Shin-ichi Araki

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi request reprint Is glomerular filtration rate in children after 5 years of type 1 diabetes associated with development of albuminuria?
    Shin Ichi Araki
    Division of Nephrology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Nat Clin Pract Nephrol 2:242-3. 2006
  2. doi request reprint APOE polymorphism and diabetic nephropathy
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, 520 2192, Japan
    Clin Exp Nephrol 18:230-3. 2014
  3. pmc Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 36:1248-53. 2013
  4. doi request reprint Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: sub-analysis of the Japanese Elderly Diabetes Intervention Trial
    Shin Ichi Araki
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Geriatr Gerontol Int 12:127-33. 2012
  5. ncbi request reprint Polymorphisms of the protein kinase C-beta gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes Care 29:864-8. 2006
  6. ncbi request reprint Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study
    S Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetologia 50:867-73. 2007
  7. ncbi request reprint Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes 56:1727-30. 2007
  8. doi request reprint Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes Res Clin Pract 82:S54-8. 2008
  9. pmc Correlation between albuminuria and spontaneous platelet microaggregate formation in type 2 diabetic patients
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 32:2062-7. 2009
  10. pmc Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 33:1805-10. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Is glomerular filtration rate in children after 5 years of type 1 diabetes associated with development of albuminuria?
    Shin Ichi Araki
    Division of Nephrology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Nat Clin Pract Nephrol 2:242-3. 2006
  2. doi request reprint APOE polymorphism and diabetic nephropathy
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, 520 2192, Japan
    Clin Exp Nephrol 18:230-3. 2014
    ..Further studies are needed to explore whether genotyping of the APOE polymorphism in patients with diabetes is of value for better management in clinical practice. ..
  3. pmc Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 36:1248-53. 2013
    ..We investigated the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP), which is associated with renal tubulointerstitial damage, in renal and cardiovascular prognosis...
  4. doi request reprint Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: sub-analysis of the Japanese Elderly Diabetes Intervention Trial
    Shin Ichi Araki
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Geriatr Gerontol Int 12:127-33. 2012
    ..Diabetic nephropathy is a serious complication in patients with type 2 diabetes. The aim of this study was to explore the factors associated with the progression of this complication in elderly patients with type 2 diabetes...
  5. ncbi request reprint Polymorphisms of the protein kinase C-beta gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes Care 29:864-8. 2006
    ..We investigated the contribution of PKC-beta gene (PRKCB1) polymorphisms to diabetic kidney disease in a prospective observational follow-up study...
  6. ncbi request reprint Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study
    S Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetologia 50:867-73. 2007
    ..We investigated whether serum levels of IL-18, a proinflammatory cytokine, were a predictor of early renal dysfunction...
  7. ncbi request reprint Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes 56:1727-30. 2007
    ..The aim of this study is to investigate the clinical impact of reducing microalbuminuria in type 2 diabetic patients in an observational follow-up study...
  8. doi request reprint Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes Res Clin Pract 82:S54-8. 2008
    ..Reducing microalbuminuria is therefore considered to be an important therapeutic objective and may be a biomeasure of therapeutic success in type 2 diabetic patients...
  9. pmc Correlation between albuminuria and spontaneous platelet microaggregate formation in type 2 diabetic patients
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 32:2062-7. 2009
    ..Albuminuria in type 2 diabetic patients is a risk factor for cardiovascular disease. We investigated the correlation between albuminuria and spontaneous microaggregation of platelets (SMAP) formed under shear stress...
  10. pmc Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Care 33:1805-10. 2010
    ..The aim of this study was to determine the role of urinary type IV collagen in predicting development and progression of early diabetic nephropathy and deterioration of renal function in a longitudinal study...
  11. ncbi request reprint Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Diabetes 54:2983-7. 2005
    ..Early detection of microalbuminuria and a multifactorial control may result in improved outcomes for diabetic nephropathy and cardiovascular events...
  12. ncbi request reprint SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Biol Chem 282:151-8. 2007
    ..Our results suggest that up-regulation of SIRT1 deacetylase activity is a potentially useful therapeutic strategy for prevention of TGFbeta-related kidney disease through its effect on cell survival...
  13. ncbi request reprint Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension
    Takashi Uzu
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Hypertens 24:1627-32. 2006
    ....
  14. pmc Estrogen and raloxifene, a selective estrogen receptor modulator, ameliorate renal damage in db/db mice
    Masami Chin
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Am J Pathol 166:1629-36. 2005
    ..Thus, our findings suggest that raloxifene, which lacks the harmful effects of estrogen, is useful for the treatment of diabetic nephropathy...
  15. ncbi request reprint Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Free Radic Biol Med 40:2175-82. 2006
    ..Our results indicate that SIRT1 can prevent oxidative stress-induced apoptosis through p53 deacetylation in mesangial cells. Upregulation of SIRT1 may provide a new strategy for preventing kidney glomerular diseases...
  16. ncbi request reprint N-acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators
    Keizo Kanasaki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Biochem Biophys Res Commun 342:758-65. 2006
    ..These results suggest that p53 is the key mediator of Ac-SDKP-induced inhibition of DNA synthesis through the up-regulation of cell cycle modulators, highlighting a potential effect of Ac-SDKP on various progressive renal diseases...
  17. ncbi request reprint APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetes Care 26:2416-20. 2003
    ..The aim of this study is to clarify the conflicting results of the epsilon2/epsilon3/epsilon4 APOE polymorphism as a risk factor on diabetic nephropathy by a cohort study...
  18. ncbi request reprint Combinational effect of genes for the renin-angiotensin system in conferring susceptibility to diabetic nephropathy
    Norihisa Osawa
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Hum Genet 52:143-51. 2007
    ..00005). We concluded that RAS gene polymorphisms may contribute to the susceptibility to diabetic nephropathy in type 2 diabetes...
  19. ncbi request reprint Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Am Soc Nephrol 18:2715-23. 2007
    ..We suggest that renal lipid metabolism could serve as a new therapeutic target to prevent chronic kidney disease in patients with metabolic syndrome...
  20. ncbi request reprint C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus
    Tetsuya Makiishi
    Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Am J Kidney Dis 42:943-51. 2003
    ..However, this association in Japanese patients with type 2 diabetes mellitus and its potential role as a clinical marker remain unclear...
  21. ncbi request reprint Benidipine attenuates glomerular hypertension and reduces albuminuria in patients with metabolic syndrome
    Takashi Uzu
    Department of Medicine, Shiga University of Medical Science, Japan
    Hypertens Res 30:161-5. 2007
    ..These findings indicated that benidipine may be effective for reducing the risk of developing chronic kidney disease in patients with metabolic syndrome...
  22. ncbi request reprint Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy
    Munehiro Kitada
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes 52:2603-14. 2003
    ..We now demonstrate that oxidative stress is primarily enhanced in the diabetic glomeruli due to a PKC-beta-dependent activation of NADPH oxidase resulting in ROS generation...
  23. ncbi request reprint [Case of autosomal dominant polycystic kidney disease associated with congenital hepatic fibrosis]
    Toshiro Sugimoto
    Department of Internal Medicine, Shiga University of Medical Science, Shiga, Japan
    Nihon Jinzo Gakkai Shi 47:463-7. 2005
    ..However, both his mother and older brother had multiple renal cysts, indicating that this was an unusual case of ADPKD complicated by congenital hepatic fibrosis...
  24. ncbi request reprint N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice
    Kazuyuki Shibuya
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetes 54:838-45. 2005
    ....
  25. pmc Asialoerythropoietin prevents contrast-induced nephropathy
    Yukiyo Yokomaku
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, 520 2192, Japan
    J Am Soc Nephrol 19:321-8. 2008
    ..Overall, these findings suggest that asialoerythropoietin may have potential as a new therapeutic approach to prevent CIN given its ability to preserve renal function and directly protect renal tissue...
  26. ncbi request reprint [Urinary type IV collagen as a biological marker for diagnosis of diabetic nephropathies]
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:362-6. 2005
  27. ncbi request reprint [Management of blood glucose in diabetic patients undergoing dialysis therapy]
    Daisuke Koya
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 62:114-7. 2004
  28. ncbi request reprint [Kidney and hypertension]
    Shin Ichi Araki
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 61:1124-9. 2003
    ..This review is an attempt to highlight a renal role on the development of hypertension, especially in diabetic nephropathy...
  29. ncbi request reprint Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy
    Masumi Kamiyama
    Laboratory for Diabetic Nephropathy, SNP Research Centre, Institute of Physical and Chemical Research, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Hum Genet 122:397-407. 2007
    ..G, P = 0.03, odds ratio = 1.91, 95% CI 1.07-3.42). These results suggest that the NCALD gene is a likely candidate for conferring susceptibility to diabetic nephropathy...
  30. doi request reprint Impact of renin-angiotensin system inhibition on microalbuminuria in type 2 diabetes: a post hoc analysis of the Shiga Microalbuminuria Reduction Trial (SMART)
    Takashi Uzu
    Hypertens Res 31:1171-6. 2008
    ..Therefore, RAS inhibitors are first-line drugs for hypertensive patients with type 2 diabetes and microalbuminuria...
  31. ncbi request reprint Relation between polymorphisms G1704T and G82S of RAGE gene and diabetic retinopathy in Japanese type 2 diabetic patients
    Atsunori Kashiwagi
    Intern Med 44:397-8. 2005
  32. ncbi request reprint Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus
    Shin Ichi Araki
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 14:2015-24. 2003
    ..It is concluded that DNA sequence differences in the promoter of PRKCB1 contribute to diabetic nephropathy susceptibility in type I diabetes mellitus...
  33. ncbi request reprint [Glucose metabolism in the kidney]
    Shin Ichi Araki
    Third Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 60:336-41. 2002
  34. ncbi request reprint Minor effect of GLUT1 polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes
    Daniel P K Ng
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 51:2264-9. 2002
    ..Although these SNPs confer a considerable personal risk for diabetic nephropathy, they account for a limited proportion of cases among type 1 diabetic patients...