K Ogita

Summary

Affiliation: Setsunan University
Country: Japan

Publications

  1. ncbi request reprint Activation of c-Jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice
    Makoto Shuto
    Department of Medical Pharmacy, Setsunan University Faculty of Pharmaceutical Sciences, Osaka, Japan
    J Pharmacol Sci 109:60-70. 2009
  2. doi request reprint Lithium promotes neuronal repair and ameliorates depression-like behavior following trimethyltin-induced neuronal loss in the dentate gyrus
    Masanori Yoneyama
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    PLoS ONE 9:e87953. 2014
  3. ncbi request reprint [Activated microglial cells trigger neurogenesis following neuronal loss in the dentate gyrus of adult mice]
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1, Nagaotoge cho, Hirakata 573 0101, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:281-5. 2012
  4. doi request reprint Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Neurosci Lett 511:116-9. 2012
  5. ncbi request reprint Localization of activator protein-1 complex with DNA binding activity in mitochondria of murine brain after in vivo treatment with kainate
    Kiyokazu Ogita
    Department of Pharmacology, Research Institute of Drug Safety, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka 573 0101, Japan
    J Neurosci 22:2561-70. 2002
  6. ncbi request reprint Transcription factor activator protein-1 expressed by kainate treatment can bind to the non-coding region of mitochondrial genome in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan
    J Neurosci Res 73:794-802. 2003
  7. ncbi request reprint In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 48:810-21. 2005
  8. ncbi request reprint In vivo activation of c-Jun N-terminal kinase signaling cascade prior to granule cell death induced by trimethyltin in the dentate gyrus of mice
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 47:619-30. 2004
  9. ncbi request reprint Enhanced binding activity of nuclear antioxidant-response element through possible formation of Nrf2/Fos-B complex after in vivo treatment with kainate in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 46:580-9. 2004
  10. ncbi request reprint In vivo neuroprotective role of NMDA receptors against kainate-induced excitotoxicity in murine hippocampal pyramidal neurons
    Kiyokazu Ogita
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    J Neurochem 85:1336-46. 2003

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Activation of c-Jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice
    Makoto Shuto
    Department of Medical Pharmacy, Setsunan University Faculty of Pharmaceutical Sciences, Osaka, Japan
    J Pharmacol Sci 109:60-70. 2009
    ..Taken together, our data suggest that the neuronal damage induced by TMT was independent of excitotoxicity but that at least some of it was dependent on the JNK cascades in primary cultures of cortical neurons...
  2. doi request reprint Lithium promotes neuronal repair and ameliorates depression-like behavior following trimethyltin-induced neuronal loss in the dentate gyrus
    Masanori Yoneyama
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    PLoS ONE 9:e87953. 2014
    ....
  3. ncbi request reprint [Activated microglial cells trigger neurogenesis following neuronal loss in the dentate gyrus of adult mice]
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1, Nagaotoge cho, Hirakata 573 0101, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:281-5. 2012
    ....
  4. doi request reprint Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Neurosci Lett 511:116-9. 2012
    ..In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice...
  5. ncbi request reprint Localization of activator protein-1 complex with DNA binding activity in mitochondria of murine brain after in vivo treatment with kainate
    Kiyokazu Ogita
    Department of Pharmacology, Research Institute of Drug Safety, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka 573 0101, Japan
    J Neurosci 22:2561-70. 2002
    ....
  6. ncbi request reprint Transcription factor activator protein-1 expressed by kainate treatment can bind to the non-coding region of mitochondrial genome in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan
    J Neurosci Res 73:794-802. 2003
    ..These results suggest that the AP-1 complex expressed by in vivo kainate treatment would bind to AP-1-like sites in the non-coding region of the mitochondrial genome after translocation into mitochondria from murine hippocampus...
  7. ncbi request reprint In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 48:810-21. 2005
    ..Taken together, in vivo activation of NMDA receptors is capable of protecting against kainate-induced neuronal damage through blockade of DNA fragmentation induced by deoxyribonuclease II in the murine hippocampus...
  8. ncbi request reprint In vivo activation of c-Jun N-terminal kinase signaling cascade prior to granule cell death induced by trimethyltin in the dentate gyrus of mice
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 47:619-30. 2004
    ..The prior activation of this pathway could be at least in part involved in the TMT-induced neural damage seen in the dentate granule cells of mice...
  9. ncbi request reprint Enhanced binding activity of nuclear antioxidant-response element through possible formation of Nrf2/Fos-B complex after in vivo treatment with kainate in murine hippocampus
    Kiyokazu Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 46:580-9. 2004
    ..Taken together, kainate signals may enhance nuclear ARE binding through an interaction between constitutive Nrf2 with inducible Fos-B expressed in murine hippocampus...
  10. ncbi request reprint In vivo neuroprotective role of NMDA receptors against kainate-induced excitotoxicity in murine hippocampal pyramidal neurons
    Kiyokazu Ogita
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    J Neurochem 85:1336-46. 2003
    ..Taken together these results indicate that in vivo activation of NMDA receptors is capable of protecting against kainate-induced neuronal damage through blockade of DNA fragmentation in murine hippocampus...
  11. ncbi request reprint Decrease in level of APG-2, a member of the heat shock protein 110 family, in murine brain following systemic administration of kainic acid
    K Ogita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 41:285-93. 2001
    ..These findings indicate that the transient decrease in APG-2 expression is one of the intracellular events elicited by signals peculiar to KA, but not by those peculiar to NMDA, in telencephalon of murine brain...
  12. ncbi request reprint Effects of glutathione depletion by 2-cyclohexen-1-one on excitatory amino acids-induced enhancement of activator protein-1 DNA binding in murine hippocampus
    K Ogita
    Department of Pharmacology, Setsunan University, Hirakata, Osaka, Japan
    J Neurochem 76:1905-15. 2001
    ..These results suggest that endogenous glutathione may be at least in part involved in molecular mechanisms underlying transcriptional control by KA, but not by NMDA, signals of cellular functions...
  13. ncbi request reprint Regeneration of granule neurons after lesioning of hippocampal dentate gyrus: evaluation using adult mice treated with trimethyltin chloride as a model
    Kiyokazu Ogita
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    J Neurosci Res 82:609-21. 2005
    ..Taken together, our data indicate that the hippocampal dentate gyrus itself is capable of regenerating the neuronal cell layer through rapid enhancement of neurogenesis after injury...
  14. ncbi request reprint Identification of three additional members of rat protein kinase C family: delta-, epsilon- and zeta-subspecies
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    FEBS Lett 226:125-8. 1987
    ..The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli...
  15. pmc Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C
    Y Ono
    Central Research Division, Takeda Chemical Industries, Osaka, Japan
    Nucleic Acids Res 16:5199-200. 1988
  16. ncbi request reprint The structure, expression, and properties of additional members of the protein kinase C family
    Y Ono
    Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan
    J Biol Chem 263:6927-32. 1988
    ..Northern blot analysis suggests that the new members of protein kinase C exist in the brain and some other tissues...
  17. ncbi request reprint Selectively high expression of the transcription factor AP1 in telencephalic structures of epileptic E1 mice
    Y Yoneda
    Department of Pharmacology, Setsunan University, Osaka, Japan
    Neurosci Lett 161:161-4. 1993
    ..These results suggest that the transcription factor AP1 may be at least in part responsible for molecular mechanisms underlying pathogenesis of a variety of abnormal symptoms observed in epileptic El mice...
  18. ncbi request reprint Selective potentiation of DNA binding activities of both activator protein 1 and cyclic AMP response element binding protein through in vivo activation of N-methyl-D-aspartate receptor complex in mouse brain
    K Ogita
    Department of Pharmacology, Setsunan University, Osaka, Japan
    J Neurochem 63:525-34. 1994
    ..These results support the proposal that an intracerebroventricular injection of NMDA may selectively potentiate DNA binding activities of both AP1 and CREB through activation of the NMDA receptor complex in mouse brain...
  19. doi request reprint Altered expression of heat shock protein 110 family members in mouse hippocampal neurons following trimethyltin treatment in vivo and in vitro
    Masanori Yoneyama
    Department of Pharmacology, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Neuropharmacology 55:693-703. 2008
    ..Taken together, our data suggest that APG-1 and APG-2 may play different roles from HSP105 in neurons damaged by TMT...
  20. ncbi request reprint In vivo depletion of endogenous glutathione facilitates trimethyltin-induced neuronal damage in the dentate gyrus of mice by enhancing oxidative stress
    Masanori Yoneyama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neurochem Int 52:761-9. 2008
    ..We conclude that endogenous glutathione protectively regulates neuronal damage induced by TMT by attenuating oxidative stress...
  21. doi request reprint High susceptibility of cortical neural progenitor cells to trimethyltin toxicity: involvement of both caspases and calpain in cell death
    Masanori Yoneyama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Neurochem Int 55:257-64. 2009
    ..Taken together, our data indicate that neural progenitor cells are highly susceptible to TMT in undergoing cell death via the activation of 2 parallel pathways, ones involving calpain and the other, caspase-3...
  22. doi request reprint Altered expression of DJ-1 in the hippocampal cells following in vivo and in vitro neuronal damage induced by trimethyltin
    Reiko Nagashima
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neurosci Lett 440:232-6. 2008
    ..TMT treatment produced a dramatic expression of DJ-1 in the astrocytes in the cultures. Taken together, our data suggest that the DJ-1 protein is positively regulated in response to oxidative stress induced by TMT...
  23. ncbi request reprint [Protective effects of N-methyl-D-aspartate against neuronal damages]
    Hiroaki Okuda
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, 45 1, Nagaotoge cho, Hirakata, 573 0101 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 22:153-8. 2002
    ..Taken together, NMDA receptors play the roles of both "accelerator" and "brake" in glutamate-induced neuronal damage...
  24. ncbi request reprint N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100
    Y Yoneda
    Department of Pharmacology, Setsunan University, Hirakata, Japan
    Biochim Biophys Acta 1012:74-80. 1989
    ..These results suggest that synaptic membranes may indeed contain the NMDA-sensitive receptors which are disclosed by Triton X-100 treatment...
  25. pmc Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    Takashi Fujita
    Department of Pharmacology, Setsunan University, Hirakata, Japan
    J Cell Biol 166:85-95. 2004
    ..These findings demonstrate that Runx2 and PI3K-Akt signaling are mutually dependent on each other in the regulation of osteoblast and chondrocyte differentiation and their migration...
  26. doi request reprint Enhanced expression of RNase L as a novel intracellular signal generated by NMDA receptors in mouse cortical neurons
    Chie Sugiyama
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neurochem Int 53:71-8. 2008
    ..Taken together, our data suggest that expression of RNase L is a signal generated by NMDA receptor in cortical neurons. RNase L expression and RNA degradation may be events that cause neuronal damage induced by NMDA receptor activation...
  27. ncbi request reprint Molecular cloning of the m-Golsyn gene and its expression in the mouse brain
    Eishi Funakoshi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Gene Expr 13:27-40. 2006
    ..These results indicate that the m-Golsyn protein may play an important role in intracellular protein transport in neuronal cells of the brain...
  28. ncbi request reprint Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells
    Akiko Yamamuro
    Faculty of Pharmaceutical Sciences, Departments of Pharmacotherapeutics, Setsunan University, 45 1 Nagaotoge cho, 573 0101 Hirakata, Osaka, Japan
    Neurochem Res 31:657-64. 2006
    ..This increase was prevented by N-acetylcysteine. Taken together, our data indicate that ER dysfunction is at least in part involved in the mechanisms underlying cell death induced by 6-OHDA in SH-SY5Y cells...
  29. doi request reprint Enhanced neurogenesis in the olfactory bulb in adult mice after injury induced by acute treatment with trimethyltin
    Masanori Yoneyama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University Hirakata, Osaka, Japan
    J Neurosci Res 88:1242-51. 2010
    ..Taken together, our data suggest that the OB has the ability to undergo enhanced neurogenesis following TMT-induced neuronal injury in adult mice...
  30. ncbi request reprint Expression of m-Golsyn/Syntabulin gene during mouse brain development
    Eishi Funakoshi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neurosci Lett 403:244-9. 2006
    ..These results may indicate a significant role for this protein in neuronal cells and other types of cells such as those of the choroid plexus and ciliary body...
  31. ncbi request reprint Possible in vivo crosstalk between transcription factors with zinc-finger and leucine-zipper motifs in murine peripheral but not central excitable tissues
    Y Azuma
    Department of Pharmacology, Setsunan University, Hirakata, Osaka, Japan
    Neurochem Int 32:325-36. 1998
    ....
  32. ncbi request reprint Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium
    T Kimura
    Faculty of Medicine, Osaka University, 2 2, Yamadaoka, Suita, Osaka, 5650871, Japan
    Biochem Biophys Res Commun 264:86-92. 1999
    ..The highly specific binding of hMafF to the US-2 motif in the human OTR gene, together with its pattern of expression, supports a role for hMafF in OTR gene upregulation at term...
  33. doi request reprint In vivo acute treatment with trimethyltin chloride causes neuronal degeneration in the murine olfactory bulb and anterior olfactory nucleus by different cascades in each region
    Koichi Kawada
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University Hirakata, Osaka, Japan
    J Neurosci Res 86:1635-46. 2008
    ..Taken together, our results suggest that TMT is capable of causing neuronal degeneration in the murine OB and AON through different cascades in the two structures...
  34. ncbi request reprint Enhanced expression of glutathione S-transferase in the hippocampus following acute treatment with trimethyltin in vivo
    Reiko Nagashima
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan
    J Pharmacol Sci 113:267-70. 2010
    ..Our data suggest the prolonged elevation of GST activity in the hippocampus following TMT treatment through enhanced expression of the GST Ya/Yc...
  35. ncbi request reprint Acoustic overstimulation facilitates the expression of glutamate-cysteine ligase catalytic subunit probably through enhanced DNA binding of activator protein-1 and/or NF-kappaB in the murine cochlea
    Reiko Nagashima
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Neurochem Int 51:209-15. 2007
    ..These results suggest that intense noise exposure facilitates the expression of GCL catalytic subunit in the cochlea possibly through the activation of transcription factors including AP-1 and NF-kappaB...
  36. ncbi request reprint Decreased level of mitochondrial RNA by glutamate in cultured cortical neurons
    Chie Sugiyama
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    Neuroreport 18:827-30. 2007
    ..These results suggest that the activation of glutamate signals negatively regulated the expression of mitochondrial mRNA, without affecting the level of mitochondrial DNA...
  37. ncbi request reprint Possible dysfunction of ionotropic glutamate receptors in cerebellum of epileptic E1 mouse brain
    Y Yoneda
    Department of Pharmacology, Setsunan University, Osaka, Japan
    Neurochem Int 25:273-85. 1994
    ..These results suggest that dysfunction of cerebellar Glu receptors may be at least in part responsible for a variety of abnormal symptoms observed in epileptic El mice...
  38. pmc Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties
    Y Ono
    Central Research Division, Takeda Chemical Industries, Osaka, Japan
    Proc Natl Acad Sci U S A 86:3099-103. 1989
    ..The structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from, other subspecies of protein kinase C. Perhaps, this subspecies belongs to another entity of the enzyme family...
  39. ncbi request reprint Enhanced biosynthesis of glutathione in the spiral ganglion of the cochlea after in vivo treatment with dexamethasone in mice
    Reiko Nagashima
    Department of Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences, 45 1 Nagaotoge cho, Hirakata, Osaka 573 0101, Japan
    Brain Res 1117:101-8. 2006
    ..Taken together, DEX has the ability to facilitate GSH biosynthesis through enhanced expression of gamma-GCS in the cochlear spiral ganglion...
  40. doi request reprint Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells
    Masanori Yoneyama
    Department of Pharmacology, Setsunan University, Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    Neurochem Int 56:740-6. 2010
    ..These data suggest that endogenous ROS and nitric oxide are essential for the proliferation of embryonic neural stem/progenitor cells...
  41. ncbi request reprint Endogenous and exogenous glucocorticoids prevent trimethyltin from causing neuronal degeneration of the mouse brain in vivo: involvement of oxidative stress pathways
    Makoto Shuto
    Department of Medical Pharmacy, Setsunan University Faculty of Pharmaceutical Sciences, Hirakata, Osaka, Japan
    J Pharmacol Sci 110:424-36. 2009
    ..Taken together, our data suggest that endogenous and exogenous glucocorticoids prevent neurodegeneration induced by TMT in the central nervous system by attenuating intensive oxidative stress and associated signaling pathways...
  42. ncbi request reprint Transcriptional factors in the cochlea within the inner ear
    Reiko Nagashima
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan
    J Pharmacol Sci 99:301-6. 2005
    ..These include activator protein-1 and nuclear factor-kappa B, glucocorticoid receptor, and so on. Based on recent reports and our investigation, in this article we review possible functions and expression of these transcription factors...
  43. ncbi request reprint Constitutive expression of heterologous N-methyl-D-aspartate receptor subunits in rat adrenal medulla
    Eiichi Hinoi
    Department of Molecular Pharmacology, Kanazawa University Faculty of Pharmaceutical Sciences, Kanazawa, Ishikawa, Japan
    J Neurosci Res 68:36-45. 2002
    ....
  44. ncbi request reprint Nuclear condensation of cyclic adenosine monophosphate responsive element-binding protein in discrete murine brain structures
    Nobuyuki Kuramoto
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Neurosci Res 80:667-76. 2005
    ....
  45. ncbi request reprint Fos-B expression is required for polyamine-induced increase in nuclear activator protein-1 DNA binding in discrete structures of murine brain
    Keiji Inoue
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology, Ishikawa, Japan
    J Neurosci Res 74:199-209. 2003
    ..These results suggest that expression of Fos-B protein may be required for modulation of nuclear gene transcription by both SPD and SPN through stimulation DNA-binding activity of AP1 complex in murine central structures...
  46. ncbi request reprint Apparent presence of Ser133-phosphorylated cyclic AMP response element binding protein (pCREB) in brain mitochondria is due to cross-reactivity of pCREB antibodies with pyruvate dehydrogenase
    Jan Pláteník
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Neurochem 95:1446-60. 2005
    ..In conclusion, this study confirms the presence of pCREB-like IR in brain mitochondria that, after careful scrutiny, turned out to be pyruvate dehydrogenase rather than authentic CREB...
  47. ncbi request reprint Possible correlation between abilities of a variety of polyamines to increase activator protein-1 DNA binding and to inhibit [3H]spermidine transport in nuclear fractions of murine brain
    Keiji Inoue
    Kanazawa University Graduate School of Natural Science and Technology, 13 1 Takara machi, Kanazawa, 920 0934 Ishikawa, Japan
    Brain Res 987:126-30. 2003
    ..These results suggest that polyamines may affect gene transcription by AP1 complex after incorporation into the nucleus in rodent brain...
  48. ncbi request reprint A possible novel mechanism underlying temperature-dependent uptake of [3H]spermidine in nuclear fractions of murine brain
    Nobuyuki Kuramoto
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Brain Res 981:78-84. 2003
    ..These results suggest the possible presence of a hitherto unidentified nuclear transport system for particular polyamines in murine brain...
  49. ncbi request reprint Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation
    Masatsugu Masuda
    Department of Otolaryngology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1068:237-47. 2006
    ..These results suggest that NF-kappaB may have a detrimental role in the response to acoustic overstimulation in the cochlea of mice...
  50. ncbi request reprint Modulation of DNA binding of nuclear transcription factors with leucine-zipper motifs by particular endogenous polyamines in murine central and peripheral excitable tissues
    Nobuyuki Kuramoto
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology, 13 1 Takara machi, Ishikawa 920 0934, Japan
    Brain Res 967:170-80. 2003
    ..These results suggest that both spermine and spermidine may modulate gene transcription through cis- and trans-actions on AP1 binding in the nucleus in murine central and peripheral structures with high excitability...
  51. ncbi request reprint Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea
    Ken Shizuki
    Department of Otolaryngology, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Neurosci Lett 320:73-6. 2002
    ..Since the threshold shift was temporary, the expression of c-Fos is therefore considered to contribute to the survival or protective function of the organ of Corti...
  52. ncbi request reprint Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice
    Yoshiko Morita
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann N Y Acad Sci 1070:450-6. 2006
    ..The present article suggests that PACAP is involved in the corticosterone release in some pathological conditions but not in the basal state...
  53. ncbi request reprint Recent studies on the trimethyltin actions in central nervous systems
    Norihito Shintani
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita City, Japan
    Yakugaku Zasshi 127:451-61. 2007
    ..In this review, we briefly summarize the previous studies and discuss the current status of research on TMT...