Keisei Okamoto

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi Epigenetics: a way to understand the origin and biology of testicular germ cell tumors
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 19:504-11. 2012
  2. ncbi Epigenetic profile of testicular germ cell tumours
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Int J Androl 30:385-92; discussion 392. 2007
  3. ncbi XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, 520 2192, Shiga, Japan
    Lancet 363:40-2. 2004
  4. ncbi Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Mol Carcinog 51:711-22. 2012
  5. ncbi Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Genes Chromosomes Cancer 38:97-101. 2003
  6. ncbi Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
  7. ncbi Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors
    Cheng Zhang
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    Genes Chromosomes Cancer 43:104-12. 2005
  8. ncbi The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    J Urol 169:1546-52. 2003
  9. ncbi DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010
  10. ncbi Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
    Oncogene 23:6163-9. 2004

Collaborators

  • Takahiro Kawakami
  • Tokuhiro Chano
  • Susumu Kageyama
  • C J Kim
  • Hiroshi Ushida
  • Yusaku Okada
  • Hidetoshi Okabe
  • Kahori Minami
  • Ryo Ikari
  • Ryoji Kushima
  • Cheng Zhang
  • Zenkai Nishikawa
  • Kenjiro Katoh
  • Shuichi Koizumi
  • Hiroko Kita
  • Kazuyoshi Johnin
  • Tetsuya Yoshida
  • Akira Kataoka
  • Yoshihiko Wakabayashi
  • Hiroki Soga

Detail Information

Publications17

  1. ncbi Epigenetics: a way to understand the origin and biology of testicular germ cell tumors
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 19:504-11. 2012
    ..This review summarizes recent research progress in the epigenetics of testicular germ cell tumors in an attempt to explain the abovementioned biological and clinical characteristics of testicular germ cell tumors...
  2. ncbi Epigenetic profile of testicular germ cell tumours
    Keisei Okamoto
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Int J Androl 30:385-92; discussion 392. 2007
    ..These data suggest that unmethylated DNA fragments in TGCTs may have diagnostic implications. Further elucidation of epigenetic profiles in TGCTs is expected to provide a new insight into the biology of this disease...
  3. ncbi XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, 520 2192, Shiga, Japan
    Lancet 363:40-2. 2004
    ..Male somatic cells, however, show complete methylation through the CpG sites, including the minimum promoter and XIST-conserved repeats. Identification of a XIST unmethylated fragment in male plasma might be diagnostic for TGCTs...
  4. ncbi Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Mol Carcinog 51:711-22. 2012
    ..The results indicate that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences differ between TGCTs and cancer cells of somatic tissue origin...
  5. ncbi Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Genes Chromosomes Cancer 38:97-101. 2003
    ....
  6. ncbi Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
    ..The present data have shown that gain of methylation upstream of the untranslated GTL2 leads to pathological downregulation of DLK1 in RCCs...
  7. ncbi Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors
    Cheng Zhang
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    Genes Chromosomes Cancer 43:104-12. 2005
    ....
  8. ncbi The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    J Urol 169:1546-52. 2003
    ..The current study was designed to shed light on the question whether the multiple X chromosomes in testicular germ cell tumor are active or inactive through a complex mechanism of X chromosomal gain and XIST expression...
  9. ncbi DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010
    ..Testicular germ cell tumors (TGCT) have a unique epigenetic profile distinct from that of other types of cancer. Elucidation of these properties has a potential to identify novel markers for TGCTs...
  10. ncbi Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
    Oncogene 23:6163-9. 2004
    ..The biological significance of the loss-of-inactive X and gain-of-active X in the oncogenesis of Klinefelter syndrome and female-derived cancer cells are discussed...
  11. ncbi Therapeutic potential of SOX2 inhibition for embryonal carcinoma
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Urol 187:1876-81. 2012
    ..Control of embryonal carcinoma cells is crucial to manage nonseminomatous germ cell tumors. We established SOX2 targeting therapy in an embryonal carcinoma model...
  12. ncbi Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non-seminomatous germ cell tumor with malignant transformation
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga
    Int J Urol 20:544-6. 2013
    ..This case highlights an issue related to adjuvant chemotherapy for testicular germ cell tumors with components of malignant transformation...
  13. ncbi Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Urology 61:226-30. 2003
    ..The data also demonstrated that multiple tumor suppressor genes are simultaneously inactivated in renal cell carcinoma-derived cell lines by distinctive mechanisms...
  14. ncbi Primary synovial sarcoma arising from a crossed ectopic kidney with fusion
    Susumu Kageyama
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 17:96-8. 2010
    ..To our knowledge, this is the first case of primary synovial sarcoma arising from a crossed ectopic kidney with fusion...
  15. ncbi A rare case of multiple schwannomas presenting with scrotal mass: a probable case of schwannomatosis
    Ryo Ikari
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 17:734-6. 2010
    ..In this regard, the present case highlights the importance of thorough history taking in patients with scrotal schwannoma...
  16. ncbi Transitional cell carcinoma in a single ectopic ureter opening into the ejaculatory duct
    Zenkai Nishikawa
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Urology 60:912. 2002
    ..To our knowledge, we report the first case of primary transitional cell carcinoma in a single ectopic ureter with a dysplastic kidney that terminated in the ejaculatory duct...
  17. ncbi The MET proto-oncogene is not a major target for the gain of chromosome 7 in testicular germ-cell tumors of adolescents
    Takahiro Kawakami
    Virchows Arch 444:480-1. 2004