Masaki Nishimura

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. doi request reprint Age-related modulation of γ-secretase activity in non-human primate brains
    Masaki Nishimura
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan
    J Neurochem 123:21-8. 2012
  2. pmc Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo, 060 0812, Japan
    Mol Neurodegener 7:50. 2012
  3. pmc Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex
    Yachiyo Mitsuishi
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520 2192, Japan
    J Biol Chem 285:14920-31. 2010
  4. doi request reprint Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting γ-cleavage of amyloid precursor protein
    Hiroshi Hasegawa
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Neurochem 115:771-81. 2010
  5. ncbi request reprint Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2
    Hua Qin Wang
    Neurology Unit, Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
    Hum Mol Genet 14:1889-902. 2005
  6. pmc Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter
    Akinori Matsuo
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    J Biol Chem 286:5836-45. 2011
  7. ncbi request reprint Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
    Yoshifumi Nakaya
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Biol Chem 280:19070-7. 2005

Collaborators

Detail Information

Publications7

  1. doi request reprint Age-related modulation of γ-secretase activity in non-human primate brains
    Masaki Nishimura
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan
    J Neurochem 123:21-8. 2012
    ..Similar modulation may predispose aged human brains to Alzheimer's disease...
  2. pmc Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo, 060 0812, Japan
    Mol Neurodegener 7:50. 2012
    ..However, the molecular linkage between epileptic seizures and Aβ generation in AD remains unclear...
  3. pmc Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex
    Yachiyo Mitsuishi
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520 2192, Japan
    J Biol Chem 285:14920-31. 2010
    ..Our results suggest that CRB2 functions as an inhibitory binding protein that is involved in the formation of a mature but inactive pool of the gamma-secretase complex...
  4. doi request reprint Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting γ-cleavage of amyloid precursor protein
    Hiroshi Hasegawa
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Neurochem 115:771-81. 2010
    ..Our findings suggest that dilysine ER-retrieval signal-containing p24 proteins, p24α(2) and p24δ(1), bind with γ-secretase complexes and collaborate in attenuating γ-cleavage of APP...
  5. ncbi request reprint Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2
    Hua Qin Wang
    Neurology Unit, Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
    Hum Mol Genet 14:1889-902. 2005
    ..Excessive pro-apoptotic activity of PS1/2 may play a role in the pathogenesis of FAD...
  6. pmc Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter
    Akinori Matsuo
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    J Biol Chem 286:5836-45. 2011
    ..Our results suggest that ChAT activates the transcription of selected target genes in neuronal cells. Both enzymatic activity and nuclear translocation of ChAT are required for its transcriptional enhancement...
  7. ncbi request reprint Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
    Yoshifumi Nakaya
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Biol Chem 280:19070-7. 2005
    ....