Y Maruo

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi request reprint [UDP-glucuronosyltransferase]
    Yoshihiro Maruo
    Department of Pediatrics, Biology Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Nihon Eiseigaku Zasshi 56:629-33. 2002
  2. pmc Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome
    Katsuyuki Matsui
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520 2192, Japan
    BMC Gastroenterol 10:57. 2010
  3. ncbi request reprint Polymorphism of UDP-glucuronosyltransferase and drug metabolism
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Curr Drug Metab 6:91-9. 2005
  4. ncbi request reprint Crigler-Najjar syndrome type II caused by a homozygous triple mutation [T-3279G, A(TA)7TAA, and H39D] of UGT1A1
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Otsu, Shiga 530 2192, Japan
    J Pediatr Gastroenterol Nutr 42:236-9. 2006
  5. ncbi request reprint Co-occurrence of three different mutations in the bilirubin UDP-glucuronosyltransferase gene in a Chinese family with Crigler-Najjar syndrome type I and Gilbert's syndrome
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Seta, Otsu, Japan
    Clin Genet 64:420-3. 2003
  6. doi request reprint Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520 2192, Japan
    J Clin Endocrinol Metab 93:4261-7. 2008
  7. ncbi request reprint Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520 2192, Japan
    Hum Genet 115:525-6. 2004
  8. ncbi request reprint Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan
    Pediatrics 106:E59. 2000
  9. ncbi request reprint Chemotherapy-induced unconjugated hyperbilirubinemia caused by a mutation of the bilirubin uridine-5'-diphosphate-glucuronosyltransferase gene
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
    J Pediatr Hematol Oncol 23:45-7. 2001
  10. doi request reprint Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)
    Hiroko Takahashi
    Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    Basic Clin Pharmacol Toxicol 103:131-6. 2008

Collaborators

  • Hiroshi Sato
  • H Sawa
  • Masaki Ito
  • Y Takeuchi
  • Ali K Topaloglu
  • Motoko Yamaguchi
  • S Wada
  • K Yamamoto
  • Akira Kumakura
  • Naoki Itano
  • Erkin Serdaroglu
  • Tomoyuki Takano
  • Asami Mori
  • Masaru Iwai
  • Junichi Kaneko
  • Katsuyuki Matsui
  • Mitsutaka Shiota
  • Hiroko Takahashi
  • Hiroshi Ideguchi
  • Kenichi Sugita
  • Masatoshi Makuuchi
  • Yasuhiko Sugawara
  • Norihiro Kokudo
  • Ikuko Kakizaki
  • Keisuke Takeuchi
  • Junichi Arita
  • Tatsuyuki Sokoda
  • Masaki Ohno
  • Yuko Sakaue
  • Shie Akabori
  • Chihiro Sawai
  • Takashi Taga
  • Atsuko Hata
  • Hidekazu Nakanishi
  • Junko Asada
  • Hitoshi Nishida
  • Junko Kato
  • Takashi Sugihara
  • Ken Watanabe
  • Takakazu Yoshioka
  • Daisuke Hata
  • Akira Tsuchioka
  • Hidemitsu Kurosawa
  • Toshio Fujiwara
  • Mitsuoki Eguchi
  • Sumihito Tamura
  • Hiroshi Imamura
  • Tomoaki Ishihara
  • Masahiko Kaito
  • Tadashi Yasuda
  • Koji Kimata
  • Kaoru Kojima
  • Masahiko Endo
  • Yoshinao Kobayashi
  • Satoka Mita
  • Yukihiko Adachi
  • Shigenori Tamaki
  • Rumi Mifuji
  • Keiichi Takagaki
  • Makoto Kuroda
  • Toshio Itani
  • Jun Araki
  • Reiji Kannagi
  • Takuya Hashimoto
  • Kazuto Okuno

Detail Information

Publications25

  1. ncbi request reprint [UDP-glucuronosyltransferase]
    Yoshihiro Maruo
    Department of Pediatrics, Biology Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Nihon Eiseigaku Zasshi 56:629-33. 2002
    ..These polymorphisms of UGTs might contribute to individual variations of drug metabolism and toxicity as well as inherited diseases...
  2. pmc Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome
    Katsuyuki Matsui
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520 2192, Japan
    BMC Gastroenterol 10:57. 2010
    ..Although several polymorphisms have been found to link with A(TA)7TAA, the combined effect of regulatory polymorphisms in the development of Gilbert syndrome remains unclear...
  3. ncbi request reprint Polymorphism of UDP-glucuronosyltransferase and drug metabolism
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Curr Drug Metab 6:91-9. 2005
    ..Understanding of these polymorphisms is essential for the prevention of adverse effects of a considerable number of drugs and to predict cancer risks...
  4. ncbi request reprint Crigler-Najjar syndrome type II caused by a homozygous triple mutation [T-3279G, A(TA)7TAA, and H39D] of UGT1A1
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Otsu, Shiga 530 2192, Japan
    J Pediatr Gastroenterol Nutr 42:236-9. 2006
  5. ncbi request reprint Co-occurrence of three different mutations in the bilirubin UDP-glucuronosyltransferase gene in a Chinese family with Crigler-Najjar syndrome type I and Gilbert's syndrome
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Seta, Otsu, Japan
    Clin Genet 64:420-3. 2003
    ..The results also suggest the importance of the accumulation of prevalent or polymorphic mutation in the etiology of Gilbert's syndrome and Crigler-Najjar syndrome type II...
  6. doi request reprint Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520 2192, Japan
    J Clin Endocrinol Metab 93:4261-7. 2008
    ..Previous reports suggest that biallelic mutations of DUOX2 cause permanent congenital hypothyroidism and that monoallelic mutations cause transient congenital hypothyroidism...
  7. ncbi request reprint Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520 2192, Japan
    Hum Genet 115:525-6. 2004
    ..All 23 patients were also homozygous for T-3279G, indicating that T-3279G and A(TA)7TAA were linked. The decrease in transcription caused by both mutations together may be essential to the syndrome...
  8. ncbi request reprint Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan
    Pediatrics 106:E59. 2000
    ..We analyzed the bilirubin UGT1A1 of infants with prolonged unconjugated hyperbilirubinemia associated with breast milk to ascertain whether genetic factors are involved. Patients and..
  9. ncbi request reprint Chemotherapy-induced unconjugated hyperbilirubinemia caused by a mutation of the bilirubin uridine-5'-diphosphate-glucuronosyltransferase gene
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
    J Pediatr Hematol Oncol 23:45-7. 2001
    ..The genes of the two patients revealed an identical heterozygous missense mutation in exon 1 (211G-->A: G71R). This UGT1A1 mutation may be the basis of chemotherapy-induced unconjugated hyperbilirubinemia...
  10. doi request reprint Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)
    Hiroko Takahashi
    Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    Basic Clin Pharmacol Toxicol 103:131-6. 2008
    ..Carriers of D256N may be at risk of suffering adverse effects of propofol and other substrates that are primarily metabolized by UGT1A9...
  11. ncbi request reprint Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity
    Masaru Iwai
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Hum Genet 49:123-8. 2004
    ..Several UGT 1A3 polymorphisms exist in the Japanese population, having different levels of activity. These polymorphisms are capable of affecting the steady state levels of estrogens, and may increase sensitivity to adverse drug effects...
  12. ncbi request reprint A case of anorexia nervosa with hyperbilirubinaemia in a patient homozygous for a mutation in the bilirubin UDP-glucuronosyltransferase gene
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
    Eur J Pediatr 158:547-9. 1999
    ....
  13. doi request reprint Conformational change of UGT1A1 by a novel missense mutation (p.L131P) causing Crigler-Najjar syndrome type I
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    J Pediatr Gastroenterol Nutr 46:308-11. 2008
  14. ncbi request reprint Gilbert syndrome caused by a homozygous missense mutation (Tyr486Asp) of bilirubin UDP-glucuronosyltransferase gene
    Y Maruo
    Department of Pediatrics, Shiga University of Medical Science, Japan
    J Pediatr 132:1045-7. 1998
    ..We conclude that Gilbert syndrome in some patients results from homozygous missense mutations of the UDP-glucuronosyltransferase gene...
  15. doi request reprint Seizure susceptibility due to antihistamines in febrile seizures
    Tomoyuki Takano
    Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Pediatr Neurol 42:277-9. 2010
    ....
  16. ncbi request reprint A novel missense mutation of the bilirubin UDP-glucuronosyltransferase gene in a Turkish patient with Crigler-Najjar syndrome type 1
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Pediatr Gastroenterol Nutr 37:627-30. 2003
  17. ncbi request reprint UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation
    Asami Mori
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan
    Drug Metab Dispos 33:672-5. 2005
    ..This study shows the importance of identifying patients with the L48V polymorphism when calculating dosage, and when considering the potential adverse effects of drugs that are substrates of UGT1A4...
  18. ncbi request reprint Severe hyperbilirubinemia in a 10-year-old girl with a combined disorder of hereditary spherocytosis and Gilbert syndrome
    Kenichi Sugita
    Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Pediatr Int 49:540-2. 2007
  19. ncbi request reprint Effect of a conserved mutation in uridine diphosphate glucuronosyltransferase 1A1 and 1A6 on glucuronidation of a metabolite of flutamide
    Masaki Ito
    Second Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Eur J Clin Pharmacol 58:11-4. 2002
    ....
  20. doi request reprint Hereditary spherocytosis in 3 children coexisting with UDP-glucuronyl transferase 1A1 deficiency
    Mitsutaka Shiota
    Department of Pediatrics, Kitano Hospital, Tazuke Kofukai, Medical Research Institute, Osaka, Japan
    J Pediatr Hematol Oncol 31:121-3. 2009
    ..We report here the importance of careful evaluation of mild hereditary spherocytosis masking UDP-glucuronyltransferase 1A1 deficiency...
  21. ncbi request reprint Liver resection in patients with Gilbert's syndrome
    Junichi Arita
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Surgery 134:835-7. 2003
  22. ncbi request reprint Liver transplantation using donors with Gilbert syndrome
    Junichi Kaneko
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Transplantation 82:282-5. 2006
    ..Total bilirubin levels of the recipients of GS donors were higher than those of recipients of non-GS donors. Living donor liver transplantation is safe for both donors with GS and their recipients...
  23. ncbi request reprint Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects
    Keisuke Takeuchi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Mie, Japan
    J Gastroenterol Hepatol 19:1023-8. 2004
    ....
  24. ncbi request reprint A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone
    Ikuko Kakizaki
    Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Biol Chem 279:33281-9. 2004
    ..We propose a novel mechanism for the MU-mediated inhibition of HA synthesis involving the glucuronidation of MU by endogenous UGT resulting in a depletion of UDP-GlcUA...
  25. ncbi request reprint A pediatric patient with sporadic dentatorubral pallidoluysian atrophy
    Tomoyuki Takano
    Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Pediatr Neurol 28:72-3. 2003
    ..Gene analysis of the patient's parents was not performed. The molecular mechanisms of the occurrence of sporadic cases have not been clarified...