Research Topics
Genomes and Genes
| Hidetoshi OkabeSummaryAffiliation: Shiga University of Medical Science Country: Japan Publications
| Collaborators
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Detail Information
Publications
Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipomaKanji Mori
Department of Clinical Laboratory Medicine, Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, 520 2192, Japan
BMC Musculoskelet Disord 5:20. 2004..Previously, little attention has been paid to pathogenic features of muscle fibers around an intramuscular lipoma...
Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathwayKahori Minami
Department of Microbiology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
J Virol 81:11106-15. 2007....
RB1CC1 activates the p16 promoter through the interaction with hSNF5Yasuko Ochi
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 219, Japan
Oncol Rep 26:805-12. 2011..Evaluation of the RB1CC1 mechanism of action is expected to provide useful information for clinical practice and future therapeutic strategies in human cancers...- RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patientsTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
PLoS ONE 5:e15737. 2010.... 
GADD34 induces p21 expression and cellular senescenceKahori Minami
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Oncol Rep 17:1481-5. 2007..These findings suggest that GADD34 contributes to the regulation of p21 expression, and that it suppresses cellular proliferation through the induction of cellular senescence...- DNMT3L is a novel marker and is essential for the growth of human embryonal carcinomaKahori Minami
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
Clin Cancer Res 16:2751-9. 2010..Testicular germ cell tumors (TGCT) have a unique epigenetic profile distinct from that of other types of cancer. Elucidation of these properties has a potential to identify novel markers for TGCTs... - RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancerTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
PLoS ONE 5:e11404. 2010..Evaluation of RB1CC1 expression combined with RB1 and p53 status is expected to provide useful information in clinical practice and future therapeutic strategies in breast cancer... - Methylation profile of DNA repetitive elements in human testicular germ cell tumorHiroshi Ushida
Department of Urology, Shiga University of Medical Science, Shiga, Japan
Mol Carcinog 51:711-22. 2012..The results indicate that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences differ between TGCTs and cancer cells of somatic tissue origin... - Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinomaFumiyoshi Kojima
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
Oncol Rep 23:927-31. 2010..Therefore, CPE therapy may be a potential therapeutic target for EBV-associated non-keratinizing NPC, since our results clearly showed claudin-3 and/or -4 expression in all cases studied... - Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancersHitosuke Tameno
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Japan
Head Neck 34:674-80. 2012..7.. - Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradationTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Int J Mol Med 18:425-32. 2006..RB1CC1 preserved cell size without cell cycle progression especially in neuromuscular tissues, and the abundance contributed to the non-proliferating enlarged cell phenotype... - RB1CC1 activates the promoter and expression of RB1 in human cancerKaichiro Ikebuchi
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
Int J Cancer 125:861-7. 2009..Evaluation of RB1CC1 in various types of human cancer tissues is expected to provide useful information for clinical practice and future therapeutic strategies... - Detection of lymph node micrometastasis in pN0 early gastric cancer: efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancerHiromichi Sonoda
Department of Surgery, Shiga University of Medical Science, Shiga 520 2192, Japan
Oncol Rep 16:411-6. 2006..LMM detected in this manner may prove useful in broadening the indications for endoscopic mucosal resection in elevated-type cancer... - RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cellsKeiichi Kontani
Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
Int J Mol Med 12:767-9. 2003..These data suggested that RB1CC1 induces the expression of RB1, especially of underphosphorylated forms, then suppresses cell cycle progression in human neoplastic cells... - Re-evaluation of histogenesis of gastric carcinomas: a comparative histopathological study between Helicobacter pylori-negative and H. pylori-positive casesRie Kakinoki
Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, 520 2192, Japan
Dig Dis Sci 54:614-20. 2009..pylori-infection, i.e., ongoing atrophy... - RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseasesTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Brain Res 1168:97-105. 2007..These observations may have implications for the pathogenesis of Alzheimer's disease... - Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluationRyoji Kushima
Division of Diagnostic Pathology, Shiga University of Medical Science, Seta, Otsu, 520 2192 Shiga, Japan
Virchows Arch 446:537-41. 2005..2, 2q14.1-ter, 5q31.3-32, 6q23-24, 8q23-24.2, 11q22.3-24 and 18q21.1-22. This is the first case of pyloric gland adenoma found to arise in Barrett's epithelium of the esophagus, showing its unstable and precancerous nature... - Hepatocellular carcinoma occurring in a Crohn's disease patientMitsuaki Ishida
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
World J Gastroenterol 16:3215-8. 2010..These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors... - RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinomaAkihito Arai
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
Cancer Res 71:4598-607. 2011..Our findings offer a preclinical proof of concept for RECQL1 and WRN proteins as novel therapeutic targets to treat aggressive HNSCC and perhaps other cancers... - Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile ductMitsuaki Ishida
Mitsuaki Ishida, Fumiyoshi Kojima, Machiko Hotta, Hidetoshi Okabe, Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
World J Gastrointest Oncol 3:111-5. 2011..Therefore, additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract... - RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfismIchiro Nishimura
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
J Biol Chem 286:43925-32. 2011..Accordingly, human genotypic variants of RB1CC1 that either stimulate or inhibit RB1CC1 transcription in vivo may cause body size variations... - Therapeutic potential of SOX2 inhibition for embryonal carcinomaHiroshi Ushida
Department of Urology, Shiga University of Medical Science, Shiga, Japan
J Urol 187:1876-81. 2012..Control of embryonal carcinoma cells is crucial to manage nonseminomatous germ cell tumors. We established SOX2 targeting therapy in an embryonal carcinoma model... - Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cellsTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
Oncol Rep 11:1257-63. 2004..Molecular and biological characterization of these genes will yield further insight into the features between MDR and tumor progression in human osteosarcomas... - GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stressRyosuke Watanabe
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Int J Mol Med 19:475-83. 2007..GADD34 may find clinical potential as a target drug for the treatment of mTOR-associated diseases... - A case of retroperitoneal immature teratoma with nephroblastic componentsMitsuaki Ishida
Department of Clinical Laboratory Medicine, Division of Diagnostic Pathology Shiga University of Medical Science, Shiga, Japan
J Pediatr Hematol Oncol 34:e22-5. 2012..The prognosis of retroperitoneal teratomas with nephroblastic components has not yet been established, therefore, additional case studies are needed... - Immunohistochemical demonstration of D2-40 in basal cell carcinomas of the skinMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
J Cutan Pathol 35:926-30. 2008.... - Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors)Mitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Oncol Rep 21:113-7. 2009.... - IgG4-related inflammatory aneurysm of the aortic archMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
Pathol Int 59:269-73. 2009..Further studies are needed to clarify the spectrum of IgG4-related sclerosing disease in the cardiovascular system... - A case of porocarcinoma arising in pigmented hidroacanthoma simplex with multiple lymph node, liver and bone metastasesMitsuaki Ishida
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan
J Cutan Pathol 38:227-31. 2011..Ishida M, Hotta M, Kushima R, Okabe H. A case of porocarcinoma arising in pigmented hidroacanthoma simplex with multiple lymph node, liver and bone metastases... - CD8-positive granulomatous mycosis fungoides: a case report with review of the literatureMitsuaki Ishida
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
J Cutan Pathol 37:1072-6. 2010..In addition, the prognosis of GMF, especially CD8-positive GMF, is still controversial. Additional studies are required to clarify the clinicopathological features of CD8-positive GMF... - Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cellsTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
Am J Pathol 161:359-64. 2002.... - Expression and regulation of RB1CC1 in developing murine and human tissuesNoriko Bamba
Department of Pediatrics, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 529 2192, Japan
Int J Mol Med 14:583-7. 2004..These results suggested that more Rb1cc1 is expressed throughout developing murine than in human tissues, and that RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice... - Preparation of mouse monoclonal antibody for RB1CC1 and its clinical applicationYusuke Hama
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
PLoS ONE 7:e32052. 2012..These monoclonal antibodies will help to generate new opportunities in scientific examinations in biology and clinical medicine... - Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafunginTakao Ogawa
Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
Auris Nasus Larynx 39:224-8. 2012..The early diagnosis, surgical debridement and a new combination therapy with liposomal amphotericin B and micafungin were effective. This new combination antifungal therapy will be useful for the treatment of mucormycosis... - Hepatic reactive lymphoid hyperplasia in a patient with primary biliary cirrhosisMitsuaki Ishida
Mitsuaki Ishida, Fumiyoshi Kojima, Machiko Hotta, Hidetoshi Okabe, Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
World J Hepatol 2:387-91. 2010..Pre-operative diagnosis of hepatic RLH by clinical imaging is extremely difficult. Therefore, a needle biopsy could be useful to make a diagnosis of hepatic RLH, especially to differentiate from metastatic gastrointestinal carcinoma... - Isolation, characterization and mapping of the mouse and human RB1CC1 genesTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
Gene 291:29-34. 2002..2 and 57 kb on chromosome 1A2-4, respectively. Conserved sequence motifs and nuclear localization suggest that the RB1CC1 proteins function as transcription factors... - Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese malesKanji Mori
Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, Japan
Am J Med Genet A 130:169-71. 2004..Haplotype analysis did not demonstrate more significant association. The CYP17 SNP is associated with SNSA in HLA-B27-negative Japanese males... - Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasmsMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
Oncol Rep 18:633-7. 2007..However, loss of its expression was observed in cases with metastases (3/5) and can be regarded as an additional parameter to predict the risk of metastasis in rectal well-differentiated endocrine neoplasms... - Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinomaYoshitomo Ozaki
Second Department of Surgery, Shiga University of Medical Science, Otsu, Japan
Cancer 95:1954-62. 2002..M2BP is expected to be useful as a tumor marker and a target antigen in cancer immunotherapy... - Thymic papillo-tubular adenocarcinoma containing a cyst: report of a caseKoji Teramoto
Department of Surgery, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
Surg Today 42:988-91. 2012..Pathological examination of the tumor revealed a primary thymic papillo-tubular adenocarcinoma resembling a tumor of gut origin. Thymic adenocarcinomas, particularly of the tubular subtype, are extremely rare... - Detection of lymph node micrometastasis in gastric cancer by MUC2 RT-PCR: usefulness in pT1 casesHiromichi Sonoda
Department of Surgery, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
J Surg Oncol 88:63-70. 2004..The distribution of lymph node micrometastases detected by this method may be useful in minimally invasive procedures for gastric cancer, especially pT1 cases... - HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancerMinako Fujita
Department of Surgery, Shiga University of Medical Science, Shiga 520 2192, Japan
Mol Med Report 1:225-30. 2008..However, cases with a favourable response to gefitinib did not always express EGFR. Gefitinib appears to suppress growth signal pathways other than EGFR-tyrosine kinase activation in non-small cell lung cancers... - Expression of macrophage inflammatory protein-1alpha in Schwann cell tumorsKanji Mori
Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
Neuropathology 24:131-5. 2004..Furthermore, various levels of MIP-1alpha expression in these tumors were implicated to be correlated with histological variations... - Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal glandMitsuaki Ishida
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu 520 2192, Japan
Rinsho Byori 57:746-51. 2009..And further study is needed to clarify the clinicopathological features of the lacrimal ductal adenocarcinoma... - Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skinMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
Oncol Rep 22:733-7. 2009..beta III is a potential candidate for inclusion to the panel of immunohistochemical markers to distinguish small BCCs from non-neoplastic hair buds, because non-neoplastic hair follicles are not positive for beta III... - Pulmonary infarction associated with bronchogenic carcinomaMasashi Takahashi
Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
Radiat Med 26:76-80. 2008..We conclude that pulmonary infarction should be considered as a differential diagnosis when peripheral pulmonary nodules or masses are located in the same lobe as the primary cancer... - Identification of RB1CC1, a novel human gene that can induce RB1 in various human cellsTokuhiro Chano
Department of Basic Science for Health and Nursing, Shiga University of Medical Science, Tsukinowa cho, Otsu, Shiga 520 2192, Japan
Oncogene 21:1295-8. 2002..Moreover, introduction of wild-type RB1CC1 significantly induced RB1 expression in human leukemic cells. These data suggest that RB1CC1 may be a key regulator of RB1 gene expression... - [Proposal of possible diagnostic strategy for intravascular large B-cell lymphoma--usefulness of biopsy from senile hemangioma]Mitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
Rinsho Byori 60:201-5. 2012.... - Cytologic and immunophenotypic features of CD34+ stem cells in body cavity fluidsHideo Kataoka
Department of Clinical Laboratory, Saiseikai Shiga Hospital, Imperial Gift Foundation, Inc, Shiga, Japan
Acta Cytol 56:401-7. 2012.... - Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septumMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Pathol Int 59:670-5. 2009..The present case suggests that IgG4-related sclerosing lesion can occur in the maxillary sinus and nasal septum, and represents an extension of the spectrum of IgG4-related sclerosing disease... - Cytological features of myxoid adrenocortical adenoma with a pseudoglandular component: a case report with differential diagnostic considerationsMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
Diagn Cytopathol 36:576-80. 2008..Careful observation of these cytological features and positive immunoreactivity to Melan A, alpha-inhibin and synaptophysin can lead to the correct diagnosis... - [A case of primary mucinous carcinoma with endocrine differentiation of the skin]Mitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Ohtsu 520 2192, Japan
Rinsho Byori 56:455-8. 2008..To clarify the difference and/or similarity between mucinous carcinoma of the breast and MCS, immunohistochemical and cytogenetic analyses of additional cases of MCS are required... - A rare case of multiple schwannomas presenting with scrotal mass: a probable case of schwannomatosisRyo Ikari
Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
Int J Urol 17:734-6. 2010..In this regard, the present case highlights the importance of thorough history taking in patients with scrotal schwannoma... - Combined effect of hydrogen peroxide induced oxidative stress and IL-1 alpha on IL-8 production in CaCo-2 cells (a human colon carcinoma cell line) and normal intestinal epithelial cellsKazuo Yamamoto
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta Tsukinowa, Ohtsu, Shiga, Japan
Inflammation 27:123-8. 2003..Exposure to hydrogen peroxide, followed by IL-1alpha, enhanced IL-8 production over that achieved with IL-1alpha alone. Thus, oxidative stress and IL-1alpha were observed to cooperatively enhance IL-8 production... - Case of Bowen's disease accompanying syringofibroadenomaMitsuaki Ishida
Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu 520 2192, Japan
Rinsho Byori 59:470-4. 2011..In this report, we summarize the clinicopathological features of carcinoma accompanying syringofibroadenoma and discuss the nature of syringofibroadenoma... - Tentorial schwannoma in a 64-year-old female: case reportNaoki Nitta
Department of Neurosurgery, Shiga University of Medical Science, Otsu, Shiga, Japan
Neurol Med Chir (Tokyo) 51:239-43. 2011..The present case of tentorial schwannoma not associated with the cranial nerves is extremely rare. Schwannoma should be included in the differential diagnosis of tumors arising from the tentorium... - Co-expression of neuronal intermediate filaments, peripherin and α-internexin in human well-differentiated endocrine neoplasms (carcinoid tumors) of the appendixMitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
Mol Med Report 1:191-5. 2008..It is uncertain whether the expression of peripherin and/or α-internexin is present in the well-differentiated endocrine neoplasms of other organs; further analysis is required to clarify this issue... - [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin]Mitsuaki Ishida
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu
Rinsho Byori 54:781-4. 2006.... - Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinomaTakahiro Kawakami
Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
Hum Mol Genet 15:821-30. 2006..The present data have shown that gain of methylation upstream of the untranslated GTL2 leads to pathological downregulation of DLK1 in RCCs... - Mediastinal seminoma occurring in Down syndromeMitsuaki Ishida
Department of Clinical Laboratory Medicine, Division of Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
J Pediatr Hematol Oncol 34:387-8. 2012..Histopathological findings of the resected tumor were typical of seminoma. This case indicates that seminoma can occur in the mediastinum in addition to testis in Down syndrome... - Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glandsRyoji Kushima
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192 Japan
Virchows Arch 440:655-9. 2002..Therefore the present carcinoma is thought to have developed under induction of gastric-foveolar differentiation in a manner very similar to that of gastric metaplasia in hyperplastic Brunner's glands... - Truncating mutations of RB1CC1 in human breast cancerTokuhiro Chano
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
Nat Genet 31:285-8. 2002..In all seven cancers, both RB1CC1 alleles were inactivated; two showed compound heterozygous deletions. Thus, RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor-suppressor gene... - Expression of E-cadherin in chordomas: diagnostic marker and possible role of tumor cell affinityKanji Mori
Department of Orthopedic Surgery, Shiga University of Medical Science, Otsu, Japan
Virchows Arch 440:123-7. 2002..Furthermore, we speculate that E-cadherin may play a role in tumor cell adhesion and is also involved with histological and clinical features in chordomas... - Collagenous gastritis in a young Japanese womanYuri Kajino
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
Pathol Int 53:174-8. 2003..The size of the collagen band did not change for 2 years. These findings suggest that subepithelial collagen deposition was due to an abnormal local immune response based on generalized allergic disorder... - Role of alternative splicing of periostin in human bladder carcinogenesisChul Jang Kim
Department of Urology, Kohka Public Hospital, Kohka, Shiga 528 0014, Japan
Int J Oncol 32:161-9. 2008..These results indicate that the loss of WT periostin by down-regulation and/or alternative splicing, which produces Variant I, is closely correlated with the development of bladder cancer... - Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasiaSuzuko Moritani
Department of Pathology and Clinical Laboratories, Nagoya Medical Center, 4 1 1, Sannomaru, Naka ku, Nagoya, Aichi, 460 0001, Japan
Virchows Arch 450:539-47. 2007.... - Target specificities of estrogen receptor-related receptors: analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target geneMst Hasina Akter
Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo, Japan
J Biochem 143:395-406. 2008..In vivo binding of ERRalpha to the Rb1cc1 promoter region was confirmed by the chromatin immunoprecipitation assay. Thus, Rb1cc1 is a target gene of ERRalpha, driven by a novel type of recognition sequence... - Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasmsNatsuko Tatsumi
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo-ku, 602-8566 Kyoto, Japan
Virchows Arch 448:756-62. 2006..These results suggest that gastric-type mucins play an important role in the initial step of CC-tumorigenesis, and CK7 and gastric-type mucins may be useful in the differential diagnosis between UC-associated neoplasms and sporadic ones... - [HER2 protein in the serum and nipple discharge]Hidetoshi Okabe
Department of Laboratory Medicine, Shiga University of Medical Science
Nippon Rinsho 63:753-5. 2005 - Rb1cc1 is critical for myoblast differentiation through Rb1 regulationRyosuke Watanabe
Department of Applied Biological Science, Faculty of Science and Technology, Science University of Tokyo, 278 0022 Chiba, Japan
Virchows Arch 447:643-8. 2005..These results indicated that Rb1cc1 is a potent regulator of the Rb1 pathway and a novel mediator that plays a crucial role in muscular differentiation. Rb1cc1 expression is, thus, a prerequisite for myogenic differentiation... - [Significance of extracellular matrix determined by immunostains and histochemical stains in a case of pulmonary epithelioid hemangioendothelioma]Hideo Saito
Aichi Health Promotion Foundation, Nagoya 462-0844
Rinsho Byori 53:213-6. 2005..These findings suggested that enhanced basement membrane protein synthesis in PEH seems to be responsible for the accumulation of abundant ECM. Analysis of the ECM seems to be quite useful for the differential diagnosis of this tumor... - Eosinophilic cell change of the endometrium: a possible relationship to mucinous differentiationSuzuko Moritani
Department of Pathology and Clinical Laboratories, Nagoya Medical Center, Nagoya, Aichi, Japan
Mod Pathol 18:1243-8. 2005..Most of the endometrial changes characterized by cytoplasmic eosinophilia may be subtypes of immature mucinous metaplasia which express a mucin core protein but are not fully glycosylated... - Highly anaplastic extraventricular ependymoma arising in an adult, mimicking metastatic adenocarcinoma with heavy stromal inflammation and emperiporesisSuzuko Moritani
Department of Pathology, Saiseikai Shiga Hospital Imperial Gift Foundation Inc, Ohtsu, Japan
Pathol Int 53:539-46. 2003..Although this tumor might be classified to at least WHO grade III from the histology and aggressive behavior, the exact grading is still controversial because of the rarity of such cases...