Kazuya Shinozaki

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi request reprint [Molecular mechanism of vascular dysfunction in the insulin-resistant state]
    Kazuya Shinozaki
    Nihon Yakurigaku Zasshi 125:285-90. 2005
  2. ncbi request reprint Neurogenic cerebral vasodilation mediated by nitric oxide
    Tomio Okamura
    Department of Pharmacology, Shiga University of Medical Science, Seta, Ohtsu, Japan
    Jpn J Pharmacol 88:32-8. 2002
  3. ncbi request reprint Malfunction of vascular control in lifestyle-related diseases: mechanisms underlying endothelial dysfunction in the insulin-resistant state
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Pharmacol Sci 96:401-5. 2004
  4. ncbi request reprint Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Cardiovasc Pharmacol 49:122-30. 2007
  5. ncbi request reprint Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu, Japan
    Hypertension 43:255-62. 2004
  6. ncbi request reprint Mechanisms underlying endothelium-dependent, nitric oxide- and prostanoid-independent relaxation in monkey and dog coronary arteries
    Hideyuki Fujioka
    Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:488-95. 2002
  7. ncbi request reprint Molecular mechanisms of impaired endothelial function associated with insulin resistance
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan
    Curr Drug Targets Cardiovasc Haematol Disord 4:1-11. 2004
  8. ncbi request reprint Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan
    J Pharmacol Sci 91:187-91. 2003
  9. ncbi request reprint Effects of capsaicin and nitric oxide synthase inhibitor on increase in cerebral blood flow induced by sensory and parasympathetic nerve stimulation in the rat
    Kazuhide Ayajiki
    Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    J Appl Physiol 98:1792-8. 2005
  10. ncbi request reprint Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan
    J Cardiovasc Pharmacol 46:505-12. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint [Molecular mechanism of vascular dysfunction in the insulin-resistant state]
    Kazuya Shinozaki
    Nihon Yakurigaku Zasshi 125:285-90. 2005
  2. ncbi request reprint Neurogenic cerebral vasodilation mediated by nitric oxide
    Tomio Okamura
    Department of Pharmacology, Shiga University of Medical Science, Seta, Ohtsu, Japan
    Jpn J Pharmacol 88:32-8. 2002
    ..Our findings suggest that the nitroxidergic (nitrergic) nerve plays a physiologically important role to maintain a steady blood supply to the brain...
  3. ncbi request reprint Malfunction of vascular control in lifestyle-related diseases: mechanisms underlying endothelial dysfunction in the insulin-resistant state
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Pharmacol Sci 96:401-5. 2004
    ..These results indicate that generation of superoxide anion from NAD(P)H oxidases and an uncoupled eNOS may be pathogenic factors for impaired endothelial function and hypertension in the insulin-resistant state...
  4. ncbi request reprint Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Cardiovasc Pharmacol 49:122-30. 2007
    ..Pitavastatin restores vascular dysfunction by inhibiting NAD(P)H oxidase activity and uncoupled eNOS-dependent O(2)(-) production...
  5. ncbi request reprint Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu, Japan
    Hypertension 43:255-62. 2004
    ..The novel observation of insulin resistance-induced upregulation of AT1 receptor expression could explain the association of insulin resistance with endothelial dysfunction and hypertension...
  6. ncbi request reprint Mechanisms underlying endothelium-dependent, nitric oxide- and prostanoid-independent relaxation in monkey and dog coronary arteries
    Hideyuki Fujioka
    Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:488-95. 2002
    ....
  7. ncbi request reprint Molecular mechanisms of impaired endothelial function associated with insulin resistance
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan
    Curr Drug Targets Cardiovasc Haematol Disord 4:1-11. 2004
    ..These results indicate that abnormal pteridine metabolism contributes to causing endothelial dysfunction and the enhancement of vascular oxidative stress in the insulin-resistant state...
  8. ncbi request reprint Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan
    J Pharmacol Sci 91:187-91. 2003
    ....
  9. ncbi request reprint Effects of capsaicin and nitric oxide synthase inhibitor on increase in cerebral blood flow induced by sensory and parasympathetic nerve stimulation in the rat
    Kazuhide Ayajiki
    Department of Pharmacology, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    J Appl Physiol 98:1792-8. 2005
    ..The afferent impulses by nerve stimulation may stimulate the trigeminal nerve and lead to the rapid increase in MABP, which partly contributes to the increase in CBF...
  10. ncbi request reprint Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats
    Kazuya Shinozaki
    Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan
    J Cardiovasc Pharmacol 46:505-12. 2005
    ..These findings suggest that intramuscular GTP-CH1 gene transfer using atelocollagen serves as a useful method of long-term systemic delivery of BH4 and the treatment of endothelial dysfunction...
  11. ncbi request reprint [Mechanisms of nitric oxide production]
    Kazuhide Ayajiki
    Department of Pharmacology, Shiga University of Medical Science
    Nihon Rinsho 62:446-50. 2004