-6. 2011
  5. doi request reprint Transcardiac increase in norepinephrine and prognosis in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Eur J Heart Fail 10:1208-14. 2008
  6. ncbi request reprint Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure
    Takayoshi Tsutamoto
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
    Eur J Heart Fail 9:1032-7. 2007
  7. ncbi request reprint Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu 520 2192, Japan
    Circ J 71:915-21. 2007
  8. ncbi request reprint Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Eur Heart J 28:1723-30. 2007
  9. ncbi request reprint Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N-terminal pro-BNP in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Eur J Heart Fail 9:667-73. 2007
  10. ncbi request reprint Relationship between transcardiac gradient of endothelin-1 and left ventricular remodelling in patients with first anterior myocardial infarction
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Eur Heart J 24:346-55. 2003

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Beneficial effect of perindopril on cardiac sympathetic nerve activity and brain natriuretic peptide in patients with chronic heart failure: comparison with enalapril
    Takayoshi Tsutamoto
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 72:740-6. 2008
    ..In patients with chronic heart failure (CHF), it remains unclear whether perindopril is more cardioprotective than enalapril...
  2. ncbi request reprint Relationship between renal function and plasma brain natriuretic peptide in patients with heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    J Am Coll Cardiol 47:582-6. 2006
    ..This study sought to evaluate the relationship between brain natriuretic peptide (BNP), renal function, and the severity of congestive heart failure (CHF)...
  3. ncbi request reprint Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and N-terminal proBNP and prognosis in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 71:1873-8. 2007
    ..No previous study has compared the transcardiac gradient of cardiac natriuretic peptides and prognosis...
  4. ncbi request reprint Effect of atorvastatin vs. rosuvastatin on cardiac sympathetic nerve activity in non-diabetic patients with dilated cardiomyopathy
    Takayoshi Tsutamoto
    Toyosato Hospital, Shiga, Japan
    Circ J 75:2160-6. 2011
    ..Effects of statin therapy on cardiac sympathetic nerve activity in patients with chronic heart failure (CHF) have not previously been evaluated...
  5. doi request reprint Transcardiac increase in norepinephrine and prognosis in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Eur J Heart Fail 10:1208-14. 2008
    ..No previous study has compared the transcardiac gradient of norepinephrine (NE) and the prognosis of patients with chronic heart failure (CHF)...
  6. ncbi request reprint Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure
    Takayoshi Tsutamoto
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
    Eur J Heart Fail 9:1032-7. 2007
    ..Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in patients with chronic heart failure (CHF)...
  7. ncbi request reprint Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu 520 2192, Japan
    Circ J 71:915-21. 2007
    ..Plasma renin activity (PRA) may be limited to angiotensinogen levels, which decrease in patients with heart failure (HF) because of liver congestion...
  8. ncbi request reprint Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Eur Heart J 28:1723-30. 2007
    ....
  9. ncbi request reprint Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N-terminal pro-BNP in patients with chronic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Eur J Heart Fail 9:667-73. 2007
    ..Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and NT-pro-BNP has not been performed previously...
  10. ncbi request reprint Relationship between transcardiac gradient of endothelin-1 and left ventricular remodelling in patients with first anterior myocardial infarction
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Eur Heart J 24:346-55. 2003
    ..Conclusions These results indicate that elevated circulating ET-1 is extracted through the heart in patients with a first anterior AMI and that the extracted ET-1 plays a significant role in modulating post-infarct LV remodelling...
  11. ncbi request reprint Transcardiac gradient of aldosterone before and after spironolactone in patients with congestive heart failure
    Takayoshi Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Cardiovasc Pharmacol 41:S19-22. 2003
    ..This suggests that spironolactone blocks the effects of aldosterone on the failing heart in congestive heart failure patients with dilated cardiomyopathy...
  12. ncbi request reprint Effects of long-acting calcium channel antagonists on neurohumoral factors: comparison of nifedipine coat-core with amlodipine
    Takayoshi Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Cardiovasc Pharmacol 41:S77-81. 2003
    ..The results also suggest that the duration of action of nifedipine formulations is an important determinant for nifedipine-induced hyperactivity in the reflex sympathetic nerve and the renin-angiotensin systems...
  13. ncbi request reprint Mineralocorticoid receptor antagonist spironolactone improves left ventricular remodeling in patients with congestive heart failure and acute myocardial infarction
    Takayoshi Tsutamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Nihon Yakurigaku Zasshi 124:90-100. 2004
    ..These findings indicate that AB combined with standard therapy can prevent LV remodeling in patients with CHF and AMI, suggesting that the failing heart is the target organ of the aldosterone...
  14. doi request reprint Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension
    Takayoshi Tsutamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Hypertens Res 32:670-4. 2009
    ..These findings indicate that the effect of efonidipine on the suppression of plasma ALD was sustained for at least 18 months and that long-term efonidipine therapy decreases LVMI in patients with essential hypertension...
  15. ncbi request reprint Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Am Coll Cardiol 38:1485-90. 2001
    ..The study evaluated the relationship between plasma cardiotrophin-1 (CT-1) concentration and left ventricular (LV) mass in dilated cardiomyopathy (DCM) patients with congestive heart failure (CHF)...
  16. doi request reprint Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure
    Takayoshi Tsutamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Eur J Heart Fail 11:653-8. 2009
    ..Both serum cardiac troponin T (cTnT) and renal function are prognostic predictors in patients with chronic heart failure (CHF). We aimed to evaluate the relationship between renal function and serum cTnT...
  17. doi request reprint Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Am Heart J 159:63-7. 2010
    ..However, the clinical use has limitations due to the low sensitivity of a conventional commercial assay system. Recently, a high sensitive-cTnI (hs-cTnI) commercial assay has become available...
  18. ncbi request reprint Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 31:391-8. 1998
    ....
  19. doi request reprint Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension
    Takayoshi Tsutamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Hypertens Res 33:118-22. 2010
    ....
  20. ncbi request reprint Relationship between endothelin-1 extraction in the peripheral circulation and systemic vascular resistance in patients with severe congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 33:530-7. 1999
    ....
  21. ncbi request reprint Angiotensin II type 1 receptor antagonist decreases plasma levels of tumor necrosis factor alpha, interleukin-6 and soluble adhesion molecules in patients with chronic heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Am Coll Cardiol 35:714-21. 2000
    ..To evaluate the effects of an angiotensin (Ang II) type 1 receptor antagonist on immune markers in patients with congestive heart failure (CHF)...
  22. ncbi request reprint Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 36:838-44. 2000
    ..The study evaluated the transcardiac extraction or spillover of aldosterone (ALDO) in normal subjects and in patients with congestive heart failure (CHF)...
  23. ncbi request reprint Transcardiac extraction of circulating endothelin-1 across the failing heart
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Cardiol 86:524-8. 2000
    ....
  24. doi request reprint Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failure
    Takayoshi Tsutamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Eur J Heart Fail 11:1195-201. 2009
    ..To compare the effects of lipophilic simvastatin and hydrophilic rosuvastatin on plasma adiponectin and glycated haemoglobin A1c (HbA1c) levels in patients with non-ischaemic chronic heart failure (NICHF)...
  25. ncbi request reprint Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Am Coll Cardiol 37:2086-92. 2001
    ..This study evaluated oxidative stress in the failing ventricle in patients with dilated cardiomyopathy (DCM)...
  26. ncbi request reprint Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 37:1228-33. 2001
    ..We sought to evaluate the effects of spironolactone on neurohumoral factors and left ventricular remodeling in patients with congestive heart failure (CHF)...
  27. ncbi request reprint Transcardiac increase in tumor necrosis factor-alpha and left ventricular end-diastolic volume in patients with dilated cardiomyopathy
    Takayoshi Tsutamoto
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Eur J Heart Fail 6:173-80. 2004
    ....
  28. ncbi request reprint Inhibition of aldosterone and endothelin-1 by carperitide was attenuated with more than 1 week of infusion in patients with congestive heart failure
    Chitose Ishikawa
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    J Cardiovasc Pharmacol 46:513-8. 2005
    ....
  29. doi request reprint Serum cortisol as a useful predictor of cardiac events in patients with chronic heart failure: the impact of oxidative stress
    Masayuki Yamaji
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Circ Heart Fail 2:608-15. 2009
    ..We evaluated cardiac event prediction using cortisol levels in chronic heart failure, in comparison with ALD, adrenocorticotropic hormone, and brain natriuretic peptide (BNP), and the impact of oxidative stress...
  30. ncbi request reprint Endogenous bradykinin suppresses myocardial fibrosis through the cardiac-generated endothelin system under chronic angiotensin-converting enzyme inhibition in heart failure
    Masanori Fujii
    Intensive Care Unit, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Cardiovasc Pharmacol 44:S346-9. 2004
    ..In conclusion, bradykinin may prevent cardiac fibrosis in part via suppression of the local endothelin system in the failing heart through the enhancement of nitric oxide production under chronic angiotensin-converting enzyme inhibition...
  31. ncbi request reprint Long-term treatment with a phosphodiesterase type 5 inhibitor improves pulmonary hypertension secondary to heart failure through enhancing the natriuretic peptides-cGMP pathway
    Takashi Yamamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Cardiovasc Pharmacol 44:596-600. 2004
    ..These results indicated that long-term treatment with a PDE5 inhibitor improved pulmonary hypertension secondary to HF and the NPs-cGMP pathway contributed to this therapeutic effect...
  32. ncbi request reprint Dose-dependent prognostic effect of carvedilol in patients with chronic heart failure--special reference to transcardiac [corrected] gradient of norepinephrine
    Keizo Nishiyama
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 73:2270-5. 2009
    ..The effect of the dose of carvedilol on cardiac sympathetic nerve activity (CSA) and mortality remain uncertain in patients with chronic heart failure (CHF)...
  33. ncbi request reprint Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure
    Takehiro Matsumoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Circulation 107:2555-8. 2003
    ..Therefore, selective chymase blockade seems to be an important strategy in the prevention of cardiac remodeling..
  34. ncbi request reprint Effect of carvedilol on plasma adiponectin concentration in patients with chronic heart failure
    Masayuki Yamaji
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 73:1067-73. 2009
    ..Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are reported to increase the plasma adiponectin concentration, but the effect of beta-blockers on plasma adiponectin in patients with CHF remains unknown...
  35. ncbi request reprint Chronic administration of phosphodiesterase type 5 inhibitor suppresses renal production of endothelin-1 in dogs with congestive heart failure
    Takashi Yamamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Clin Sci (Lond) 103:258S-262S. 2002
    ..001 respectively). Our results indicate that chronic PDE5 inhibition ameliorates the antagonistic relationship between renal ANP and ET-1 through the cGMP pathway, subsequently preventing renal dysfunction during the progression of CHF...
  36. ncbi request reprint Chronic effects of an endothelin-converting enzyme inhibitor on cardiorenal and hormonal function in heart failure
    Atsuyuki Wada
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Clin Sci (Lond) 103:254S-257S. 2002
    ..These results indicate that the role of ECE in CHF is important and that chronic ECE inhibition could possess therapeutic potential in the treatment of CHF not only on haemodynamics but also in the prevention of fluid retention...
  37. ncbi request reprint Serum level of uric acid, partly secreted from the failing heart, is a prognostic marker in patients with congestive heart failure
    Hiroshi Sakai
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 70:1006-11. 2006
    ..However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriuretic peptide (BNP)...
  38. ncbi request reprint Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension
    Toshinari Tanaka
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Hypertens Res 30:691-7. 2007
    ....
  39. ncbi request reprint Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure
    Masato Ohnishi
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520 2192, Japan
    Clin Sci (Lond) 103:241S-244S. 2002
    ....
  40. ncbi request reprint Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure
    Takashi Tsutsui
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Am Coll Cardiol 39:957-62. 2002
    ..The aim of this study was to evaluate the relationship between plasma oxidized low-density lipoprotein (oxLDL), a marker of oxidative stress, and the prognosis of patients with chronic congestive heart failure (CHF)...
  41. ncbi request reprint Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor
    Tomoyuki Takayama
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Circ J 68:1067-75. 2004
    ..The present study examined both the involvement of vascular NAD(P)H oxidase in endothelial dysfunction in dogs with tachycardia-induced CHF and the therapeutic effect of a statin (pitavastatin)...
  42. ncbi request reprint Relationship between interleukin-6 production in the lungs and pulmonary vascular resistance in patients with congestive heart failure
    Naoko Mabuchi
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Chest 121:1195-202. 2002
    ..We evaluated whether interleukin (IL)-6 is produced in the pulmonary circulation and investigated the relationship between IL-6 spillover in the lung and pulmonary vascular resistance (PVR) in patients with congestive heart failure (CHF)...
  43. doi request reprint Clinical features of myocardial triglyceride in different types of cardiomyopathy assessed by proton magnetic resonance spectroscopy: comparison with myocardial creatine
    Ichiro Nakae
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan
    J Card Fail 16:812-22. 2010
    ..The aims of this study were to assess myocardial triglyceride (TG) and creatine (CR) in different types of cardiomyopathy and to investigate whether they are related to the severity of cardiac dysfunction...
  44. ncbi request reprint [Comparative effects of losartan and amlodipine on activities of sympathetic nerve, renin-angiotensin-aldosterone system and brain natriuretic peptide in the elderly hypertensive patients]
    Takayoshi Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science
    Nihon Ronen Igakkai Zasshi 39:303-7. 2002
    ..01), whereas there were not any changes in BNP concentrations. These findings suggested that losartan might be superior to amlodipine in prevention of chronic or intermittent sympathetic hyperactivity and enhanced R-A-A system...
  45. ncbi request reprint Plasma NT-proBNP as a more reliable biomarker of endogenous cardiac natriuretic peptides than BNP during carperitide infusion
    Keizo Nishiyama
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Int Heart J 50:183-90. 2009
    ..06) and after stopping carperitide (0.59 +/- 0.07). During carperitide infusion, plasma NT-proBNP may be a more reliable marker of endogenous cardiac natriuretic peptides than plasmaBNP, which may be increased by carperitide infusion...
  46. ncbi request reprint Direct comparison of brain natriuretic peptide (BNP) and N-terminal pro-BNP secretion and extent of coronary artery stenosis in patients with stable coronary artery disease
    Hiroshi Sakai
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu
    Circ J 71:499-505. 2007
    ..Therefore, this study evaluated the relationship between BNP and NT-proBNP secretion, plasma levels and the severity of coronary artery stenosis in patients with stable coronary artery disease (CAD)...
  47. doi request reprint Effect of atrial natriuretic peptide on adiponectin in patients with heart failure
    Toshinari Tanaka
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520 2192, Japan
    Eur J Heart Fail 10:360-6. 2008
    ..The adipocyte-specific cytokine adiponectin, has cardioprotective effects, correlates with endogenous cardiac natriuretic peptides and adipocyte has guanylyl cyclase-A receptors of natriuretic peptides...
  48. ncbi request reprint Effect of carperitide on plasma adiponectin levels in acute decompensated heart failure patients with diabetes mellitus
    Masayuki Yamaji
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 73:2264-9. 2009
    ..It is reported that adiponectin has a cardioprotective effect and is decreased in type 2 diabetes mellitus (DM)...
  49. ncbi request reprint Impact of oxidative stress on plasma adiponectin in patients with chronic heart failure
    Toshinari Tanaka
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 72:563-8. 2008
    ..Plasma levels of both adiponectin and biomarkers of oxidative stress are increased and have a prognostic impact on CHF patients...
  50. ncbi request reprint Prediction of mortality by high-sensitivity C-reactive protein and brain natriuretic peptide in patients with dilated cardiomyopathy
    Chitose Ishikawa
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 70:857-63. 2006
    ..In the present study, whether CRP provides prognostic information in DCM patients was evaluated...
  51. ncbi request reprint Relationship between biological variation in B-type natriuretic peptide and plasma renin concentration in stable outpatients with dilated cardiomyopathy
    Keizo Nishiyama
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan
    Circ J 75:1897-904. 2011
    ....
  52. ncbi request reprint Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction
    M Hayashi
    First Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan
    J Am Coll Cardiol 38:1375-82. 2001
    ..CONCLUSIONS: These results indicate that plasma ALD is extracted through the heart in patients with AMI at the acute phase and that the extracted ALD plays an important role in modulating post-infarct LV remodeling...
  53. ncbi request reprint Biological variation of brain natriuretic peptide and cardiac events in stable outpatients with nonischemic chronic heart failure
    Keizo Nishiyama
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Circ J 75:341-7. 2011
    ..To evaluate the biological variation and prognostic value of brain natriuretic peptide (BNP) for stable outpatients with nonischemic chronic heart failure (NICHF)...
  54. ncbi request reprint Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure
    Tomohiro Dohke
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    J Card Fail 12:77-84. 2006
    ....
  55. ncbi request reprint Bradykinin improves left ventricular diastolic function under long-term angiotensin-converting enzyme inhibition in heart failure
    Masanori Fujii
    First Department of Internal Medicine, Central Research Laboratory, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Hypertension 39:952-7. 2002
    ....
  56. ncbi request reprint Impairments of myocardial sympathetic activity may reflect the progression of myocardial damage or dysfunction in hypertrophic cardiomyopathy
    Shinro Matsuo
    Department of Internal Medicine, Shiga University of Medical Science, Shiga, Japan
    J Nucl Cardiol 9:407-12. 2002
    ..However, the mechanism of such abnormalities remains unknown. In part, the high plasma level of B-type natriuretic peptide (BNP) reportedly reflects myocardial damage in addition to hemodynamic disorder...
  57. doi request reprint Prognostic value of serial measurements of highly sensitive cardiac troponin I in stable outpatients with nonischemic chronic heart failure
    Chiho Kawahara
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Am Heart J 162:639-45. 2011
    ..However, the prognostic role of serial measurements of hs-cTnI in stable outpatients with CHF remains unknown...
  58. ncbi request reprint Proton magnetic resonance spectroscopy can detect creatine depletion associated with the progression of heart failure in cardiomyopathy
    Ichiro Nakae
    Department of Cardiovascular and Respiratory Medicine, Seta, Otsu, Japan
    J Am Coll Cardiol 42:1587-93. 2003
    ..This study noninvasively examined total creatine (CR) of the myocardium in dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) using proton magnetic resonance spectroscopy ((1)H-MRS)...
  59. ncbi request reprint Prognostic role of high-sensitivity cardiac troponin T in patients with nonischemic dilated cardiomyopathy
    Chiho Kawahara
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 75:656-61. 2011
    ..However, its clinical use is limited by the low sensitivity of the conventional commercial assay system. Recently, a highly sensitive cTnT (hs-cTnT) assay has become commercially available...
  60. ncbi request reprint Prognostic value of repeated 123I-metaiodobenzylguanidine imaging in patients with dilated cardiomyopathy with congestive heart failure before and after optimized treatments--comparison with neurohumoral factors
    Toshiki Matsui
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Circ J 66:537-43. 2002
    ....
  61. doi request reprint Effect of eplerenone versus spironolactone on cortisol and hemoglobin A₁(c) levels in patients with chronic heart failure
    Masayuki Yamaji
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Am Heart J 160:915-21. 2010
    ..We compared the metabolic effect of a selective mineralocorticoid receptor blocker eplerenone with spironolactone in CHF patients...
  62. ncbi request reprint Myocardial creatine concentration in various nonischemic heart diseases assessed by 1H magnetic resonance spectroscopy
    Ichiro Nakae
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Circ J 69:711-6. 2005
    ..In the present study, we investigated total creatine (CR) levels in various diseased hearts using 1H MRS...
  63. ncbi request reprint Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT
    Ichiro Nakae
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Ann Nucl Med 21:315-23. 2007
    ....
  64. ncbi request reprint Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    J Card Fail 7:322-8. 2001
    ..Plasma sFas is a useful prognostic marker independent of neurohumoral factors, suggesting that immune activation and/or apoptosis play a significant role in the pathogenesis of CHF...
  65. ncbi request reprint [Left ventricular remodeling post myocardial infarction]
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:323-9. 2005
  66. ncbi request reprint [Brain natriuretic peptide]
    Takayoshi Tsutamoto
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu 520 2192
    Rinsho Byori 52:655-68. 2004
    ..In addition, BNP-guided treatment of heart failure may reduce total cardiovascular events, and delayed time to first event combination with intensive clinically guided treatment...
  67. ncbi request reprint Digitalis increases brain natriuretic peptide in patients with severe congestive heart failure
    T Tsutamoto
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Am Heart J 134:910-6. 1997
    ....
  68. ncbi request reprint A novel clinical indicator using Tc-99m sestamibi for evaluating cardiac mitochondrial function in patients with cardiomyopathies
    Shinro Matsuo
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan
    J Nucl Cardiol 14:215-20. 2007
    ..This study was designed to test the hypothesis that MIBI washout can be used to evaluate the severity of congestive heart failure in comparison to other clinical parameters in patients with cardiomyopathies...
  69. ncbi request reprint Significant roles of endothelin-A- and -B-receptors in renal function in congestive heart failure
    M Ohnishi
    The First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Cardiovasc Pharmacol 36:S140-3. 2000
    ..Acute ET(A)-receptor antagonism may therefore be more beneficial to diuresis than dual ET(A)/ET(B)-receptor inhibition in heart failure...
  70. ncbi request reprint Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism
    A Wada
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu
    Circulation 99:570-7. 1999
    ..Our acute complementary data may support the importance of the role of ECE in CHF and provide a rationale foundation for investigating the usefulness of long-term treatment with ECE inhibitors in CHF...
  71. ncbi request reprint Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure
    A Wada
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 30:1385-92. 1997
    ....
  72. ncbi request reprint Endothelin-1 promotes vascular structural remodeling during the progression of heart failure prevention of vascular remodeling using a specific endothelin-converting enzyme inhibitor
    X Wang
    First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Life Sci 69:2477-88. 2001
    ..05). In conclusion, ET-1 plays a critical role in the structural deterioration of the vasculature during the progression of CHF, and ECE inhibitors can prevent the development of vascular remodeling...
  73. doi request reprint Endothelin-1 as a predictor of atrial fibrillation recurrence after pulmonary vein isolation
    Yuko Nakazawa
    Department of Cardiovascular and Respiratory Medicine, Heart Rhythm Center, Shiga University of Medical Science, Otsu, Japan
    Heart Rhythm 6:725-30. 2009
    ..Although endothelin-1 (ET-1) is involved in atrial remodeling, it is unknown whether plasma ET-1 level before PVI can be used as a predictive factor for AF recurrence...
  74. ncbi request reprint Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction
    M Hayashi
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 37:1820-6. 2001
    ..CONCLUSIONS: These findings indicate that in patients with a first anterior AMI, an ANP infusion can prevent LV remodeling better than can GTN, and effectively suppresses aldosterone, angiotensin II and ET-1...
  75. ncbi request reprint [Plasma brain natriuretic peptide as a useful biomarker of heart failure]
    Takayoshi Tsutamoto
    Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
    Nihon Rinsho 65:417-25. 2007
  76. ncbi request reprint Relation between myocardial response to dobutamine stress and sympathetic nerve activation in patients with idiopathic dilated cardiomyopathy: a comparison of 123I-MIBG scintigraphic and echocardiographic data
    H Naruse
    First Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Ann Nucl Med 14:427-32. 2000
    ..703, p = 0.0107), and with the change in wall motion (r = 0.664, p = 0.0185). Wall motion, especially in the myocardial response to dobutamine stress, is related to sympathetic nerve activity in heart failure...
  77. ncbi request reprint Effect of an angiotensin II type 1 receptor blocker, valsartan, on neurohumoral factors in patients with hypertension: comparison with a long-acting calcium channel antagonist, amlodipine
    Yasunori Ohbayashi
    The Department of Cardiology, Nagahama Red Cross Hospital, Nagahama, Japan
    J Cardiovasc Pharmacol 42:S71-4. 2003
    ..These findings suggested that valsartan is probably superior to amlodipine with respect to less activation of the sympathetic nervous system and preventing upregulation of the renin-angiotensin-aldosterone system...
  78. ncbi request reprint Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial in
    Masaru Hayashi
    Department of Cardivascular Medicine, Nagahama City Hospital, Nagahama, Japan
    Circulation 107:2559-65. 2003
    ..In patients with acute myocardial infarction, we demonstrated that ALD was extracted through the infarct heart and extracting ALD-stimulated post-infarct left ventricular (LV) remodeling...
  79. ncbi request reprint [Prognosis in patients with advanced heart failure]
    Atsuyuki Wada
    Center of Cardiovascular Disease and Heart Failure, Kusatsu General Hospital
    Nihon Rinsho 65:295-9. 2007