Nobuto Shibata

Summary

Country: Japan

Publications

  1. request reprint
    Shibata N, Ohnuma T, Higashi S, Usui C, Ohkubo T, Kitajima A, et al. Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. Neurobiol Aging. 2005;26:1011-4 pubmed
    ..LD of the 5A/6A polymorphism with rs679620 was relatively strong. These results suggest that the common polymorphisms of MMP-9 and MMP-3 investigated here are not associated with AD. ..
  2. request reprint
    Shibata N, Ohnuma T, Higashi S, Higashi M, Usui C, Ohkubo T, et al. Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease. J Gerontol A Biol Sci Med Sci. 2006;61:660-2 pubmed
    ..For the USF 2 gene, the two SNPs did not show significant association with onset of AD. Our study suggests that the three SNPs of the USF 1 gene and two SNPs of the USF 2 gene presented here are not associated with onset of AD. ..
  3. Shibata N, Kuerban B, Komatsu M, Ohnuma T, Baba H, Arai H. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. J Alzheimers Dis. 2010;20:417-21 pubmed publisher
    ..Although rs729211 showed marginal association in the APOE4 negative group, the linkage disequilibrium analysis results suggest this to be a false positive. ..
  4. request reprint
    Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, et al. Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet. 2002;114:436-9 pubmed
    ..These findings suggest that the IL-6prom G allele which may affect plasma IL-6 concentration might be a risk factor for sporadic AD in Japanese. ..
  5. Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H. Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2008;26:161-4 pubmed publisher
    ..We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either. Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD. ..
  6. Shibata N, Ohnuma T, Baba H, Arai H. No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2009;27:273-7 pubmed publisher
    ..In addition, we did not observe any synergetic association between the SNPs studied and apolipoprotein E in our AD patients. Further genetic studies are needed to clarify the relationship between the two genes and AD. ..
  7. Shibata N, Ohnuma T, Baba H, Arai H. Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2009;28:325-9 pubmed publisher
    ..Despite the relatively small sample size, our results indicate a possible genetic association between TDP- 43 and AD. Further genetic studies are needed to clarify the relationship between the TDP-43 gene and AD. ..

Locale

Detail Information

Publications7

  1. request reprint
    Shibata N, Ohnuma T, Higashi S, Usui C, Ohkubo T, Kitajima A, et al. Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. Neurobiol Aging. 2005;26:1011-4 pubmed
    ..LD of the 5A/6A polymorphism with rs679620 was relatively strong. These results suggest that the common polymorphisms of MMP-9 and MMP-3 investigated here are not associated with AD. ..
  2. request reprint
    Shibata N, Ohnuma T, Higashi S, Higashi M, Usui C, Ohkubo T, et al. Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease. J Gerontol A Biol Sci Med Sci. 2006;61:660-2 pubmed
    ..For the USF 2 gene, the two SNPs did not show significant association with onset of AD. Our study suggests that the three SNPs of the USF 1 gene and two SNPs of the USF 2 gene presented here are not associated with onset of AD. ..
  3. Shibata N, Kuerban B, Komatsu M, Ohnuma T, Baba H, Arai H. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. J Alzheimers Dis. 2010;20:417-21 pubmed publisher
    ..Although rs729211 showed marginal association in the APOE4 negative group, the linkage disequilibrium analysis results suggest this to be a false positive. ..
  4. request reprint
    Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, et al. Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet. 2002;114:436-9 pubmed
    ..These findings suggest that the IL-6prom G allele which may affect plasma IL-6 concentration might be a risk factor for sporadic AD in Japanese. ..
  5. Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H. Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2008;26:161-4 pubmed publisher
    ..We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either. Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD. ..
  6. Shibata N, Ohnuma T, Baba H, Arai H. No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2009;27:273-7 pubmed publisher
    ..In addition, we did not observe any synergetic association between the SNPs studied and apolipoprotein E in our AD patients. Further genetic studies are needed to clarify the relationship between the two genes and AD. ..
  7. Shibata N, Ohnuma T, Baba H, Arai H. Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2009;28:325-9 pubmed publisher
    ..Despite the relatively small sample size, our results indicate a possible genetic association between TDP- 43 and AD. Further genetic studies are needed to clarify the relationship between the TDP-43 gene and AD. ..