Akira Andoh

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. ncbi Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
    Y Amakata
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Ostu, Japan
    Clin Exp Immunol 124:214-22. 2001
  2. ncbi Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 2-10-1 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan
    J Gastroenterol 38:134-41. 2003
  3. ncbi Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease
    Akira Andoh
    Division of Mucosal Immunology, Graduate School, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Gastroenterol 47:1298-307. 2012
  4. ncbi Rapid intestinal ischaemia-reperfusion injury is suppressed in genetically mast cell-deficient Ws/Ws rats
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Clin Exp Immunol 116:90-3. 1999
  5. ncbi Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis
    A Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Aliment Pharmacol Ther 29:75-82. 2009
  6. ncbi A case of Crohn's disease involving the gallbladder
    Akira Andoh
    Department of Internal Medicine, Surgery and Clinical Laboratory Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 12:977-8. 2006
  7. ncbi Sodium butyrate enhances complement-mediated cell injury via down-regulation of decay-accelerating factor expression in colonic cancer cells
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Cancer Immunol Immunother 50:663-72. 2002
  8. ncbi Mucosal cytokine network in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 14:5154-61. 2008
  9. ncbi Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Japan
    J Gastroenterol Hepatol 23:1373-7. 2008
  10. ncbi Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Oncol Rep 16:103-7. 2006

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
    Y Amakata
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Ostu, Japan
    Clin Exp Immunol 124:214-22. 2001
    ..These results indicate that the activation of NK cells by DCs is partially mediated by IL-12 secretion, and that direct contact between DCs and NK cells play a major role in this response...
  2. ncbi Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 2-10-1 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan
    J Gastroenterol 38:134-41. 2003
    ..These effects may be brought about by an increase of butyrate production and adsorption of bile acids...
  3. ncbi Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease
    Akira Andoh
    Division of Mucosal Immunology, Graduate School, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Gastroenterol 47:1298-307. 2012
    ..We analyzed the fecal microbiota profiles of patients with Crohn's disease (CD) at 4 inflammatory bowel disease (IBD) centers located in different districts in Japan...
  4. ncbi Rapid intestinal ischaemia-reperfusion injury is suppressed in genetically mast cell-deficient Ws/Ws rats
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Clin Exp Immunol 116:90-3. 1999
    ..These results provide direct evidence for the role of mast cells in the pathogenesis of intestinal ischaemia-reperfusion injury...
  5. ncbi Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis
    A Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Aliment Pharmacol Ther 29:75-82. 2009
    ..Terminal restriction fragment length polymorphism (T-RFLP) analyses are powerful tools to assess the diversity of complex microbiota. T-RFLPs permit rapid comparisons of microbiota from many samples...
  6. ncbi A case of Crohn's disease involving the gallbladder
    Akira Andoh
    Department of Internal Medicine, Surgery and Clinical Laboratory Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 12:977-8. 2006
    ..When cholecystectomy is performed in a patient with Crohn's disease, the possibility of gallbladder involvement should be carefully examined by histopathological tests...
  7. ncbi Sodium butyrate enhances complement-mediated cell injury via down-regulation of decay-accelerating factor expression in colonic cancer cells
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Cancer Immunol Immunother 50:663-72. 2002
    ..These observations indicate that both a down-regulation of DAF expression and the induction of susceptibility to complement attack contribute to the anti-tumor effects of butyrate in colonic cancer...
  8. ncbi Mucosal cytokine network in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 14:5154-61. 2008
    ..In this manuscript, we focus on the biological activities of recently-reported cytokines [Interleukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-alpha in the pathophysiology of IBD...
  9. ncbi Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Japan
    J Gastroenterol Hepatol 23:1373-7. 2008
    ..The aim of this study was to assess 6-TGN concentrations in Japanese IBD patients...
  10. ncbi Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Oncol Rep 16:103-7. 2006
    ....
  11. ncbi Elevated serum anti-carbonic anhydrase II antibodies in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 9:499-502. 2002
    ..These results suggest that autoimmune responses against CA II may be involved in the pathogenesis of UC, and similar mechanism may participate in the development of pancreatic lesions in UC patients...
  12. ncbi Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 12:4452-60. 2006
    ..Therapeutic approaches to modulate balance of intestinal microflora and their potential mechanisms of action are also discussed...
  13. ncbi Role of dietary fiber and short-chain fatty acids in the colon
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Curr Pharm Des 9:347-58. 2003
    ..SCFAs increase the susceptibility of colon cancer cells to complement-mediated cell injury. In this review, new aspects of functions of SCFAs are focused and summarized...
  14. ncbi IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
    J Immunol 169:1683-7. 2002
    ..Because cooperation between NF-kappaB and IRF-1 is important in the TNF-alpha-induced RANTES gene expression, the major mechanism mediating the inhibitory effect of IL-17 may be achieved by the inhibition of IRF-1 DNA-binding activity...
  15. ncbi Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Biochim Biophys Acta 1591:69-74. 2002
    ..This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha...
  16. ncbi Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Int J Mol Med 10:631-4. 2002
    ..In conclusion, IL-4, in particular IL-4 plus IL-17, induced IL-6 secretion in human colonic myofibroblasts. Th2 immune responses might play an important role in the pathogenesis of gut inflammation...
  17. ncbi Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut
    Akira Andoh
    Department of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Pharmacol Ther 114:94-106. 2007
    ..Recent therapeutic strategies targeting BM stem cells for IBD patients were also documented...
  18. ncbi Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Gastroenterology 129:969-84. 2005
    ..We investigated IL-22 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and analyzed its biologic activities in human colonic subepithelial myofibroblasts (SEMFs)...
  19. ncbi N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 12:721-5. 2003
    ..The effects of the n-3 fatty acids were associated with blockage of mucosal IL-6 secretion. Our data suggest that n-3 fatty acid-rich diet may be applicable for enteral nutrition in the treatment of IBD patients...
  20. ncbi Recent advances in molecular approaches to gut microbiota in inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Curr Pharm Des 15:2066-73. 2009
    ..This review focuses on recent advances in the molecular ecological approaches for studying the gut microbiota in IBD...
  21. ncbi Counter-regulatory effect of sodium butyrate on tumour necrosis factor-alpha (TNF-alpha)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Clin Exp Immunol 118:23-9. 1999
    ..Butyrate action has been discussed with its activity to induce histone hyperacetylation, but its counter-regulatory effect on complement biosynthesis may be closely associated with the modulation of transcription factor activation...
  22. ncbi Serum selenoprotein-P levels in patients with inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Nutrition 21:574-9. 2005
    ..Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease...
  23. ncbi Transforming growth factor-beta1 acts as a potent inhibitor of complement C3 biosynthesis in human pancreatic cancer cell lines
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Pancreas 20:138-45. 2000
    ..This action of TGF-beta1 did not correlate with NF-kappaB activation, but associated with the translocation of Fos protein into the nucleus...
  24. ncbi Suppression of inflammatory cytokine secretion by granulocyte/monocyte adsorptive apheresis in active ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Ther Apher Dial 9:123-7. 2005
    ..The induction of hyporesponsiveness to pro-inflammatory cytokines may be an important factor mediating the clinical effects of granulocyte/macrophage adsorptive apheresis in UC patients...
  25. ncbi Epimorphin expression in human colonic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 13:57-61. 2004
    ..The localization of epimorphin may indicate a potential role in maintaining normal tissue structure in normal and IBD mucosa...
  26. ncbi Role of complement activation and mast cell degranulation in the pathogenesis of rapid intestinal ischemia/reperfusion injury in rats
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Digestion 63:103-7. 2001
    ..A regulation of the complement activation and MMC degranulation may be one of the clinical strategies for prevention of I/R-induced mucosal injury...
  27. ncbi Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn's disease using terminal restriction fragment length polymorphism analysis
    Akira Andoh
    Division of Mucosal Immunology, Graduate School of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    J Gastroenterol 46:479-86. 2011
    ..In this study, we performed T-RFLP analysis of the fecal microbiota from patients with ulcerative colitis (UC) and those with Crohn's disease (CD)...
  28. ncbi Fibroblast growth factor-2 stimulates interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreas 29:278-83. 2004
    ..In the present study, to evaluate the proinflammatory nature of FGF-2, we investigated the effects of FGF-2 on IL-6 secretion in human pancreatic periacinar myofibroblasts...
  29. ncbi Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Japan
    Clin Exp Immunol 125:56-63. 2001
    ..The combination of IL-17 with IFN-gamma synergistically enhanced chemokine secretion. These effects of IL-17 and IFN-gamma might play an important role in the inflammatory responses in the intestinal mucosa...
  30. ncbi Leukocytapheresis therapy modulates circulating t cell subsets in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Ther Apher Dial 9:270-6. 2005
    ..The Th1/Th2 ratio was significantly decreased after LCAP therapy. Some of the immuno-suppressive effects of LCAP therapy may be associated with a modulation of circulating T cell subsets...
  31. ncbi Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    J Immunol 183:687-95. 2009
    ..IL-24 derived from colonic SEMFs acts on colonic epithelial cells to elicit JAK1/STAT-3 activation and the expression of SOCS3 and mucins, supporting their suppressive effects on mucosal inflammation in IBD...
  32. ncbi Inhibitory effects of somatostatin on tumor necrosis factor-alpha-induced interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 10:89-93. 2002
    ..These findings suggest that some of the therapeutic actions of somatostatin on acute pancreatitis might be mediated by reducing local IL-6 secretion in the pancreas...
  33. ncbi Terminal restriction fragment length polymorphism analysis of the diversity of fecal microbiota in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Inflamm Bowel Dis 13:955-62. 2007
    ..This permits rapid comparison of microbiota from many samples. In this study, we performed T-RFLP analysis of the fecal microbiota from patients with ulcerative colitis (UC)...
  34. ncbi Matrix metalloproteinase-3 secretion from human pancreatic periacinar myofibroblasts in response to inflammatory mediators
    Osamu Inatomi
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreas 34:126-32. 2007
    ..However, the regulation of MMP-3 secretion in the pancreas remains unclear. In this study, we assessed the expression of MMP-3 in human pancreatic periacinar myofibroblasts...
  35. ncbi Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts
    Kazuhito Tasaki
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreatology 3:414-21. 2003
    ..Thus, human pancreatic periacinar myofibroblasts may play an important role in the remodeling of damaged pancreatic tissue in chronic pancreatitis via MMP-1 secretion...
  36. ncbi Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Internal Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Int J Mol Med 19:941-6. 2007
    ..In conclusion, we demonstrated that IL-31 is a potent inducer of proinflammatory mediators in human colonic SEMFs. IL-31 may function as a proinflammatory cytokine derived from Th2 cells...
  37. ncbi IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts
    Kazunori Hata
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G1035-44. 2002
    ..This was dependent on the enhancement of IL-6 mRNA stability. In conclusion, human SEMFs secreted IL-6, IL-8, and MCP-1 in response to IL-17. These responses might play an important role in the pathogenesis of gut inflammation...
  38. ncbi Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines
    Ayako Kobori
    Division of Gastroenterology, Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Shiga, 520 2192, Japan
    World J Gastroenterol 16:2355-61. 2010
    ..To investigate the effects of butyrate on interleukin (IL)-32alpha expression in epithelial cell lines...
  39. ncbi FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice
    Takashi Nishimura
    Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 14:5851-6. 2008
    ..To investigate the effects of FR167653 on the development of dextran sulfate sodium (DSS)-induced colitis in mice...
  40. ncbi Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts
    Zhuobin Zhang
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 15:79-83. 2005
    ..In conclusion, this is the first report demonstrating that IL-23 p19 mRNA is inducible in colonic myofibroblasts by IL-1beta and TNF-alpha. The p19 expression in these cells might play a role in mucosal immune responses...
  41. ncbi Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-32alpha induction in human pancreatic periacinar myofibroblasts
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G831-8. 2008
    ..IL-32alpha mRNA expression is dependent on interactions between the phosphatidylinositol 3-kinase/Akt-pathway and the NF-kappaB/AP-1 system...
  42. ncbi Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520-2192, Japan
    J Gastroenterol 40:802-10. 2005
    ..CONCLUSIONS: IL-17 augments TNF-alpha-induced G- and GM-CSF release via transcriptional and posttranscriptional mechanisms...
  43. ncbi Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients
    Takashi Nishimura
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Mol Med Rep 5:517-20. 2012
    ..In conclusion, the ITPA genotypes may be a useful marker for prediction of RBV-induced anemia...
  44. ncbi IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators
    Mitsue Shimada
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Immunol 168:861-8. 2002
    ..In conclusion, pancreatic periacinar myofibroblasts secreted a large amount of IL-6 in response to proinflammatory cytokines. These cells might play an important role in the pathogenesis of acute pancreatitis via IL-6 secretion...
  45. ncbi Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 59:531-41. 2010
    ..The effects of IL33 on the functions of human pancreatic myofibroblasts were also investigated...
  46. ncbi Interleukin-32 expression in the pancreas
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Biol Chem 284:17868-76. 2009
    ..Pancreatic duct cells are the local source of IL-32, and IL-32 may play an important role in inflammatory responses and pancreatic cancer growth...
  47. ncbi Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis
    Yasuyuki Deguchi
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 52:2993-8. 2007
    ..In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients...
  48. ncbi Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection
    Yasuharu Saito
    Department of Endoscopic Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Dig Dis Sci 53:330-3. 2008
    ..Due to the biodegradable features of this stent, longer term studies are necessary to investigate the relationship between the expected disappearance of the stent and the patency of the stricture...
  49. ncbi Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways
    Shigeki Bamba
    Department of Internal Medicine, Shiga Univ of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G529-38. 2003
    ..Intestinal SEMFs secreted IL-11 in response to IL-1beta- and TGF-beta1. Mucosal IL-11 secretion might be important as an anti-inflammatory response in the pathogenesis of intestinal inflammation...
  50. ncbi Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis
    Ayako Kobori
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol 45:999-1007. 2010
    ....
  51. ncbi Endoscopic submucosal dissection combined with the placement of biodegradable stents for recurrent esophageal cancer after chemoradiotherapy
    Yosuke Mochizuki
    Division of Digestive Endoscopy, Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    J Gastrointest Cancer 43:324-8. 2012
    ..One month later, the patient reported a feeling of obstruction. An endoscopic examination revealed food stuck in the stents, this was removed, and balloon dilatation provided good passage which has been maintained for 7 months...
  52. ncbi Usefulness of bispectral monitoring of conscious sedation during endoscopic mucosal dissection
    Kazunori Hata
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 15:595-8. 2009
    ..To assess the usefulness of bispectral index (BIS) monitoring in order to carry out endoscopic submucosal dissection (ESD) safely and with patients' satisfaction...
  53. ncbi Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
    J Gastroenterol 42:746-53. 2007
    ..We investigated the potential role of interleukin (IL)-17 family members (IL-17A to IL-17F) in the induction of inflammatory responses in human colonic subepithelial myofibroblasts (SEMFs)...
  54. ncbi A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29
    Hirotsugu Imaeda
    Department of Medicine, Graduate School of Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Mol Med Rep 4:483-7. 2011
    ..The mRNA expression of this new isoform was significantly elevated in the inflamed mucosa of IBD patients. A new isoform of the IL-32 transcript may play an anti-inflammatory role in the inflamed mucosa of IBD...
  55. ncbi Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Oncol Rep 28:1597-605. 2012
    ..Therefore, the molecular mass distribution of the DSS differed between each part in the lumen. As an early stage event, DSS induced colitis through cell cycle arrest and apoptosis according to its molecular mass...
  56. ncbi Interleukin-17 and lipopolysaccharides synergistically induce cyclooxygenase-2 expression in human intestinal myofibroblasts
    Zhuobin Zhang
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol Hepatol 20:619-27. 2005
    ..These findings suggest that COX-2 expression and prostaglandin synthesis might be regulated by both T-cell-derived factor (IL-17) and bacterial products (LPS) in the inflamed mucosa...
  57. ncbi The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis
    Hiromitsu Ban
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Oncol Rep 25:1699-703. 2011
    ..DPP-IV inhibitors are thought to promote the proliferation of the intestinal epithelium. However, the amelioration of DSS-induced colitis was only partial...
  58. ncbi Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis
    Yasuharu Saito
    Division of Endoscopic Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 13:3977-80. 2007
    ..To report 13 patients with benign esophageal stenosis treated with the biodegradable stent...
  59. ncbi Factors affecting the efficacy of cyclosporin A therapy for refractory ulcerative colitis
    Shigeki Bamba
    Division of Gastroenterology, Department of Internal Medicine, Shiga University of Medical Science, Japan
    J Gastroenterol Hepatol 25:494-8. 2010
    ..We retrospectively investigated patients with refractory UC treated with CSA therapy to elucidate the efficacy and the prognostic factors...
  60. ncbi Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts
    Takato Kawamura
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 54:238-45. 2009
    ..In this report, we investigated how SCFAs modulate matrix metalloproteinase (MMP) secretion from human colonic subepithelial myofibroblasts (SEMFs)...
  61. ncbi Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17
    Shigeki Bamba
    Division of Gastroenterology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan
    J Gastroenterol 38:548-54. 2003
    ..CONCLUSIONS: Colonic SEMFs actively secreted MMP-3 in response to IL-17, IL-1beta, and TNF-alpha. This was coupled with TIMP-1 secretion. Colonic SEMFs may play an important role in ECM turnover via MMP secretion...
  62. ncbi Interleukin-32α expression in human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Medicine, Graduate School of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Int J Mol Med 27:263-8. 2011
    ..Human colonic SEMFs expressed IL-32α in response to IL-1ß and TNF-α. IL-32α mRNA expression depends on the phosphatidylinositol 3-kinase and the NF-κB system...
  63. ncbi Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease
    Hiromitsu Ban
    Department of Medicine, Shiga University of Medical Science, Otsu
    Intern Med 47:1645-8. 2008
    ..TPMT activity is dependent on the genetic polymorphism of high-versus low-metabolizing alleles. We investigated the association between TPMT genotypes and myelosuppression in Japanese IBD patients...
  64. ncbi Feasibility of five days of consecutive leukocytapheresis for the treatment of ulcerative colitis: a preliminary study
    Tomoyuki Tsujikawa
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Ther Apher Dial 13:14-8. 2009
    ..This preliminary study showed that five consecutive LCAP sessions are safe and feasible for active UC patients. The therapeutic efficacy and suitable patients for this treatment protocol should be confirmed by further studies...
  65. ncbi The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease
    Hiromistu Ban
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol 45:1014-21. 2010
    ..In this study, we investigated the association between MRP4 G2269A polymorphism and thiopurine sensitivity in Japanese IBD patients...
  66. ncbi Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts
    Osamu Inatomi
    Department of Internal Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan
    Int J Mol Med 18:497-503. 2006
    ..We demonstrated expression of amphiregulin and epiregulin in SEMFs. Amphiregulin and epiregulin may play an important role in the mechanism underlying wound healing in damaged colonic mucosa...
  67. ncbi Chemoradiation therapy followed by endoscopic submucosal dissection for esophageal cancer
    Yasuharu Saito
    Division of Endoscopy, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 53:3242-5. 2008
    ..All patients were recurrence-free for 6 months to 2.5 years. The combination of CRT plus subsequent ESD may be useful for treating patients with esophageal cancer who are not fit to undergo surgery...
  68. ncbi A pilot study of leukocytapheresis efficacy with 1.5 liter blood processing volume in patients with ulcerative colitis
    Masaaki Shimada
    Department of Gastroenterology, National Hospital Organization, Nagoya Medical Center, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ther Apher Dial 12:368-73. 2008
    ..5L-LCAP therapy. 1.5L-LCAP was clinically effective for active UC patients. Cellular responses induced by 1.5L-LCAP were similar to those induced by a standard LCAP session...
  69. ncbi Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts
    T Okuno
    Dept. of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan
    Scand J Gastroenterol 37:317-24. 2002
    ..Thus, colonic subepithelial myofibroblasts may play an important role in the pathophysiology of inflammation in the colon...
  70. ncbi Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response
    Akira Andoh
    Department of Gastroenterology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan
    J Gastroenterol 40:1089-99. 2005
  71. ncbi [Cytoapheresis for IBD]
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science
    Nippon Rinsho 63:836-42. 2005
    ..In this paper, three types of cytoapheresis [leukocytapheresis (LCAP), granulocytapheresis (GCAP), and centrifugal leukocyte apheresis] are reviewed...
  72. ncbi Intestinal subepithelial myofibroblasts in inflammatory bowel diseases
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520-2192, Japan
    J Gastroenterol 37:33-7. 2002
    ..In particular, PDGF had a strong stimulatory effect. We concluded that colonic SEMFs may play an important role in the repair process of IBD...
  73. ncbi Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts
    Hirofumi Yasui
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, Japan
    Digestion 69:34-44. 2004
    ..Furthermore, FGF-2 dose-dependently induced FGF-2 mRNA expression in these cells. CONCLUSIONS: FGF-2 may be one of important regulatory factors for extracellular matrix turnover via a modulation of MMP and TIMP secretion from SEMFs...
  74. ncbi Immunohistochemical analysis of cell cycle-regulating-protein (p21, p27, and Ki-67) expression in gastroesophageal reflux disease
    Yorihiro Nishiyama
    Department of Gastroenterology, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan
    J Gastroenterol 37:905-11. 2002
    ..The evaluation of these responses may be helpful in the diagnosis of endoscopically negative GERD...
  75. ncbi Newly developed biodegradable stents for benign gastrointestinal tract stenoses: a preliminary clinical trial
    Toyohiko Tanaka
    Department of Radiology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Digestion 74:199-205. 2006
    ..The stenosis had not recurred at the six-month follow-up examination. In conclusion, the newly developed biodegradable stents were useful in treating benign stenoses of the alimentary tract...
  76. ncbi An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment
    Atsushi Sakuraba
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Gastroenterol 104:2990-5. 2009
    ..The aim of this study was to assess the clinical efficacy and safety of intensive GMA treatment in patients with active UC...
  77. ncbi Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan
    Gut 52:65-70. 2003
    ..CONCLUSIONS: IL-17 expression in the mucosa and serum was increased in IBD patients. It is likely that IL-17 expression in IBD may be associated with altered immune and inflammatory responses in the intestinal mucosa...
  78. ncbi The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease
    T Sugihara
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Clin Exp Immunol 160:386-93. 2010
    ..C3 and IL-17 mRNA expressions are enhanced, with a strong correlation, in the inflamed mucosa of IBD patients. Part of these clinical findings was considered to be mediated by the colonic SEMF response to IL-17...
  79. ncbi Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    J Gastroenterol 42:29-33. 2007
    ..Furthermore, based on the data from our laboratory, interaction between Th-17 cells and colonic subepithelial myofibroblasts may play an important role in the pathophysiology of IBS and IBD...
  80. ncbi A case of severe acute pancreatitis treated with CTR-001 direct hemoperfusion for cytokine apheresis
    Takao Saotome
    Critical and Intensive Care Medicine, Shiga University of Medical Science, Shiga, Japan
    Ther Apher Dial 9:367-71. 2005
    ..0+/-1.9 pg/mL, P=0.726) did not decrease statistically. Therefore, we conclude that in this case, cytokine apheresis using a CTR-001 cartridge was effective for reducing the pro-inflammatory cytokines during severe acute pancreatitis...
  81. ncbi Hepatocellular carcinoma occurring in a Crohn's disease patient
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    World J Gastroenterol 16:3215-8. 2010
    ..These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors...
  82. ncbi Operative indications for patients with refractory or severe ulcerative colitis
    Tomoyuki Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science, Shiga, Japan
    Hepatogastroenterology 52:1470-3. 2005
    ..Since new treatments using cyclosporin A and leukocytapheresis have been developed, we analyzed historical changes in the operative indications for UC...
  83. ncbi Enteral and parenteral nutrition therapy for Crohn's disease
    Tomoyuki Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Curr Pharm Des 9:323-32. 2003
    ....
  84. ncbi Supplement of a chitosan and ascorbic acid mixture for Crohn's disease: a pilot study
    Tomoyuki Tsujikawa
    Department of Internal Medicine, Division of Gastroenterology, Shiga University of Medical Science, and the Kirin Brewery Co, Ltd, Research Institute of Life Science, Shiga, Japan
    Nutrition 19:137-9. 2003
    ..We designed a pilot trial to investigate the tolerability and amount of fat excretion after the oral administration of a chitosan and ascorbic mixture for inactive Crohn's disease...
  85. ncbi A case of toxic shock-like syndrome presenting with serious hypoproteinaemia because of a protein-losing gastroenteropathy
    K Tasaki
    Department of Internal Medicine, Shiga University of Medical Science, Ohtsu, Shiga, Japan
    J Intern Med 250:174-9. 2001
    ..Considering these histological findings, some immunological mechanism which lead the activation of cytotoxic T-lymphocytes may play an important role in the pathogenesis of this rare intestinal manifestation of TSLS...
  86. ncbi Trisomy 10 as the sole abnormality in biphenotypic leukemia
    T Inoue
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Leuk Lymphoma 39:405-9. 2000
    ..No case of biphenotypic leukemia with trisomy 10 has been previously reported, until now...
  87. ncbi Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease
    M Shioya
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Clin Exp Immunol 149:480-6. 2007
    ..Epithelial IL-32alpha expression was increased in IBD patients, and in CD patients in particular. IL-32alpha might be involved in the pathophysiology of IBD as a proinflammatory cytokine and a mediator of innate immune response...
  88. ncbi Interleukin-17 stimulates chemokine (interleukin-8 and monocyte chemoattractant protein-1) secretion in human pancreatic periacinar myofibroblasts
    H Takaya
    Dept. of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Japan
    Scand J Gastroenterol 37:239-45. 2002
    ..The combination of IL-17 with IFN-gamma further enhances chemokine secretion. These findings indicate a linkage between T-cell-mediated immunity and inflammatory responses in the pancreas...
  89. ncbi Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Gastroenterology 119:211-9. 2000
    ..We have previously isolated and characterized human pancreatic periacinar myofibroblasts. In this study, to define the role of these cells in the pathogenesis of acute pancreatitis, we investigated chemokine expression in them...
  90. ncbi Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)
    K Yamamoto
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Biochim Biophys Acta 1526:10-2. 2001
    ..We demonstrate here that oxidative stress, induced by H(2)O(2), promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR...
  91. ncbi Medium-chain triglycerides modulate ileitis induced by trinitrobenzene sulfonic acid
    T Tsujikawa
    The Second Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Gastroenterol Hepatol 14:1166-72. 1999
    ..Dietary fat in Crohn's disease is still a controversial risk factor for IBD. We therefore also studied the effects of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) on TNBS ileitis...
  92. ncbi Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine: preliminary experiences
    T Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science Hospital, Shiga, Japan
    Endoscopy 40:11-5. 2008
    ..The aim of the present study was to evaluate the insertion technique, the safety, and the clinical impact of the SBE system...
  93. ncbi Ligation of the Fas antigen stimulates chemokine secretion in pancreatic cancer cell line PANC-1
    M Shimada
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Gastroenterol Hepatol 16:1060-7. 2001
    ..CONCLUSION: Our results indicate that Fas Ag stimulation can induce chemokine secretion in PANC-1 cells, suggesting the contribution of Fas stimulation to the accumulation of immune cells in pancreatic cancer tissue...
  94. ncbi Sequential changes in luminal microflora and mucosal cytokine expression during developing of colitis in HLA-B27/beta2-microglobulin transgenic rats
    K Hata
    Dept. of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Scand J Gastroenterol 36:1185-92. 2001
    ..The colonization of anaerobic bacteria, especially Bacteroides spp., may be initiating and promoting these cytokine responses...
  95. ncbi Medium-chain triglyceride-rich enteral nutrition is more effective than low-fat enteral nutrition in rat colitis, but is equal in enteritis
    T Tsujikawa
    Second Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Gastroenterol 36:673-80. 2001
    ..We suggest that Twinline may be more useful to improve nutritional status and to reduce the mucosal inflammation in rat colitis, but that Twinline is equal in effect to Elental for rat enteritis...
  96. ncbi Epithelial expression of caveolin-2, but not caveolin-1, is enhanced in the inflamed mucosa of patients with ulcerative colitis
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Inflamm Bowel Dis 7:210-4. 2001
    ..Furthermore, our results suggest that there are differences in the phenotypic features of epithelial cells between UC and Crohn's disease...
  97. ncbi Changes in serum diamine oxidase activity during chemotherapy in patients with hematological malignancies
    T Tsujikawa
    The Second Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Otsu, Japan
    Cancer Lett 147:195-8. 1999
    ..As the dosage of anti-cancer drugs increased, DAO activity decreased more, but its activity was not related to other parameters. These findings suggest that serum DAO could be used as an indicator of mucosal injury during chemotherapy...
  98. ncbi Characterization of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis
    H Matsuda
    Department of Internal Medicine, Social Insurance Shiga Hospital, Otsu, Japan
    J Gastroenterol Hepatol 15:61-8. 2000
    ..Based on the hypothesis that the pathogenesis of UC may be closely associated with the mucosal microflora, we investigated alterations in the mucosa-associated microflora of UC patients...
  99. ncbi Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery, 10-1-2 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan
    J Gastroenterol 37:67-72. 2002
    ..CONCLUSIONS: Oral GBF therapy may have the potency to reduce clinical activity of UC. We believe that these results support the use of GBF administration as a new adjunct therapy for UC...
  100. ncbi Suppression of interleukin-1beta- and tumor necrosis factor-alpha-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, 520-2192, Japan
    J Gastroenterol 39:1150-7. 2004
    ..The induction of hyporesponsiveness to proinflammatory cytokines may be an important factor mediating the clinical effects of LCAP in UC patients...
  101. ncbi Butyrate blocks interferon-gamma-inducible protein-10 release in human intestinal subepithelial myofibroblasts
    Osamu Inatomi
    Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, 520-2192, Japan
    J Gastroenterol 40:483-9. 2005
    ..The regulation of IP-10 release by IFN-gamma and butyrate may play an important role in controlling chronic mucosal inflammation in pathological entities such as IBD...