Tokuhiro Chano

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. pmc Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application
    Yusuke Hama
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    PLoS ONE 7:e32052. 2012
  2. pmc Association of p62/SQSTM1 excess and oral carcinogenesis
    Takuma Inui
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 8:e74398. 2013
  3. ncbi request reprint [Application of novel clinicopathological biomarkers]
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 60:167-73. 2012
  4. ncbi request reprint Mechanical stress induces the expression of high molecular mass heat shock protein in human chondrocytic cell line CS-OKB
    T Chano
    Department of Basic Science for Health and Nursing, Shiga University of Medical Science, Otsu, Japan
    Osteoarthritis Cartilage 8:115-9. 2000
  5. ncbi request reprint Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 18:425-32. 2006
  6. pmc RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e11404. 2010
  7. pmc RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e15737. 2010
  8. ncbi request reprint RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Brain Res 1168:97-105. 2007
  9. ncbi request reprint Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Oncol Rep 11:1257-63. 2004
  10. pmc Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Pathol 161:359-64. 2002

Collaborators

Detail Information

Publications45

  1. pmc Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application
    Yusuke Hama
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    PLoS ONE 7:e32052. 2012
    ..These monoclonal antibodies will help to generate new opportunities in scientific examinations in biology and clinical medicine...
  2. pmc Association of p62/SQSTM1 excess and oral carcinogenesis
    Takuma Inui
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 8:e74398. 2013
    ..Immunohistochemical evaluation of p62/SQSTM1 may be a potential significant marker to identify early carcinogenesis, chemo-radiotherapeutic resistance or poor prognosis of oral squamous cell carcinomas. ..
  3. ncbi request reprint [Application of novel clinicopathological biomarkers]
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Rinsho Byori 60:167-73. 2012
    ..These novel biomarkers such as RB1CC1, RecQ, and DNMT3L provide new insight into cancer diagnosis and therapy; and will help to realize the order-made medicine...
  4. ncbi request reprint Mechanical stress induces the expression of high molecular mass heat shock protein in human chondrocytic cell line CS-OKB
    T Chano
    Department of Basic Science for Health and Nursing, Shiga University of Medical Science, Otsu, Japan
    Osteoarthritis Cartilage 8:115-9. 2000
    ..Mechanical stress is an important regulator of chondrocyte function, but it is unknown how chondrocytes respond to mechanical stress. This study was performed to clarify the underlying mechanisms in human chondrocytes...
  5. ncbi request reprint Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 18:425-32. 2006
    ..RB1CC1 preserved cell size without cell cycle progression especially in neuromuscular tissues, and the abundance contributed to the non-proliferating enlarged cell phenotype...
  6. pmc RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e11404. 2010
    ..Evaluation of RB1CC1 expression combined with RB1 and p53 status is expected to provide useful information in clinical practice and future therapeutic strategies in breast cancer...
  7. pmc RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    PLoS ONE 5:e15737. 2010
    ....
  8. ncbi request reprint RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Brain Res 1168:97-105. 2007
    ..These observations may have implications for the pathogenesis of Alzheimer's disease...
  9. ncbi request reprint Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Oncol Rep 11:1257-63. 2004
    ..Molecular and biological characterization of these genes will yield further insight into the features between MDR and tumor progression in human osteosarcomas...
  10. pmc Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Pathol 161:359-64. 2002
    ....
  11. ncbi request reprint Isolation, characterization and mapping of the mouse and human RB1CC1 genes
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Gene 291:29-34. 2002
    ..2 and 57 kb on chromosome 1A2-4, respectively. Conserved sequence motifs and nuclear localization suggest that the RB1CC1 proteins function as transcription factors...
  12. ncbi request reprint Truncating mutations of RB1CC1 in human breast cancer
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Nat Genet 31:285-8. 2002
    ..In all seven cancers, both RB1CC1 alleles were inactivated; two showed compound heterozygous deletions. Thus, RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor-suppressor gene...
  13. ncbi request reprint Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells
    Tokuhiro Chano
    Department of Basic Science for Health and Nursing, Shiga University of Medical Science, Tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Oncogene 21:1295-8. 2002
    ..Moreover, introduction of wild-type RB1CC1 significantly induced RB1 expression in human leukemic cells. These data suggest that RB1CC1 may be a key regulator of RB1 gene expression...
  14. pmc Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway
    Kahori Minami
    Department of Microbiology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Virol 81:11106-15. 2007
    ....
  15. doi request reprint RB1CC1 activates the p16 promoter through the interaction with hSNF5
    Yasuko Ochi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 219, Japan
    Oncol Rep 26:805-12. 2011
    ..Evaluation of the RB1CC1 mechanism of action is expected to provide useful information for clinical practice and future therapeutic strategies in human cancers...
  16. ncbi request reprint GADD34 induces p21 expression and cellular senescence
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Oncol Rep 17:1481-5. 2007
    ..These findings suggest that GADD34 contributes to the regulation of p21 expression, and that it suppresses cellular proliferation through the induction of cellular senescence...
  17. doi request reprint RB1CC1 activates the promoter and expression of RB1 in human cancer
    Kaichiro Ikebuchi
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Int J Cancer 125:861-7. 2009
    ..Evaluation of RB1CC1 in various types of human cancer tissues is expected to provide useful information for clinical practice and future therapeutic strategies...
  18. ncbi request reprint GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
    Ryosuke Watanabe
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 19:475-83. 2007
    ..GADD34 may find clinical potential as a target drug for the treatment of mTOR-associated diseases...
  19. ncbi request reprint RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells
    Keiichi Kontani
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 12:767-9. 2003
    ..These data suggested that RB1CC1 induces the expression of RB1, especially of underphosphorylated forms, then suppresses cell cycle progression in human neoplastic cells...
  20. doi request reprint DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma
    Kahori Minami
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Clin Cancer Res 16:2751-9. 2010
    ..Testicular germ cell tumors (TGCT) have a unique epigenetic profile distinct from that of other types of cancer. Elucidation of these properties has a potential to identify novel markers for TGCTs...
  21. ncbi request reprint Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs
    Yukihiro Tambe
    Department of Microbiology, Shiga University of Medical Science, Setatsukinowa cho, Otsu, Shiga 520 2192, Japan
    Carcinogenesis 28:777-84. 2007
    ..The present results thus indicate that drs contributes to the suppression of malignant tumor formation, and this suppression is closely correlated with drs-mediated apoptosis...
  22. doi request reprint Methylation profile of DNA repetitive elements in human testicular germ cell tumor
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    Mol Carcinog 51:711-22. 2012
    ..The results indicate that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences differ between TGCTs and cancer cells of somatic tissue origin...
  23. doi request reprint Therapeutic potential of SOX2 inhibition for embryonal carcinoma
    Hiroshi Ushida
    Department of Urology, Shiga University of Medical Science, Shiga, Japan
    J Urol 187:1876-81. 2012
    ..Control of embryonal carcinoma cells is crucial to manage nonseminomatous germ cell tumors. We established SOX2 targeting therapy in an embryonal carcinoma model...
  24. doi request reprint Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers
    Hitosuke Tameno
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Japan
    Head Neck 34:674-80. 2012
    ..7..
  25. doi request reprint RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma
    Akihito Arai
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan
    Cancer Res 71:4598-607. 2011
    ..Our findings offer a preclinical proof of concept for RECQL1 and WRN proteins as novel therapeutic targets to treat aggressive HNSCC and perhaps other cancers...
  26. doi request reprint The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum
    Yukihiro Tambe
    Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Setatsukinowa cho, Otsu, Shiga 520 2192, Japan
    Cancer Lett 283:74-83. 2009
    ..In addition, drs could associate with Rab24 and the association between drs and Rab24 was enhanced during autophagy. Drs was also co-localized with Rab24 on punctuated structures during autophagy...
  27. doi request reprint Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway
    Yukihiro Tambe
    Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Setatsukinowa cho, Otsu, Shiga, Japan
    Cancer Lett 314:82-91. 2012
    ..Drs protein could associate with stress-inducible GADD34 to form a complex with TSC1/2, which suppresses mTOR activity. These findings indicate that Drs suppresses viral replication via mTOR-dependent pathway...
  28. pmc Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation
    Takahiro Isono
    Central Reseach Laboratory, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 8:e60397. 2013
    ..Taken together, our results suggest N-GlcNAc2-modified proteins produced under glucose deprivation caused unfolded protein response in the ER, and that this response induced G2/M arrest...
  29. pmc RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism
    Ichiro Nishimura
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Biol Chem 286:43925-32. 2011
    ..Accordingly, human genotypic variants of RB1CC1 that either stimulate or inhibit RB1CC1 transcription in vivo may cause body size variations...
  30. ncbi request reprint Expression and regulation of RB1CC1 in developing murine and human tissues
    Noriko Bamba
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 529 2192, Japan
    Int J Mol Med 14:583-7. 2004
    ..These results suggested that more Rb1cc1 is expressed throughout developing murine than in human tissues, and that RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice...
  31. pmc Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma
    Kanji Mori
    Department of Clinical Laboratory Medicine, Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, 520 2192, Japan
    BMC Musculoskelet Disord 5:20. 2004
    ..Previously, little attention has been paid to pathogenic features of muscle fibers around an intramuscular lipoma...
  32. ncbi request reprint Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma
    Yoshitomo Ozaki
    Second Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    Cancer 95:1954-62. 2002
    ..Therefore, it would be beneficial for M2BP to be targeted in cancer immunotherapy...
  33. ncbi request reprint Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese males
    Kanji Mori
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, Japan
    Am J Med Genet A 130:169-71. 2004
    ..Haplotype analysis did not demonstrate more significant association. The CYP17 SNP is associated with SNSA in HLA-B27-negative Japanese males...
  34. ncbi request reprint Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
    ..The present data have shown that gain of methylation upstream of the untranslated GTL2 leads to pathological downregulation of DLK1 in RCCs...
  35. ncbi request reprint Expression of E-cadherin in chordomas: diagnostic marker and possible role of tumor cell affinity
    Kanji Mori
    Department of Orthopedic Surgery, Shiga University of Medical Science, Otsu, Japan
    Virchows Arch 440:123-7. 2002
    ..Furthermore, we speculate that E-cadherin may play a role in tumor cell adhesion and is also involved with histological and clinical features in chordomas...
  36. doi request reprint A global transcriptome analysis of a dog model of congestive heart failure with the human genome as a reference
    Takahiro Isono
    Central Research Laboratory, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Card Fail 18:872-8. 2012
    ..Although there are some advantages in a dog CHF model, transcriptome analyses in dogs are limited by the relative lack of genomic information...
  37. ncbi request reprint Expression of macrophage inflammatory protein-1alpha in Schwann cell tumors
    Kanji Mori
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Neuropathology 24:131-5. 2004
    ..Furthermore, various levels of MIP-1alpha expression in these tumors were implicated to be correlated with histological variations...
  38. ncbi request reprint Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Oncol Rep 18:633-7. 2007
    ..However, loss of its expression was observed in cases with metastases (3/5) and can be regarded as an additional parameter to predict the risk of metastasis in rectal well-differentiated endocrine neoplasms...
  39. pmc Glucose Deprivation Induces G2/M Transition-Arrest and Cell Death in N-GlcNAc2-Modified Protein-Producing Renal Carcinoma Cells
    Takahiro Isono
    Central Reseach Laboratory, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 9:e96168. 2014
    ..Further studies to clarify these findings will lead to the development of novel chemotherapeutic treatments for renal cancer. ..
  40. ncbi request reprint Identification and characterization of the human long form of Sox5 (L-SOX5) gene
    Toshiyuki Ikeda
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN The Institute of Physical and Chemical Research, c o Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Gene 298:59-68. 2002
    ..Like SOX6, L-SOX5 shows strong expression in chondrocytes and striated muscles, indicating a likely role in human cartilage and muscle development...
  41. ncbi request reprint Rb1cc1 is critical for myoblast differentiation through Rb1 regulation
    Ryosuke Watanabe
    Department of Applied Biological Science, Faculty of Science and Technology, Science University of Tokyo, 278 0022 Chiba, Japan
    Virchows Arch 447:643-8. 2005
    ..These results indicated that Rb1cc1 is a potent regulator of the Rb1 pathway and a novel mediator that plays a crucial role in muscular differentiation. Rb1cc1 expression is, thus, a prerequisite for myogenic differentiation...
  42. ncbi request reprint [HER2 protein in the serum and nipple discharge]
    Hidetoshi Okabe
    Department of Laboratory Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:753-5. 2005
  43. ncbi request reprint Target specificities of estrogen receptor-related receptors: analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene
    Mst Hasina Akter
    Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo, Japan
    J Biochem 143:395-406. 2008
    ..In vivo binding of ERRalpha to the Rb1cc1 promoter region was confirmed by the chromatin immunoprecipitation assay. Thus, Rb1cc1 is a target gene of ERRalpha, driven by a novel type of recognition sequence...
  44. ncbi request reprint Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma
    Takashi Tsuchiya
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata, Japan
    Cancer Genet Cytogenet 158:148-55. 2005
    ..When considering tumor development in primary chondrosarcoma, we should include mutations in EXT2, along with the status of other members of the EXT gene family...
  45. ncbi request reprint Role of alternative splicing of periostin in human bladder carcinogenesis
    Chul Jang Kim
    Department of Urology, Kohka Public Hospital, Kohka, Shiga 528 0014, Japan
    Int J Oncol 32:161-9. 2008
    ..These results indicate that the loss of WT periostin by down-regulation and/or alternative splicing, which produces Variant I, is closely correlated with the development of bladder cancer...