Hidetoshi Okabe

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi request reprint Cytoplasmic non-epithelial mucin accumulation associated with CD44 in an astrocytic tumor with signet ring features
    Hidetoshi Okabe
    Division of Diagnostic Pathology, Department of Laboratory Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, 520 2192, Japan
    Brain Tumor Pathol 31:124-30. 2014
  2. ncbi request reprint [Problems to be solved to qualify to receive laboratory examination management fee III or IV for board-certified doctors in the fields of both laboratory medicine and anatomical pathology]
    Hidetoshi Okabe
    Department of Laboratory Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 61:547-51. 2013
  3. pmc Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma
    Kanji Mori
    Department of Clinical Laboratory Medicine, Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, 520 2192, Japan
    BMC Musculoskelet Disord 5:20. 2004
  4. pmc Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway
    Kahori Minami
    Department of Microbiology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Virol 81:11106-15. 2007
  5. doi request reprint RB1CC1 activates the p16 promoter through the interaction with hSNF5
    Yasuko Ochi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 219, Japan
    Oncol Rep 26:805-12. 2011
  6. pmc RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e15737. 2010
  7. ncbi request reprint GADD34 induces p21 expression and cellular senescence
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Oncol Rep 17:1481-5. 2007
  8. doi request reprint DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010
  9. pmc RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e11404. 2010
  10. doi request reprint Therapeutic potential of SOX2 inhibition for embryonal carcinoma
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Urol 187:1876-81. 2012

Detail Information

Publications92

  1. ncbi request reprint Cytoplasmic non-epithelial mucin accumulation associated with CD44 in an astrocytic tumor with signet ring features
    Hidetoshi Okabe
    Division of Diagnostic Pathology, Department of Laboratory Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, 520 2192, Japan
    Brain Tumor Pathol 31:124-30. 2014
    ..The tumor has not recurred for more than 3 years after the irradiation therapy following the second surgery, but further clinical observation is needed to evaluate the exact clinical behavior of this unusual tumor...
  2. ncbi request reprint [Problems to be solved to qualify to receive laboratory examination management fee III or IV for board-certified doctors in the fields of both laboratory medicine and anatomical pathology]
    Hidetoshi Okabe
    Department of Laboratory Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 61:547-51. 2013
    ..Consultation regarding laboratory data analysis is required, and experience in diagnostic pathology is beneficial for data interpretation or tissue sample handling in the field of neoplastic diseases...
  3. pmc Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma
    Kanji Mori
    Department of Clinical Laboratory Medicine, Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, 520 2192, Japan
    BMC Musculoskelet Disord 5:20. 2004
    ..Previously, little attention has been paid to pathogenic features of muscle fibers around an intramuscular lipoma...
  4. pmc Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway
    Kahori Minami
    Department of Microbiology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Virol 81:11106-15. 2007
    ....
  5. doi request reprint RB1CC1 activates the p16 promoter through the interaction with hSNF5
    Yasuko Ochi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 219, Japan
    Oncol Rep 26:805-12. 2011
    ..Evaluation of the RB1CC1 mechanism of action is expected to provide useful information for clinical practice and future therapeutic strategies in human cancers...
  6. pmc RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e15737. 2010
    ....
  7. ncbi request reprint GADD34 induces p21 expression and cellular senescence
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Oncol Rep 17:1481-5. 2007
    ..These findings suggest that GADD34 contributes to the regulation of p21 expression, and that it suppresses cellular proliferation through the induction of cellular senescence...
  8. doi request reprint DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010
    ..Testicular germ cell tumors (TGCT) have a unique epigenetic profile distinct from that of other types of cancer. Elucidation of these properties has a potential to identify novel markers for TGCTs...
  9. pmc RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e11404. 2010
    ..Evaluation of RB1CC1 expression combined with RB1 and p53 status is expected to provide useful information in clinical practice and future therapeutic strategies in breast cancer...
  10. doi request reprint Therapeutic potential of SOX2 inhibition for embryonal carcinoma
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Urol 187:1876-81. 2012
    ..Control of embryonal carcinoma cells is crucial to manage nonseminomatous germ cell tumors. We established SOX2 targeting therapy in an embryonal carcinoma model...
  11. doi request reprint Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Mol Carcinog 51:711-22. 2012
    ..The results indicate that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences differ between TGCTs and cancer cells of somatic tissue origin...
  12. ncbi request reprint Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma
    Fumiyoshi Kojima
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
    Oncol Rep 23:927-31. 2010
    ..Therefore, CPE therapy may be a potential therapeutic target for EBV-associated non-keratinizing NPC, since our results clearly showed claudin-3 and/or -4 expression in all cases studied...
  13. ncbi request reprint RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells
    Keiichi Kontani
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 12:767-9. 2003
    ..These data suggested that RB1CC1 induces the expression of RB1, especially of underphosphorylated forms, then suppresses cell cycle progression in human neoplastic cells...
  14. doi request reprint Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers
    Hitosuke Tameno
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Japan
    Head Neck 34:674-80. 2012
    ..7..
  15. ncbi request reprint Detection of lymph node micrometastasis in pN0 early gastric cancer: efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer
    Hiromichi Sonoda
    Department of Surgery, Shiga University of Medical Science, Shiga 520 2192, Japan
    Oncol Rep 16:411-6. 2006
    ..LMM detected in this manner may prove useful in broadening the indications for endoscopic mucosal resection in elevated-type cancer...
  16. doi request reprint RB1CC1 activates the promoter and expression of RB1 in human cancer
    Kaichiro Ikebuchi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Int J Cancer 125:861-7. 2009
    ..Evaluation of RB1CC1 in various types of human cancer tissues is expected to provide useful information for clinical practice and future therapeutic strategies...
  17. ncbi request reprint Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 18:425-32. 2006
    ..RB1CC1 preserved cell size without cell cycle progression especially in neuromuscular tissues, and the abundance contributed to the non-proliferating enlarged cell phenotype...
  18. pmc Occurrence of Epstein-Barr virus-associated plasmacytic lymphoproliferative disorder after antithymocyte globulin therapy for aplastic anemia: a case report with review of the literature
    Ryota Nakanishi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 7:1748-54. 2014
    ..Therefore, detailed histopathological and immunohistochemical analyses are needed for correct diagnosis and treatment, and additional studies are needed to clarify the clinicopathological features of EBV-LPD after IST for AA...
  19. pmc Primary cutaneous anaplastic large cell lymphoma occurring in an atopic dermatitis patient: a case report with review of the literature with emphasis on their association
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan Division of Diagnostic pathology, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 7:1735-41. 2014
    ..Therefore, albeit extremely rare, AD patients with C-ALCL should be monitored closely, and additional clinicopathological studies are needed to clarify the pathogenesis of C-ALCL occurring in patients with AD. ..
  20. doi request reprint Mediastinal seminoma: a case report with special emphasis on SALL4 as a new immunocytochemical marker
    Nozomi Iwamoto
    Division of Diagnostic Pathology, Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Diagn Cytopathol 41:821-4. 2013
    ....
  21. pmc Occurrence of anaplastic large cell lymphoma following IgG4-related autoimmune pancreatitis and cholecystitis and diffuse large B-cell lymphoma
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan Division of Diagnostic pathology, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 6:2560-8. 2013
    ..It has been suggested that the incidence of malignant lymphoma may be high in patients with IgG4-related sclerosing disease, therefore, intense medical follow-up is important in patients with this disorder. ..
  22. pmc Anaplastic lymphoma kinase-positive large B-cell lymphoma: a case report with emphasis on the cytological features of the pleural effusion
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan Division of Diagnostic pathology, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 6:2631-5. 2013
    ..Albeit extremely rare, ALK-positive LBCL shows aggressive clinical course, thus, recognition of the cytomorphological features of this type of malignant lymphoma is important for early and correct diagnosis. ..
  23. pmc Clinicopathological features of acute promyelocytic leukemia: an experience in one institute emphasizing the morphological and immunophenotypic changes at the time of relapse
    Miyuki Yoshii
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 6:2192-8. 2013
    ..Therefore, a comprehensive approach with emphasis on combined morphological, immunophenotypic, and cytogenetic analyses is important for diagnosis and appropriate treatment of relapsed APL. ..
  24. ncbi request reprint GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
    Ryosuke Watanabe
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 19:475-83. 2007
    ..GADD34 may find clinical potential as a target drug for the treatment of mTOR-associated diseases...
  25. pmc Methotrexate-related Epstein-Barr virus-associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan Division of Diagnostic pathology, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 6:2237-41. 2013
    ..Moreover, immunosenescence can also be a cause of EBV-associated LPD. Therefore, recognition of the occurrence of this disorder in the oral cavity and consideration of the clinical history can facilitate the correct diagnosis. ..
  26. doi request reprint Re-evaluation of histogenesis of gastric carcinomas: a comparative histopathological study between Helicobacter pylori-negative and H. pylori-positive cases
    Rie Kakinoki
    Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, 520 2192, Japan
    Dig Dis Sci 54:614-20. 2009
    ..pylori-infection, i.e., ongoing atrophy...
  27. ncbi request reprint RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Brain Res 1168:97-105. 2007
    ..These observations may have implications for the pathogenesis of Alzheimer's disease...
  28. pmc Hepatocellular carcinoma occurring in a Crohn's disease patient
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    World J Gastroenterol 16:3215-8. 2010
    ..These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors...
  29. pmc Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct
    Mitsuaki Ishida
    Mitsuaki Ishida, Fumiyoshi Kojima, Machiko Hotta, Hidetoshi Okabe, Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    World J Gastrointest Oncol 3:111-5. 2011
    ..Therefore, additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract...
  30. doi request reprint RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma
    Akihito Arai
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Cancer Res 71:4598-607. 2011
    ..Our findings offer a preclinical proof of concept for RECQL1 and WRN proteins as novel therapeutic targets to treat aggressive HNSCC and perhaps other cancers...
  31. ncbi request reprint Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation
    Ryoji Kushima
    Division of Diagnostic Pathology, Shiga University of Medical Science, Seta, Otsu, 520 2192 Shiga, Japan
    Virchows Arch 446:537-41. 2005
    ..2, 2q14.1-ter, 5q31.3-32, 6q23-24, 8q23-24.2, 11q22.3-24 and 18q21.1-22. This is the first case of pyloric gland adenoma found to arise in Barrett's epithelium of the esophagus, showing its unstable and precancerous nature...
  32. pmc Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature
    Ryota Nakanishi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Clin Exp Pathol 6:1677-82. 2013
    ....
  33. pmc Pleomorphic lobular carcinoma in a male breast: a case report with review of the literature
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
    Int J Clin Exp Pathol 6:1441-4. 2013
    ..The clinicopathological features of ILC of male breast remains unclear; therefore, additional studies are needed to clarify them. ..
  34. pmc Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation
    Takahiro Isono
    Central Reseach Laboratory, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 8:e60397. 2013
    ..Taken together, our results suggest N-GlcNAc2-modified proteins produced under glucose deprivation caused unfolded protein response in the ER, and that this response induced G2/M arrest...
  35. pmc RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism
    Ichiro Nishimura
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Biol Chem 286:43925-32. 2011
    ..Accordingly, human genotypic variants of RB1CC1 that either stimulate or inhibit RB1CC1 transcription in vivo may cause body size variations...
  36. ncbi request reprint Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Oncol Rep 11:1257-63. 2004
    ..Molecular and biological characterization of these genes will yield further insight into the features between MDR and tumor progression in human osteosarcomas...
  37. pmc Concomitant occurrence of IgG4-related pleuritis and periaortitis: a case report with review of the literature
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, Japan Division of Diagnostic pathology, Shiga University of Medical Science Shiga, Japan
    Int J Clin Exp Pathol 7:808-14. 2014
    ....
  38. doi request reprint A case of retroperitoneal immature teratoma with nephroblastic components
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Division of Diagnostic Pathology Shiga University of Medical Science, Shiga, Japan
    J Pediatr Hematol Oncol 34:e22-5. 2012
    ..The prognosis of retroperitoneal teratomas with nephroblastic components has not yet been established, therefore, additional case studies are needed...
  39. doi request reprint A case of porocarcinoma arising in pigmented hidroacanthoma simplex with multiple lymph node, liver and bone metastases
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Cutan Pathol 38:227-31. 2011
    ..Ishida M, Hotta M, Kushima R, Okabe H. A case of porocarcinoma arising in pigmented hidroacanthoma simplex with multiple lymph node, liver and bone metastases...
  40. pmc Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Pathol 161:359-64. 2002
    ....
  41. ncbi request reprint Expression and regulation of RB1CC1 in developing murine and human tissues
    Noriko Bamba
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 529 2192, Japan
    Int J Mol Med 14:583-7. 2004
    ..These results suggested that more Rb1cc1 is expressed throughout developing murine than in human tissues, and that RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice...
  42. doi request reprint IgG4-related inflammatory aneurysm of the aortic arch
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Pathol Int 59:269-73. 2009
    ..Further studies are needed to clarify the spectrum of IgG4-related sclerosing disease in the cardiovascular system...
  43. ncbi request reprint Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors)
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Oncol Rep 21:113-7. 2009
    ....
  44. doi request reprint Immunohistochemical demonstration of D2-40 in basal cell carcinomas of the skin
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    J Cutan Pathol 35:926-30. 2008
    ....
  45. doi request reprint CD8-positive granulomatous mycosis fungoides: a case report with review of the literature
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
    J Cutan Pathol 37:1072-6. 2010
    ..In addition, the prognosis of GMF, especially CD8-positive GMF, is still controversial. Additional studies are required to clarify the clinicopathological features of CD8-positive GMF...
  46. ncbi request reprint Surgery-induced peritoneal cancer cells in patients who have undergone curative gastrectomy for gastric cancer
    Katsushi Takebayashi
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    Ann Surg Oncol 21:1991-7. 2014
    ..Some patients who undergo curative gastrectomy with lymph node dissection (LND) for gastric cancer (GC) show subsequent peritoneal metastasis. The source of these metastatic cells remains unclear...
  47. ncbi request reprint [A case of primary mucinous carcinoma with endocrine differentiation of the skin]
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Ohtsu 520 2192, Japan
    Rinsho Byori 56:455-8. 2008
    ..To clarify the difference and/or similarity between mucinous carcinoma of the breast and MCS, immunohistochemical and cytogenetic analyses of additional cases of MCS are required...
  48. doi request reprint Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non-seminomatous germ cell tumor with malignant transformation
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 20:544-6. 2013
    ..This case highlights an issue related to adjuvant chemotherapy for testicular germ cell tumors with components of malignant transformation...
  49. doi request reprint Ascitic fluid due to type II herpes simplex virus infection: report of a case with immunocytochemical confirmation
    Keiko Yoshida
    Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
    Diagn Cytopathol 41:354-9. 2013
    ....
  50. doi request reprint Thymic papillo-tubular adenocarcinoma containing a cyst: report of a case
    Koji Teramoto
    Department of Surgery, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Surg Today 42:988-91. 2012
    ..Pathological examination of the tumor revealed a primary thymic papillo-tubular adenocarcinoma resembling a tumor of gut origin. Thymic adenocarcinomas, particularly of the tubular subtype, are extremely rare...
  51. doi request reprint Pulmonary infarction associated with bronchogenic carcinoma
    Masashi Takahashi
    Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
    Radiat Med 26:76-80. 2008
    ..We conclude that pulmonary infarction should be considered as a differential diagnosis when peripheral pulmonary nodules or masses are located in the same lobe as the primary cancer...
  52. ncbi request reprint [HER2 protein in the serum and nipple discharge]
    Hidetoshi Okabe
    Department of Laboratory Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:753-5. 2005
  53. pmc Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application
    Yusuke Hama
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    PLoS ONE 7:e32052. 2012
    ..These monoclonal antibodies will help to generate new opportunities in scientific examinations in biology and clinical medicine...
  54. doi request reprint Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin
    Takao Ogawa
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Auris Nasus Larynx 39:224-8. 2012
    ..The early diagnosis, surgical debridement and a new combination therapy with liposomal amphotericin B and micafungin were effective. This new combination antifungal therapy will be useful for the treatment of mucormycosis...
  55. pmc Hepatic reactive lymphoid hyperplasia in a patient with primary biliary cirrhosis
    Mitsuaki Ishida
    Mitsuaki Ishida, Fumiyoshi Kojima, Machiko Hotta, Hidetoshi Okabe, Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    World J Hepatol 2:387-91. 2010
    ..Pre-operative diagnosis of hepatic RLH by clinical imaging is extremely difficult. Therefore, a needle biopsy could be useful to make a diagnosis of hepatic RLH, especially to differentiate from metastatic gastrointestinal carcinoma...
  56. ncbi request reprint Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Oncol Rep 18:633-7. 2007
    ..However, loss of its expression was observed in cases with metastases (3/5) and can be regarded as an additional parameter to predict the risk of metastasis in rectal well-differentiated endocrine neoplasms...
  57. ncbi request reprint Isolation, characterization and mapping of the mouse and human RB1CC1 genes
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Gene 291:29-34. 2002
    ..2 and 57 kb on chromosome 1A2-4, respectively. Conserved sequence motifs and nuclear localization suggest that the RB1CC1 proteins function as transcription factors...
  58. ncbi request reprint Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese males
    Kanji Mori
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, Japan
    Am J Med Genet A 130:169-71. 2004
    ..Haplotype analysis did not demonstrate more significant association. The CYP17 SNP is associated with SNSA in HLA-B27-negative Japanese males...
  59. ncbi request reprint Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma
    Yoshitomo Ozaki
    Second Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    Cancer 95:1954-62. 2002
    ..Therefore, it would be beneficial for M2BP to be targeted in cancer immunotherapy...
  60. ncbi request reprint Colloid carcinoma of the uterine cervix: a case report with respect to immunohistochemical analyses
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
    Int J Gynecol Pathol 33:248-52. 2014
    ..Moreover, this case clearly demonstrates that the occurrence of cervical colloid carcinoma correlates with high-risk human papillomavirus. ..
  61. pmc Sarcomatoid carcinoma with small cell carcinoma component of the urinary bladder: a case report with review of the literature
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Clin Exp Pathol 6:1671-6. 2013
    ..However, recent molecular analyses demonstrated a monoclonal origin of both components. This theory can account for the various types of carcinomatous components in this tumor as seen in the present case. ..
  62. ncbi request reprint Expression of macrophage inflammatory protein-1alpha in Schwann cell tumors
    Kanji Mori
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Neuropathology 24:131-5. 2004
    ..Furthermore, various levels of MIP-1alpha expression in these tumors were implicated to be correlated with histological variations...
  63. ncbi request reprint Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 57:746-51. 2009
    ..And further study is needed to clarify the clinicopathological features of the lacrimal ductal adenocarcinoma...
  64. ncbi request reprint HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer
    Minako Fujita
    Department of Surgery, Shiga University of Medical Science, Shiga 520 2192, Japan
    Mol Med Report 1:225-30. 2008
    ..However, cases with a favourable response to gefitinib did not always express EGFR. Gefitinib appears to suppress growth signal pathways other than EGFR-tyrosine kinase activation in non-small cell lung cancers...
  65. ncbi request reprint Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skin
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Oncol Rep 22:733-7. 2009
    ..beta III is a potential candidate for inclusion to the panel of immunohistochemical markers to distinguish small BCCs from non-neoplastic hair buds, because non-neoplastic hair follicles are not positive for beta III...
  66. ncbi request reprint Detection of lymph node micrometastasis in gastric cancer by MUC2 RT-PCR: usefulness in pT1 cases
    Hiromichi Sonoda
    Department of Surgery, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    J Surg Oncol 88:63-70. 2004
    ....
  67. ncbi request reprint Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells
    Tokuhiro Chano
    Department of Basic Science for Health and Nursing, Shiga University of Medical Science, Tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Oncogene 21:1295-8. 2002
    ..Moreover, introduction of wild-type RB1CC1 significantly induced RB1 expression in human leukemic cells. These data suggest that RB1CC1 may be a key regulator of RB1 gene expression...
  68. pmc Association of p62/SQSTM1 excess and oral carcinogenesis
    Takuma Inui
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 8:e74398. 2013
    ..Immunohistochemical evaluation of p62/SQSTM1 may be a potential significant marker to identify early carcinogenesis, chemo-radiotherapeutic resistance or poor prognosis of oral squamous cell carcinomas. ..
  69. doi request reprint Cytologic and immunophenotypic features of CD34+ stem cells in body cavity fluids
    Hideo Kataoka
    Department of Clinical Laboratory, Saiseikai Shiga Hospital, Imperial Gift Foundation, Inc, Shiga, Japan
    Acta Cytol 56:401-7. 2012
    ....
  70. ncbi request reprint [Proposal of possible diagnostic strategy for intravascular large B-cell lymphoma--usefulness of biopsy from senile hemangioma]
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 60:201-5. 2012
    ....
  71. ncbi request reprint Combined effect of hydrogen peroxide induced oxidative stress and IL-1 alpha on IL-8 production in CaCo-2 cells (a human colon carcinoma cell line) and normal intestinal epithelial cells
    Kazuo Yamamoto
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta Tsukinowa, Ohtsu, Shiga, Japan
    Inflammation 27:123-8. 2003
    ..Exposure to hydrogen peroxide, followed by IL-1alpha, enhanced IL-8 production over that achieved with IL-1alpha alone. Thus, oxidative stress and IL-1alpha were observed to cooperatively enhance IL-8 production...
  72. doi request reprint Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Pathol Int 59:670-5. 2009
    ..The present case suggests that IgG4-related sclerosing lesion can occur in the maxillary sinus and nasal septum, and represents an extension of the spectrum of IgG4-related sclerosing disease...
  73. doi request reprint Cytological features of myxoid adrenocortical adenoma with a pseudoglandular component: a case report with differential diagnostic considerations
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Diagn Cytopathol 36:576-80. 2008
    ..Careful observation of these cytological features and positive immunoreactivity to Melan A, alpha-inhibin and synaptophysin can lead to the correct diagnosis...
  74. ncbi request reprint A rare case of multiple schwannomas presenting with scrotal mass: a probable case of schwannomatosis
    Ryo Ikari
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Urol 17:734-6. 2010
    ..In this regard, the present case highlights the importance of thorough history taking in patients with scrotal schwannoma...
  75. ncbi request reprint Case of Bowen's disease accompanying syringofibroadenoma
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 59:470-4. 2011
    ..In this report, we summarize the clinicopathological features of carcinoma accompanying syringofibroadenoma and discuss the nature of syringofibroadenoma...
  76. ncbi request reprint [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin]
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu
    Rinsho Byori 54:781-4. 2006
    ....
  77. ncbi request reprint Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
    ..The present data have shown that gain of methylation upstream of the untranslated GTL2 leads to pathological downregulation of DLK1 in RCCs...
  78. ncbi request reprint Tentorial schwannoma in a 64-year-old female: case report
    Naoki Nitta
    Department of Neurosurgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    Neurol Med Chir (Tokyo) 51:239-43. 2011
    ..The present case of tentorial schwannoma not associated with the cranial nerves is extremely rare. Schwannoma should be included in the differential diagnosis of tumors arising from the tentorium...
  79. ncbi request reprint Co-expression of neuronal intermediate filaments, peripherin and α-internexin in human well-differentiated endocrine neoplasms (carcinoid tumors) of the appendix
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Mol Med Report 1:191-5. 2008
    ..It is uncertain whether the expression of peripherin and/or α-internexin is present in the well-differentiated endocrine neoplasms of other organs; further analysis is required to clarify this issue...
  80. doi request reprint Mediastinal seminoma occurring in Down syndrome
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
    J Pediatr Hematol Oncol 34:387-8. 2012
    ..Histopathological findings of the resected tumor were typical of seminoma. This case indicates that seminoma can occur in the mediastinum in addition to testis in Down syndrome...
  81. ncbi request reprint Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands
    Ryoji Kushima
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192 Japan
    Virchows Arch 440:655-9. 2002
    ..Therefore the present carcinoma is thought to have developed under induction of gastric-foveolar differentiation in a manner very similar to that of gastric metaplasia in hyperplastic Brunner's glands...
  82. ncbi request reprint Collagenous gastritis in a young Japanese woman
    Yuri Kajino
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Pathol Int 53:174-8. 2003
    ..The size of the collagen band did not change for 2 years. These findings suggest that subepithelial collagen deposition was due to an abnormal local immune response based on generalized allergic disorder...
  83. ncbi request reprint Truncating mutations of RB1CC1 in human breast cancer
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Nat Genet 31:285-8. 2002
    ..In all seven cancers, both RB1CC1 alleles were inactivated; two showed compound heterozygous deletions. Thus, RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor-suppressor gene...
  84. ncbi request reprint Expression of E-cadherin in chordomas: diagnostic marker and possible role of tumor cell affinity
    Kanji Mori
    Department of Orthopedic Surgery, Shiga University of Medical Science, Otsu, Japan
    Virchows Arch 440:123-7. 2002
    ..Furthermore, we speculate that E-cadherin may play a role in tumor cell adhesion and is also involved with histological and clinical features in chordomas...
  85. ncbi request reprint Role of alternative splicing of periostin in human bladder carcinogenesis
    Chul Jang Kim
    Department of Urology, Kohka Public Hospital, Kohka, Shiga 528 0014, Japan
    Int J Oncol 32:161-9. 2008
    ..These results indicate that the loss of WT periostin by down-regulation and/or alternative splicing, which produces Variant I, is closely correlated with the development of bladder cancer...
  86. ncbi request reprint Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia
    Suzuko Moritani
    Department of Pathology and Clinical Laboratories, Nagoya Medical Center, 4 1 1, Sannomaru, Naka ku, Nagoya, Aichi, 460 0001, Japan
    Virchows Arch 450:539-47. 2007
    ....
  87. ncbi request reprint Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms
    Natsuko Tatsumi
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo ku, 602 8566 Kyoto, Japan
    Virchows Arch 448:756-62. 2006
    ..These results suggest that gastric-type mucins play an important role in the initial step of CC-tumorigenesis, and CK7 and gastric-type mucins may be useful in the differential diagnosis between UC-associated neoplasms and sporadic ones...
  88. ncbi request reprint Rb1cc1 is critical for myoblast differentiation through Rb1 regulation
    Ryosuke Watanabe
    Department of Applied Biological Science, Faculty of Science and Technology, Science University of Tokyo, 278 0022 Chiba, Japan
    Virchows Arch 447:643-8. 2005
    ..These results indicated that Rb1cc1 is a potent regulator of the Rb1 pathway and a novel mediator that plays a crucial role in muscular differentiation. Rb1cc1 expression is, thus, a prerequisite for myogenic differentiation...
  89. ncbi request reprint Target specificities of estrogen receptor-related receptors: analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene
    Mst Hasina Akter
    Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo, Japan
    J Biochem 143:395-406. 2008
    ..In vivo binding of ERRalpha to the Rb1cc1 promoter region was confirmed by the chromatin immunoprecipitation assay. Thus, Rb1cc1 is a target gene of ERRalpha, driven by a novel type of recognition sequence...
  90. ncbi request reprint [Significance of extracellular matrix determined by immunostains and histochemical stains in a case of pulmonary epithelioid hemangioendothelioma]
    Hideo Saito
    Aichi Health Promotion Foundation, Nagoya 462 0844
    Rinsho Byori 53:213-6. 2005
    ..These findings suggested that enhanced basement membrane protein synthesis in PEH seems to be responsible for the accumulation of abundant ECM. Analysis of the ECM seems to be quite useful for the differential diagnosis of this tumor...
  91. ncbi request reprint Eosinophilic cell change of the endometrium: a possible relationship to mucinous differentiation
    Suzuko Moritani
    Department of Pathology and Clinical Laboratories, Nagoya Medical Center, Nagoya, Aichi, Japan
    Mod Pathol 18:1243-8. 2005
    ..Most of the endometrial changes characterized by cytoplasmic eosinophilia may be subtypes of immature mucinous metaplasia which express a mucin core protein but are not fully glycosylated...
  92. ncbi request reprint Highly anaplastic extraventricular ependymoma arising in an adult, mimicking metastatic adenocarcinoma with heavy stromal inflammation and emperiporesis
    Suzuko Moritani
    Department of Pathology, Saiseikai Shiga Hospital Imperial Gift Foundation Inc, Ohtsu, Japan
    Pathol Int 53:539-46. 2003
    ..Although this tumor might be classified to at least WHO grade III from the histology and aggressive behavior, the exact grading is still controversial because of the rarity of such cases...