Hiroo Imai

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. doi request reprint Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect
    Hisao Ueyama
    Department of Molecular Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Biochem Biophys Res Commun 424:152-7. 2012
  2. ncbi request reprint Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies
    Hisao Ueyama
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Biochem Biophys Res Commun 294:205-9. 2002
  3. doi request reprint Analysis of introns and promoters of L/M visual pigment genes in relation to deutan color-vision deficiency with an array of normal gene orders
    Hisao Ueyama
    Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Seta, Otsu, Japan
    J Hum Genet 54:525-30. 2009
  4. ncbi request reprint Protan color vision deficiency with a unique order of green-red as the first two genes of a visual pigment array
    Hisao Ueyama
    Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    J Hum Genet 51:686-94. 2006
  5. pmc An A-71C substitution in a green gene at the second position in the red/green visual-pigment gene array is associated with deutan color-vision deficiency
    Hisao Ueyama
    Departments of Medical Biochemistry and Ophthalmology, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Proc Natl Acad Sci U S A 100:3357-62. 2003
  6. ncbi request reprint An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays
    Hisao Ueyama
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    J Hum Genet 49:548-57. 2004
  7. ncbi request reprint Analysis of L-cone/M-cone visual pigment gene arrays in Japanese males with protan color-vision deficiency
    Hisao Ueyama
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Vision Res 44:2241-52. 2004
  8. ncbi request reprint Direct observation of the complex formation of GDP-bound transducin with the rhodopsin intermediate having a visible absorption maximum in rod outer segment membranes
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan, and CREST, Japan Science and Technology Agency, Japan
    Biochemistry 44:9936-43. 2005
  9. ncbi request reprint Variations in long- and middle-wavelength-sensitive opsin gene loci in crab-eating monkeys
    Akishi Onishi
    Laboratory for Speciation Mechanisms I, National Institute for Basic Biology, 38, Nishigonaka, Myodaijicho, Okazaki 444 8585, Japan
    Vision Res 42:281-92. 2002
  10. ncbi request reprint Generation of knock-in mice carrying third cones with spectral sensitivity different from S and L cones
    Akishi Onishi
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 22:1145-56. 2005

Collaborators

  • Yoshinori Shichida
  • Akihisa Terakita
  • KAREN CARLETON
  • Ole Seehausen
  • Atsuko Saito
  • Hidenori Tachida
  • H Kandori
  • M Ishiguro
  • Martine E Maan
  • Satoshi Koike
  • Hisao Ueyama
  • Shoko Tanabe
  • Shinichi Yamade
  • Akishi Onishi
  • Takahiro Hirano
  • Shigeki Kuwayama
  • Takefumi Morizumi
  • Kei Tsutsui
  • Sanae Muraki-Oda
  • Sanae Oda
  • Iwao Ohkubo
  • Osamu Chisaka
  • Yohey Terai
  • Tohru Sugawara
  • Yasuhiro Nishida
  • Michio Imafuku
  • Keisuke Sakurai
  • Shingo Kurumada
  • Yoshiki Ueda
  • Norihiro Okada
  • Kenichi Terao
  • Takashi Kodama
  • Akimori Wada
  • Osamu Takenaka
  • Akichika Mikami
  • Hisakazu Ogita
  • Takahiro Yamashita
  • Masahito Ohji
  • Jiro Usukura
  • Kei Nakatani
  • Satoshi B Sato
  • Toshihide Kobayashi
  • Isamu Shimizu
  • Kumiko Ishii
  • Tetsu Sato
  • Nellie Konijnendijk
  • Shinji Mizoiri
  • Hillary D J Mrosso
  • Kazuhiko Takahashi
  • Masayoshi Ito
  • Naoko Fujioka
  • Takeshi Sasaki
  • Masakatsu Watanabe
  • Hisashi Ogawa
  • Yoshihito Honda
  • Masao Tachibana
  • Takahiro Sakai
  • Migaku Teramoto
  • Stephan Koblmüller
  • George F Turner
  • Hisao Kobayashi
  • Shin Ichi Itoh
  • Toshifumi Udono
  • Yoshinori Fujiyoshi
  • Christian Sturmbauer
  • Jun Hasegawa
  • Yoshiko Emi
  • Tomoko Doi
  • Ryuzo Torii
  • Yao Hua Li
  • Gui Lian Fu
  • La ongsri Atchaneeyasakul
  • Patcharee Lertrit
  • Yoshiaki Oyama
  • Kenji Kitahara
  • In Taek Lim
  • Charal Eakavhibata
  • Puttipongse Varavudhi
  • Akitoshi Hanazawa
  • Don Moon Kim
  • Tetsuo Yamamori
  • Achmad Farajallah
  • Xiang Guo Zheng
  • Miki Ida-Hosonuma
  • Hidehiko Komatsu
  • Kazuo Yoshihara
  • Shunji Goto
  • Bambang Suryobroto

Detail Information

Publications28

  1. doi request reprint Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect
    Hisao Ueyama
    Department of Molecular Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Biochem Biophys Res Commun 424:152-7. 2012
    ..These results suggest that complete skipping of exon 3 at splicing, due to the unique haplotype of the exon, causes loss of expression of L-opsin in these men...
  2. ncbi request reprint Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies
    Hisao Ueyama
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Biochem Biophys Res Commun 294:205-9. 2002
    ..Therefore these three mutant opsins are likely to be affected in the folding process, resulting in a loss of function as a visual pigment...
  3. doi request reprint Analysis of introns and promoters of L/M visual pigment genes in relation to deutan color-vision deficiency with an array of normal gene orders
    Hisao Ueyama
    Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Seta, Otsu, Japan
    J Hum Genet 54:525-30. 2009
    ..These results suggest that the -71A --> C substitution is not in linkage disequilibrium with an intronic mutation, but the substitution itself may affect the transcription of the M gene, leading to deutan deficiency...
  4. ncbi request reprint Protan color vision deficiency with a unique order of green-red as the first two genes of a visual pigment array
    Hisao Ueyama
    Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    J Hum Genet 51:686-94. 2006
    ..The red gene had no mutations in the exons and exon/intron boundaries, but had an A-71C substitution in the promoter in both participants...
  5. pmc An A-71C substitution in a green gene at the second position in the red/green visual-pigment gene array is associated with deutan color-vision deficiency
    Hisao Ueyama
    Departments of Medical Biochemistry and Ophthalmology, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Proc Natl Acad Sci U S A 100:3357-62. 2003
    ..In Japanese and presumably other Asian populations further downstream genes with -71C comprise a reservoir of the visual-pigment genes that cause deutan color-vision deficiency by unequal crossing over between the intergenic regions...
  6. ncbi request reprint An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays
    Hisao Ueyama
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    J Hum Genet 49:548-57. 2004
    ....
  7. ncbi request reprint Analysis of L-cone/M-cone visual pigment gene arrays in Japanese males with protan color-vision deficiency
    Hisao Ueyama
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu 520 2192, Japan
    Vision Res 44:2241-52. 2004
    ..Genotype-phenotype relationships in protan color-vision deficiency are discussed...
  8. ncbi request reprint Direct observation of the complex formation of GDP-bound transducin with the rhodopsin intermediate having a visible absorption maximum in rod outer segment membranes
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan, and CREST, Japan Science and Technology Agency, Japan
    Biochemistry 44:9936-43. 2005
    ..Our results strongly suggest that the protein conformational change of the rhodopsin intermediate after binding to Gt is important for the induction of the nucleotide release from the alpha-subunit of Gt...
  9. ncbi request reprint Variations in long- and middle-wavelength-sensitive opsin gene loci in crab-eating monkeys
    Akishi Onishi
    Laboratory for Speciation Mechanisms I, National Institute for Basic Biology, 38, Nishigonaka, Myodaijicho, Okazaki 444 8585, Japan
    Vision Res 42:281-92. 2002
    ..The two variants were found only in Java Island, Indonesia, and South Thailand, respectively. The data suggest that the frequency of each genotype is different among Old World primates...
  10. ncbi request reprint Generation of knock-in mice carrying third cones with spectral sensitivity different from S and L cones
    Akishi Onishi
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 22:1145-56. 2005
    ....
  11. ncbi request reprint Identification of a protanomalous chimpanzee by molecular genetic and electroretinogram analyses
    Kenichi Terao
    Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Vision Res 45:1225-35. 2005
    ..Unlike in humans, a polymorphic difference in the copy number of the genes and a polymorphic base substitution at amino acid position 180 were not frequently observed in chimpanzees...
  12. ncbi request reprint Conserved proline residue at position 189 in cone visual pigments as a determinant of molecular properties different from rhodopsins
    Shigeki Kuwayama
    Department of Biophysics, Graduate School of Science, Kyoto University, and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Kyoto 606 8502, Japan
    Biochemistry 41:15245-52. 2002
    ..The completely conserved nature of proline at position 189 could provide a clue to the molecular evolution of the pigments...
  13. ncbi request reprint Amino acid residues responsible for the meta-III decay rates in rod and cone visual pigments
    Shigeki Kuwayama
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, and CREST, Japan Science and Technology Agency, Kyoto, Japan
    Biochemistry 44:2208-15. 2005
    ....
  14. pmc Parallelism of amino acid changes at the RH1 affecting spectral sensitivity among deep-water cichlids from Lakes Tanganyika and Malawi
    Tohru Sugawara
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 102:5448-53. 2005
    ..The parallel evolution of the same mutation at the same amino acid position suggests that the number of genetic changes underlying the appearance of similar traits in cichlid diversification may be fewer than previously expected...
  15. doi request reprint Speciation through sensory drive in cichlid fish
    Ole Seehausen
    Institute of Zoology, University of Bern, Baltzerstr 6, CH 3012 Bern, Switzerland
    Nature 455:620-6. 2008
    ..Our results also provide a mechanistic explanation for the collapse of cichlid fish species diversity during the anthropogenic eutrophication of Lake Victoria...
  16. doi request reprint E113 is required for the efficient photoisomerization of the unprotonated chromophore in a UV-absorbing visual pigment
    Kei Tsutsui
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 47:10829-33. 2008
    ..These results suggest that E113 facilitates photoisomerization in both UV-absorbing and visible light-absorbing visual pigments and provide a possible explanation for the complete conservation of E113 among vertebrate UV pigments...
  17. ncbi request reprint Sexual difference in color sense in a lycaenid butterfly, Narathura japonica
    Michio Imafuku
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan
    Zoolog Sci 24:611-3. 2007
    ..This male-specific UV-sensitivity is discussed in terms of ecological factors...
  18. pmc Physiological properties of rod photoreceptor cells in green-sensitive cone pigment knock-in mice
    Keisuke Sakurai
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kyoto 606 8502, Japan
    J Gen Physiol 130:21-40. 2007
    ..Therefore, the abilities of rhodopsin to generate a large single photon response and to retain high thermal stability in darkness are factors that have been necessary for the evolution of scotopic vision...
  19. ncbi request reprint Photoisomerization efficiency in UV-absorbing visual pigments: protein-directed isomerization of an unprotonated retinal Schiff base
    Kei Tsutsui
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 46:6437-45. 2007
    ..These results suggest that the mouse UV pigment has a specific mechanism for the efficient photoisomerization of its unprotonated Schiff base chromophore...
  20. ncbi request reprint Stage-specific association of apolipoprotein A-I and E in developing mouse retina
    Shingo Kurumada
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Invest Ophthalmol Vis Sci 48:1815-23. 2007
    ..To characterize the intercellular lipid transport systems in differentiating retina...
  21. pmc Molecular properties of rhodopsin and rod function
    Hiroo Imai
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kyoto 606 8502, Japan
    J Biol Chem 282:6677-84. 2007
    ..Thus, the present study clearly reveals how the molecular properties of rhodopsin affect the amplitude, shape, and kinetics of the rod response...
  22. pmc Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids
    Yohey Terai
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    PLoS Biol 4:e433. 2006
    ..The divergent evolution of the visual system coincides with divergence in male breeding coloration, consistent with incipient ecological by-product speciation...
  23. ncbi request reprint Constraints of opsin structure on the ligand-binding site: studies with ring-fused retinals
    Takahiro Hirano
    Suntory Institute for Bioorganic Research, Shimamoto, Osaka, Japan
    Photochem Photobiol 76:606-15. 2002
    ..The structural models suggested that hula twist is a primary process for the photoisomerization of the analog chromophores...
  24. ncbi request reprint Assignment of the vibrational modes of the chromophores of iodopsin and bathoiodopsin: low-temperature fourier transform infrared spectroscopy of 13C- and 2H-labeled iodopsins
    Takahiro Hirano
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 45:1285-94. 2006
    ..These results indicated that iodopsin's chromophore has a unique structure near its center and that this difference is enhanced by the binding of chloride nearby...
  25. ncbi request reprint Two-step mechanism of interaction of rhodopsin intermediates with the C-terminal region of the transducin alpha-subunit
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kyoto 606 8502
    J Biochem 134:259-67. 2003
    ..These results indicate that rearrangement of the C-terminal region of Gt(alpha) after the binding of a rhodopsin intermediate is necessary for the GDP-GTP exchange reaction on Gt(alpha)...
  26. ncbi request reprint Effect of anion binding on the thermal reverse reaction of bathoiodopsin: anion stabilizes two forms of iodopsin
    Takahiro Hirano
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Biochemistry 42:12700-7. 2003
    ..Thus, iodopsin exhibits two conformational states, each of which is stabilized by the binding of chloride and nitrate, respectively...
  27. ncbi request reprint Expression and localization of an exogenous G protein-coupled receptor fused with the rhodopsin C-terminal sequence in the retinal rod cells of knockin mice
    Takashi Kodama
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Exp Eye Res 80:859-69. 2005
    ..In addition, a substantial fraction of the hET(B)R was successfully transported to the outer segment, suggesting that the addition of the C-terminal sequence of rhodopsin enabled hET(B)R to be translocated to the outer segment...
  28. ncbi request reprint Molecular properties of rod and cone visual pigments from purified chicken cone pigments to mouse rhodopsin in situ
    Hiroo Imai
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Photochem Photobiol Sci 4:667-74. 2005
    ..In the present paper, we summarize the spectroscopic properties of cone pigments and describe our studies with mouse rhodopsin utilizing a high performance charge coupled device (CCD) spectrophotometer...