Akira Andoh

Summary

Affiliation: Shiga University of Medical Science
Country: Japan

Publications

  1. pmc Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
    Y Amakata
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Ostu, Japan
    Clin Exp Immunol 124:214-22. 2001
  2. pmc Genetic lineages of undifferentiated-type gastric carcinomas analysed by unsupervised clustering of genomic DNA microarray data
    Ayano Sonoda
    Department of Pathology, Division of Molecular and Diagnostic Pathology, Shiga University of Medical Science, Otsu 520 2192, Japan
    BMC Med Genomics 6:25. 2013
  3. pmc Threaded biliary inside stents are a safe and effective therapeutic option in cases of malignant hilar obstruction
    Osamu Inatomi
    Division of Gastroenterology, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga, Japan
    BMC Gastroenterol 13:31. 2013
  4. doi request reprint Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease
    Akira Andoh
    Division of Mucosal Immunology, Graduate School, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Gastroenterol 47:1298-307. 2012
  5. ncbi request reprint Serum selenoprotein-P levels in patients with inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Nutrition 21:574-9. 2005
  6. ncbi request reprint Suppression of inflammatory cytokine secretion by granulocyte/monocyte adsorptive apheresis in active ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Ther Apher Dial 9:123-7. 2005
  7. ncbi request reprint Fibroblast growth factor-2 stimulates interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreas 29:278-83. 2004
  8. ncbi request reprint Epimorphin expression in human colonic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 13:57-61. 2004
  9. ncbi request reprint N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 12:721-5. 2003
  10. ncbi request reprint Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut
    Akira Andoh
    Department of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Pharmacol Ther 114:94-106. 2007

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. pmc Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
    Y Amakata
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Ostu, Japan
    Clin Exp Immunol 124:214-22. 2001
    ..These results indicate that the activation of NK cells by DCs is partially mediated by IL-12 secretion, and that direct contact between DCs and NK cells play a major role in this response...
  2. pmc Genetic lineages of undifferentiated-type gastric carcinomas analysed by unsupervised clustering of genomic DNA microarray data
    Ayano Sonoda
    Department of Pathology, Division of Molecular and Diagnostic Pathology, Shiga University of Medical Science, Otsu 520 2192, Japan
    BMC Med Genomics 6:25. 2013
    ....
  3. pmc Threaded biliary inside stents are a safe and effective therapeutic option in cases of malignant hilar obstruction
    Osamu Inatomi
    Division of Gastroenterology, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga, Japan
    BMC Gastroenterol 13:31. 2013
    ..In this study, we evaluated the safety and efficacy of placing a threaded stent above the sphincter of Oddi (threaded inside plastic stents, threaded PS) and compared the results with those of other stent types...
  4. doi request reprint Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease
    Akira Andoh
    Division of Mucosal Immunology, Graduate School, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Gastroenterol 47:1298-307. 2012
    ..We analyzed the fecal microbiota profiles of patients with Crohn's disease (CD) at 4 inflammatory bowel disease (IBD) centers located in different districts in Japan...
  5. ncbi request reprint Serum selenoprotein-P levels in patients with inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Nutrition 21:574-9. 2005
    ..Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease...
  6. ncbi request reprint Suppression of inflammatory cytokine secretion by granulocyte/monocyte adsorptive apheresis in active ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Ther Apher Dial 9:123-7. 2005
    ..The induction of hyporesponsiveness to pro-inflammatory cytokines may be an important factor mediating the clinical effects of granulocyte/macrophage adsorptive apheresis in UC patients...
  7. ncbi request reprint Fibroblast growth factor-2 stimulates interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreas 29:278-83. 2004
    ..In the present study, to evaluate the proinflammatory nature of FGF-2, we investigated the effects of FGF-2 on IL-6 secretion in human pancreatic periacinar myofibroblasts...
  8. ncbi request reprint Epimorphin expression in human colonic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 13:57-61. 2004
    ..The localization of epimorphin may indicate a potential role in maintaining normal tissue structure in normal and IBD mucosa...
  9. ncbi request reprint N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 12:721-5. 2003
    ..The effects of the n-3 fatty acids were associated with blockage of mucosal IL-6 secretion. Our data suggest that n-3 fatty acid-rich diet may be applicable for enteral nutrition in the treatment of IBD patients...
  10. ncbi request reprint Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut
    Akira Andoh
    Department of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Pharmacol Ther 114:94-106. 2007
    ..Recent therapeutic strategies targeting BM stem cells for IBD patients were also documented...
  11. ncbi request reprint Role of dietary fiber and short-chain fatty acids in the colon
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Curr Pharm Des 9:347-58. 2003
    ..SCFAs increase the susceptibility of colon cancer cells to complement-mediated cell injury. In this review, new aspects of functions of SCFAs are focused and summarized...
  12. ncbi request reprint Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Int J Mol Med 10:631-4. 2002
    ..In conclusion, IL-4, in particular IL-4 plus IL-17, induced IL-6 secretion in human colonic myofibroblasts. Th2 immune responses might play an important role in the pathogenesis of gut inflammation...
  13. ncbi request reprint Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Biochim Biophys Acta 1591:69-74. 2002
    ..This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha...
  14. ncbi request reprint Leukocytapheresis therapy modulates circulating t cell subsets in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Ther Apher Dial 9:270-6. 2005
    ..The Th1/Th2 ratio was significantly decreased after LCAP therapy. Some of the immuno-suppressive effects of LCAP therapy may be associated with a modulation of circulating T cell subsets...
  15. ncbi request reprint Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Gastroenterology 129:969-84. 2005
    ..We investigated IL-22 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and analyzed its biologic activities in human colonic subepithelial myofibroblasts (SEMFs)...
  16. ncbi request reprint A case of Crohn's disease involving the gallbladder
    Akira Andoh
    Department of Internal Medicine, Surgery and Clinical Laboratory Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 12:977-8. 2006
    ..When cholecystectomy is performed in a patient with Crohn's disease, the possibility of gallbladder involvement should be carefully examined by histopathological tests...
  17. doi request reprint Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn's disease using terminal restriction fragment length polymorphism analysis
    Akira Andoh
    Division of Mucosal Immunology, Graduate School of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    J Gastroenterol 46:479-86. 2011
    ..In this study, we performed T-RFLP analysis of the fecal microbiota from patients with ulcerative colitis (UC) and those with Crohn's disease (CD)...
  18. pmc Mucosal cytokine network in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 14:5154-61. 2008
    ..In this manuscript, we focus on the biological activities of recently-reported cytokines [Interleukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-alpha in the pathophysiology of IBD...
  19. doi request reprint Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    J Immunol 183:687-95. 2009
    ..IL-24 derived from colonic SEMFs acts on colonic epithelial cells to elicit JAK1/STAT-3 activation and the expression of SOCS3 and mucins, supporting their suppressive effects on mucosal inflammation in IBD...
  20. ncbi request reprint Recent advances in molecular approaches to gut microbiota in inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Curr Pharm Des 15:2066-73. 2009
    ..This review focuses on recent advances in the molecular ecological approaches for studying the gut microbiota in IBD...
  21. doi request reprint Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis
    A Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Aliment Pharmacol Ther 29:75-82. 2009
    ..Terminal restriction fragment length polymorphism (T-RFLP) analyses are powerful tools to assess the diversity of complex microbiota. T-RFLPs permit rapid comparisons of microbiota from many samples...
  22. doi request reprint Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease
    Akira Andoh
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Japan
    J Gastroenterol Hepatol 23:1373-7. 2008
    ..The aim of this study was to assess 6-TGN concentrations in Japanese IBD patients...
  23. ncbi request reprint Terminal restriction fragment length polymorphism analysis of the diversity of fecal microbiota in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Inflamm Bowel Dis 13:955-62. 2007
    ..This permits rapid comparison of microbiota from many samples. In this study, we performed T-RFLP analysis of the fecal microbiota from patients with ulcerative colitis (UC)...
  24. ncbi request reprint Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 12:4452-60. 2006
    ..Therapeutic approaches to modulate balance of intestinal microflora and their potential mechanisms of action are also discussed...
  25. ncbi request reprint Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Oncol Rep 16:103-7. 2006
    ....
  26. ncbi request reprint IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts
    Akira Andoh
    Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
    J Immunol 169:1683-7. 2002
    ..Because cooperation between NF-kappaB and IRF-1 is important in the TNF-alpha-induced RANTES gene expression, the major mechanism mediating the inhibitory effect of IL-17 may be achieved by the inhibition of IRF-1 DNA-binding activity...
  27. ncbi request reprint Elevated serum anti-carbonic anhydrase II antibodies in patients with ulcerative colitis
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 9:499-502. 2002
    ..These results suggest that autoimmune responses against CA II may be involved in the pathogenesis of UC, and similar mechanism may participate in the development of pancreatic lesions in UC patients...
  28. ncbi request reprint Sodium butyrate enhances complement-mediated cell injury via down-regulation of decay-accelerating factor expression in colonic cancer cells
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Cancer Immunol Immunother 50:663-72. 2002
    ..These observations indicate that both a down-regulation of DAF expression and the induction of susceptibility to complement attack contribute to the anti-tumor effects of butyrate in colonic cancer...
  29. ncbi request reprint Inhibitory effects of somatostatin on tumor necrosis factor-alpha-induced interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 10:89-93. 2002
    ..These findings suggest that some of the therapeutic actions of somatostatin on acute pancreatitis might be mediated by reducing local IL-6 secretion in the pancreas...
  30. ncbi request reprint Role of complement activation and mast cell degranulation in the pathogenesis of rapid intestinal ischemia/reperfusion injury in rats
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Digestion 63:103-7. 2001
    ..A regulation of the complement activation and MMC degranulation may be one of the clinical strategies for prevention of I/R-induced mucosal injury...
  31. pmc Counter-regulatory effect of sodium butyrate on tumour necrosis factor-alpha (TNF-alpha)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Clin Exp Immunol 118:23-9. 1999
    ..Butyrate action has been discussed with its activity to induce histone hyperacetylation, but its counter-regulatory effect on complement biosynthesis may be closely associated with the modulation of transcription factor activation...
  32. ncbi request reprint Transforming growth factor-beta1 acts as a potent inhibitor of complement C3 biosynthesis in human pancreatic cancer cell lines
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Pancreas 20:138-45. 2000
    ..This action of TGF-beta1 did not correlate with NF-kappaB activation, but associated with the translocation of Fos protein into the nucleus...
  33. pmc Rapid intestinal ischaemia-reperfusion injury is suppressed in genetically mast cell-deficient Ws/Ws rats
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Clin Exp Immunol 116:90-3. 1999
    ..These results provide direct evidence for the role of mast cells in the pathogenesis of intestinal ischaemia-reperfusion injury...
  34. pmc Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Japan
    Clin Exp Immunol 125:56-63. 2001
    ..The combination of IL-17 with IFN-gamma synergistically enhanced chemokine secretion. These effects of IL-17 and IFN-gamma might play an important role in the inflammatory responses in the intestinal mucosa...
  35. ncbi request reprint Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts
    Kazuhito Tasaki
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreatology 3:414-21. 2003
    ..Thus, human pancreatic periacinar myofibroblasts may play an important role in the remodeling of damaged pancreatic tissue in chronic pancreatitis via MMP-1 secretion...
  36. ncbi request reprint Matrix metalloproteinase-3 secretion from human pancreatic periacinar myofibroblasts in response to inflammatory mediators
    Osamu Inatomi
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreas 34:126-32. 2007
    ..However, the regulation of MMP-3 secretion in the pancreas remains unclear. In this study, we assessed the expression of MMP-3 in human pancreatic periacinar myofibroblasts...
  37. ncbi request reprint Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Internal Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Int J Mol Med 19:941-6. 2007
    ..In conclusion, we demonstrated that IL-31 is a potent inducer of proinflammatory mediators in human colonic SEMFs. IL-31 may function as a proinflammatory cytokine derived from Th2 cells...
  38. ncbi request reprint IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts
    Kazunori Hata
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G1035-44. 2002
    ..This was dependent on the enhancement of IL-6 mRNA stability. In conclusion, human SEMFs secreted IL-6, IL-8, and MCP-1 in response to IL-17. These responses might play an important role in the pathogenesis of gut inflammation...
  39. pmc FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice
    Takashi Nishimura
    Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 14:5851-6. 2008
    ..To investigate the effects of FR167653 on the development of dextran sulfate sodium (DSS)-induced colitis in mice...
  40. pmc Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines
    Ayako Kobori
    Division of Gastroenterology, Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Shiga, 520 2192, Japan
    World J Gastroenterol 16:2355-61. 2010
    ..To investigate the effects of butyrate on interleukin (IL)-32alpha expression in epithelial cell lines...
  41. doi request reprint Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-32alpha induction in human pancreatic periacinar myofibroblasts
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G831-8. 2008
    ..IL-32alpha mRNA expression is dependent on interactions between the phosphatidylinositol 3-kinase/Akt-pathway and the NF-kappaB/AP-1 system...
  42. ncbi request reprint Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts
    Zhuobin Zhang
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Int J Mol Med 15:79-83. 2005
    ..In conclusion, this is the first report demonstrating that IL-23 p19 mRNA is inducible in colonic myofibroblasts by IL-1beta and TNF-alpha. The p19 expression in these cells might play a role in mucosal immune responses...
  43. ncbi request reprint Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    J Gastroenterol 40:802-10. 2005
    ..Interleukin (IL)-17 is a newly identified T-cell-specific cytokine. In this study, we investigated the effects of IL-17 on colony-stimulating factor (CSF) release in human colonic subepithelial myofibroblasts (SEMFs)...
  44. doi request reprint Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients
    Takashi Nishimura
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Mol Med Rep 5:517-20. 2012
    ..In conclusion, the ITPA genotypes may be a useful marker for prediction of RBV-induced anemia...
  45. ncbi request reprint IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators
    Mitsue Shimada
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Immunol 168:861-8. 2002
    ..In conclusion, pancreatic periacinar myofibroblasts secreted a large amount of IL-6 in response to proinflammatory cytokines. These cells might play an important role in the pathogenesis of acute pancreatitis via IL-6 secretion...
  46. pmc Interleukin-32 expression in the pancreas
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Biol Chem 284:17868-76. 2009
    ..Pancreatic duct cells are the local source of IL-32, and IL-32 may play an important role in inflammatory responses and pancreatic cancer growth...
  47. doi request reprint Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts
    Atsushi Nishida
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 59:531-41. 2010
    ..The effects of IL33 on the functions of human pancreatic myofibroblasts were also investigated...
  48. ncbi request reprint Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection
    Yasuharu Saito
    Department of Endoscopic Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Dig Dis Sci 53:330-3. 2008
    ..Due to the biodegradable features of this stent, longer term studies are necessary to investigate the relationship between the expected disappearance of the stent and the patency of the stricture...
  49. ncbi request reprint Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis
    Yasuyuki Deguchi
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 52:2993-8. 2007
    ..In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients...
  50. ncbi request reprint Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways
    Shigeki Bamba
    Department of Internal Medicine, Shiga Univ of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G529-38. 2003
    ..Intestinal SEMFs secreted IL-11 in response to IL-1beta- and TGF-beta1. Mucosal IL-11 secretion might be important as an anti-inflammatory response in the pathogenesis of intestinal inflammation...
  51. doi request reprint Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis
    Ayako Kobori
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol 45:999-1007. 2010
    ....
  52. doi request reprint Endoscopic submucosal dissection combined with the placement of biodegradable stents for recurrent esophageal cancer after chemoradiotherapy
    Yosuke Mochizuki
    Division of Digestive Endoscopy, Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    J Gastrointest Cancer 43:324-8. 2012
    ..One month later, the patient reported a feeling of obstruction. An endoscopic examination revealed food stuck in the stents, this was removed, and balloon dilatation provided good passage which has been maintained for 7 months...
  53. ncbi request reprint Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520 2192, Japan
    J Gastroenterol 42:746-53. 2007
    ..We investigated the potential role of interleukin (IL)-17 family members (IL-17A to IL-17F) in the induction of inflammatory responses in human colonic subepithelial myofibroblasts (SEMFs)...
  54. doi request reprint A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29
    Hirotsugu Imaeda
    Department of Medicine, Graduate School of Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Mol Med Rep 4:483-7. 2011
    ..The mRNA expression of this new isoform was significantly elevated in the inflamed mucosa of IBD patients. A new isoform of the IL-32 transcript may play an anti-inflammatory role in the inflamed mucosa of IBD...
  55. pmc Usefulness of bispectral monitoring of conscious sedation during endoscopic mucosal dissection
    Kazunori Hata
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 15:595-8. 2009
    ..To assess the usefulness of bispectral index (BIS) monitoring in order to carry out endoscopic submucosal dissection (ESD) safely and with patients' satisfaction...
  56. doi request reprint Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Oncol Rep 28:1597-605. 2012
    ..Therefore, the molecular mass distribution of the DSS differed between each part in the lumen. As an early stage event, DSS induced colitis through cell cycle arrest and apoptosis according to its molecular mass...
  57. doi request reprint Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts
    Takato Kawamura
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 54:238-45. 2009
    ..In this report, we investigated how SCFAs modulate matrix metalloproteinase (MMP) secretion from human colonic subepithelial myofibroblasts (SEMFs)...
  58. doi request reprint Factors affecting the efficacy of cyclosporin A therapy for refractory ulcerative colitis
    Shigeki Bamba
    Division of Gastroenterology, Department of Internal Medicine, Shiga University of Medical Science, Japan
    J Gastroenterol Hepatol 25:494-8. 2010
    ..We retrospectively investigated patients with refractory UC treated with CSA therapy to elucidate the efficacy and the prognostic factors...
  59. ncbi request reprint Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17
    Shigeki Bamba
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    J Gastroenterol 38:548-54. 2003
    ..In this study, we investigated the effects of interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF)-alpha on matrix metalloproteinase (MMP)-3 secretion in colonic SEMFs...
  60. ncbi request reprint Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis
    Yasuharu Saito
    Division of Endoscopic Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    World J Gastroenterol 13:3977-80. 2007
    ..To report 13 patients with benign esophageal stenosis treated with the biodegradable stent...
  61. doi request reprint The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis
    Hiromitsu Ban
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Oncol Rep 25:1699-703. 2011
    ..DPP-IV inhibitors are thought to promote the proliferation of the intestinal epithelium. However, the amelioration of DSS-induced colitis was only partial...
  62. ncbi request reprint Interleukin-17 and lipopolysaccharides synergistically induce cyclooxygenase-2 expression in human intestinal myofibroblasts
    Zhuobin Zhang
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol Hepatol 20:619-27. 2005
    ..In the present study the effects of interleukin (IL)-17 and lipopolysaccharides (LPS) on cyclooxygenase (COX) expression in colonic SEMF were investigated...
  63. ncbi request reprint Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease
    Hiromitsu Ban
    Department of Medicine, Shiga University of Medical Science, Otsu
    Intern Med 47:1645-8. 2008
    ..TPMT activity is dependent on the genetic polymorphism of high-versus low-metabolizing alleles. We investigated the association between TPMT genotypes and myelosuppression in Japanese IBD patients...
  64. doi request reprint Feasibility of five days of consecutive leukocytapheresis for the treatment of ulcerative colitis: a preliminary study
    Tomoyuki Tsujikawa
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Ther Apher Dial 13:14-8. 2009
    ..This preliminary study showed that five consecutive LCAP sessions are safe and feasible for active UC patients. The therapeutic efficacy and suitable patients for this treatment protocol should be confirmed by further studies...
  65. doi request reprint Interleukin-32α expression in human colonic subepithelial myofibroblasts
    Yuhki Yagi
    Department of Medicine, Graduate School of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Int J Mol Med 27:263-8. 2011
    ..Human colonic SEMFs expressed IL-32α in response to IL-1ß and TNF-α. IL-32α mRNA expression depends on the phosphatidylinositol 3-kinase and the NF-κB system...
  66. doi request reprint The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease
    Hiromistu Ban
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    J Gastroenterol 45:1014-21. 2010
    ..In this study, we investigated the association between MRP4 G2269A polymorphism and thiopurine sensitivity in Japanese IBD patients...
  67. ncbi request reprint Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts
    Osamu Inatomi
    Department of Internal Medicine, Shiga University of Medical Science, Otsu 520 2192, Japan
    Int J Mol Med 18:497-503. 2006
    ..We demonstrated expression of amphiregulin and epiregulin in SEMFs. Amphiregulin and epiregulin may play an important role in the mechanism underlying wound healing in damaged colonic mucosa...
  68. doi request reprint Chemoradiation therapy followed by endoscopic submucosal dissection for esophageal cancer
    Yasuharu Saito
    Division of Endoscopy, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    Dig Dis Sci 53:3242-5. 2008
    ..All patients were recurrence-free for 6 months to 2.5 years. The combination of CRT plus subsequent ESD may be useful for treating patients with esophageal cancer who are not fit to undergo surgery...
  69. doi request reprint A pilot study of leukocytapheresis efficacy with 1.5 liter blood processing volume in patients with ulcerative colitis
    Masaaki Shimada
    Department of Gastroenterology, National Hospital Organization, Nagoya Medical Center, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ther Apher Dial 12:368-73. 2008
    ..5L-LCAP therapy. 1.5L-LCAP was clinically effective for active UC patients. Cellular responses induced by 1.5L-LCAP were similar to those induced by a standard LCAP session...
  70. ncbi request reprint Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts
    T Okuno
    Dept of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Scand J Gastroenterol 37:317-24. 2002
    ....
  71. ncbi request reprint Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts
    Hirofumi Yasui
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Digestion 69:34-44. 2004
    ..We investigated the effects of fibroblast growth factor (FGF)-2 on the secretion of MMPs and TIMPs in human intestinal subepithelial myofibroblasts (SEMFs)...
  72. ncbi request reprint Intestinal subepithelial myofibroblasts in inflammatory bowel diseases
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Gastroenterol 37:33-7. 2002
    ..In particular, PDGF had a strong stimulatory effect. We concluded that colonic SEMFs may play an important role in the repair process of IBD...
  73. ncbi request reprint [Cytoapheresis for IBD]
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:836-42. 2005
    ..In this paper, three types of cytoapheresis [leukocytapheresis (LCAP), granulocytapheresis (GCAP), and centrifugal leukocyte apheresis] are reviewed...
  74. ncbi request reprint Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response
    Akira Andoh
    Department of Gastroenterology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520 2192, Japan
    J Gastroenterol 40:1089-99. 2005
  75. ncbi request reprint Immunohistochemical analysis of cell cycle-regulating-protein (p21, p27, and Ki-67) expression in gastroesophageal reflux disease
    Yorihiro Nishiyama
    Department of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    J Gastroenterol 37:905-11. 2002
    ..The aim of this study was to carry out an immunohistochemical analysis of cell cycle-regulating-protein (p21, p27, and Ki-67) expression in endoscopic biopsy samples obtained using angled biopsy forceps...
  76. ncbi request reprint Newly developed biodegradable stents for benign gastrointestinal tract stenoses: a preliminary clinical trial
    Toyohiko Tanaka
    Department of Radiology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Digestion 74:199-205. 2006
    ..The stenosis had not recurred at the six-month follow-up examination. In conclusion, the newly developed biodegradable stents were useful in treating benign stenoses of the alimentary tract...
  77. doi request reprint An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment
    Atsushi Sakuraba
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Gastroenterol 104:2990-5. 2009
    ..The aim of this study was to assess the clinical efficacy and safety of intensive GMA treatment in patients with active UC...
  78. pmc Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 52:65-70. 2003
    ..Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease (IBD)...
  79. pmc The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease
    T Sugihara
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Clin Exp Immunol 160:386-93. 2010
    ..C3 and IL-17 mRNA expressions are enhanced, with a strong correlation, in the inflamed mucosa of IBD patients. Part of these clinical findings was considered to be mediated by the colonic SEMF response to IL-17...
  80. ncbi request reprint Operative indications for patients with refractory or severe ulcerative colitis
    Tomoyuki Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science, Shiga, Japan
    Hepatogastroenterology 52:1470-3. 2005
    ..Since new treatments using cyclosporin A and leukocytapheresis have been developed, we analyzed historical changes in the operative indications for UC...
  81. pmc Hepatocellular carcinoma occurring in a Crohn's disease patient
    Mitsuaki Ishida
    Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    World J Gastroenterol 16:3215-8. 2010
    ..These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors...
  82. ncbi request reprint A case of severe acute pancreatitis treated with CTR-001 direct hemoperfusion for cytokine apheresis
    Takao Saotome
    Critical and Intensive Care Medicine, Shiga University of Medical Science, Shiga, Japan
    Ther Apher Dial 9:367-71. 2005
    ..0+/-1.9 pg/mL, P=0.726) did not decrease statistically. Therefore, we conclude that in this case, cytokine apheresis using a CTR-001 cartridge was effective for reducing the pro-inflammatory cytokines during severe acute pancreatitis...
  83. ncbi request reprint Supplement of a chitosan and ascorbic acid mixture for Crohn's disease: a pilot study
    Tomoyuki Tsujikawa
    Department of Internal Medicine, Division of Gastroenterology, Shiga University of Medical Science, and the Kirin Brewery Co, Ltd, Research Institute of Life Science, Shiga, Japan
    Nutrition 19:137-9. 2003
    ..We designed a pilot trial to investigate the tolerability and amount of fat excretion after the oral administration of a chitosan and ascorbic mixture for inactive Crohn's disease...
  84. ncbi request reprint Enteral and parenteral nutrition therapy for Crohn's disease
    Tomoyuki Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Curr Pharm Des 9:323-32. 2003
    ....
  85. ncbi request reprint Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520 2192, Japan
    J Gastroenterol 42:29-33. 2007
    ..Furthermore, based on the data from our laboratory, interaction between Th-17 cells and colonic subepithelial myofibroblasts may play an important role in the pathophysiology of IBS and IBD...
  86. ncbi request reprint Medium-chain triglycerides modulate ileitis induced by trinitrobenzene sulfonic acid
    T Tsujikawa
    The Second Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Gastroenterol Hepatol 14:1166-72. 1999
    ..Dietary fat in Crohn's disease is still a controversial risk factor for IBD. We therefore also studied the effects of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) on TNBS ileitis...
  87. ncbi request reprint Interleukin-17 stimulates chemokine (interleukin-8 and monocyte chemoattractant protein-1) secretion in human pancreatic periacinar myofibroblasts
    H Takaya
    Dept of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Japan
    Scand J Gastroenterol 37:239-45. 2002
    ..In this study, we investigated the effects of CD4+ T-cell-derived cytokines on chemokine secretion in human pancreatic periacinar myofibroblasts...
  88. ncbi request reprint Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Gastroenterology 119:211-9. 2000
    ..We have previously isolated and characterized human pancreatic periacinar myofibroblasts. In this study, to define the role of these cells in the pathogenesis of acute pancreatitis, we investigated chemokine expression in them...
  89. ncbi request reprint Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine: preliminary experiences
    T Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science Hospital, Shiga, Japan
    Endoscopy 40:11-5. 2008
    ..The aim of the present study was to evaluate the insertion technique, the safety, and the clinical impact of the SBE system...
  90. ncbi request reprint A case of toxic shock-like syndrome presenting with serious hypoproteinaemia because of a protein-losing gastroenteropathy
    K Tasaki
    Department of Internal Medicine, Shiga University of Medical Science, Ohtsu, Shiga, Japan
    J Intern Med 250:174-9. 2001
    ..Considering these histological findings, some immunological mechanism which lead the activation of cytotoxic T-lymphocytes may play an important role in the pathogenesis of this rare intestinal manifestation of TSLS...
  91. pmc Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease
    M Shioya
    Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan
    Clin Exp Immunol 149:480-6. 2007
    ..Epithelial IL-32alpha expression was increased in IBD patients, and in CD patients in particular. IL-32alpha might be involved in the pathophysiology of IBD as a proinflammatory cytokine and a mediator of innate immune response...
  92. ncbi request reprint Trisomy 10 as the sole abnormality in biphenotypic leukemia
    T Inoue
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Leuk Lymphoma 39:405-9. 2000
    ..No case of biphenotypic leukemia with trisomy 10 has been previously reported, until now...
  93. ncbi request reprint Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)
    K Yamamoto
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan
    Biochim Biophys Acta 1526:10-2. 2001
    ..We demonstrate here that oxidative stress, induced by H(2)O(2), promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR...
  94. ncbi request reprint Ligation of the Fas antigen stimulates chemokine secretion in pancreatic cancer cell line PANC-1
    M Shimada
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    J Gastroenterol Hepatol 16:1060-7. 2001
    ..CONCLUSION: Our results indicate that Fas Ag stimulation can induce chemokine secretion in PANC-1 cells, suggesting the contribution of Fas stimulation to the accumulation of immune cells in pancreatic cancer tissue...
  95. ncbi request reprint Medium-chain triglyceride-rich enteral nutrition is more effective than low-fat enteral nutrition in rat colitis, but is equal in enteritis
    T Tsujikawa
    Second Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Gastroenterol 36:673-80. 2001
    ..We suggest that Twinline may be more useful to improve nutritional status and to reduce the mucosal inflammation in rat colitis, but that Twinline is equal in effect to Elental for rat enteritis...
  96. ncbi request reprint Sequential changes in luminal microflora and mucosal cytokine expression during developing of colitis in HLA-B27/beta2-microglobulin transgenic rats
    K Hata
    Dept. of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Scand J Gastroenterol 36:1185-92. 2001
    ..The colonization of anaerobic bacteria, especially Bacteroides spp., may be initiating and promoting these cytokine responses...
  97. ncbi request reprint Characterization of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis
    H Matsuda
    Department of Internal Medicine, Social Insurance Shiga Hospital, Otsu, Japan
    J Gastroenterol Hepatol 15:61-8. 2000
    ..Based on the hypothesis that the pathogenesis of UC may be closely associated with the mucosal microflora, we investigated alterations in the mucosa-associated microflora of UC patients...
  98. ncbi request reprint Epithelial expression of caveolin-2, but not caveolin-1, is enhanced in the inflamed mucosa of patients with ulcerative colitis
    A Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Japan
    Inflamm Bowel Dis 7:210-4. 2001
    ..Furthermore, our results suggest that there are differences in the phenotypic features of epithelial cells between UC and Crohn's disease...
  99. ncbi request reprint Changes in serum diamine oxidase activity during chemotherapy in patients with hematological malignancies
    T Tsujikawa
    The Second Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Otsu, Japan
    Cancer Lett 147:195-8. 1999
    ..As the dosage of anti-cancer drugs increased, DAO activity decreased more, but its activity was not related to other parameters. These findings suggest that serum DAO could be used as an indicator of mucosal injury during chemotherapy...
  100. ncbi request reprint Mast cells may not play a crucial role in the pathogenesis of experimental closed duodenal loop-induced pancreatitis in rats
    Yoshio Araki
    Department of Internal Medicine, Nagahama Red Cross Hospital, Nagahama, Shiga, Japan
    Pancreas 24:298-302. 2002
    ..Ws/Ws rats have a small deletion of the c-kit gene and are deficient in both mucosal-type mast cells and connective tissue-type mast cells...
  101. ncbi request reprint Modification of intestinal flora in the treatment of inflammatory bowel disease
    Osamu Kanauchi
    Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 10 1 2 Shinkawa Chuo ku, Tokyo, 104 8288, Japan
    Curr Pharm Des 9:333-46. 2003
    ..The use of antibiotics continues to be of interest. Although these strategies hold great promise and appear to be useful in some settings, more clinical study is needed to firmly establish the relevance of these therapies...