Keisei Okamoto

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. doi request reprint Epigenetics: a way to understand the origin and biology of testicular germ cell tumors
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 19:504-11. 2012
  2. ncbi request reprint Epigenetic profile of testicular germ cell tumours
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Int J Androl 30:385-92; discussion 392. 2007
  3. ncbi request reprint XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, 520 2192, Shiga, Japan
    Lancet 363:40-2. 2004
  4. doi request reprint Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Mol Carcinog 51:711-22. 2012
  5. ncbi request reprint Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Genes Chromosomes Cancer 38:97-101. 2003
  6. doi request reprint Therapeutic potential of SOX2 inhibition for embryonal carcinoma
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Urol 187:1876-81. 2012
  7. ncbi request reprint Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
  8. ncbi request reprint The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    J Urol 169:1546-52. 2003
  9. ncbi request reprint Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors
    Cheng Zhang
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    Genes Chromosomes Cancer 43:104-12. 2005
  10. doi request reprint DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010

Collaborators

  • Takahiro Kawakami
  • Tokuhiro Chano
  • Cheng Zhang
  • Susumu Kageyama
  • C J Kim
  • Hiroshi Ushida
  • Yusaku Okada
  • Hidetoshi Okabe
  • Kahori Minami
  • Kazuyoshi Johnin
  • Ryo Ikari
  • Ryoji Kushima
  • Zenkai Nishikawa
  • Yoshitaka Murakami
  • Kiyoshi Murata
  • Kenjiro Katoh
  • Ryutaro Takazakura
  • Akira Furukawa
  • Shuichi Koizumi
  • Hiroko Kita
  • Tetsuya Yoshida
  • Akira Kataoka
  • Yoshihiko Wakabayashi
  • Hiroki Soga

Detail Information

Publications18

  1. doi request reprint Epigenetics: a way to understand the origin and biology of testicular germ cell tumors
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 19:504-11. 2012
    ..This review summarizes recent research progress in the epigenetics of testicular germ cell tumors in an attempt to explain the abovementioned biological and clinical characteristics of testicular germ cell tumors...
  2. ncbi request reprint Epigenetic profile of testicular germ cell tumours
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Int J Androl 30:385-92; discussion 392. 2007
    ..These data suggest that unmethylated DNA fragments in TGCTs may have diagnostic implications. Further elucidation of epigenetic profiles in TGCTs is expected to provide a new insight into the biology of this disease...
  3. ncbi request reprint XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, 520 2192, Shiga, Japan
    Lancet 363:40-2. 2004
    ..Male somatic cells, however, show complete methylation through the CpG sites, including the minimum promoter and XIST-conserved repeats. Identification of a XIST unmethylated fragment in male plasma might be diagnostic for TGCTs...
  4. doi request reprint Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Mol Carcinog 51:711-22. 2012
    ..The results indicate that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences differ between TGCTs and cancer cells of somatic tissue origin...
  5. ncbi request reprint Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Genes Chromosomes Cancer 38:97-101. 2003
    ....
  6. doi request reprint Therapeutic potential of SOX2 inhibition for embryonal carcinoma
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Urol 187:1876-81. 2012
    ..Control of embryonal carcinoma cells is crucial to manage nonseminomatous germ cell tumors. We established SOX2 targeting therapy in an embryonal carcinoma model...
  7. ncbi request reprint Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
    ..The present data have shown that gain of methylation upstream of the untranslated GTL2 leads to pathological downregulation of DLK1 in RCCs...
  8. ncbi request reprint The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    J Urol 169:1546-52. 2003
    ..The current study was designed to shed light on the question whether the multiple X chromosomes in testicular germ cell tumor are active or inactive through a complex mechanism of X chromosomal gain and XIST expression...
  9. ncbi request reprint Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors
    Cheng Zhang
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    Genes Chromosomes Cancer 43:104-12. 2005
    ....
  10. doi request reprint DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010
    ..Testicular germ cell tumors (TGCT) have a unique epigenetic profile distinct from that of other types of cancer. Elucidation of these properties has a potential to identify novel markers for TGCTs...
  11. ncbi request reprint Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Oncogene 23:6163-9. 2004
    ..The biological significance of the loss-of-inactive X and gain-of-active X in the oncogenesis of Klinefelter syndrome and female-derived cancer cells are discussed...
  12. doi request reprint Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non-seminomatous germ cell tumor with malignant transformation
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 20:544-6. 2013
    ..This case highlights an issue related to adjuvant chemotherapy for testicular germ cell tumors with components of malignant transformation...
  13. ncbi request reprint Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Urology 61:226-30. 2003
    ..Aberrant promoter methylation is commonly found in human cancers. Nonetheless, it is challenging to demonstrate that methylation of a specific gene results in gene inactivation...
  14. doi request reprint Magnetic resonance voiding cystourethrography (MRVCUG): a potential alternative to standard VCUG
    Kazuyoshi Johnin
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Magn Reson Imaging 38:897-904. 2013
    ..To evaluate the accuracy and feasibility of magnetic resonance voiding cystourethrography (MRVCUG), with or without contrast medium, in detecting vesicoureteral reflux (VUR) by comparison with conventional voiding cystourethrography (VCUG)...
  15. doi request reprint A rare case of multiple schwannomas presenting with scrotal mass: a probable case of schwannomatosis
    Ryo Ikari
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 17:734-6. 2010
    ..In this regard, the present case highlights the importance of thorough history taking in patients with scrotal schwannoma...
  16. doi request reprint Primary synovial sarcoma arising from a crossed ectopic kidney with fusion
    Susumu Kageyama
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 17:96-8. 2010
    ..To our knowledge, this is the first case of primary synovial sarcoma arising from a crossed ectopic kidney with fusion...
  17. ncbi request reprint Transitional cell carcinoma in a single ectopic ureter opening into the ejaculatory duct
    Zenkai Nishikawa
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Urology 60:912. 2002
    ..To our knowledge, we report the first case of primary transitional cell carcinoma in a single ectopic ureter with a dysplastic kidney that terminated in the ejaculatory duct...
  18. ncbi request reprint The MET proto-oncogene is not a major target for the gain of chromosome 7 in testicular germ-cell tumors of adolescents
    Takahiro Kawakami
    Virchows Arch 444:480-1. 2004